SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 1, 2014, Pages 167-177

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings

(8) Lee, Hyun a Mittal, Anuradha a Patel, Kavankumar a Gatuz, Joseph L a Truong, Lena a Torres, Jaime a Mulhearn, Debbie C a Johnson, Michael E a

a UNIVERSITY OF ILLINOIS AT CHICAGO (United States)

Author keywords

Docking; High throughput screening; Pharmacophore modeling; SARS 3CLpro; Surface plasmon resonance; Virtual screening

Indexed keywords

3 CHYMOTRYPSIN LIKE CYSTEINE PROTEASE; ANTIVIRUS AGENT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR DOCKING; PHARMACOPHORE; SARS CORONAVIRUS; SURFACE PLASMON RESONANCE; VIRTUAL REALITY;

SARS CORONAVIRUS;

3 CHYMOTRYPSIN-LIKE CYSTEINE PROTEASE; 3CL(PRO); COMPUTATIONAL SOLVENT MAPPING; CSM; DOCKING; EQUILIBRIUM DISSOCIATION CONSTANT; FLUORESCENCE RESONANCE ENERGY TRANSFER; FRET; HIGH-THROUGHPUT SCREENING; HTS; INHIBITION CONSTANT; K(D); K(I); MD; MLPCN; MOLECULAR DYNAMICS; MOLECULAR LIBRARIES PROBE PRODUCTION CENTERS NETWORK; PHARMACOPHORE MODELING; RECEIVER OPERATING CHARACTERISTIC; RMSD; ROC; ROOT MEAN SQUARE DEVIATION; SARS 3CL(PRO); SARS-COV; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; SPR; SURFACE PLASMON RESONANCE; VIRTUAL SCREENING; VS;

HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SARS VIRUS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84891494439 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.11.041 Document Type: Article

Times cited : (50)

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