메뉴 건너뛰기




Volumn 47, Issue 11, 2009, Pages 2716-2722

Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells

Author keywords

Comet assay; hOGG1; RT PCR; Single strand breaks

Indexed keywords

8 HYDROXYGUANINE; DNA; DNA GLYCOSYLTRANSFERASE; FLAVONOID; HYDROGEN PEROXIDE; MESSENGER RNA; QUERCETIN;

EID: 70350202529     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.07.033     Document Type: Article
Times cited : (64)

References (47)
  • 1
    • 0033004488 scopus 로고    scopus 로고
    • Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures
    • Abalea V., Cillard J., Dubos M.P., Sergent O., Cillard P., and Morel I. Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures. Free Radic. Biol. Med. 26 11-12 (1999) 1457-1466
    • (1999) Free Radic. Biol. Med. , vol.26 , Issue.11-12 , pp. 1457-1466
    • Abalea, V.1    Cillard, J.2    Dubos, M.P.3    Sergent, O.4    Cillard, P.5    Morel, I.6
  • 3
    • 0345874648 scopus 로고    scopus 로고
    • Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes
    • Astley S.B., Elliott R.M., Archer D.B., and Southon S. Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes. Br. J. Nutr. 91 1 (2004) 63-72
    • (2004) Br. J. Nutr. , vol.91 , Issue.1 , pp. 63-72
    • Astley, S.B.1    Elliott, R.M.2    Archer, D.B.3    Southon, S.4
  • 4
    • 50649108365 scopus 로고    scopus 로고
    • Base excision repair and its role in maintaining genome stability
    • Baute J., and Depicker A. Base excision repair and its role in maintaining genome stability. Crit. Rev. Biochem. Mol. Biol. 43 4 (2008) 239-276
    • (2008) Crit. Rev. Biochem. Mol. Biol. , vol.43 , Issue.4 , pp. 239-276
    • Baute, J.1    Depicker, A.2
  • 5
    • 0025004502 scopus 로고
    • Flavonoid as antioxidants:determination of radical-scavenging efficiencies
    • Bors W., Heller W., Michel C., and Saran M. Flavonoid as antioxidants:determination of radical-scavenging efficiencies. Meth. Enzymol. 186 (1990) 343-355
    • (1990) Meth. Enzymol. , vol.186 , pp. 343-355
    • Bors, W.1    Heller, W.2    Michel, C.3    Saran, M.4
  • 6
    • 0032963031 scopus 로고    scopus 로고
    • Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism
    • Boulton D.W., Walle U.K., and Walle T. Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism. J. Pharm. Pharmacol. 51 3 (1999) 353-359
    • (1999) J. Pharm. Pharmacol. , vol.51 , Issue.3 , pp. 353-359
    • Boulton, D.W.1    Walle, U.K.2    Walle, T.3
  • 8
    • 0036120739 scopus 로고    scopus 로고
    • Human 8-oxoguanine DNA glycosylase 1 mRNA expression as an oxidative stress exposure biomarker of cooking oil fumes
    • Cherng S.H., Huang K.H., Yang S.C., Wu T.C., Yang J.L., and Lee H. Human 8-oxoguanine DNA glycosylase 1 mRNA expression as an oxidative stress exposure biomarker of cooking oil fumes. J. Toxicol. Environ. Health A 65 3-4 (2002) 265-278
    • (2002) J. Toxicol. Environ. Health A , vol.65 , Issue.3-4 , pp. 265-278
    • Cherng, S.H.1    Huang, K.H.2    Yang, S.C.3    Wu, T.C.4    Yang, J.L.5    Lee, H.6
  • 9
    • 0032508052 scopus 로고    scopus 로고
    • Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours
    • Chevillard S., Radicella J.P., Levalois C., Lebeau J., Poupon M.F., Oudard S., Dutrillaux B., and Boiteux S. Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. Oncogene 16 23 (1998) 3083-3086
    • (1998) Oncogene , vol.16 , Issue.23 , pp. 3083-3086
    • Chevillard, S.1    Radicella, J.P.2    Levalois, C.3    Lebeau, J.4    Poupon, M.F.5    Oudard, S.6    Dutrillaux, B.7    Boiteux, S.8
  • 10
    • 4644335014 scopus 로고    scopus 로고
    • Colorectal cancer and inherited mutations in base-excision repair
    • Chow E., Thirlwell C., Macrae F., and Lipton L. Colorectal cancer and inherited mutations in base-excision repair. Lancet Oncol. 5 (2004) 600-606
