A data-driven approach to modeling the tripartite structure of multidrug resistance efflux pumps

Proteins: Structure, Function and Bioinformatics

Volumn 83, Issue 1, 2015, Pages 46-65

  Phillips, Joshua L ^a,b   Gnanakaran, S ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b MIDDLE TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

AmrAB OprA; Burkholderia pseudomallei; Drug resistance; Drug translocation; Efflux pump; FRODAN; Geometrical simulations; Membrane transporter; MexAB OprM; Tripartite structures

Indexed keywords

ADAPTOR PROTEIN; BACTERIAL PROTEIN; INNER MEMBRANE PROTEIN ACRB; INNER MEMBRANE PROTEIN AMRAB; INNER MEMBRANE PROTEIN OPRA; INNER MEMBRANE PROTEIN TOLC; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN CUSBA; MULTIDRUG RESISTANCE PROTEIN MEXA; MULTIDRUG RESISTANCE PROTEIN MEXAB; MULTIDRUG RESISTANCE PROTEIN MEXB; MULTIDRUG RESISTANCE PROTEIN OPRM; OUTER MEMBRANE PROTEIN; UNCLASSIFIED DRUG; AMINO ACID; CARRIER PROTEIN; DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; DRUG TRANSPORT; GEOMETRY; INNER MEMBRANE; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SIMULATION; BURKHOLDERIA PSEUDOMALLEI; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; MULTIDRUG RESISTANCE; NONLINEAR SYSTEM; PRINCIPAL COMPONENT ANALYSIS; PROTEIN SECONDARY STRUCTURE; STRUCTURAL HOMOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

BACTERIA (MICROORGANISMS); BURKHOLDERIA PSEUDOMALLEI; NEGIBACTERIA;

AMINO ACIDS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; BURKHOLDERIA PSEUDOMALLEI; COMPUTER SIMULATION; DRUG RESISTANCE, MULTIPLE; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; NONLINEAR DYNAMICS; PHARMACEUTICAL PREPARATIONS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, SECONDARY; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84930933476     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24632     Document Type: Article

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