OmpA is the principal nonspecific slow porin of Acinetobacter baumannii

Journal of Bacteriology

Volumn 194, Issue 15, 2012, Pages 4089-4096

  Sugawara, Etsuko ^a   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZTREONAM; CARBENICILLIN; CEFALORIDINE; CEFALOTIN; CEFOTAXIME; CHLORAMPHENICOL; GENTAMICIN; IMIPENEM; NITROCEFIN; NOVOBIOCIN; OUTER MEMBRANE PROTEIN A; PENICILLIN G; POLYMYXIN B; PORIN; PROTEIN OMPAAB; TETRACYCLINE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ARTICLE; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CONTROLLED STUDY; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; CELL MEMBRANE PERMEABILITY; CEPHALORIDINE; CEPHALOTHIN; GENE DELETION; PORINS;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ESCHERICHIA COLI; ESCHERICHIA COLI K12; PSEUDOMONAS AERUGINOSA;

EID: 84866342585     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00435-12     Document Type: Article

References (51)

1. Adams MD, et al. 2008. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J. Bacteriol.. 190:8053-8064.
2. Ames GF, Spudich EN, Nikaido H. 1974. Protein composition of the outer membrane of Salmonella typhimurium: effect of lipopolysaccharide mutations. J. Bacteriol.. 117:406-416.
3. Angus BL, Carey AM, Caron DA, Kropinski AM, Hancock RE. 1982. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant. Antimicrob. Agents Chemother.. 21:299-309.
4. Bonomo RA, Szabo D. 2006. Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin. Infect. Dis. 43(Suppl 2):S49-S56.
5. Bou G, Cervero G, Dominguez MA, Quereda C, Martinez-Beltran J. 2000. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of β-lactamases. J. Clin. Microbiol.. 38:3299-3305.
6. Brenner DJ, Krieg NR, Staley JT. 2005. Bergey's manual of systematic bacteriology, 2nd ed, vol 2, part A. Springer, New York, NY.
7. Brown S, Young HK, Amyes SG. 2005. Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina. Clin. Microbiol. Infect.. 11:15-23.
8. Catel-Ferreira M, et al. 2011. Structure-function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii. J. Antimicrob. Chemother.. 66:2053-2056.
9. Clark RB. 1996. Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein. J. Antimicrob. Chemother.. 38:245-251.
10. Coyne S, Courvalin P, Perichon B. 2011. Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrob. Agents Chemother.. 55:947-953.
11. Damier-Piolle L, Magnet S, Bremont S, Lambert T, Courvalin P. 2008. AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother.. 52:557-562.
12. DÉ E, De Mot R, Orange N, Saint N, Molle G. 1995. Channel-forming properties and structural homology of major outer membrane proteins from Pseudomonas fluorescens MFO and OE 28.3. FEMS Microbiol. Lett.. 127:267-272.
13. Dupont M, Pages JM, Lafitte D, Siroy A, Bollet C. 2005. Identification of an OprD homologue in Acinetobacter baumannii. J. Proteome Res.. 4:2386-2390.
14. Fukuoka T, et al. 1993. Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane. Antimicrob. Agents Chemother.. 37:322-327.
15. Gribun A, Nitzan Y, Pechatnikov I, Hershkovits G, Katcoff DJ. 2003. Molecular and structural characterization of the HMP-AB gene encoding a pore-forming protein from a clinical isolate of Acinetobacter baumannii. Curr. Microbiol.. 47:434-443.
16. Hancock RE, Brinkman FS. 2002. Function of Pseudomonas porins in uptake and efflux. Annu. Rev. Microbiol.. 56:17-38.
17. Hoang TT, Karkhoff-Schweizer RR, Kutchma AJ, Schweizer HP. 1998. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene. 212:77-86.
18. Jyothisri K, Deepak V, Rajeswari MR. 1999. Purification and characterization of a major 40 kDa outer membrane protein of Acinetobacter baumannii. FEBS Lett.. 443:57-60.
19. Li XZ, Ma D, Livermore DM, Nikaido H. 1994. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to β-lactam resistance. Antimicrob. Agents Chemother.. 38:1742-1752.
20. Limansky AS, Mussi MA, Viale AM. 2002. Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance. J. Clin. Microbiol.. 40:4776-4778.
21. Magnet S, Courvalin P, Lambert T. 2001. Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother.. 45:3375-3380.
22. Mussi MA, Limansky AS, Viale AM. 2005. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of β-barrel outer membrane proteins. Antimicrob. Agents Chemother.. 49:1432-1440.
23. Nestorovich EM, Sugawara E, Nikaido H, Bezrukov SM. 2006. Pseudomonas aeruginosa porin OprF: properties of the channel. J. Biol. Chem.. 281:16230-16237.
