Toward the rational design of carbapenem uptake in pseudomonas aeruginosa

Chemistry and Biology

Volumn 22, Issue 4, 2015, Pages 535-547

  Isabella, Vincent M ^a   Campbell, Arthur J ^b   Manchester, John ^c   Sylvester, Mark ^c   Nayar, Asha S ^c   Ferguson, Keith E ^c   Tommasi, Ruben ^c   Miller, Alita A ^c  

^a SYNLOGIC   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; MEROPENEM; OCCD1 PROTEIN; OCCD3 PROTEIN; OUTER MEMBRANE PROTEIN; UNCLASSIFIED DRUG; CARBAPENEM DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL OUTER MEMBRANE; CELL ASSAY; COMPUTATIONAL METADYNAMICS SIMULATION; DRUG DESIGN; HETEROLOGOUS EXPRESSION; MOLECULAR INTERACTION; OUTER MEMBRANE; PERMEABILITY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SIMULATION; BINDING SITE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

AMINO ACID SUBSTITUTION; BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; CARBAPENEMS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; SUBSTRATE SPECIFICITY;

EID: 84928400801     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.03.018     Document Type: Article

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