The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4

GLIA

Volumn 62, Issue 5, 2014, Pages 667-679

  Pannell, Maria ^a   Szulzewsky, Frank ^a   Matyash, Vitali ^a   Wolf, Susanne A ^a   Kettenmann, Helmut ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

IFN ; IL 4; LPS; Microglia; Neurohormone receptor; Neurotransmitter receptor

Indexed keywords

ANGIOTENSIN II; CALCIUM; DOPAMINE; ENDOTHELIN; GALANIN; GAMMA INTERFERON; HISTAMINE; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; NEUROHORMONE; NEUROTENSIN; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; NICOTINE; SEROTONIN; SOMATOSTATIN; SUBSTANCE P; VASOPRESSIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL SUBPOPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; INFLAMMATION; LYMPHOCYTE; MICROGLIA; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; DRUG EFFECTS; METABOLISM;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; INTERFERON-GAMMA; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROTRANSMITTER AGENTS;

EID: 84896319990     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22633     Document Type: Article

References (17)

1. Biber K, Neumann H, Inoue K, Boddeke HWGM. 2007. Neuronal 'On' and 'Off' signals control microglia. Trends Neurosci 30:596-602.
2. Eichhoff G, Brawek B, Garaschuk O. 2011. Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo. Biochim Biophys Acta 1813:1014-1024.
3. Farber K, Pannasch U, Kettenmann H. 2005. Dopamine and noradrenaline control distinct functions in rodent microglial cells. Mol Cell Neurosci 29:128-138.
4. Giulian D, Baker TJ. 1986. Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
5. Hanisch U-K, Kettenmann H. 2007. Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10:1387-1394.
6. Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D. 2006. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9:1512-1519.
7. Kettenmann H, Hanisch U-K, Noda M, Verkhratsky A. 2011. Physiology of microglia. Physiol Rev 91:461-553.
8. Krabbe G, Halle A, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, Miller KR, Prokop S, Kettenmann H, Heppner FL. 2013. Functional impairment of microglia coincides with βeta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One 8:e60921.
9. Krabbe G, Matyash V, Pannasch U, Mamer L, Boddeke HWGM, Kettenmann H. 2012. Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity. Brain Behav Immun 26:419-428.
10. Kuhn SA, van Landeghem FKH, Zacharias R, Färber K, Rappert A, Pavlovic S, Hoffmann A, Nolte C, Kettenmann H. 2004. Microglia express GABA(B) receptors to modulate interleukin release. Mol Cell Neurosci 25:312-322.
11. Marascuilo LA. 1966. Large-sample multiple comparisons. Psychol Bull 65:280-290.
12. Nikodemova M, Watters JJ. 2012. Efficient isolation of live microglia with preserved phenotypes from adult mouse brain. J Neuroinflammation 9:147.
13. Pocock JM, Kettenmann H. 2007. Neurotransmitter receptors on microglia. Trends Neurosci 30:527-535.
14. Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HWGM, Chuang H-N, Pukrop T, Wessels JT, Jürgens T, Merkler D, Brück W, Schnaars M, Simons M, Kettenmann H, Hanisch UK. 2012. Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia. Glia 60:1930-1943.
15. 2+) sensor. Cell Calcium 49:365-375.
16. Verzani J. 2005. Using R for introductory statistics. Chapman and Hall/CRC Press, Taylor & Francis, Boca Raton, USA.
17. Wilson EB. 1927. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc 22:209-212.