    • (2004) Lancet Oncol. , vol.5 , pp. 600-606
    • Chow, E.1    Thirlwell, C.2    Macrae, F.3    Lipton, L.4
  • 11
    • 1842832244 scopus 로고    scopus 로고
    • Repair of oxidative DNA damage: assessing its contribution to cancer prevention
    • Collins A., and Harrington V. Repair of oxidative DNA damage: assessing its contribution to cancer prevention. Mutagenesis 17 6 (2002) 489-493
    • (2002) Mutagenesis , vol.17 , Issue.6 , pp. 489-493
    • Collins, A.1    Harrington, V.2
  • 13
    • 27844439469 scopus 로고    scopus 로고
    • Overview of mechanisms of cancer chemopreventive agents
    • De Flora S., and Ferguson L.R. Overview of mechanisms of cancer chemopreventive agents. Mutat. Res. 591 1-2 (2005) 8-15
    • (2005) Mutat. Res. , vol.591 , Issue.1-2 , pp. 8-15
    • De Flora, S.1    Ferguson, L.R.2
  • 14
    • 33847630719 scopus 로고    scopus 로고
    • Co-ordination of DNA single strand break repair
    • Dianov G.L., and Parsons J.L. Co-ordination of DNA single strand break repair. DNA Repair (Amst.) 6 4 (2007) 454-460
    • (2007) DNA Repair (Amst.) , vol.6 , Issue.4 , pp. 454-460
    • Dianov, G.L.1    Parsons, J.L.2
  • 15
    • 0030918017 scopus 로고    scopus 로고
    • The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimidines) and growth in human cells
    • Duthie S.J., Johnson W., and Dobson V.L. The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimidines) and growth in human cells. Mutat. Res. 390 1-2 (1997) 141-151
    • (1997) Mutat. Res. , vol.390 , Issue.1-2 , pp. 141-151
    • Duthie, S.J.1    Johnson, W.2    Dobson, V.L.3
  • 16
    • 0036679809 scopus 로고    scopus 로고
    • Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics
    • Galati G., Sabzevari O., Wilson J.X., and O'Brien P.J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177 1 (2002) 91-104
    • (2002) Toxicology , vol.177 , Issue.1 , pp. 91-104
    • Galati, G.1    Sabzevari, O.2    Wilson, J.X.3    O'Brien, P.J.4
  • 18
    • 31444451689 scopus 로고    scopus 로고
    • 2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis
    • 2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Apoptosis 11 1 (2006) 39-46
    • (2006) Apoptosis , vol.11 , Issue.1 , pp. 39-46
    • Gautam, D.K.1    Misro, M.M.2    Chaki, S.P.3    Sehgal, N.4
  • 19
  • 20
    • 0032462852 scopus 로고    scopus 로고
    • Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies
    • Halliwell B. Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies. Free Radic. Res. 29 6 (1998) 469-486
    • (1998) Free Radic. Res. , vol.29 , Issue.6 , pp. 469-486
    • Halliwell, B.1
  • 21
    • 33845580481 scopus 로고    scopus 로고
    • Dietary polyphenols: good, bad, or indifferent for your health?
    • Halliwell B. Dietary polyphenols: good, bad, or indifferent for your health?. Cardiovasc. Res. 73 2 (2007) 341-347
    • (2007) Cardiovasc. Res. , vol.73 , Issue.2 , pp. 341-347
    • Halliwell, B.1
  • 22
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity including lack of genotoxic/carcinogenic properties
    • Harwood M., Danielelwska-Nikiel B., Borzelleca J., Flann G., Williams G., and Lines T. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity including lack of genotoxic/carcinogenic properties. Food Chem. Tox. 45 (2007) 2179-2205
    • (2007) Food Chem. Tox. , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielelwska-Nikiel, B.2    Borzelleca, J.3    Flann, G.4    Williams, G.5    Lines, T.6
  • 23
    • 0036197907 scopus 로고    scopus 로고
    • Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells
    • Hodges N.J., and Chipman J.K. Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells. Carcinogenesis 23 1 (2002) 55-60
    • (2002) Carcinogenesis , vol.23 , Issue.1 , pp. 55-60
