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Volumn 118, Issue 8, 2016, Pages 1327-1336

Brain-gut-bone marrow axis: Implications for hypertension and related therapeutics

Author keywords

blood pressure; bone marrow; dysbiosis; hypertension; microbiota

Indexed keywords

AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE REGULATION; BONE MARROW; BRAIN; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DYSBIOSIS; HEMATOPOIETIC CELL; HUMAN; HYPERTENSION; INTESTINE; INTESTINE FLORA; LIFESTYLE MODIFICATION; MORBIDITY; MORTALITY; NERVOUS SYSTEM INFLAMMATION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SLEEP DISORDERED BREATHING; ANIMAL; GASTROINTESTINAL TRACT; INTESTINE INNERVATION; METABOLISM; PHYSIOLOGY; RISK REDUCTION;

EID: 84963838320     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.307709     Document Type: Review
Times cited : (100)

References (110)
  • 1
    • 84893549987 scopus 로고    scopus 로고
    • 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)
    • James PA, Oparil S, Carter BL, 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014 311 507 520. doi: 10.1001/jama.2013.284427
    • (2014) JAMA , vol.311 , pp. 507-520
    • James, P.A.1    Oparil, S.2    Carter, B.L.3
  • 2
    • 84988892839 scopus 로고    scopus 로고
    • Hypertension prevalence and control among adults: United States, 2011-2014
    • Yoon SS, Carroll MD, Fryar CD, Hypertension prevalence and control among adults: United states, 2011-2014. NCHS Data Brief 2015 1 8
    • (2015) NCHS Data Brief , pp. 1-8
    • Yoon, S.S.1    Carroll, M.D.2    Fryar, C.D.3
  • 3
    • 84903852937 scopus 로고    scopus 로고
    • Reply to 'Resistant hypertension revisited: Definition and true prevalence'.
    • Smith SM, Pepine CJ, Cooper-DeHoff RM, Reply to 'Resistant hypertension revisited: definition and true prevalence'. J Hypertens 2014 32 1547. doi: 10.1097/HJH.0000000000000220
    • (2014) J Hypertens , vol.32 , pp. 1547
    • Smith, S.M.1    Pepine, C.J.2    Cooper-DeHoff, R.M.3
  • 4
    • 84871611550 scopus 로고    scopus 로고
    • Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats
    • Waki H, Hendy EB, Hindmarch CC, Gouraud S, Toward M, Kasparov S, Murphy D, Paton JF, Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. Hypertension 2013 61 194 201. doi: 10.1161/HYPERTENSIONAHA.112.192252
    • (2013) Hypertension , vol.61 , pp. 194-201
    • Waki, H.1    Hendy, E.B.2    Hindmarch, C.C.3    Gouraud, S.4    Toward, M.5    Kasparov, S.6    Murphy, D.7    Paton, J.F.8
  • 6
    • 83655184676 scopus 로고    scopus 로고
    • Angiotensin II-induced hypertension is modulated by nuclear factor-κBin the paraventricular nucleus
    • Cardinale JP, Sriramula S, Mariappan N, Agarwal D, Francis J, Angiotensin II-induced hypertension is modulated by nuclear factor-κBin the paraventricular nucleus. Hypertension 2012 59 113 121. doi: 10.1161/HYPERTENSIONAHA.111.182154
    • (2012) Hypertension , vol.59 , pp. 113-121
    • Cardinale, J.P.1    Sriramula, S.2    Mariappan, N.3    Agarwal, D.4    Francis, J.5
  • 7
    • 84943177996 scopus 로고    scopus 로고
    • Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR
    • Masson GS, Nair AR, Silva Soares PP, Michelini LC, Francis J, Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR. Am J Physiol Heart Circ Physiol 2015 309 H1115 H1122. doi: 10.1152/ajpheart.00349.2015
    • (2015) Am J Physiol Heart Circ Physiol , vol.309 , pp. H1115-H1122
    • Masson, G.S.1    Nair, A.R.2    Silva Soares, P.P.3    Michelini, L.C.4    Francis, J.5
  • 8
    • 84908236929 scopus 로고    scopus 로고
    • Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats
    • Song XA, Jia LL, Cui W, Zhang M, Chen W, Yuan ZY, Guo J, Li HH, Zhu GQ, Liu H, Kang YM, Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats. Toxicol Appl Pharmacol 2014 281 101 108. doi: 10.1016/j.taap.2014.09.004
    • (2014) Toxicol Appl Pharmacol , vol.281 , pp. 101-108
    • Song, X.A.1    Jia, L.L.2    Cui, W.3    Zhang, M.4    Chen, W.5    Yuan, Z.Y.6    Guo, J.7    Li, H.H.8    Zhu, G.Q.9    Liu, H.10    Kang, Y.M.11
  • 9
    • 80052037697 scopus 로고    scopus 로고
    • The role of the brain renin-angiotensin system in hypertension: Implications for new treatment