24. Nikaido H. 1989. Outer membrane barrier as a mechanism of antimicrobial resistance. Antimicrob. Agents Chemother.. 33:1831-1836.
25. Nikaido H, Nikaido K, Harayama S. 1991. Identification and characterization of porins in Pseudomonas aeruginosa. J. Biol. Chem.. 266:770-779.
26. Nikaido H, Normark S. 1987. Sensitivity of Escherichia coli to various β-lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β-lactamases: a quantitative predictive treatment. Mol. Microbiol.. 1:29-36.
27. Nikaido H, Rosenberg EY. 1981. Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli. J. Gen. Physiol.. 77:121-135.
28. Nikaido H, Rosenberg EY, Foulds J. 1983. Porin channels in Escherichia coli: studies with β-lactams in intact cells. J. Bacteriol.. 153:232-240.
29. Nikaido H, Vaara M. 1985. Molecular basis of bacterial outer membrane permeability. Microbiol. Rev.. 49:1-32.
30. Nitzan Y, Pechatnikov I, Bar-El D, Wexler H. 1999. Isolation and characterization of heat-modifiable proteins from the outer membrane of Porphyromonas asaccharolytica and Acinetobacter baumannii. Anaerobe. 5:43-50.
31. O'Callaghan CH, Morris A, Kirby SM, Shingler AH. 1972. Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrob. Agents Chemother.. 1:283-288.
32. Peleg AY, Seifert H, Paterson DL. 2008. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev.. 21:538-582.
33. Perilli M, et al. 1996. Characterization of the chromosomal cephalosporinases produced by Acinetobacter lwoffii and Acinetobacter baumannii clinical isolates. Antimicrob. Agents Chemother.. 40:715-719.
34. Philippon LN, Naas T, Bouthors AT, Barakett V, Nordmann P. 1997. OXA-18, a class D clavulanic acid-inhibited extended-spectrum β-lactamase from Pseudomonas aeruginosa. Antimicrob. Agents Chemother.. 41:2188-2195.
35. Quale J, Bratu S, Landman D, Heddurshetti R. 2003. Molecular epidemiology and mechanisms of carbapenem resistance in Acinetobacter baumannii endemic in New York City. Clin. Infect. Dis.. 37:214-220.
36. Ried G, Koebnik R, Hindennach I, Mutschler B, Henning U. 1994. Membrane topology and assembly of the outer membrane protein OmpA of Escherichia coli K12. Mol. Gen. Genet.. 243:127-135.
37. Sato K, Nakae T. 1991. Outer membrane permeability of Acinetobacter calcoaceticus and its implication in antibiotic resistance. J. Antimicrob. Chemother.. 28:35-45.
38. Schagger H, von Jagow G. 1991. Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal. Biochem.. 199:223-231.
39. Sugawara E, Nagano K, Nikaido H. 2010. Factors affecting the folding of Pseudomonas aeruginosa OprF porin into the one-domain open conformer. mBio 1(4):e00228-10. doi:10.1128/mBio.00228-10.
40. Sugawara E, Nestorovich EM, Bezrukov SM, Nikaido H. 2006. Pseudomonas aeruginosa porin OprF exists in two different conformations. J. Biol. Chem.. 281:16220-16229.
41. Sugawara E, Nikaido H. 1992. Pore-forming activity of OmpA protein of Escherichia coli. J. Biol. Chem.. 267:2507-2511.
42. Sugawara E, Nikaido H. 1994. OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms. J. Biol. Chem.. 269:17981-17987.
43. Sugawara E, Nikaido H. 2004. OmpA/OprF: slow porins or channels produced by alternative folding of outer membrane proteins, p 119-138. In Benz R (ed), Bacterial and eukaryotic porins: structure, function, mechanism. Wiley-VCH, Weinheim, Germany.
44. Sugawara E, Steiert M, Rouhani S, Nikaido H. 1996. Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa. J. Bacteriol.. 178:6067-6069.
45. Trias J, Nikaido H. 1990. Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother.. 34:52-57.
46. Trias J, Nikaido H. 1990. Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides. J. Biol. Chem.. 265:15680-15684.
47. Vila J, Marti S, Sanchez-Cespedes J. 2007. Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. J. Antimicrob. Chemother.. 59:1210-1215.
48. Woodruff WA, Hancock RE. 1988. Construction and characterization of Pseudomonas aeruginosa protein F-deficient mutants after in vitro and in vivo insertion mutagenesis of the cloned gene. J. Bacteriol.. 170:2592-2598.
49. Yoshimura F, Nikaido H. 1982. Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J. Bacteriol.. 152:636-642.
50. Yoshimura F, Zalman LS, Nikaido H. 1983. Purification and properties of Pseudomonas aeruginosa porin. J. Biol. Chem.. 258:2308-2314.
51. Zimmermann W, Rosselet A. 1977. Function of the outer membrane of Escherichia coli as a permeability barrier to β-lactam antibiotics. Antimicrob. Agents Chemother.. 12:368-372.