    • Hodges, N.J.1    Chipman, J.K.2
  • 25
    • 0035109485 scopus 로고    scopus 로고
    • Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos
    • Kim H.N., Morimoto Y., Tsuda T., Ootsuyama Y., Hirohashi M., Hirano T., Tanaka I., Lim Y., Yun I.G., and Kasai H. Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos. Carcinogenesis 22 2 (2001) 265-269
    • (2001) Carcinogenesis , vol.22 , Issue.2 , pp. 265-269
    • Kim, H.N.1    Morimoto, Y.2    Tsuda, T.3    Ootsuyama, Y.4    Hirohashi, M.5    Hirano, T.6    Tanaka, I.7    Lim, Y.8    Yun, I.G.9    Kasai, H.10
  • 27
    • 0034709554 scopus 로고    scopus 로고
    • Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media
    • Long L.H., Clement M.V., and Halliwell B. Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem. Biophys. Res. Commun. 273 1 (2000) 50-53
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , Issue.1 , pp. 50-53
    • Long, L.H.1    Clement, M.V.2    Halliwell, B.3
  • 29
    • 0019370338 scopus 로고
    • Activity of the plant flavanol quercetin in the mouse lymphoma L5178Y TK+/-mutation, DNA single-strand break and Balb/c 3T3 chemical transformation assays
    • Meltz M., and MacGregor J. Activity of the plant flavanol quercetin in the mouse lymphoma L5178Y TK+/-mutation, DNA single-strand break and Balb/c 3T3 chemical transformation assays. Mutat. Res. 88 (1981) 317-324
    • (1981) Mutat. Res. , vol.88 , pp. 317-324
    • Meltz, M.1    MacGregor, J.2
  • 31
    • 36849037908 scopus 로고    scopus 로고
    • Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels
    • Min K., and Ebeler S.E. Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. Food Chem. Toxicol. 46 1 (2008) 96-104
    • (2008) Food Chem. Toxicol. , vol.46 , Issue.1 , pp. 96-104
    • Min, K.1    Ebeler, S.E.2
  • 32
    • 3042686779 scopus 로고    scopus 로고
    • Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair
    • Moller P., and Loft S. Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair. Mutat. Res. 551 1-2 (2004) 79-89
    • (2004) Mutat. Res. , vol.551 , Issue.1-2 , pp. 79-89
    • Moller, P.1    Loft, S.2
  • 33
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 1-2 (1983) 55-63
    • (1983) J. Immunol. Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 34
    • 0033956743 scopus 로고    scopus 로고
    • Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals
    • O'Brien N.M., Woods J.A., Aherne S.A., and O'Callaghan Y.C. Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. Biochem. Soc. Trans. 28 2 (2000) 22-26
    • (2000) Biochem. Soc. Trans. , vol.28 , Issue.2 , pp. 22-26
    • O'Brien, N.M.1    Woods, J.A.2    Aherne, S.A.3    O'Callaghan, Y.C.4
  • 35
    • 24344433138 scopus 로고    scopus 로고
    • Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage
    • Powell C.L., Swenberg J.A., and Rusyn I. Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage. Cancer Lett. 229 1 (2005) 1-11
    • (2005) Cancer Lett. , vol.229 , Issue.1 , pp. 1-11
    • Powell, C.L.1    Swenberg, J.A.2    Rusyn, I.3
  • 36
    • 0242643755 scopus 로고    scopus 로고
    • Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation
    • Risom L., Dybdahl M., Bornholdt J., Vogel U., Wallin H., Moller P., and Loft S. Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation. Carcinogenesis 24 11 (2003) 1847-1852
    • (2003) Carcinogenesis , vol.24 , Issue.11 , pp. 1847-1852
    • Risom, L.1    Dybdahl, M.2    Bornholdt, J.3    Vogel, U.4    Wallin, H.5    Moller, P.6    Loft, S.7
  • 37
    • 36048970121 scopus 로고    scopus 로고
    • Protective effects of Hibiscus tiliaceus L. methanolic extract to V79 cells against cytotoxicity and genotoxicity induced by hydrogen peroxide and tert-butyl-hydroperoxide