    • Marc Y, Llorens-Cortes C, The role of the brain renin-angiotensin system in hypertension: implications for new treatment. Prog Neurobiol 2011 95 89 103. doi: 10.1016/j.pneurobio.2011.06.006
    • (2011) Prog Neurobiol , vol.95 , pp. 89-103
    • Marc, Y.1    Llorens-Cortes, C.2
  • 10
    • 84878280158 scopus 로고    scopus 로고
    • Angiotensin II causes imbalance between pro- and anti-inflammatory cytokines by modulating GSK-3β in neuronal culture
    • Agarwal D, Dange RB, Raizada MK, Francis J, Angiotensin II causes imbalance between pro- and anti-inflammatory cytokines by modulating GSK-3β in neuronal culture. Br J Pharmacol 2013 169 860 874. doi: 10.1111/bph.12177
    • (2013) Br J Pharmacol , vol.169 , pp. 860-874
    • Agarwal, D.1    Dange, R.B.2    Raizada, M.K.3    Francis, J.4
  • 11
    • 84924234276 scopus 로고    scopus 로고
    • Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation
    • Sriramula S, Xia H, Xu P, Lazartigues E, Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. Hypertension 2015 65 577 586. doi: 10.1161/HYPERTENSIONAHA.114.04691
    • (2015) Hypertension , vol.65 , pp. 577-586
    • Sriramula, S.1    Xia, H.2    Xu, P.3    Lazartigues, E.4
  • 12
    • 84886089553 scopus 로고    scopus 로고
    • Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension
    • Xia H, Sriramula S, Chhabra KH, Lazartigues E, Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. Circ Res 2013 113 1087 1096. doi: 10.1161/CIRCRESAHA.113.301811
    • (2013) Circ Res , vol.113 , pp. 1087-1096
    • Xia, H.1    Sriramula, S.2    Chhabra, K.H.3    Lazartigues, E.4
  • 14
    • 84951568289 scopus 로고    scopus 로고
    • Central renin-angiotensin system activation and inflammation induced by high-fat diet sensitize angiotensin II-elicited hypertension
    • Xue B, Thunhorst RL, Yu Y, Guo F, Beltz TG, Felder RB, Johnson AK, Central renin-angiotensin system activation and inflammation induced by high-fat diet sensitize angiotensin ii-elicited hypertension. Hypertension 2016 67 163 170. doi: 10.1161/HYPERTENSIONAHA.115.06263
    • (2016) Hypertension , vol.67 , pp. 163-170
    • Xue, B.1    Thunhorst, R.L.2    Yu, Y.3    Guo, F.4    Beltz, T.G.5    Felder, R.B.6    Johnson, A.K.7
  • 15
    • 84937500876 scopus 로고    scopus 로고
    • Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat
    • Wei SG, Yu Y, Zhang ZH, Felder RB, Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat. Hypertension 2015 65 1126 1133. doi: 10.1161/HYPERTENSIONAHA.114.05112
    • (2015) Hypertension , vol.65 , pp. 1126-1133
    • Wei, S.G.1    Yu, Y.2    Zhang, Z.H.3    Felder, R.B.4
  • 16
    • 84877774737 scopus 로고    scopus 로고
    • Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension
    • Sriramula S, Cardinale JP, Francis J, Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension. PLoS One 2013 8 e63847. doi: 10.1371/journal.pone.0063847
    • (2013) PLoS One , vol.8 , pp. e63847
    • Sriramula, S.1    Cardinale, J.P.2    Francis, J.3
  • 17
    • 84880717057 scopus 로고    scopus 로고
    • Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines
    • Wei SG, Zhang ZH, Beltz TG, Yu Y, Johnson AK, Felder RB, Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines. Hypertension 2013 62 118 125. doi: 10.1161/HYPERTENSIONAHA.113.01404
    • (2013) Hypertension , vol.62 , pp. 118-125
    • Wei, S.G.1    Zhang, Z.H.2    Beltz, T.G.3    Yu, Y.4    Johnson, A.K.5    Felder, R.B.6
  • 18
    • 84940706936 scopus 로고    scopus 로고
    • Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control
    • de Kloet AD, Liu M, Rodríguez V, Krause EG, Sumners C, Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control. Am J Physiol Regul Integr Comp Physiol 2015 309 R444 R458. doi: 10.1152/ajpregu.00078.2015
    • (2015) Am J Physiol Regul Integr Comp Physiol , vol.309 , pp. R444-R458
    • De Kloet, A.D.1    Liu, M.2    Rodríguez, V.3    Krause, E.G.4    Sumners, C.5
  • 19
    • 84872176512 scopus 로고    scopus 로고
    • Microglia: New roles for the synaptic stripper
    • Kettenmann H, Kirchhoff F, Verkhratsky A, Microglia: new roles for the synaptic stripper. Neuron 2013 77 10 18. doi: 10.1016/j.neuron.2012.12.023
    • (2013) Neuron , vol.77 , pp. 10-18
    • Kettenmann, H.1    Kirchhoff, F.2    Verkhratsky, A.3
  • 21
    • 84937569806 scopus 로고    scopus 로고
