Inhibition of TNF in the Brain Reverses Alterations in RAS Components and Attenuates Angiotensin II-Induced Hypertension

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Sriramula, Srinivas ^a,b   Cardinale, Jeffrey P ^a   Francis, Joseph ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; ETANERCEPT; INTERLEUKIN 10; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXIDATIVE STRESS; PARAVENTRICULAR THALAMIC NUCLEUS; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TELEMETRY;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; BRAIN; CYTOKINES; HYPERTENSION; IMMUNOGLOBULIN G; MALE; OXIDATIVE STRESS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TUMOR NECROSIS FACTOR; RENIN-ANGIOTENSIN SYSTEM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84877774737     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063847     Document Type: Article

References (38)

1. Davisson RL, (2003) Physiological genomic analysis of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 285: R498-511.
2. Xu P, Sriramula S, Lazartigues E, (2011) ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good. Am J Physiol Regul Integr Comp Physiol 300: R804-817.
3. Bader M, Ganten D, (2002) It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system. Circ Res 90: 8-10.
4. Sakai K, Sigmund CD, (2005) Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. Curr Hypertens Rep 7: 135-140.
5. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, et al. (2003) The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol 35: 901-918.
6. Baltatu OC, Campos LA, Bader M, (2011) Local renin-angiotensin system and the brain-a continuous quest for knowledge. Peptides 32: 1083-1086.
7. Veerasingham SJ, Raizada MK, (2003) Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br J Pharmacol 139: 191-202.
8. Bruner CA, Fink GD, (1986) Neurohumoral contributions to chronic angiotensin-induced hypertension. Am J Physiol 250: H52-61.
9. Simpson JB, (1981) The circumventricular organs and the central actions of angiotensin. Neuroendocrinology 32: 248-256.
10. Fink GD, Bruner CA, Mangiapane ML, (1987) Area postrema is critical for angiotensin-induced hypertension in rats. Hypertension 9: 355-361.
11. Martin DS, Segura T, Haywood JR, (1991) Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat. Hypertension 18: 48-55.
12. Zhu GQ, Gao L, Patel KP, Zucker IH, Wang W, (2004) ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J Appl Physiol 97: 1746-1754.
13. Kang YM, Ma Y, Zheng JP, Elks C, Sriramula S, et al. (2009) Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovasc Res 82: 503-512.
14. Shi P, Diez-Freire C, Jun JY, Qi Y, Katovich MJ, et al. (2010) Brain microglial cytokines in neurogenic hypertension. Hypertension 56: 297-303.
15. Sriramula S, Cardinale JP, Lazartigues E, Francis J, (2011) ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovasc Res 92: 401-408.
16. Zubcevic J, Waki H, Raizada MK, Paton JF, (2011) Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension. Hypertension 57: 1026-1033.
17. Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, et al. (2010) Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res 107: 263-270.
18. Francis J, Weiss RM, Johnson AK, Felder RB, (2003) Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats. Am J Physiol Regul Integr Comp Physiol 284: R328-335.
19. Gao L, Wang W, Li YL, Schultz HD, Liu D, et al. (2004) Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase. Circ Res 95: 937-944.
20. Sriramula S, Haque M, Majid DS, Francis J, (2008) Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension 51: 1345-1351.
21. Lu Y, Chen J, Yin X, Zhao H, (2009) Angiotensin II receptor 1 involved in the central pressor response induced by interleukin-1 beta in the paraventricular nucleus. Neurol Res 31: 420-424.
22. Goffe B, Cather JC, (2003) Etanercept: An overview. J Am Acad Dermatol 49: S105-111.
23. Muller DN, Shagdarsuren E, Park JK, Dechend R, Mervaala E, et al. (2002) Immunosuppressive treatment protects against angiotensin II-induced renal damage. Am J Pathol 161: 1679-1693.
24. Elmarakby AA, Quigley JE, Pollock DM, Imig JD, (2006) Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. Hypertension 47: 557-562.
25. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, et al. (2007) Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 204: 2449-2460.
26. Zhang C, Hein TW, Wang W, Ren Y, Shipley RD, et al. (2006) Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles. J Mol Cell Cardiol 40: 247-257.
27. Turnbull AV, Pitossi FJ, Lebrun JJ, Lee S, Meltzer JC, et al. (1997) Inhibition of tumor necrosis factor-alpha action within the CNS markedly reduces the plasma adrenocorticotropin response to peripheral local inflammation in rats. J Neurosci 17: 3262-3273.
28. Yu Y, Zhang ZH, Wei SG, Chu Y, Weiss RM, et al. (2007) Central gene transfer of interleukin-10 reduces hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction. Circ Res 101: 304-312.
29. Paul M, Poyan Mehr A, Kreutz R, (2006) Physiology of local renin-angiotensin systems. Physiol Rev 86: 747-803.
30. Sasamura H, Nakazato Y, Hayashida T, Kitamura Y, Hayashi M, et al. (1997) Regulation of vascular type 1 angiotensin receptors by cytokines. Hypertension 30: 35-41.
31. Arenas IA, Xu Y, Lopez-Jaramillo P, Davidge ST, (2004) Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha. Am J Physiol Cell Physiol 286: C779-784.
32. Agarwal D, Welsch MA, Keller JN, Francis J, (2011) Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR. Basic Res Cardiol 106: 1069-1085.
33. Xia H, Feng Y, Obr TD, Hickman PJ, Lazartigues E, (2009) Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension 53: 210-216.
34. Paravicini TM, Touyz RM, (2006) Redox signaling in hypertension. Cardiovasc Res 71: 247-258.
35. Nishiyama A, Fukui T, Fujisawa Y, Rahman M, Tian RX, et al. (2001) Systemic and regional hemodynamic responses to tempol in angiotensin II-infused hypertensive rats. Hypertension 37: 77-83.
36. Infanger DW, Sharma RV, Davisson RL, (2006) NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal 8: 1583-1596.
37. Xue B, Beltz TG, Johnson RF, Guo F, Hay M, et al. (2012) PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice. Am J Physiol Heart Circ Physiol 302: H733-741.
38. Fujita M, Ando K, Nagae A, Fujita T, (2007) Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt-sensitive hypertension. Hypertension 50: 360-367.