    • Rosa R.M., Moura D.J., Melecchi M.I., dos Santos R.S., Richter M.F., Camarao E.B., Henriques J.A., de Paula Ramos A.L., and Saffi J. Protective effects of Hibiscus tiliaceus L. methanolic extract to V79 cells against cytotoxicity and genotoxicity induced by hydrogen peroxide and tert-butyl-hydroperoxide. Toxicol. In Vitro 21 8 (2007) 1442-1452
    • (2007) Toxicol. In Vitro , vol.21 , Issue.8 , pp. 1442-1452
    • Rosa, R.M.1    Moura, D.J.2    Melecchi, M.I.3    dos Santos, R.S.4    Richter, M.F.5    Camarao, E.B.6    Henriques, J.A.7    de Paula Ramos, A.L.8    Saffi, J.9
  • 39
    • 0037195158 scopus 로고    scopus 로고
    • Selenomethionine regulation of p53 by a ref1-dependent redox mechanism
    • Seo Y.R., Kelley M.R., and Smith M.L. Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proc. Natl. Acad. Sci. USA 99 22 (2002) 14548-14553
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.22 , pp. 14548-14553
    • Seo, Y.R.1    Kelley, M.R.2    Smith, M.L.3
  • 40
    • 56949098646 scopus 로고    scopus 로고
    • Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 Cells
    • Silva J., Gomes A., and Coutinho O. Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 Cells. Eur. J. Pharm. 601 (2008) 50-60
    • (2008) Eur. J. Pharm. , vol.601 , pp. 50-60
    • Silva, J.1    Gomes, A.2    Coutinho, O.3
  • 41
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 175 1 (1988) 184-191
    • (1988) Exp. Cell. Res. , vol.175 , Issue.1 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 42
    • 0033949307 scopus 로고    scopus 로고
    • Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect
    • Torbergsen A.C., and Collins A.R. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur. J. Nutr. 39 2 (2000) 80-85
    • (2000) Eur. J. Nutr. , vol.39 , Issue.2 , pp. 80-85
    • Torbergsen, A.C.1    Collins, A.R.2
  • 43
    • 34248166587 scopus 로고    scopus 로고
    • Dietary and genetic modulation of DNA repair in healthy human adults
    • Tyson J., and Mathers J.C. Dietary and genetic modulation of DNA repair in healthy human adults. Proc. Nutr. Soc. 66 1 (2007) 42-51
    • (2007) Proc. Nutr. Soc. , vol.66 , Issue.1 , pp. 42-51
    • Tyson, J.1    Mathers, J.C.2
  • 44
    • 14944364739 scopus 로고    scopus 로고
    • Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis
    • Watjen W., Michels G., Steffan B., Niering P., Chovolou Y., Kampkotter A., Tran-Thi Q.H., Proksch P., and Kahl R. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J. Nutr. 135 3 (2005) 525-531
    • (2005) J. Nutr. , vol.135 , Issue.3 , pp. 525-531
    • Watjen, W.1    Michels, G.2    Steffan, B.3    Niering, P.4    Chovolou, Y.5    Kampkotter, A.6    Tran-Thi, Q.H.7    Proksch, P.8    Kahl, R.9
  • 45
    • 52349112273 scopus 로고    scopus 로고
    • Anthocyanin interactions with DNA: intercalation, topoisomerase I inhibition and oxidative reactions
    • Webb M.R., Min K., and Ebeler S.E. Anthocyanin interactions with DNA: intercalation, topoisomerase I inhibition and oxidative reactions. J. Food Biochem. 32 (2008) 576-596
    • (2008) J. Food Biochem. , vol.32 , pp. 576-596
    • Webb, M.R.1    Min, K.2    Ebeler, S.E.3
  • 46
    • 0033065619 scopus 로고    scopus 로고
    • Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II)
    • Yamashita N., Tanemura H., and Kawanishi S. Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II). Mutat. Res. 425 1 (1999) 107-115
    • (1999) Mutat. Res. , vol.425 , Issue.1 , pp. 107-115
    • Yamashita, N.1    Tanemura, H.2    Kawanishi, S.3
  • 47
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: putting checkpoints in perspective
    • Zhou B.B., and Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 408 6811 (2000) 433-439
    • (2000) Nature , vol.408 , Issue.6811 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.