메뉴 건너뛰기




Volumn 1, Issue 11, 2016, Pages 512-522

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches to Bypass It

Author keywords

Gram negative resistance; multidrug efflux; outer membrane; permeability barrier

Indexed keywords

ANTIBIOTIC AGENT; LIPOPOLYSACCHARIDE; OUTER MEMBRANE PROTEIN;

EID: 84963979272     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.5b00097     Document Type: Article
Times cited : (446)

References (124)
  • 1
    • 10944272743 scopus 로고    scopus 로고
    • Antibacterial resistance worldwide: Causes, challenges and responses
    • Levy, S. B. and Marshall, B. (2004) Antibacterial resistance worldwide: causes, challenges and responses Nat. Med. 10, S122 10.1038/nm1145
    • (2004) Nat. Med. , vol.10 , pp. S122
    • Levy, S.B.1    Marshall, B.2
  • 2
    • 84870946642 scopus 로고    scopus 로고
    • For the National Healthcare Safety Network, T., and Participating, N. F. Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
    • Sievert, D. M. P., Ricks, P. P., Edwards, J. R. M. S., Schneider, A. M. P. H., Patel, J. P., Srinivasan, A. M. D., Kallen, A. M. D., Limbago, B. P., and Fridkin, S. M. D. (2013) For the National Healthcare Safety Network, T., and Participating, N. F. Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010 Infect. Control Hospital Epidemiol. 34, 1-14 10.1086/668770
    • (2013) Infect. Control Hospital Epidemiol. , vol.34 , pp. 1-14
    • Sievert, D.M.P.1    Ricks, P.P.2    Edwards, J.R.M.S.3    Schneider, A.M.P.H.4    Patel, J.P.5    Srinivasan, A.M.D.6    Kallen, A.M.D.7    Limbago, B.P.8    Fridkin, S.M.D.9
  • 3
    • 16644364407 scopus 로고    scopus 로고
    • The need for new antibiotics
    • Livermore, D. M. (2004) The need for new antibiotics Clin. Microbiol. Infect. 10 (Suppl. 4) 1-9 10.1111/j.1465-0691.2004.1004.x
    • (2004) Clin. Microbiol. Infect. , vol.10 , pp. 1-9
    • Livermore, D.M.1
  • 5
    • 84856662229 scopus 로고    scopus 로고
    • Mechanisms of Resistance and Clinical Relevance of Resistance to β-Lactams, Glycopeptides, and Fluoroquinolones
    • Rice, L. B. (2012) Mechanisms of Resistance and Clinical Relevance of Resistance to β-Lactams, Glycopeptides, and Fluoroquinolones Mayo Clin. Proc. 87, 198-208 10.1016/j.mayocp.2011.12.003
    • (2012) Mayo Clin. Proc. , vol.87 , pp. 198-208
    • Rice, L.B.1
  • 6
    • 84928429317 scopus 로고    scopus 로고
    • Emerging Issues in Gram-Negative Bacterial Resistance: An Update for the Practicing Clinician
    • Vasoo, S., Barreto, J. N., and Tosh, P. K. (2015) Emerging Issues in Gram-Negative Bacterial Resistance: An Update for the Practicing Clinician Mayo Clin. Proc. 90, 395-403 10.1016/j.mayocp.2014.12.002
    • (2015) Mayo Clin. Proc. , vol.90 , pp. 395-403
    • Vasoo, S.1    Barreto, J.N.2    Tosh, P.K.3
  • 7
    • 78751477224 scopus 로고    scopus 로고
    • Challenges of Antibacterial Discovery
    • Silver, L. L. (2011) Challenges of Antibacterial Discovery Clin. Microbiol. Rev. 24, 71-109 10.1128/CMR.00030-10
    • (2011) Clin. Microbiol. Rev. , vol.24 , pp. 71-109
    • Silver, L.L.1
  • 8
    • 84861423745 scopus 로고    scopus 로고
    • Antibiotics: Recover the lost art of drug discovery
    • Lewis, K. (2012) Antibiotics: Recover the lost art of drug discovery Nature 485, 439-440 10.1038/485439a
    • (2012) Nature , vol.485 , pp. 439-440
    • Lewis, K.1
  • 9
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., and Feeney, P. J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 46, 3-26 10.1016/S0169-409X(00)00129-0
    • (2001) Adv. Drug Delivery Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 10
    • 67649225181 scopus 로고    scopus 로고
    • Mechanisms of drug efflux and strategies to combat them. Preface
    • Zgurskaya, H. I. (2009) Mechanisms of drug efflux and strategies to combat them. Preface Biochim. Biophys. Acta, Proteins Proteomics 1794, 723-724 10.1016/j.bbapap.2009.03.017
    • (2009) Biochim. Biophys. Acta, Proteins Proteomics , vol.1794 , pp. 723-724
    • Zgurskaya, H.I.1
  • 11
    • 65249146929 scopus 로고    scopus 로고
    • Multidrug Resistance in Bacteria
    • Nikaido, H. (2009) Multidrug Resistance in Bacteria Annu. Rev. Biochem. 78, 119-146 10.1146/annurev.biochem.78.082907.145923
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 119-146
    • Nikaido, H.1
  • 12
    • 84926035587 scopus 로고    scopus 로고
    • The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
    • Li, X.-Z., Plésiat, P., and Nikaido, H. (2015) The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria Clin. Microbiol. Rev. 28, 337-418 10.1128/CMR.00117-14
    • (2015) Clin. Microbiol. Rev. , vol.28 , pp. 337-418
    • Li, X.-Z.1    Plésiat, P.2    Nikaido, H.3
  • 13
    • 64649088018 scopus 로고    scopus 로고
    • Outer membrane permeability and antibiotic resistance
    • Delcour, A. H. (2009) Outer membrane permeability and antibiotic resistance Biochim. Biophys. Acta, Proteins Proteomics 1794, 808-816 10.1016/j.bbapap.2008.11.005
    • (2009) Biochim. Biophys. Acta, Proteins Proteomics , vol.1794 , pp. 808-816
    • Delcour, A.H.1
  • 14
    • 0347479229 scopus 로고    scopus 로고
    • Molecular basis of bacterial outer membrane permeability revisited