    • Microglia participate in neurogenic regulation of hypertension
    • Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P, Shi P, Microglia participate in neurogenic regulation of hypertension. Hypertension 2015 66 309 316. doi: 10.1161/HYPERTENSIONAHA.115.05333
    • (2015) Hypertension , vol.66 , pp. 309-316
    • Shen, X.Z.1    Li, Y.2    Li, L.3    Shah, K.H.4    Bernstein, K.E.5    Lyden, P.6    Shi, P.7
  • 22
    • 84896319990 scopus 로고    scopus 로고
    • The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4
    • Pannell M, Szulzewsky F, Matyash V, Wolf SA, Kettenmann H, The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ and IL-4. Glia 2014 62 667 679. doi: 10.1002/glia.22633
    • (2014) Glia , vol.62 , pp. 667-679
    • Pannell, M.1    Szulzewsky, F.2    Matyash, V.3    Wolf, S.A.4    Kettenmann, H.5
  • 23
    • 84920936666 scopus 로고    scopus 로고
    • Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation
    • Rodriguez-Perez AI, Borrajo A, Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL, Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation. Glia 2015 63 466 482. doi: 10.1002/glia.22765
    • (2015) Glia , vol.63 , pp. 466-482
    • Rodriguez-Perez, A.I.1    Borrajo, A.2    Rodriguez-Pallares, J.3    Guerra, M.J.4    Labandeira-Garcia, J.L.5
  • 24
    • 38349094462 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor kappaB and activator protein-1 activation
    • Miyoshi M, Miyano K, Moriyama N, Taniguchi M, Watanabe T, Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor kappaB and activator protein-1 activation. Eur J Neurosci 2008 27 343 351. doi: 10.1111/j.1460-9568.2007.06014.x
    • (2008) Eur J Neurosci , vol.27 , pp. 343-351
    • Miyoshi, M.1    Miyano, K.2    Moriyama, N.3    Taniguchi, M.4    Watanabe, T.5
  • 25
    • 84943371338 scopus 로고    scopus 로고
    • Angiotensin-II, the Brain, and Hypertension: An Update
    • Young CN, Davisson RL, Angiotensin-II, the Brain, and Hypertension: An Update. Hypertension 2015 66 920 926. doi: 10.1161/HYPERTENSIONAHA.115.03624
    • (2015) Hypertension , vol.66 , pp. 920-926
    • Young, C.N.1    Davisson, R.L.2
  • 26
    • 31044450303 scopus 로고    scopus 로고
    • Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow
    • Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, Frenette PS, Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006 124 407 421. doi: 10.1016/j.cell.2005.10.041
    • (2006) Cell , vol.124 , pp. 407-421
    • Katayama, Y.1    Battista, M.2    Kao, W.M.3    Hidalgo, A.4    Peired, A.J.5    Thomas, S.A.6    Frenette, P.S.7
  • 27
    • 84929178412 scopus 로고    scopus 로고
    • Neural regulation of hematopoiesis, inflammation, and cancer
    • Hanoun M, Maryanovich M, Arnal-Estapé A, Frenette PS, Neural regulation of hematopoiesis, inflammation, and cancer. Neuron 2015 86 360 373. doi: 10.1016/j.neuron.2015.01.026
    • (2015) Neuron , vol.86 , pp. 360-373
    • Hanoun, M.1    Maryanovich, M.2    Arnal-Estapé, A.3    Frenette, P.S.4
  • 28
    • 39749164920 scopus 로고    scopus 로고
    • Haematopoietic stem cell release is regulated by circadian oscillations
    • Méndez-Ferrer S, Lucas D, Battista M, Frenette PS, Haematopoietic stem cell release is regulated by circadian oscillations. Nature 2008 452 442 447. doi: 10.1038/nature06685
    • (2008) Nature , vol.452 , pp. 442-447
    • Méndez-Ferrer, S.1    Lucas, D.2    Battista, M.3    Frenette, P.S.4
  • 29
    • 0030961055 scopus 로고    scopus 로고
    • Bone marrow innervation regulates cellular retention in the murine haemopoietic system
    • Afan AM, Broome CS, Nicholls SE, Whetton AD, Miyan JA, Bone marrow innervation regulates cellular retention in the murine haemopoietic system. Br J Haematol 1997 98 569 577
    • (1997) Br J Haematol , vol.98 , pp. 569-577
    • Afan, A.M.1    Broome, C.S.2    Nicholls, S.E.3    Whetton, A.D.4    Miyan, J.A.5
  • 31
    • 84859548724 scopus 로고    scopus 로고
    • Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects
    • Amadesi S, Reni C, Katare R, Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation 2012 125 1774 1786, S1. doi: 10.1161/CIRCULATIONAHA.111.089763
    • (2012) Circulation , vol.125 , pp. 1774-1786
    • Amadesi, S.1    Reni, C.2    Katare, R.3
