Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay

Journal of the American Chemical Society

Volumn 138, Issue 11, 2016, Pages 3844-3855

  Surovtseva, Yulia V ^a   Jairam, Vikram ^b   Salem, Ahmed F ^b   Sundaram, Ranjini K ^b   Bindra, Ranjit S ^b   Herzon, Seth B ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; CHROMOPHORES; DNA; HEART; IONIZING RADIATION; MOLECULES; PROTEINS; REPAIR; SUGARS;

ADJUVANT CHEMOTHERAPY; ANTICANCER ACTIVITIES; DNA DOUBLE STRAND BREAKS; IMMUNOFLUORESCENCE ASSAY; NEOCARZINOSTATIN CHROMOPHORES; P53 BINDING PROTEIN 1 (53BP1); SMALL MOLECULE INHIBITOR; UBIQUITIN-PROTEIN LIGASES;

ASSAYS;

BINDING PROTEIN; CARDIAC GLYCOSIDE; DNA DAMAGE CHECKPOINT PROTEIN 1; DOUBLE STRANDED DNA; E3 UBIQUITIN PROTEIN LIGASE RING FINGER PROTEIN 8; HISTONE H2AX; P53 BINDING PROTEIN 1; PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; MOLECULAR LIBRARY;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DENSITY; CELL VIABILITY; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA REPAIR; DOUBLE STRANDED DNA BREAK; HEART ATRIUM ARRHYTHMIA; HEART FAILURE; IMMUNOFLUORESCENCE TEST; MOLECULAR RECOGNITION; PHENOTYPE; DNA END JOINING REPAIR; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; MOLECULAR LIBRARY; PHARMACOLOGY; PROCEDURES; TUMOR CELL LINE;

CARDIAC GLYCOSIDES; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; SMALL MOLECULE LIBRARIES;

EID: 84962053999     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b00162     Document Type: Article

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