    • Nikaido, H. (2003) Molecular basis of bacterial outer membrane permeability revisited Microbiol. Mol. Biol. Rev.: MMBR 67, 593-656 10.1128/MMBR.67.4.593-656.2003
    • (2003) Microbiol. Mol. Biol. Rev.: MMBR , vol.67 , pp. 593-656
    • Nikaido, H.1
  • 15
    • 33845886664 scopus 로고    scopus 로고
    • Waltzing transporters and 'the dance macabre' between humans and bacteria
    • Lomovskaya, O., Zgurskaya, H. I., Totrov, M., and Watkins, W. J. (2007) Waltzing transporters and 'the dance macabre' between humans and bacteria Nat. Rev. Drug Discovery 6, 56-65 10.1038/nrd2200
    • (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 56-65
    • Lomovskaya, O.1    Zgurskaya, H.I.2    Totrov, M.3    Watkins, W.J.4
  • 16
    • 70349218869 scopus 로고    scopus 로고
    • Multicomponent drug efflux complexes: Architecture and mechanism of assembly
    • Zgurskaya, H. I. (2009) Multicomponent drug efflux complexes: architecture and mechanism of assembly Future Microbiol. 4, 919-932 10.2217/fmb.09.62
    • (2009) Future Microbiol. , vol.4 , pp. 919-932
    • Zgurskaya, H.I.1
  • 17
    • 0033039934 scopus 로고    scopus 로고
    • In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM
    • Ziha-Zarifi, I., Llanes, C., Kohler, T., Pechere, J. C., and Plesiat, P. (1999) In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM Antimicrob. Agents Chemother. 43, 287-291
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 287-291
    • Ziha-Zarifi, I.1    Llanes, C.2    Kohler, T.3    Pechere, J.C.4    Plesiat, P.5
  • 18
    • 78751683371 scopus 로고    scopus 로고
    • Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance
    • Swick, M. C., Morgan-Linnell, S. K., Carlson, K. M., and Zechiedrich, L. (2011) Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance Antimicrob. Agents Chemother. 55, 921-924 10.1128/AAC.00996-10
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 921-924
    • Swick, M.C.1    Morgan-Linnell, S.K.2    Carlson, K.M.3    Zechiedrich, L.4
  • 20
    • 76749117483 scopus 로고    scopus 로고
    • Mechanisms of resistance to ciprofloxacin, ampicillin/sulbactam and imipenem in Acinetobacter baumannii clinical isolates in Taiwan
    • Chiu, C.-H., Lee, H.-Y., Tseng, L.-Y., Chen, C.-L., Chia, J.-H., Su, L.-H., and Liu, S.-Y. (2010) Mechanisms of resistance to ciprofloxacin, ampicillin/sulbactam and imipenem in Acinetobacter baumannii clinical isolates in Taiwan Int. J. Antimicrob. Agents 35, 382-386 10.1016/j.ijantimicag.2009.12.009
    • (2010) Int. J. Antimicrob. Agents , vol.35 , pp. 382-386
    • Chiu, C.-H.1    Lee, H.-Y.2    Tseng, L.-Y.3    Chen, C.-L.4    Chia, J.-H.5    Su, L.-H.6    Liu, S.-Y.7
  • 21
    • 0345528960 scopus 로고    scopus 로고
    • Structure of bacterial lipopolysaccharides
    • Caroff, M. and Karibian, D. (2003) Structure of bacterial lipopolysaccharides Carbohydr. Res. 338, 2431-2447 10.1016/j.carres.2003.07.010
    • (2003) Carbohydr. Res. , vol.338 , pp. 2431-2447
    • Caroff, M.1    Karibian, D.2
  • 22
    • 79960855994 scopus 로고    scopus 로고
    • Structural diversity of the core oligosaccharide domain of Pseudomonas aeruginosa lipopolysaccharide
    • Kocincova, D. and Lam, J. S. (2011) Structural diversity of the core oligosaccharide domain of Pseudomonas aeruginosa lipopolysaccharide Biochemistry 76, 755-760 10.1134/S0006297911070054
    • (2011) Biochemistry , vol.76 , pp. 755-760
    • Kocincova, D.1    Lam, J.S.2
  • 23
    • 34547531757 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa lipopolysaccharide: A major virulence factor, initiator of inflammation and target for effective immunity
    • Pier, G. B. (2007) Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity Int. J. Med. Microbiol. 297, 277-295 10.1016/j.ijmm.2007.03.012
    • (2007) Int. J. Med. Microbiol. , vol.297 , pp. 277-295
    • Pier, G.B.1
  • 25
    • 0345767201 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4
    • Ernst, R. K., Hajjar, A. M., Tsai, J. H., Moskowitz, S. M., Wilson, C. B., and Miller, S. I. (2003) Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4 J. Endotoxin Res. 9, 395-400 10.1177/09680519030090060201
    • (2003) J. Endotoxin Res. , vol.9 , pp. 395-400
    • Ernst, R.K.1    Hajjar, A.M.2    Tsai, J.H.3    Moskowitz, S.M.4    Wilson, C.B.5    Miller, S.I.6
  • 26
    • 58149107409 scopus 로고    scopus 로고
    • Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides
    • De Soyza, A., Silipo, A., Lanzetta, R., Govan, J. R., and Molinaro, A. (2008) Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides Innate Immun. 14, 127-144 10.1177/1753425908093984
    • (2008) Innate Immun. , vol.14 , pp. 127-144
    • De Soyza, A.1    Silipo, A.2    Lanzetta, R.3    Govan, J.R.4    Molinaro, A.5
  • 28
    • 0026608845 scopus 로고
    • Outer membranes of Gram-negative bacteria are permeable to steroid probes
    • Plésiat, P. and Nikaido, H. (1992) Outer membranes of Gram-negative bacteria are permeable to steroid probes Mol. Microbiol. 6, 1323-1333 10.1111/j.1365-2958.1992.tb00853.x
    • (1992) Mol. Microbiol. , vol.6 , pp. 1323-1333
    • Plésiat, P.1    Nikaido, H.2
  • 29
    • 0030778846 scopus 로고    scopus 로고
    • Use of steroids to monitor alterations in the outer membrane of Pseudomonas aeruginosa