  • 32
    • 84942988696 scopus 로고    scopus 로고
    • Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes
    • Dang Z, Maselli D, Spinetti G, Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes. Diabetologia 2015 58 2653 2662. doi: 10.1007/s00125-015-3735-0
    • (2015) Diabetologia , vol.58 , pp. 2653-2662
    • Dang, Z.1    Maselli, D.2    Spinetti, G.3
  • 33
    • 84860335038 scopus 로고    scopus 로고
    • Norepinephrine reuptake inhibition promotes mobilization in mice: Potential impact to rescue low stem cell yields
    • Lucas D, Bruns I, Battista M, Mendez-Ferrer S, Magnon C, Kunisaki Y, Frenette PS, Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields. Blood 2012 119 3962 3965. doi: 10.1182/blood-2011-07-367102
    • (2012) Blood , vol.119 , pp. 3962-3965
    • Lucas, D.1    Bruns, I.2    Battista, M.3    Mendez-Ferrer, S.4    Magnon, C.5    Kunisaki, Y.6    Frenette, P.S.7
  • 34
    • 84863903383 scopus 로고    scopus 로고
    • Myocardial infarction accelerates atherosclerosis
    • Dutta P, Courties G, Wei Y, Myocardial infarction accelerates atherosclerosis. Nature 2012 487 325 329. doi: 10.1038/nature11260
    • (2012) Nature , vol.487 , pp. 325-329
    • Dutta, P.1    Courties, G.2    Wei, Y.3
  • 36
    • 84929155889 scopus 로고    scopus 로고
    • Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
    • Dutta P, Sager HB, Stengel KR, Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell 2015 16 477 487. doi: 10.1016/j.stem.2015.04.008
    • (2015) Cell Stem Cell , vol.16 , pp. 477-487
    • Dutta, P.1    Sager, H.B.2    Stengel, K.R.3
  • 38
    • 84958040356 scopus 로고    scopus 로고
    • Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem Cells
    • Kim S, Zingler M, Harrison JK, Scott EW, Cogle CR, Luo D, Raizada MK, Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem Cells. Hypertension 2016 67 574 584. doi: 10.1161/HYPERTENSIONAHA.115.06474
    • (2016) Hypertension , vol.67 , pp. 574-584
    • Kim, S.1    Zingler, M.2    Harrison, J.K.3    Scott, E.W.4    Cogle, C.R.5    Luo, D.6    Raizada, M.K.7
  • 41
    • 84898866718 scopus 로고    scopus 로고
    • Autonomic regulation of cellular immune function
    • Bellinger DL, Lorton D, Autonomic regulation of cellular immune function. Auton Neurosci 2014 182 15 41. doi: 10.1016/j.autneu.2014.01.006
    • (2014) Auton Neurosci , vol.182 , pp. 15-41
    • Bellinger, D.L.1    Lorton, D.2
  • 44
    • 84867733063 scopus 로고    scopus 로고
    • Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension
    • Harwani SC, Chapleau MW, Legge KL, Ballas ZK, Abboud FM, Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension. Circ Res 2012 111 1190 1197. doi: 10.1161/CIRCRESAHA.112.277475
    • (2012) Circ Res , vol.111 , pp. 1190-1197
    • Harwani, S.C.1    Chapleau, M.W.2    Legge, K.L.3    Ballas, Z.K.4    Abboud, F.M.5
  • 45
    • 77955171998 scopus 로고    scopus 로고
    • Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension
    • Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, Gordon FJ, Harrison DG, Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res 2010 107 263 270. doi: 10.1161/CIRCRESAHA.110.217299
    • (2010) Circ Res , vol.107 , pp. 263-270
    • Marvar, P.J.1    Thabet, S.R.2    Guzik, T.J.3    Lob, H.E.4    McCann, L.A.5    Weyand, C.6    Gordon, F.J.7    Harrison, D.G.8
  • 46
    • 84926625549 scopus 로고    scopus 로고
    • Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation
    • Slota C, Shi A, Chen G, Bevans M, Weng NP, Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation. Brain Behav Immun 2015 46 168 179. doi: 10.1016/j.bbi.2015.01.015
    • (2015) Brain Behav Immun , vol.46 , pp. 168-179
    • Slota, C.1    Shi, A.2    Chen, G.3    Bevans, M.4    Weng, N.P.5
  • 49
    • 84896690774 scopus 로고    scopus 로고
    • Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice
    • Ataka K, Asakawa A, Nagaishi K, Kaimoto K, Sawada A, Hayakawa Y, Tatezawa R, Inui A, Fujimiya M, Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. PLoS One 2013 8 e81744. doi: 10.1371/journal.pone.0081744
    • (2013) PLoS One , vol.8 , pp. e81744
    • Ataka, K.1    Asakawa, A.2    Nagaishi, K.3    Kaimoto, K.4    Sawada, A.5    Hayakawa, Y.6    Tatezawa, R.7    Inui, A.8    Fujimiya, M.9
  • 53
