Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation

Hypertension

Volumn 65, Issue 3, 2015, Pages 577-586

  Sriramula, Srinivas ^a   Xia, Huijing ^a   Xu, Ping ^a   Lazartigues, Eric ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

angiotensin converting enzyme 2; cyclooxygenases; hypertension; paraventricular nucleus; renin angiotensin system

Indexed keywords

3 NITROTYROSINE; ANGIOTENSIN CONVERTING ENZYME 2; CATALASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEOXYCORTICOSTERONE ACETATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEURONAL NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE DISMUTASE; ANTIOXIDANT; DIPEPTIDYL CARBOXYPEPTIDASE; ISOENZYME; MEMBRANE PROTEIN; NITRIC OXIDE SYNTHASE; PTGS1 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENE SILENCING; HYPERTENSION; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; ENCEPHALITIS; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; BRAIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DESOXYCORTICOSTERONE ACETATE; DISEASE MODELS, ANIMAL; ENCEPHALITIS; GENE SILENCING; HYPERTENSION; ISOENZYMES; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PEPTIDYL-DIPEPTIDASE A; PROTO-ONCOGENE PROTEINS C-AKT; UP-REGULATION;

EID: 84924234276     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04691     Document Type: Article

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