    • Plesiat, P., Aires, J. R., Godard, C., and Köhler, T. (1997) Use of steroids to monitor alterations in the outer membrane of Pseudomonas aeruginosa J. Bacteriol. 179, 7004-7010
    • (1997) J. Bacteriol. , vol.179 , pp. 7004-7010
    • Plesiat, P.1    Aires, J.R.2    Godard, C.3    Köhler, T.4
  • 30
    • 0345528960 scopus 로고    scopus 로고
    • Structure of bacterial lipopolysaccharides
    • Caroff, M. and Karibian, D. (2003) Structure of bacterial lipopolysaccharides Carbohydr. Res. 338, 2431-2447 10.1016/j.carres.2003.07.010
    • (2003) Carbohydr. Res. , vol.338 , pp. 2431-2447
    • Caroff, M.1    Karibian, D.2
  • 31
    • 34047095991 scopus 로고    scopus 로고
    • Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa
    • Knirel, Y. A., Bystrova, O. V., Kocharova, N. A., Zahringer, U., and Pier, G. B. (2006) Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa J. Endotoxin Res. 12, 324-336 10.1179/096805106X118906
    • (2006) J. Endotoxin Res. , vol.12 , pp. 324-336
    • Knirel, Y.A.1    Bystrova, O.V.2    Kocharova, N.A.3    Zahringer, U.4    Pier, G.B.5
  • 33
    • 0344235237 scopus 로고    scopus 로고
    • Structure of the core-oligosaccharide with a characteristic d -glycero-α- d -talo-oct-2-ulosylonate-(2→4)-3-deoxy- d -manno-oct-2-ulosonate [α-Ko-(2→4)-Kdo] disaccharide in the lipopolysaccharide from Burkholderia cepacia
    • Isshiki, Y., Zähringer, U., and Kawahara, K. (2003) Structure of the core-oligosaccharide with a characteristic d -glycero-α- d -talo-oct-2-ulosylonate-(2→4)-3-deoxy- d -manno-oct-2-ulosonate [α-Ko-(2→4)-Kdo] disaccharide in the lipopolysaccharide from Burkholderia cepacia Carbohydr. Res. 338, 2659-2666 10.1016/j.carres.2003.07.005
    • (2003) Carbohydr. Res. , vol.338 , pp. 2659-2666
    • Isshiki, Y.1    Zähringer, U.2    Kawahara, K.3
  • 34
    • 0030811916 scopus 로고    scopus 로고
    • Structural Investigation of the Lipopolysaccharide from Acinetobacter haemolyticus Strain NCTC 10305 (ATCC 17906, DNA Group 4)
    • Vinogradov, E. V., Müller-Loennies, S., Petersen, B. O., Meshkov, S., Thomas-Oates, J. E., Holst, O., and Brade, H. (1997) Structural Investigation of the Lipopolysaccharide from Acinetobacter haemolyticus Strain NCTC 10305 (ATCC 17906, DNA Group 4) Eur. J. Biochem. 247, 82-90 10.1111/j.1432-1033.1997.00082.x
    • (1997) Eur. J. Biochem. , vol.247 , pp. 82-90
    • Vinogradov, E.V.1    Müller-Loennies, S.2    Petersen, B.O.3    Meshkov, S.4    Thomas-Oates, J.E.5    Holst, O.6    Brade, H.7
  • 35
    • 0038785886 scopus 로고    scopus 로고
    • Review: Lipopolysaccharide of Burkholderia cepacia complex
    • Vinion-Dubiel, A. D. and Goldberg, J. B. (2003) Review: Lipopolysaccharide of Burkholderia cepacia complex J. Endotoxin Res. 9, 201-213 10.1177/09680519030090040101
    • (2003) J. Endotoxin Res. , vol.9 , pp. 201-213
    • Vinion-Dubiel, A.D.1    Goldberg, J.B.2
  • 36
    • 35048828537 scopus 로고    scopus 로고
    • PhoPQ-Mediated Regulation Produces a More Robust Permeability Barrier in the Outer Membrane of Salmonella enterica Serovar Typhimurium
    • Murata, T., Tseng, W., Guina, T., Miller, S. I., and Nikaido, H. (2007) PhoPQ-Mediated Regulation Produces a More Robust Permeability Barrier in the Outer Membrane of Salmonella enterica Serovar Typhimurium J. Bacteriol. 189, 7213-7222 10.1128/JB.00973-07
    • (2007) J. Bacteriol. , vol.189 , pp. 7213-7222
    • Murata, T.1    Tseng, W.2    Guina, T.3    Miller, S.I.4    Nikaido, H.5
  • 37
    • 34548605458 scopus 로고    scopus 로고
    • Lipid A Modification Systems in Gram-Negative Bacteria
    • Raetz, C. R. H., Reynolds, C. M., Trent, M. S., and Bishop, R. E. (2007) Lipid A Modification Systems in Gram-Negative Bacteria Annu. Rev. Biochem. 76, 295-329 10.1146/annurev.biochem.76.010307.145803
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 295-329
    • Raetz, C.R.H.1    Reynolds, C.M.2    Trent, M.S.3    Bishop, R.E.4
  • 38
    • 0030984298 scopus 로고    scopus 로고
    • Regulation of Lipid A Modifications by Salmonella typhimurium Virulence Genes phoP-phoQ
    • Guo, L., Lim, K. B., Gunn, J. S., Bainbridge, B., Darveau, R. P., Hackett, M., and Miller, S. I. (1997) Regulation of Lipid A Modifications by Salmonella typhimurium Virulence Genes phoP-phoQ Science 276, 250-253 10.1126/science.276.5310.250
    • (1997) Science , vol.276 , pp. 250-253
    • Guo, L.1    Lim, K.B.2    Gunn, J.S.3    Bainbridge, B.4    Darveau, R.P.5    Hackett, M.6    Miller, S.I.7
  • 39
    • 84987804431 scopus 로고    scopus 로고
    • Mechanisms of polymyxin resistance: Acquired and intrinsic resistance in bacteria
    • Olaitan, A. O., Morand, S., and Rolain, J.-M. (2014) Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria Front. Microbiol. 5, 643 10.3389/fmicb.2014.00643
    • (2014) Front. Microbiol. , vol.5 , pp. 643
    • Olaitan, A.O.1    Morand, S.2    Rolain, J.-M.3
  • 40
    • 84924598673 scopus 로고    scopus 로고
    • Lipopolysaccharide membrane building and simulation
    • (Lütteke, T. and Frank, M. Eds.), Springer, New York
    • Jo, S., Wu, E., Stuhlsatz, D., Klauda, J., MacKerell, A., Jr., Widmalm, G., and Im, W. (2015) Lipopolysaccharide membrane building and simulation. In Glycoinformatics (Lütteke, T. and Frank, M., Eds.), pp 391-406, Springer, New York.
