Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues

Journal of the American Chemical Society

Volumn 137, Issue 3, 2015, Pages 1330-1340

  Renata, Hans ^a   Zhou, Qianghui ^a   Dünstl, Georg ^b   Felding, Jakob ^b   Merchant, Rohan R ^a   Yeh, Chien Hung ^a   Baran, Phil S ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b LEO PHARMA A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCULOSKELETAL SYSTEM;

BUTENOLIDES; CARDIOTONIC STEROIDS; CHEMICAL EQUATIONS; CONCISE SYNTHESIS; HYDROXYL GROUPS; NATURAL PRODUCTS; STEROID SKELETONS; SYNTHETIC STRATEGIES;

HYDROXYLATION;

ACETAL; ADRENOSTERONE; BUTANOL; BUTENOLIDE; CORTICOSTEROID DERIVATIVE; CORTISONE ACETATE; CUMENE HYDROPEROXIDE; HYDROXYL GROUP; HYDROXYLATED CORTICOSTEROID DERIVATIVE; KETONE; OUABAGENIN; OUABAIN; UNCLASSIFIED DRUG; CORTICOSTEROID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG SYNTHESIS; FRAGMENTATION REACTION; HUMAN; HUMAN CELL; HYDROGENATION; NUCLEOPHILICITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHOTOCHEMISTRY; PHOTOREACTIVITY; PROTON NUCLEAR MAGNETIC RESONANCE; STILLE REACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; CONFORMATION; HYDROXYLATION; SYNTHESIS;

ADRENAL CORTEX HORMONES; HYDROXYLATION; MOLECULAR CONFORMATION; OUABAIN;

EID: 84921958314     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja512022r     Document Type: Article

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