Synaptic function of nicastrin in hippocampal neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 24, 2014, Pages 8973-8978

  Lee, Sang Hun ^a   Sharma, Manu ^b   Südhof, Thomas C ^b   Shen, Jie ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM ION; CRE RECOMBINASE; GAMMA SECRETASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICASTRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM; FOREBRAIN; HIPPOCAMPUS; HIPPOCAMPUS THETA RHYTHM; KNOCKOUT MOUSE; LONG TERM POTENTIATION; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; LEARNING; LONG-TERM POTENTIATION; MEMBRANE GLYCOPROTEINS; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; NEURONAL PLASTICITY; NEURONS; PRESENILINS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 84902590776     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408554111     Document Type: Article

References (38)

1. Yu G, et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407(6800):48-54.
2. Li T, Ma G, Cai H, Price DL, Wong PC (2003) Nicastrin is required for assembly of presenilin/ gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. J Neurosci 23(8):3272-3277. (Pubitemid 36531968)
3. Li J, et al. (2003) Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model. J Biol Chem 278(35):33445-33449. (Pubitemid 37055798)
4. Shen J, et al. (1997) Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89(4): 629-639. (Pubitemid 27511773)
5. Wong PC, et al. (1997) Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387(6630):288-292. (Pubitemid 27220764)
6. Donoviel DB, et al. (1999) Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev 13(21):2801-2810.
7. Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T (1994) Notch1 is essential for postimplantation development in mice. Genes Dev 8(6):707-719. (Pubitemid 24116765)
8. Yu H, et al. (2001) APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 31(5):713-726. (Pubitemid 32907369)
9. Saura CA, et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42(1):23-36. (Pubitemid 38456965)
10. Beglopoulos V, et al. (2004) Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem 279(45): 46907-46914. (Pubitemid 39518343)
11. Wines-Samuelson M, et al. (2010) Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS ONE 5(4): e10195.
12. Tabuchi K, Chen G, Südhof TC, Shen J (2009) Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci 29(22):7290-7301.
13. Ho A, Shen J (2011) Presenilins in synaptic function and disease. Trends Mol Med 17(11):617-624.
14. Lee JH, et al. (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141(7):1146-1158.
15. Zheng J, et al. (2012) Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem 287(24):20356-20368.
16. Handler M, Yang X, Shen J (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127(12):2593-2606. (Pubitemid 30426807)
17. Wines-Samuelson M, Handler M, Shen J (2005) Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol 277(2):332-346. (Pubitemid 40022955)
18. Wines-Samuelson M, Shen J (2005) Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist 11(5):441-451. (Pubitemid 41339229)
19. Zhang D, et al. (2010) Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. J Neurochem 115(5):1215-1221.
20. Myme CI, Sugino K, Turrigiano GG, Nelson SB (2003) The NMDA-to-AMPA ratio at synapses onto layer 2/3 pyramidal neurons is conserved across prefrontal and visual cortices. J Neurophysiol 90(2):771-779. (Pubitemid 37092562)
21. Malenka RC, Nicoll RA (1999) Long-term potentiation - a decade of progress? Science 285(5435):1870-1874.
22. Stevens CF, Wesseling JF (1999) Augmentation is a potentiation of the exocytotic process. Neuron 22(1):139-146. (Pubitemid 29070100)
23. Zhang C, et al. (2009) Presenilins are essential for regulating neurotransmitter release. Nature 460(7255):632-636.
24. Mattson MP (2010) ER calcium and Alzheimer's disease: In a state of flux. Sci Signal 3(114):pe10.
25. Treiman M, Caspersen C, Christensen SB (1998) A tool coming of age: Thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Trends Pharmacol Sci 19(4): 131-135. (Pubitemid 28218535)
26. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126(5):981-993.
27. Wang B, et al. (2010) Gamma-secretase gene mutations in familial acne inversa. Science 330(6007):1065.
28. Kelleher RJ, 3rd, Shen J (2010) Genetics. Gamma-secretase and human disease. Science 330(6007):1055-1056.
29. Li CR, et al. (2011) Two novel mutations of the nicastrin gene in Chinese patients with acne inversa. Br J Dermatol 165(2):415-418.
30. Nomura Y, et al. (2013) A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa. Br J Dermatol 168(1):206-209.
31. Pink AE, Simpson MA, Desai N, Trembath RC, Barker JN (2013) γ-Secretase mutations in hidradenitis suppurativa: New insights into disease pathogenesis. J Invest Dermatol 133(3):601-607.
32. Xia X, et al. (2001) Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci USA 98(19):10863-10868. (Pubitemid 32878710)
33. Li T, et al. (2007) Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem 282(44):32264-32273. (Pubitemid 350106457)
34. Nicolas M, et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33(3):416-421. (Pubitemid 36278861)
35. Heilig EA, Xia W, Shen J, Kelleher RJ, 3rd (2010) A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem 285(29):22350-22359.
36. Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ, 3rd (2013) Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. J Neurosci 33(28):11606-11617.
37. Committee on Care and Use of Laboratory Animals (1985) Guide for the Care and Use of Laboratory Animals (Natl Inst Health, Bethesda), DHHS Publ No (NIH) 85-23.
38. Rosahl TW, et al. (1995) Essential functions of synapsins I and II in synaptic vesicle regulation. Nature 375(6531):488-493.