    • (2015) Glycoinformatics , pp. 391-406
    • Jo, S.1    Wu, E.2    Stuhlsatz, D.3    Klauda, J.4    MacKerell, A.5    Widmalm, G.6    Im, W.7
  • 41
    • 84934928427 scopus 로고    scopus 로고
    • The membranes of Gram-negative bacteria: Progress in molecular modelling and simulation
    • Khalid, S., Berglund, N. A., Holdbrook, D. A., Leung, Y. M., and Parkin, J. (2015) The membranes of Gram-negative bacteria: progress in molecular modelling and simulation Biochem. Soc. Trans. 43, 162-167 10.1042/BST20140262
    • (2015) Biochem. Soc. Trans. , vol.43 , pp. 162-167
    • Khalid, S.1    Berglund, N.A.2    Holdbrook, D.A.3    Leung, Y.M.4    Parkin, J.5
  • 42
    • 84902347383 scopus 로고    scopus 로고
    • Modeling the electrostatic potential of asymmetric lipopolysaccharide membranes: The MEMPOT algorithm implemented in DelPhi
    • Dias, R. P., Li, L., Soares, T. A., and Alexov, E. (2014) Modeling the electrostatic potential of asymmetric lipopolysaccharide membranes: the MEMPOT algorithm implemented in DelPhi J. Comput. Chem. 35, 1418-1429 10.1002/jcc.23632
    • (2014) J. Comput. Chem. , vol.35 , pp. 1418-1429
    • Dias, R.P.1    Li, L.2    Soares, T.A.3    Alexov, E.4
  • 43
    • 84889070118 scopus 로고    scopus 로고
    • Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes
    • Nascimento, A., Pontes, F. J. S., Lins, R. D., and Soares, T. A. (2014) Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes Chem. Commun. 50, 231-233 10.1039/C3CC46918B
    • (2014) Chem. Commun. , vol.50 , pp. 231-233
    • Nascimento, A.1    Pontes, F.J.S.2    Lins, R.D.3    Soares, T.A.4
  • 44
    • 84856729230 scopus 로고    scopus 로고
    • Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
    • Nikaido, H. and Pages, J. M. (2012) Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria FEMS Microbiol Rev. 36, 340-363 10.1111/j.1574-6976.2011.00290.x
    • (2012) FEMS Microbiol Rev. , vol.36 , pp. 340-363
    • Nikaido, H.1    Pages, J.M.2
  • 45
    • 56349139534 scopus 로고    scopus 로고
    • The porin and the permeating antibiotic: A selective diffusion barrier in Gram-negative bacteria
    • Pages, J. M., James, C. E., and Winterhalter, M. (2008) The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria Nat. Rev. Microbiol. 6, 893-903 10.1038/nrmicro1994
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 893-903
    • Pages, J.M.1    James, C.E.2    Winterhalter, M.3
  • 46
    • 84930804448 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics
    • Pletzer, D., Braun, Y., Dubiley, S., Lafon, C., Köhler, T., Page, M. G. P., Mourez, M., Severinov, K., and Weingart, H. (2015) The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics J. Bacteriol. 197, 2217-2228 10.1128/JB.00234-15
    • (2015) J. Bacteriol. , vol.197 , pp. 2217-2228
    • Pletzer, D.1    Braun, Y.2    Dubiley, S.3    Lafon, C.4    Köhler, T.5    Page, M.G.P.6    Mourez, M.7    Severinov, K.8    Weingart, H.9
  • 47
    • 84874217352 scopus 로고    scopus 로고
    • On the role of TolC in multidrug efflux: The function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein
    • Krishnamoorthy, G., Tikhonova, E. B., Dhamdhere, G., and Zgurskaya, H. I. (2013) On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein Mol. Microbiol. 87, 982-997 10.1111/mmi.12143
    • (2013) Mol. Microbiol. , vol.87 , pp. 982-997
    • Krishnamoorthy, G.1    Tikhonova, E.B.2    Dhamdhere, G.3    Zgurskaya, H.I.4
  • 48
    • 77949360141 scopus 로고    scopus 로고
    • AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening
    • Weeks, J. W., Celaya-Kolb, T., Pecora, S., and Misra, R. (2010) AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening Mol. Microbiol. 75, 1468-1483 10.1111/j.1365-2958.2010.07068.x
    • (2010) Mol. Microbiol. , vol.75 , pp. 1468-1483
    • Weeks, J.W.1    Celaya-Kolb, T.2    Pecora, S.3    Misra, R.4
  • 49
    • 33645545857 scopus 로고    scopus 로고
    • The outer membranes of Pseudomonads
    • (Ramos, J.-L. Ed.), Kluwer Academic/Plenum Publishers, New York
    • Tamber, S. and Hancock, R. E. (2004) The outer membranes of Pseudomonads. In Pseudomonas (Ramos, J.-L., Ed.), pp 575-601, Kluwer Academic/Plenum Publishers, New York.
    • (2004) Pseudomonas , pp. 575-601
    • Tamber, S.1    Hancock, R.E.2
  • 50
    • 84866342585 scopus 로고    scopus 로고
    • OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii
    • Sugawara, E. and Nikaido, H. (2012) OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii J. Bacteriol. 194, 4089-4096 10.1128/JB.00435-12
    • (2012) J. Bacteriol. , vol.194 , pp. 4089-4096
    • Sugawara, E.1    Nikaido, H.2
  • 51
    • 34447556772 scopus 로고    scopus 로고
    • Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii
    • Vila, J., Martí, S., and Sánchez-Céspedes, J. (2007) Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii J. Antimicrob. Chemother. 59, 1210-1215 10.1093/jac/dkl509
    • (2007) J. Antimicrob. Chemother. , vol.59 , pp. 1210-1215
    • Vila, J.1    Martí, S.2    Sánchez-Céspedes, J.3
  • 52
    • 84858441728 scopus 로고    scopus 로고
    • Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa
    • Sugawara, E., Nagano, K., and Nikaido, H. (2012) Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa FEBS J. 279, 910-918 10.1111/j.1742-4658.2012.08481.x
    • (2012) FEBS J. , vol.279 , pp. 910-918
    • Sugawara, E.1    Nagano, K.2    Nikaido, H.3
  • 53
    • 33745218065 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa Porin OprF Exists in Two Different Conformations
    • Sugawara, E., Nestorovich, E. M., Bezrukov, S. M., and Nikaido, H. (2006) Pseudomonas aeruginosa Porin OprF Exists in Two Different Conformations J. Biol. Chem. 281, 16220-16229 10.1074/jbc.M600680200
    • (2006) J. Biol. Chem. , vol.281 , pp. 16220-16229
    • Sugawara, E.1    Nestorovich, E.M.2    Bezrukov, S.M.3    Nikaido, H.4
  • 54
    • 84866342585 scopus 로고    scopus 로고
    • OmpA is the principal nonspecific slow porin of Acinetobacter baumannii
