Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: Caspase-9 inhibition provides therapeutic protection

Molecular Neurodegeneration

Volumn 7, Issue 1, 2012, Pages

  Tamayev, Robert ^a   Akpan, Nsikan ^b   Arancio, Ottavio ^b   Troy, Carol M ^b   D'Adamio, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE MUTATION; IN VIVO STUDY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CASPASE 9; CATARACT; CEREBELLAR ATAXIA; DEAFNESS; DEMENTIA; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE KNOCK-IN TECHNIQUES; MEMORY; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES;

MUS;

EID: 84872324395     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-7-60     Document Type: Article

References (33)

1. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Moller M, Braendgaard H, Plant G, Ghiso J, et al. Proc Natl Acad Sci USA 2000 97 4920 4925 10.1073/pnas.080076097 10781099 (Pubitemid 30238658)
2. Generation and Initial Characterization of FDD Knock In Mice. Giliberto L, Matsuda S, Vidal R, D'Adamio L, PLoS One 2009 4 7900 10.1371/journal.pone. 0007900 19924302
3. Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits. Tamayev R, Matsuda S, Fa M, Arancio O, D'Adamio L, Proc Natl Acad Sci USA 2010 107 20822 20827 10.1073/pnas.1011689107 21098268
4. APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant. Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L, EMBO J 2011 30 2501 2509 10.1038/emboj.2011.161 21587206
5. Increased AbetaPP processing in familial Danish dementia patients. Matsuda S, Tamayev R, D'Adamio L, J Alzheimers Dis 2011 27 385 391 21841249
6. beta- but not gamma-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. Tamayev R, Matsuda S, Arancio O, D'Adamio L, EMBO Mol Med 2012 4 171 179 10.1002/emmm.201100195 22170863
7. Inhibition of gamma-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia. Tamayev R, D'Adamio L, Mol Neurodegener 2012 7 19 10.1186/1750-1326-7-19 22537414
8. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, et al. Nature 2012 482 216 220 22278060
9. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, et al. Nature 2012 488 96 99 10.1038/nature11283 22801501
10. Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Vito P, Lacana E, D'Adamio L, Science 1996 271 521 525 10.1126/science.271.5248.521 8560270
11. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. Vito P, Ghayur T, D'Adamio L, J Biol Chem 1997 272 28315 28320 10.1074/jbc.272.45.28315 9353287 (Pubitemid 27517775)
12. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. Vito P, Wolozin B, Ganjei JK, Iwasaki K, Lacana E, D'Adamio L, J Biol Chem 1996 271 31025 31028 10.1074/jbc.271.49.31025 8940094 (Pubitemid 26408537)
13. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L, Science 1996 274 1710 1713 10.1126/science.274.5293.1710 8939861 (Pubitemid 26414902)
14. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Yamatsuji T, Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H, Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, et al. Science 1996 272 1349 1352 10.1126/science.272.5266.1349 8650548 (Pubitemid 26199978)
15. Regulation of caspases in the nervous system implications for functions in health and disease. Troy CM, Akpan N, Jean YY, Prog Mol Biol Transl Sci 2011 99 265 305 21238939
16. Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. Passer B, Pellegrini L, Russo C, Siegel RM, Lenardo MJ, Schettini G, Bachmann M, Tabaton M, D'Adamio L, J Alzheimers Dis 2000 2 289 301 12214090 (Pubitemid 32095613)
17. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE, Nat Med 2000 6 397 404 10.1038/74656 10742146 (Pubitemid 30208156)
18. SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. Madeira A, Pommet JM, Prochiantz A, Allinquant B, FASEB J 2005 19 1905 1907 16162853 (Pubitemid 41598790)
19. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M, Nature 2009 457 981 989 10.1038/nature07767 19225519
20. Human caspases: activation, specificity, and regulation. Pop C, Salvesen GS, J Biol Chem 2009 284 21777 21781 10.1074/jbc.R800084200 19473994
21. Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M, Cell 2010 141 859 871 10.1016/j.cell.2010. 03.053 20510932
22. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. McStay GP, Salvesen GS, Green DR, Cell Death Differ 2008 15 322 331 10.1038/sj.cdd.4402260 17975551
23. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, et al. J Neurosci 2011 31 8894 8904 10.1523/JNEUROSCI.0698- 11.2011 21677173
24. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. Eckelman BP, Salvesen GS, Scott FL, EMBO Rep 2006 7 988 994 10.1038/sj.embor.7400795 17016456 (Pubitemid 44480512)
25. Inhibition of human caspases by peptide-based and macromolecular inhibitors. Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA, J Biol Chem 1998 273 32608 32613 10.1074/jbc.273.49.32608 9829999 (Pubitemid 28557641)
26. In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR, Nat Cell Biol 2006 8 72 77 10.1038/ncb1340 16362053 (Pubitemid 43064799)
27. Cystatin C protects neuronal cells from amyloid-beta-induced toxicity. Tizon B, Ribe EM, Mi W, Troy CM, Levy E, J Alzheimers Dis 2010 19 885 894 20157244
28. The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, Ghiso J, Frangione B, D'Adamio L, J Biol Chem 2005 280 28912 28916 10.1074/jbc.C500217200 15983050 (Pubitemid 41161336)
29. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L, J Neurosci 2008 28 8668 8676 10.1523/JNEUROSCI.2094-08.2008 18753367
30. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. D'Amelio M, Cavallucci V, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P, Battistini L, et al. Nat Neurosci 2010 14 69 76 21151119
31. Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo SC, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, et al. Nat Neurosci 2011 14 545 547 10.1038/nn.2785 21441921
32. Preparation of organotypic hippocampal slice cultures: interface method. De Simoni A, Yu LM, Nat Protoc 2006 1 1439 1445 10.1038/nprot.2006.228 17406432
33. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Bevins RA, Besheer J, Nat Protoc 2006 1 1306 1311 10.1038/nprot.2006.205 17406415