    • 84894433066 scopus 로고    scopus 로고
    • Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier
    • Biancardi VC, Son SJ, Ahmadi S, Filosa JA, Stern JE, Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier. Hypertension 2014 63 572 579. doi: 10.1161/HYPERTENSIONAHA.113.01743
    • (2014) Hypertension , vol.63 , pp. 572-579
    • Biancardi, V.C.1    Son, S.J.2    Ahmadi, S.3    Filosa, J.A.4    Stern, J.E.5
  • 54
    • 84893922235 scopus 로고    scopus 로고
    • Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract
    • Sharkey KA, Savidge TC, Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci 2014 181 94 106. doi: 10.1016/j.autneu.2013.12.006
    • (2014) Auton Neurosci , vol.181 , pp. 94-106
    • Sharkey, K.A.1    Savidge, T.C.2
  • 55
    • 33750347509 scopus 로고    scopus 로고
    • The role of the sympathetic nervous system in intestinal inflammation
    • Straub RH, Wiest R, Strauch UG, Härle P, Schölmerich J, The role of the sympathetic nervous system in intestinal inflammation. Gut 2006 55 1640 1649. doi: 10.1136/gut.2006.091322
    • (2006) Gut , vol.55 , pp. 1640-1649
    • Straub, R.H.1    Wiest, R.2    Strauch, U.G.3    Härle, P.4    Schölmerich, J.5
  • 56
    • 0032034122 scopus 로고    scopus 로고
    • The role of sympathetic innervation of the gut in regulating mucosal immune responses
    • González-Ariki S, Husband AJ, The role of sympathetic innervation of the gut in regulating mucosal immune responses. Brain Behav Immun 1998 12 53 63. doi: 10.1006/brbi.1997.0509
    • (1998) Brain Behav Immun , vol.12 , pp. 53-63
    • González-Ariki, S.1    Husband, A.J.2
  • 58
    • 84861459865 scopus 로고    scopus 로고
    • Macrophages associated with the intrinsic and extrinsic autonomic innervation of the rat gastrointestinal tract
    • Phillips RJ, Powley TL, Macrophages associated with the intrinsic and extrinsic autonomic innervation of the rat gastrointestinal tract. Auton Neurosci 2012 169 12 27. doi: 10.1016/j.autneu.2012.02.004
    • (2012) Auton Neurosci , vol.169 , pp. 12-27
    • Phillips, R.J.1    Powley, T.L.2
  • 60
    • 84871622830 scopus 로고    scopus 로고
    • Regional sympathetic blockade attenuates activation of intestinal macrophages and reduces gut barrier failure
    • Schäper J, Wagner A, Enigk F, Brell B, Mousa SA, Habazettl H, Schäfer M, Regional sympathetic blockade attenuates activation of intestinal macrophages and reduces gut barrier failure. Anesthesiology 2013 118 134 142. doi: 10.1097/ALN.0b013e3182784c93
    • (2013) Anesthesiology , vol.118 , pp. 134-142
    • Schäper, J.1    Wagner, A.2    Enigk, F.3    Brell, B.4    Mousa, S.A.5    Habazettl, H.6    Schäfer, M.7
  • 61
    • 0023853522 scopus 로고
    • Changes in renal sympathetic nerve activity during experimental septic and endotoxin shock in conscious rats
    • Pålsson J, Ricksten SE, Delle M, Lundin S, Changes in renal sympathetic nerve activity during experimental septic and endotoxin shock in conscious rats. Circ Shock 1988 24 133 141
    • (1988) Circ Shock , vol.24 , pp. 133-141
    • Pålsson, J.1    Ricksten, S.E.2    Delle, M.3    Lundin, S.4
  • 62
    • 23244432145 scopus 로고    scopus 로고
    • Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: Key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes
    • Straub RH, Pongratz G, Weidler C, Linde HJ, Kirschning CJ, Glück T, Schölmerich J, Falk W, Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes. J Infect Dis 2005 192 560 572. doi: 10.1086/432134
    • (2005) J Infect Dis , vol.192 , pp. 560-572
    • Straub, R.H.1    Pongratz, G.2    Weidler, C.3    Linde, H.J.4    Kirschning, C.J.5    Glück, T.6    Schölmerich, J.7    Falk, W.8
  • 64
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    • Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y, Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 2004 558 263 275. doi: 10.1113/jphysiol.2004.063388
    • (2004) J Physiol , vol.558 , pp. 263-275
    • Sudo, N.1    Chida, Y.2    Aiba, Y.3    Sonoda, J.4    Oyama, N.5    Yu, X.N.6    Kubo, C.7    Koga, Y.8
  • 65
    • 84911884131 scopus 로고    scopus 로고
    • The gut microbiota influences blood-brain barrier permeability in mice
    • Braniste V, Al-Asmakh M, Kowal C, The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med 2014 6 263ra158. doi: 10.1126/scitranslmed.3009759