    • Sugawara, E. and Nikaido, H. (2012) OmpA is the principal nonspecific slow porin of Acinetobacter baumannii J. Bacteriol. 194, 4089-4096 10.1128/JB.00435-12
    • (2012) J. Bacteriol. , vol.194 , pp. 4089-4096
    • Sugawara, E.1    Nikaido, H.2
  • 55
    • 84876924253 scopus 로고    scopus 로고
    • Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa
    • Eren, E., Parkin, J., Adelanwa, A., Cheneke, B., Movileanu, L., Khalid, S., and van den Berg, B. (2013) Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa J. Biol. Chem. 288, 12042-12053 10.1074/jbc.M113.463570
    • (2013) J. Biol. Chem. , vol.288 , pp. 12042-12053
    • Eren, E.1    Parkin, J.2    Adelanwa, A.3    Cheneke, B.4    Movileanu, L.5    Khalid, S.6    Van Den Berg, B.7
  • 56
    • 33644903806 scopus 로고    scopus 로고
    • Role of the Novel OprD Family of Porins in Nutrient Uptake in Pseudomonas aeruginosa
    • Tamber, S., Ochs, M. M., and Hancock, R. E. W. (2006) Role of the Novel OprD Family of Porins in Nutrient Uptake in Pseudomonas aeruginosa J. Bacteriol. 188, 45-54 10.1128/JB.188.1.45-54.2006
    • (2006) J. Bacteriol. , vol.188 , pp. 45-54
    • Tamber, S.1    Ochs, M.M.2    Hancock, R.E.W.3
  • 57
    • 84870354012 scopus 로고    scopus 로고
    • Structural Basis for Outer Membrane Sugar Uptake in Pseudomonads
    • van den Berg, B. (2012) Structural Basis for Outer Membrane Sugar Uptake in Pseudomonads J. Biol. Chem. 287, 41044-41052 10.1074/jbc.M112.408518
    • (2012) J. Biol. Chem. , vol.287 , pp. 41044-41052
    • Van Den Berg, B.1
  • 58
    • 84934892567 scopus 로고    scopus 로고
    • Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii
    • Zahn, M., D'Agostino, T., Eren, E., Baslé, A., Ceccarelli, M., and van den Berg, B. (2015) Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii J. Mol. Biol. 427, 2329-2339 10.1016/j.jmb.2015.03.016
    • (2015) J. Mol. Biol. , vol.427 , pp. 2329-2339
    • Zahn, M.1    D'Agostino, T.2    Eren, E.3    Baslé, A.4    Ceccarelli, M.5    Van Den Berg, B.6
  • 59
    • 16244406203 scopus 로고    scopus 로고
    • Acquisition of Resistance to Carbapenems in Multidrug-Resistant Clinical Strains of Acinetobacter baumannii: Natural Insertional Inactivation of a Gene Encoding a Member of a Novel Family of β-Barrel Outer Membrane Proteins
    • Mussi, M. A., Limansky, A. S., and Viale, A. M. (2005) Acquisition of Resistance to Carbapenems in Multidrug-Resistant Clinical Strains of Acinetobacter baumannii: Natural Insertional Inactivation of a Gene Encoding a Member of a Novel Family of β-Barrel Outer Membrane Proteins Antimicrob. Agents Chemother. 49, 1432-1440 10.1128/AAC.49.4.1432-1440.2005
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 1432-1440
    • Mussi, M.A.1    Limansky, A.S.2    Viale, A.M.3
  • 60
    • 0009652780 scopus 로고
    • The outer membrane of Acinetobacter: Structure-function relationships
    • (Towner, K. J. Bergogne-Berezin, E. and Fewson, C. A. Eds.), Plenum Press, New York
    • Borneleit, P. and Kleber, H.-P. (1991) The outer membrane of Acinetobacter: structure-function relationships. In The Biology of Acinetobacter (Towner, K. J., Bergogne-Berezin, E., and Fewson, C. A., Eds.), pp 259-272, Plenum Press, New York.
    • (1991) The Biology of Acinetobacter , pp. 259-272
    • Borneleit, P.1    Kleber, H.-P.2
  • 61
    • 10944239453 scopus 로고    scopus 로고
    • Expression and refolding of Omp38 from Burkholderia pseudomallei and Burkholderia thailandensis, and its function as a diffusion porin
    • Siritapetawee, J., Prinz, H., Krittanai, C., and Suginta, W. (2004) Expression and refolding of Omp38 from Burkholderia pseudomallei and Burkholderia thailandensis, and its function as a diffusion porin Biochem. J. 384, 609-617 10.1042/BJ20041102
    • (2004) Biochem. J. , vol.384 , pp. 609-617
    • Siritapetawee, J.1    Prinz, H.2    Krittanai, C.3    Suginta, W.4
  • 62
    • 79954682717 scopus 로고    scopus 로고
    • Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain
    • Suginta, W., Mahendran, K. R., Chumjan, W., Hajjar, E., Schulte, A., Winterhalter, M., and Weingart, H. (2011) Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain Biochim. Biophys. Acta, Biomembr. 1808, 1552-1559 10.1016/j.bbamem.2010.10.018
    • (2011) Biochim. Biophys. Acta, Biomembr. , vol.1808 , pp. 1552-1559
    • Suginta, W.1    Mahendran, K.R.2    Chumjan, W.3    Hajjar, E.4    Schulte, A.5    Winterhalter, M.6    Weingart, H.7
  • 63
    • 1242314749 scopus 로고    scopus 로고
    • Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis
    • Siritapetawee, J., Prinz, H., Samosornsuk, W., Ashley, R. H., and Suginta, W. (2004) Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis Biochem. J. 377, 579-587 10.1042/bj20031118
    • (2004) Biochem. J. , vol.377 , pp. 579-587
    • Siritapetawee, J.1    Prinz, H.2    Samosornsuk, W.3    Ashley, R.H.4    Suginta, W.5
  • 65
    • 79955388745 scopus 로고    scopus 로고
    • Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC
    • Tikhonova, E. B., Yamada, Y., and Zgurskaya, H. I. (2011) Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC Chem. Biol. 18, 454-463 10.1016/j.chembiol.2011.02.011
    • (2011) Chem. Biol. , vol.18 , pp. 454-463
    • Tikhonova, E.B.1    Yamada, Y.2    Zgurskaya, H.I.3
  • 66
    • 3542998054 scopus 로고    scopus 로고
    • AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex
    • Tikhonova, E. B. and Zgurskaya, H. I. (2004) AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex J. Biol. Chem. 279, 32116-32124 10.1074/jbc.M402230200
    • (2004) J. Biol. Chem. , vol.279 , pp. 32116-32124
    • Tikhonova, E.B.1    Zgurskaya, H.I.2
  • 67
    • 0033369320 scopus 로고    scopus 로고
    • Antibiotic efflux mechanisms
    • Nikaido, H. and Zgurskaya, H. I. (1999) Antibiotic efflux mechanisms Curr. Opin. Infect. Dis. 12, 529-536 10.1097/00001432-199912000-00001
    • (1999) Curr. Opin. Infect. Dis. , vol.12 , pp. 529-536
    • Nikaido, H.1    Zgurskaya, H.I.2
  • 68
    • 84930933476 scopus 로고    scopus 로고
    • A data-driven approach to modeling the tripartite structure of multidrug resistance efflux pumps
