Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

Oncotarget

Volumn 7, Issue 11, 2016, Pages 11923-11944

  Biundo, Fabrizio ^a   Ishiwari, Keita ^a,b   Del Prete, Dolores ^a   D'Adamio, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b RESEARCH INSTITUTE ON ADDICTIONS   (United States)

Author keywords

Alzheimer; APP; Danish dementia; Gamma secretase; Gerotarget; Itm2b bri2

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA CARBOXY TERMINAL FRAGMENT PROTEIN; UNCLASSIFIED DRUG; SECRETASE;

AGE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APH1BC GENE; APH1C GENE; ARTICLE; CONTROLLED STUDY; DEMENTIA; DISEASE EXACERBATION; FAMILIAL DANISH DEMENTIA; GENE; GENE DELETION; GENE MUTATION; HETEROZYGOSITY; LEARNING; LONG TERM MEMORY; MALE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN FUNCTION; SHORT TERM MEMORY; SPATIAL MEMORY; WORKING MEMORY; ALZHEIMER DISEASE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CATARACT; CEREBELLAR ATAXIA; DISEASE MODEL; GENE TARGETING; GENETICS; HEARING IMPAIRMENT; HUMAN; MEMORY DISORDER; MUTATION; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BEHAVIOR, ANIMAL; CATARACT; CEREBELLAR ATAXIA; DEAFNESS; DEMENTIA; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; HUMANS; MALE; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION;

EID: 84962885325     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7389     Document Type: Article

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