    • (2014) Sci Transl Med , vol.6 , pp. 263ra158
    • Braniste, V.1    Al-Asmakh, M.2    Kowal, C.3
  • 66
    • 84933043202 scopus 로고    scopus 로고
    • Host microbiota constantly control maturation and function of microglia in the CNS
    • Erny D, Hrabě de Angelis AL, Jaitin D, Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 2015 18 965 977. doi: 10.1038/nn.4030
    • (2015) Nat Neurosci , vol.18 , pp. 965-977
    • Erny, D.1    Hrabě De Angelis, A.L.2    Jaitin, D.3
  • 67
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • MetaHIT Consortium MetaHIT Consortium doi: 10.1038/nature08821
    • Qin J, Li R, Raes J, MetaHIT Consortium MetaHIT Consortium A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010 464 59 65. doi: 10.1038/nature08821
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3
  • 68
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Bäckhed F, Functional interactions between the gut microbiota and host metabolism. Nature 2012 489 242 249. doi: 10.1038/nature11552
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 69
    • 69949111703 scopus 로고    scopus 로고
    • The core gut microbiome, energy balance and obesity
    • Turnbaugh PJ, Gordon JI, The core gut microbiome, energy balance and obesity. J Physiol 2009 587 4153 4158. doi: 10.1113/jphysiol.2009.174136
    • (2009) J Physiol , vol.587 , pp. 4153-4158
    • Turnbaugh, P.J.1    Gordon, J.I.2
  • 72
    • 77952243141 scopus 로고    scopus 로고
    • QIIME allows analysis of high-throughput community sequencing data
    • Caporaso JG, Kuczynski J, Stombaugh J, QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010 7 335 336. doi: 10.1038/nmeth.f.303
    • (2010) Nat Methods , vol.7 , pp. 335-336
    • Caporaso, J.G.1    Kuczynski, J.2    Stombaugh, J.3
  • 73
    • 84910125156 scopus 로고    scopus 로고
    • Determining microbial products and identifying molecular targets in the human microbiome
    • Joice R, Yasuda K, Shafquat A, Morgan XC, Huttenhower C, Determining microbial products and identifying molecular targets in the human microbiome. Cell Metab 2014 20 731 741. doi: 10.1016/j.cmet.2014.10.003
    • (2014) Cell Metab , vol.20 , pp. 731-741
    • Joice, R.1    Yasuda, K.2    Shafquat, A.3    Morgan, X.C.4    Huttenhower, C.5
  • 74
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura VK, Faith JJ, Rey FE, Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013 341 1241214. doi: 10.1126/science.1241214
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1    Faith, J.J.2    Rey, F.E.3
  • 75
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze A, Van Nood E, Holleman F, Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012 143 913 6.e7. doi: 10.1053/j.gastro.2012.06.031
    • (2012) Gastroenterology , vol.143 , pp. 913-6e7
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3
  • 77
    • 0015139957 scopus 로고
    • Tone and reactivity of vascular smooth muscle in germfree rat mesentery
    • Baez S, Gordon HA, Tone and reactivity of vascular smooth muscle in germfree rat mesentery. J Exp Med 1971 134 846 856
    • (1971) J Exp Med , vol.134 , pp. 846-856
    • Baez, S.1    Gordon, H.A.2
  • 78
    • 0020041871 scopus 로고
    • The possible involvement of intestinal bacteria in steroidal hypertension
    • Honour J, The possible involvement of intestinal bacteria in steroidal hypertension. Endocrinology 1982 110 285 287. doi: 10.1210/endo-110-1-285
    • (1982) Endocrinology , vol.110 , pp. 285-287
    • Honour, J.1
  • 79
    • 84875047650 scopus 로고    scopus 로고
    • Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    • Pluznick JL, Protzko RJ, Gevorgyan H, Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A 2013 110 4410 4415. doi: 10.1073/pnas.1215927110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 4410-4415
    • Pluznick, J.L.1    Protzko, R.J.2    Gevorgyan, H.3
  • 80
    • 84899435428 scopus 로고    scopus 로고
    • A novel scfa receptor, the microbiota, and blood pressure regulation
    • Pluznick J, A novel scfa receptor, the microbiota, and blood pressure regulation. Gut Microbes 2014 5 202 207
    • (2014) Gut Microbes , vol.5 , pp. 202-207
    • Pluznick, J.1
  • 83
    • 84877312307 scopus 로고    scopus 로고
    • Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats
    • Xu J, Ahrén IL, Prykhodko O, Olsson C, Ahrné S, Molin G, Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats. Evid Based Complement Alternat Med 2013 2013 809128. doi: 10.1155/2013/809128
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 809128
    • Xu, J.1    Ahrén, I.L.2    Prykhodko, O.3    Olsson, C.4    Ahrné, S.5    Molin, G.6
  • 85
    • 84943572751 scopus 로고    scopus 로고
    • Impact of antibiotics on arterial blood pressure in a patient with resistant hypertension - A case report
    • Qi Y, Aranda JM, Rodriguez V, Raizada MK, Pepine CJ, Impact of antibiotics on arterial blood pressure in a patient with resistant hypertension-A case report. Int J Cardiol 2015 201 157 158. doi: 10.1016/j.ijcard.2015.07.078
    • (2015) Int J Cardiol , vol.201 , pp. 157-158
    • Qi, Y.1    Aranda, J.M.2    Rodriguez, V.3    Raizada, M.K.4    Pepine, C.J.5
  • 86
    • 84928402947 scopus 로고    scopus 로고
    • Regulation of obesity-related insulin resistance with gut anti-inflammatory agents
    • Luck H, Tsai S, Chung J, Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Cell Metab 2015 21 527 542. doi: 10.1016/j.cmet.2015.03.001
    • (2015) Cell Metab , vol.21 , pp. 527-542
    • Luck, H.1    Tsai, S.2    Chung, J.3
  • 87
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008 57 1470 1481. doi: 10.2337/db07-1403
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 88
    • 84879402478 scopus 로고    scopus 로고
    • The role of the immune system in governing host-microbe interactions in the intestine
    • Brown EM, Sadarangani M, Finlay BB, The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol 2013 14 660 667. doi: 10.1038/ni.2611
    • (2013) Nat Immunol , vol.14 , pp. 660-667
    • Brown, E.M.1    Sadarangani, M.2    Finlay, B.B.3
  • 89
    • 73349099737 scopus 로고    scopus 로고
    • A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
    • Cong Y, Feng T, Fujihashi K, Schoeb TR, Elson CO, A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A 2009 106 19256 19261. doi: 10.1073/pnas.0812681106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 19256-19261
    • Cong, Y.1    Feng, T.2    Fujihashi, K.3    Schoeb, T.R.4    Elson, C.O.5
  • 90
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007 56 1761 1772. doi: 10.2337/db06-1491
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 92
    • 84886014303 scopus 로고    scopus 로고
    • Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics
    • Pastorelli L, De Salvo C, Mercado JR, Vecchi M, Pizarro TT, Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol 2013 4 280. doi: 10.3389/fimmu.2013.00280
    • (2013) Front Immunol , vol.4 , pp. 280
    • Pastorelli, L.1    De Salvo, C.2    Mercado, J.R.3    Vecchi, M.4    Pizarro, T.T.5
  • 93
    • 61749099040 scopus 로고    scopus 로고
    • Interferon-gamma regulation of intestinal epithelial permeability
    • Beaurepaire C, Smyth D, McKay DM, Interferon-gamma regulation of intestinal epithelial permeability. J Interferon Cytokine Res 2009 29 133 144. doi: 10.1089/jir.2008.0057
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 133-144
    • Beaurepaire, C.1    Smyth, D.2    McKay, D.M.3
  • 94
    • 84880653498 scopus 로고    scopus 로고
    • IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells
    • Hasnain SZ, Tauro S, Das I, Tong H, Chen AC, Jeffery PL, McDonald V, Florin TH, McGuckin MA, IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology 2013 144 357 368.e9. doi: 10.1053/j.gastro.2012.10.043
    • (2013) Gastroenterology , vol.144 , pp. 357-368e9
    • Hasnain, S.Z.1    Tauro, S.2    Das, I.3    Tong, H.4    Chen, A.C.5    Jeffery, P.L.6    McDonald, V.7    Florin, T.H.8    McGuckin, M.A.9
  • 95
    • 84923261268 scopus 로고    scopus 로고
    • Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
    • Everard A, Geurts L, Caesar R, Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat Commun 2014 5 5648. doi: 10.1038/ncomms6648
    • (2014) Nat Commun , vol.5 , pp. 5648
    • Everard, A.1    Geurts, L.2    Caesar, R.3
  • 97
    • 20944445862 scopus 로고    scopus 로고
    • Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma
    • Rousseaux C, Lefebvre B, Dubuquoy L, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med 2005 201 1205 1215. doi: 10.1084/jem.20041948
    • (2005) J Exp Med , vol.201 , pp. 1205-1215
    • Rousseaux, C.1    Lefebvre, B.2    Dubuquoy, L.3
  • 99
    • 84963830743 scopus 로고    scopus 로고
    • Altered Gut Microbiota Composition in Rag1-deficient Mice Contributes to Modulating Homeostasis of Hematopoietic Stem and Progenitor Cells
    • Kwon O, Lee S, Kim JH, Kim H, Lee SW, Altered Gut Microbiota Composition in Rag1-deficient Mice Contributes to Modulating Homeostasis of Hematopoietic Stem and Progenitor Cells. Immune Netw 2015 15 252 259. doi: 10.4110/in.2015.15.5.252
    • (2015) Immune Netw , vol.15 , pp. 252-259
    • Kwon, O.1    Lee, S.2    Kim, J.H.3    Kim, H.4    Lee, S.W.5
  • 101
    • 84937975894 scopus 로고    scopus 로고
    • Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells
    • Iraporda C, Errea A, Romanin DE, Cayet D, Pereyra E, Pignataro O, Sirard JC, Garrote GL, Abraham AG, Rumbo M, Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells. Immunobiology 2015 220 1161 1169. doi: 10.1016/j.imbio.2015.06.004
    • (2015) Immunobiology , vol.220 , pp. 1161-1169
    • Iraporda, C.1    Errea, A.2    Romanin, D.E.3    Cayet, D.4    Pereyra, E.5    Pignataro, O.6    Sirard, J.C.7    Garrote, G.L.8    Abraham, A.G.9    Rumbo, M.10
  • 102
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang PV, Hao L, Offermanns S, Medzhitov R, The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 2014 111 2247 2252. doi: 10.1073/pnas.1322269111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 103
    • 84922163095 scopus 로고    scopus 로고
    • Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
    • Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J, Kim CH, Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 2015 8 80 93. doi: 10.1038/mi.2014.44
    • (2015) Mucosal Immunol , vol.8 , pp. 80-93
    • Park, J.1    Kim, M.2    Kang, S.G.3    Jannasch, A.H.4    Cooper, B.5    Patterson, J.6    Kim, C.H.7
  • 104
    • 84960081564 scopus 로고    scopus 로고
    • Functions of innate immune cells and commensal bacteria in gut homeostasis
    • Kayama H, Takeda K, Functions of innate immune cells and commensal bacteria in gut homeostasis. J Biochem 2016 159 141 149. doi: 10.1093/jb/mvv119
    • (2016) J Biochem , vol.159 , pp. 141-149
    • Kayama, H.1    Takeda, K.2
  • 105
    • 84976879223 scopus 로고    scopus 로고
    • 6B.07: Hypertensive patients exhibit gut microbial dysbiosis and an increase in Th17 cells
    • Kim S, Rodriguez V, Santisteban M, Yang T, Qi Y, Raizada M, Pepine C, 6B.07: Hypertensive patients exhibit gut microbial dysbiosis and an increase in Th17 cells. J Hypertens 2015 33(suppl 1) e77 e78. doi: 10.1097/01.hjh.0000467562.03337.a5
    • (2015) J Hypertens , vol.331 , pp. e77-e78
    • Kim, S.1    Rodriguez, V.2    Santisteban, M.3    Yang, T.4    Qi, Y.5    Raizada, M.6    Pepine, C.7
  • 107
    • 0034133634 scopus 로고    scopus 로고
    • Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure
    • Kawase M, Hashimoto H, Hosoda M, Morita H, Hosono A, Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci 2000 83 255 263. doi: 10.3168/jds.S0022-0302(00)74872-7
    • (2000) J Dairy Sci , vol.83 , pp. 255-263
    • Kawase, M.1    Hashimoto, H.2    Hosoda, M.3    Morita, H.4    Hosono, A.5
  • 108
    • 24144437148 scopus 로고    scopus 로고
    • Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats
    • Tanida M, Yamano T, Maeda K, Okumura N, Fukushima Y, Nagai K, Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats. Neurosci Lett 2005 389 109 114. doi: 10.1016/j.neulet.2005.07.036
    • (2005) Neurosci Lett , vol.389 , pp. 109-114
    • Tanida, M.1    Yamano, T.2    Maeda, K.3    Okumura, N.4    Fukushima, Y.5    Nagai, K.6
  • 110
    • 84914675372 scopus 로고    scopus 로고
    • Effect of probiotics on blood pressure: A systematic review and meta-analysis of randomized, controlled trials
    • Khalesi S, Sun J, Buys N, Jayasinghe R, Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials. Hypertension 2014 64 897 903. doi: 10.1161/HYPERTENSIONAHA.114.03469
    • (2014) Hypertension , vol.64 , pp. 897-903
    • Khalesi, S.1    Sun, J.2    Buys, N.3    Jayasinghe, R.4


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