    • Phillips, J. L. and Gnanakaran, S. (2015) A data-driven approach to modeling the tripartite structure of multidrug resistance efflux pumps Proteins: Struct., Funct., Genet. 83, 46-65 10.1002/prot.24632
    • (2015) Proteins: Struct., Funct., Genet. , vol.83 , pp. 46-65
    • Phillips, J.L.1    Gnanakaran, S.2
  • 69
    • 0033594886 scopus 로고    scopus 로고
    • Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
    • Zgurskaya, H. I. and Nikaido, H. (1999) Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli Proc. Natl. Acad. Sci. U. S. A. 96, 7190-7195 10.1073/pnas.96.13.7190
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 7190-7195
    • Zgurskaya, H.I.1    Nikaido, H.2
  • 70
    • 0038670226 scopus 로고    scopus 로고
    • Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
    • Yu, E. W., McDermott, G., Zgurskaya, H. I., Nikaido, H., and Koshland, D. E., Jr. (2003) Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump Science 300, 976-980 10.1126/science.1083137
    • (2003) Science , vol.300 , pp. 976-980
    • Yu, E.W.1    McDermott, G.2    Zgurskaya, H.I.3    Nikaido, H.4    Koshland, D.E.5
  • 71
    • 33748670458 scopus 로고    scopus 로고
    • Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    • Murakami, S., Nakashima, R., Yamashita, E., Matsumoto, T., and Yamaguchi, A. (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism Nature 443, 173-179 10.1038/nature05076
    • (2006) Nature , vol.443 , pp. 173-179
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Matsumoto, T.4    Yamaguchi, A.5
  • 72
    • 84874431455 scopus 로고    scopus 로고
    • Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations
    • Vargiu, A. V. and Nikaido, H. (2012) Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations Proc. Natl. Acad. Sci. U. S. A. 109, 20637-20642 10.1073/pnas.1218348109
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 20637-20642
    • Vargiu, A.V.1    Nikaido, H.2
  • 73
    • 84355166442 scopus 로고    scopus 로고
    • Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
    • Nakashima, R., Sakurai, K., Yamasaki, S., Nishino, K., and Yamaguchi, A. (2011) Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket Nature 480, 565-569 10.1038/nature10641
    • (2011) Nature , vol.480 , pp. 565-569
    • Nakashima, R.1    Sakurai, K.2    Yamasaki, S.3    Nishino, K.4    Yamaguchi, A.5
  • 74
    • 65249172043 scopus 로고    scopus 로고
    • Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli
    • Nagano, K. and Nikaido, H. (2009) Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli Proc. Natl. Acad. Sci. U. S. A. 106, 5854-5858 10.1073/pnas.0901695106
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 5854-5858
    • Nagano, K.1    Nikaido, H.2
  • 75
    • 0035353081 scopus 로고    scopus 로고
    • Multidrug efflux in Pseudomonas aeruginosa: Components, mechanisms and clinical significance
    • Poole, K. and Srikumar, R. (2001) Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance Curr. Top. Med. Chem. 1, 59-71 10.2174/1568026013395605
    • (2001) Curr. Top. Med. Chem. , vol.1 , pp. 59-71
    • Poole, K.1    Srikumar, R.2
  • 76
    • 0033802637 scopus 로고    scopus 로고
    • Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa
    • Pumbwe, L. and Piddock, L. J. (2000) Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa Antimicrob. Agents Chemother. 44, 2861-2864 10.1128/AAC.44.10.2861-2864.2000
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2861-2864
    • Pumbwe, L.1    Piddock, L.J.2
  • 77
    • 1642422948 scopus 로고    scopus 로고
    • Efflux-mediated multiresistance in Gram-negative bacteria
    • Poole, K. (2004) Efflux-mediated multiresistance in Gram-negative bacteria Clin. Microbiol. Infect. 10, 12-26 10.1111/j.1469-0691.2004.00763.x
    • (2004) Clin. Microbiol. Infect. , vol.10 , pp. 12-26
    • Poole, K.1
  • 78
    • 17644369248 scopus 로고    scopus 로고
    • The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication
    • Aendekerk, S., Diggle, S. P., Song, Z., Hoiby, N., Cornelis, P., Williams, P., and Camara, M. (2005) The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication Microbiology 151, 1113-1125 10.1099/mic.0.27631-0
    • (2005) Microbiology , vol.151 , pp. 1113-1125
    • Aendekerk, S.1    Diggle, S.P.2    Song, Z.3    Hoiby, N.4    Cornelis, P.5    Williams, P.6    Camara, M.7
  • 80
    • 84927169367 scopus 로고    scopus 로고
    • Efflux Pump-mediated Drug Resistance in Burkholderia
    • Podnecky, N. L., Rhodes, K. A., and Schweizer, H. P. (2015) Efflux Pump-mediated Drug Resistance in Burkholderia Front. Microbiol. 6, 305 10.3389/fmicb.2015.00305
    • (2015) Front. Microbiol. , vol.6 , pp. 305
    • Podnecky, N.L.1    Rhodes, K.A.2    Schweizer, H.P.3
  • 81
    • 84912076708 scopus 로고    scopus 로고
    • Differential Roles of RND Efflux Pumps in Antimicrobial Drug Resistance of Sessile and Planktonic Burkholderia cenocepacia Cells
    • Buroni, S., Matthijs, N., Spadaro, F., Van Acker, H., Scoffone, V. C., Pasca, M. R., Riccardi, G., and Coenye, T. (2014) Differential Roles of RND Efflux Pumps in Antimicrobial Drug Resistance of Sessile and Planktonic Burkholderia cenocepacia Cells Antimicrob. Agents Chemother. 58, 7424-7429 10.1128/AAC.03800-14
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 7424-7429
    • Buroni, S.1    Matthijs, N.2    Spadaro, F.3    Van Acker, H.4    Scoffone, V.C.5    Pasca, M.R.6    Riccardi, G.7    Coenye, T.8
  • 82
    • 79952329632 scopus 로고    scopus 로고
    • Efflux-Mediated Antibiotic Resistance in Acinetobacter spp
    • Coyne, S., Courvalin, P., and Périchon, B. (2011) Efflux-Mediated Antibiotic Resistance in Acinetobacter spp Antimicrob. Agents Chemother. 55, 947-953 10.1128/AAC.01388-10
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 947-953
    • Coyne, S.1    Courvalin, P.2    Périchon, B.3
  • 83
    • 84928775690 scopus 로고    scopus 로고
    • Contribution of Resistance-Nodulation-Cell Division Efflux Systems to Antibiotic Resistance and Biofilm Formation in Acinetobacter baumannii
