Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2802-2806

  Watkins, William J ^a   Chong, Lee ^a   Cho, Aesop ^a   Hilgenkamp, Ramona ^a   Ludwikow, Maria ^a   Garizi, Negar ^a   Iqbal, Nadeem ^b   Barnard, John ^b   Singh, Rajeshwar ^b   Madsen, Deidre ^a   Lolans, Karen ^a   Lomovskaya, Olga ^a   Oza, Uma ^a   Kumaraswamy, Padmapriya ^a   Blecken, Andrea ^a   Bai, Shuang ^a   Loury, David J ^a   Griffith, David C ^a   Dudley, Michael N ^a  

^a Essential Therapeutics Inc   (United States)

^b NAEJA Pharmaceutical Inc   (Canada)

Author keywords

Antifungal; Candida; Efflux; Efflux pump inhibitor; EPI; Fluconazole; Quinazolinone; Synergy

Indexed keywords

1 METHYLPIPERAZINE; ALANINE DERIVATIVE; FLUCONAZOLE; PIPERAZINE DERIVATIVE; PROLINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG; URETHAN;

ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CANDIDA ALBICANS; CANDIDA GLABRATA; DRUG POTENTIATION; EFFUSION; MALE; NONHUMAN; PROTEIN BINDING; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; HEPATOCYTES; MALE; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; PIPERAZINES; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY; SERUM; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; RATTUS;

EID: 34247382088     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.047     Document Type: Article

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