    • Yoon, E.-J., Nait Chabane, Y., Goussard, S., Snesrud, E., Courvalin, P., Dé, E., and Grillot-Courvalin, C. (2015) Contribution of Resistance-Nodulation-Cell Division Efflux Systems to Antibiotic Resistance and Biofilm Formation in Acinetobacter baumannii mBio 6, e00309-15 10.1128/mBio.00309-15
    • (2015) MBio , vol.6 , pp. e00309-e00315
    • Yoon, E.-J.1    Nait Chabane, Y.2    Goussard, S.3    Snesrud, E.4    Courvalin, P.5    Dé, E.6    Grillot-Courvalin, C.7
  • 85
    • 67049115572 scopus 로고    scopus 로고
    • A coordinated network of transporters with overlapping specificities provides a robust survival strategy
    • Tal, N. and Schuldiner, S. (2009) A coordinated network of transporters with overlapping specificities provides a robust survival strategy Proc. Natl. Acad. Sci. U. S. A. 106, 9051-9056 10.1073/pnas.0902400106
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9051-9056
    • Tal, N.1    Schuldiner, S.2
  • 86
    • 0034115142 scopus 로고    scopus 로고
    • Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance
    • Lee, A., Mao, W., Warren, M. S., Mistry, A., Hoshino, K., Okumura, R., Ishida, H., and Lomovskaya, O. (2000) Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance J. Bacteriol. 182, 3142-3150 10.1128/JB.182.11.3142-3150.2000
    • (2000) J. Bacteriol. , vol.182 , pp. 3142-3150
    • Lee, A.1    Mao, W.2    Warren, M.S.3    Mistry, A.4    Hoshino, K.5    Okumura, R.6    Ishida, H.7    Lomovskaya, O.8
  • 87
    • 0036794327 scopus 로고    scopus 로고
    • Mechanistic parallels in bacterial and human multidrug efflux transporters
    • Zgurskaya, H. I. and Nikaido, H. (2002) Mechanistic parallels in bacterial and human multidrug efflux transporters Curr. Protein Pept. Sci. 3, 531-540 10.2174/1389203023380512
    • (2002) Curr. Protein Pept. Sci. , vol.3 , pp. 531-540
    • Zgurskaya, H.I.1    Nikaido, H.2
  • 88
    • 64749095033 scopus 로고    scopus 로고
    • Bacterial multidrug transport through the lens of the major facilitator superfamily
    • Fluman, N. and Bibi, E. (2009) Bacterial multidrug transport through the lens of the major facilitator superfamily Biochim. Biophys. Acta, Proteins Proteomics 1794, 738-747 10.1016/j.bbapap.2008.11.020
    • (2009) Biochim. Biophys. Acta, Proteins Proteomics , vol.1794 , pp. 738-747
    • Fluman, N.1    Bibi, E.2
  • 89
    • 64649106418 scopus 로고    scopus 로고
    • EmrE, a model for studying evolution and mechanism of ion-coupled transporters
    • Schuldiner, S. (2009) EmrE, a model for studying evolution and mechanism of ion-coupled transporters Biochim. Biophys. Acta, Proteins Proteomics 1794, 748-762 10.1016/j.bbapap.2008.12.018
    • (2009) Biochim. Biophys. Acta, Proteins Proteomics , vol.1794 , pp. 748-762
    • Schuldiner, S.1
  • 90
    • 64649085938 scopus 로고    scopus 로고
    • Multidrug efflux transporters in the MATE family
    • Kuroda, T. and Tsuchiya, T. (2009) Multidrug efflux transporters in the MATE family Biochim. Biophys. Acta, Proteins Proteomics 1794, 763-768 10.1016/j.bbapap.2008.11.012
    • (2009) Biochim. Biophys. Acta, Proteins Proteomics , vol.1794 , pp. 763-768
    • Kuroda, T.1    Tsuchiya, T.2
  • 91
    • 84893089095 scopus 로고    scopus 로고
    • Prospects for new antibiotics: A molecule-centered perspective
    • Walsh, C. T. and Wencewicz, T. A. (2014) Prospects for new antibiotics: a molecule-centered perspective J. Antibiot. 67, 7-22 10.1038/ja.2013.49
    • (2014) J. Antibiot. , vol.67 , pp. 7-22
    • Walsh, C.T.1    Wencewicz, T.A.2
  • 92
    • 77957816982 scopus 로고    scopus 로고
    • Polymyxins and their novel derivatives
    • Vaara, M. (2010) Polymyxins and their novel derivatives Curr. Opin. Microbiol. 13, 574-581 10.1016/j.mib.2010.09.002
    • (2010) Curr. Opin. Microbiol. , vol.13 , pp. 574-581
    • Vaara, M.1
  • 93
    • 84900839248 scopus 로고    scopus 로고
    • Teaching 'Old' Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative 'Superbugs'
    • Velkov, T., Roberts, K. D., Nation, R. L., Wang, J., Thompson, P. E., and Li, J. (2014) Teaching 'Old' Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative 'Superbugs' ACS Chem. Biol. 9, 1172-1177 10.1021/cb500080r
    • (2014) ACS Chem. Biol. , vol.9 , pp. 1172-1177
    • Velkov, T.1    Roberts, K.D.2    Nation, R.L.3    Wang, J.4    Thompson, P.E.5    Li, J.6
  • 94
    • 84884961808 scopus 로고    scopus 로고
    • Investigational Antimicrobial Agents of 2013
    • Pucci, M. J. and Bush, K. (2013) Investigational Antimicrobial Agents of 2013 Clin. Microbiol. Rev. 26, 792-821 10.1128/CMR.00033-13
    • (2013) Clin. Microbiol. Rev. , vol.26 , pp. 792-821
    • Pucci, M.J.1    Bush, K.2
  • 96
    • 84867155796 scopus 로고    scopus 로고
    • Chapter 2. Structure, function and binding selectivity and stereoselectivity of siderophore-iron outer membrane transporters
    • (José M. A. and Svetlana, L. Eds.), Academic Press, San Diego, CA, USA
    • Schalk, I. J., Mislin, G. L. A., and Brillet, K. (2012) Chapter 2. Structure, function and binding selectivity and stereoselectivity of siderophore-iron outer membrane transporters. In Current Topics in Membranes (José, M. A. and Svetlana, L., Eds.), pp 37-66, Academic Press, San Diego, CA, USA.
    • (2012) Current Topics in Membranes , pp. 37-66
    • Schalk, I.J.1    Mislin, G.L.A.2    Brillet, K.3
  • 97
    • 79953302147 scopus 로고    scopus 로고
    • Recent insights into iron import by bacteria
    • Braun, V. and Hantke, K. (2011) Recent insights into iron import by bacteria Curr. Opin. Chem. Biol. 15, 328-334 10.1016/j.cbpa.2011.01.005
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , pp. 328-334
    • Braun, V.1    Hantke, K.2
  • 98
    • 84938718263 scopus 로고    scopus 로고
    • Metallome of Pseudomonas aeruginosa: A role for siderophores
    • n/a-n/a
    • Cunrath, O., Geoffroy, V. A., and Schalk, I. J. (2015) Metallome of Pseudomonas aeruginosa: a role for siderophores Environ. Microbiol. n/a-n/a 10.1111/1462-2920.12971
    • (2015) Environ. Microbiol.
    • Cunrath, O.1    Geoffroy, V.A.2    Schalk, I.J.3
  • 99
    • 84872850695 scopus 로고    scopus 로고
    • Siderophore conjugates
    • Page, M. G. P. (2013) Siderophore conjugates Ann. N. Y. Acad. Sci. 1277, 115-126 10.1111/nyas.12024
    • (2013) Ann. N. Y. Acad. Sci. , vol.1277 , pp. 115-126
    • Page, M.G.P.1
  • 100
    • 77952614275 scopus 로고    scopus 로고
    • In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli
    • Page, M. G. P., Dantier, C., and Desarbre, E. (2010) In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli Antimicrob. Agents Chemother. 54, 2291-2302 10.1128/AAC.01525-09
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2291-2302
    • Page, M.G.P.1    Dantier, C.2    Desarbre, E.3
  • 101
    • 0024593455 scopus 로고
    • Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation
    • Chen, R. H., Buko, A. M., Whittern, D. N., and McAlpine, J. B. (1989) Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation J. Antibiot. 42, 512-520 10.7164/antibiotics.42.512
    • (1989) J. Antibiot. , vol.42 , pp. 512-520
    • Chen, R.H.1    Buko, A.M.2    Whittern, D.N.3    McAlpine, J.B.4
  • 102
    • 0024509967 scopus 로고
    • Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. III. Microbiologic profile
    • Fernandes, P. B., Swanson, R. N., Hardy, D. J., Hanson, C. W., Coen, L., Rasmussen, R. R., and Chen, R. H. (1989) Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. III. Microbiologic profile J. Antibiot. 42, 521-526 10.7164/antibiotics.42.521
    • (1989) J. Antibiot. , vol.42 , pp. 521-526
    • Fernandes, P.B.1    Swanson, R.N.2    Hardy, D.J.3    Hanson, C.W.4    Coen, L.5    Rasmussen, R.R.6    Chen, R.H.7
  • 103
    • 0024518180 scopus 로고
    • Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. I. Taxonomy of the producing organism and fermentation
    • Karwowski, J. P., Jackson, M., Theriault, R. J., Chen, R. H., Barlow, G. J., and Maus, M. L. (1989) Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. I. Taxonomy of the producing organism and fermentation J. Antibiot. 42, 506-511 10.7164/antibiotics.42.506
    • (1989) J. Antibiot. , vol.42 , pp. 506-511
    • Karwowski, J.P.1    Jackson, M.2    Theriault, R.J.3    Chen, R.H.4    Barlow, G.J.5    Maus, M.L.6
  • 104
    • 84885918609 scopus 로고    scopus 로고
    • High-Level Pacidamycin Resistance in Pseudomonas aeruginosa Is Mediated by an Opp Oligopeptide Permease Encoded by the opp-fabI Operon
    • Mistry, A., Warren, M. S., Cusick, J. K., Karkhoff-Schweizer, R. R., Lomovskaya, O., and Schweizer, H. P. (2013) High-Level Pacidamycin Resistance in Pseudomonas aeruginosa Is Mediated by an Opp Oligopeptide Permease Encoded by the opp-fabI Operon Antimicrob. Agents Chemother. 57, 5565-5571 10.1128/AAC.01198-13
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 5565-5571
    • Mistry, A.1    Warren, M.S.2    Cusick, J.K.3    Karkhoff-Schweizer, R.R.4    Lomovskaya, O.5    Schweizer, H.P.6
  • 105
    • 43949129098 scopus 로고    scopus 로고
    • Physicochemical properties of antibacterial compounds: Implications for drug discovery
    • O'Shea, R. and Moser, H. E. (2008) Physicochemical properties of antibacterial compounds: implications for drug discovery J. Med. Chem. 51, 2871-2878 10.1021/jm700967e
    • (2008) J. Med. Chem. , vol.51 , pp. 2871-2878
    • O'Shea, R.1    Moser, H.E.2
  • 107
    • 84914142159 scopus 로고    scopus 로고
    • General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria
    • Davis, T. D., Gerry, C. J., and Tan, D. S. (2014) General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria ACS Chem. Biol. 9, 2535-2544 10.1021/cb5003015
    • (2014) ACS Chem. Biol. , vol.9 , pp. 2535-2544
    • Davis, T.D.1    Gerry, C.J.2    Tan, D.S.3
  • 108
    • 84926648408 scopus 로고    scopus 로고
    • Thinking Outside the "bug": A Unique Assay to Measure Intracellular Drug Penetration in Gram-Negative Bacteria
    • Zhou, Y., Joubran, C., Miller-Vedam, L., Isabella, V., Nayar, A., Tentarelli, S., and Miller, A. (2015) Thinking Outside the "Bug": A Unique Assay To Measure Intracellular Drug Penetration in Gram-Negative Bacteria Anal. Chem. 87, 3579-3584 10.1021/ac504880r
    • (2015) Anal. Chem. , vol.87 , pp. 3579-3584
    • Zhou, Y.1    Joubran, C.2    Miller-Vedam, L.3    Isabella, V.4    Nayar, A.5    Tentarelli, S.6    Miller, A.7
  • 109
    • 84858742553 scopus 로고    scopus 로고
    • Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery
    • Manchester, J. I., Buurman, E. T., Bisacchi, G. S., and McLaughlin, R. E. (2012) Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery J. Med. Chem. 55, 2532-2537 10.1021/jm201275d
    • (2012) J. Med. Chem. , vol.55 , pp. 2532-2537
    • Manchester, J.I.1    Buurman, E.T.2    Bisacchi, G.S.3    McLaughlin, R.E.4
  • 110
    • 84938508995 scopus 로고    scopus 로고
    • Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent Successes
    • Parkin, J., Chavent, M., and Khalid, S. (2015) Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent Successes Biophys. J. 109, 461-468 10.1016/j.bpj.2015.06.050
    • (2015) Biophys. J. , vol.109 , pp. 461-468
    • Parkin, J.1    Chavent, M.2    Khalid, S.3
  • 111
    • 84929493561 scopus 로고    scopus 로고
    • Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: A molecular dynamics study
    • Berglund, N. A., Piggot, T. J., Jefferies, D., Sessions, R. B., Bond, P. J., and Khalid, S. (2015) Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study PLoS Comput. Biol. 11, e1004180 10.1371/journal.pcbi.1004180
    • (2015) PLoS Comput. Biol. , vol.11
    • Berglund, N.A.1    Piggot, T.J.2    Jefferies, D.3    Sessions, R.B.4    Bond, P.J.5    Khalid, S.6
  • 112
    • 12944316448 scopus 로고    scopus 로고
    • Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps
    • Bohnert, J. A. and Kern, W. V. (2005) Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps Antimicrob. Agents Chemother. 49, 849-852 10.1128/AAC.49.2.849-852.2005
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 849-852
    • Bohnert, J.A.1    Kern, W.V.2
  • 115
    • 84931261884 scopus 로고    scopus 로고
    • Recent advances toward a molecular mechanism of efflux pump inhibition
    • Opperman, T. J. and Nguyen, S. T. (2015) Recent advances toward a molecular mechanism of efflux pump inhibition Front. Microbiol. 6, e00421 10.3389/fmicb.2015.
    • (2015) Front. Microbiol. , vol.6
    • Opperman, T.J.1    Nguyen, S.T.2
  • 116
    • 84969193967 scopus 로고    scopus 로고
    • Bacterial multidrug transporters: Molecular and clinical aspects
    • (Ecker, G. F. and Chiba, P. Eds.), Wiley and Sons, Hoboken, NJ, USA
    • Lomovskaya, O., Zgurskaya, H. I., and Bostian, K. A. (2008) Bacterial multidrug transporters: molecular and clinical aspects. In Transporters as Drug Carriers (Ecker, G. F. and Chiba, P., Eds.), Wiley and Sons, Hoboken, NJ, USA.
    • (2008) Transporters As Drug Carriers
    • Lomovskaya, O.1    Zgurskaya, H.I.2    Bostian, K.A.3
  • 123
    • 0033031244 scopus 로고    scopus 로고
    • Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa
    • Lomovskaya, O. et al. 1999, Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa Antimicrob. Agents Chemother. 43, 1340-1346
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1340-1346
    • Lomovskaya, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.