Characterization of Polyphenols from Lycium ruthenicum Fruit by UPLC-Q-TOF/MSE and Their Antioxidant Activity in Caco-2 Cells

Journal of Agricultural and Food Chemistry

Volumn 64, Issue 11, 2016, Pages 2280-2288

  Wu, Tao ^a   Lv, Haiyang ^b   Wang, Fengzhong ^b   Wang, Yi ^c  

^a XIHUA UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c Xi'An Manareco New Materials Co Ltd   (China)

Author keywords

antioxidant activity; Lycium ruthenicum Murr.; MSE; polyphenols

Indexed keywords

ANTHOCYANINS; CELLS; DATA ACQUISITION; FRUITS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ANTHOCYANIN CONTENT; ANTI-OXIDANT ACTIVITIES; FRUIT EXTRACTS; LYCIUM RUTHENICUM; MSE; OXIDATIVE DAMAGE; POLYPHENOLS; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

ANTIOXIDANTS;

ANTHOCYANIN; ANTIOXIDANT; FLAVONOID; HYDROGEN PEROXIDE; POLYPHENOL;

CACO-2 CELL LINE; CHEMISTRY; DRUG EFFECTS; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE MUCOSA; LYCIUM; MASS SPECTROMETRY; OXIDATIVE STRESS; PROCEDURES;

ANTHOCYANINS; ANTIOXIDANTS; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; FRUIT; HUMANS; HYDROGEN PEROXIDE; INTESTINAL MUCOSA; LYCIUM; MASS SPECTROMETRY; OXIDATIVE STRESS; POLYPHENOLS;

EID: 84961903064     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.6b00035     Document Type: Article

References (38)

1. Lewandowska, U.; Szewczyk, K.; Hrabec, E.; Janecka, A.; Gorlach, S. Overview of Metabolism and Bioavailability Enhancement of Polyphenols J. Agric. Food Chem. 2013, 61, 12183-12199 10.1021/jf404439b
2. Embuscado, M. E. Spices and herbs: Natural sources of antioxidants-a mini review J. Funct. Foods 2015, 18 (Part B) 811-819 10.1016/j.jff.2015.03.005
3. Liu, Z.; Shu, Q.; Wang, L.; Yu, M.; Hu, Y.; Zhang, H.; Tao, Y.; Shao, Y. Genetic diversity of the endangered and medically important Lycium ruthenicum Murr. revealed by sequence-related amplified polymorphism (SRAP) markers Biochem. Syst. Ecol. 2012, 45, 86-97 10.1016/j.bse.2012.07.017
4. Ni, W.; Gao, T.; Wang, H.; Du, Y.; Li, J.; Li, C.; Wei, L.; Bi, H. Anti-fatigue activity of polysaccharides from the fruits of four Tibetan plateau indigenous medicinal plants J. Ethnopharmacol. 2013, 150, 529-535 10.1016/j.jep.2013.08.055
5. Peng, Q.; Liu, H.; Shi, S.; Li, M. Lycium ruthenicum polysaccharide attenuates inflammation through inhibiting TLR4/NF-κB signaling pathway Int. J. Biol. Macromol. 2014, 67, 330-335 10.1016/j.ijbiomac.2014.03.023
6. Duan, Y.; Chen, F.; Yao, X.; Zhu, J.; Wang, C.; Zhang, J.; Li, X. Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice Int. J. Environ. Res. Public Health 2015, 12, 8332 10.3390/ijerph120708332
7. Peng, Q.; Lv, X.; Xu, Q.; Li, Y.; Huang, L.; Du, Y. Isolation and structural characterization of the polysaccharide LRGP1 from Lycium ruthenicum Carbohydr. Polym. 2012, 90, 95-101 10.1016/j.carbpol.2012.04.067
8. Liu, Z.; Dang, J.; Wang, Q.; Yu, M.; Jiang, L.; Mei, L.; Shao, Y.; Tao, Y. Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity Int. J. Biol. Macromol. 2013, 61, 127-134 10.1016/j.ijbiomac.2013.06.042
9. Lv, X.; Wang, C.; Cheng, Y.; Huang, L.; Wang, Z. Isolation and structural characterization of a polysaccharide LRP4-A from Lycium ruthenicum Murr Carbohydr. Res. 2013, 365, 20-25 10.1016/j.carres.2012.10.013
10. Peng, Q.; Xu, Q.; Yin, H.; Huang, L.; Du, Y. Characterization of an immunologically active pectin from the fruits of Lycium ruthenicum Int. J. Biol. Macromol. 2014, 64, 69-75 10.1016/j.ijbiomac.2013.11.030
11. Zheng, J.; Ding, C.; Wang, L.; Li, G.; Shi, J.; Li, H.; Wang, H.; Suo, Y. Anthocyanins composition and antioxidant activity of wild Lycium ruthenicum Murr. from Qinghai-Tibet Plateau Food Chem. 2011, 126, 859-865 10.1016/j.foodchem.2010.11.052
12. Jin, H.; Liu, Y.; Guo, Z.; Yang, F.; Wang, J.; Li, X.; Peng, X.; Liang, X. High-Performance Liquid Chromatography Separation of cis-trans Anthocyanin Isomers from Wild Lycium ruthenicum Murr. Employing a Mixed-Mode Reversed-Phase/Strong Anion-Exchange Stationary Phase J. Agric. Food Chem. 2015, 63, 500-508 10.1021/jf504525w
13. Qiu, J.; Chen, L.; Zhu, Q.; Wang, D.; Wang, W.; Sun, X.; Liu, X.; Du, F. Screening natural antioxidants in peanut shell using DPPH-HPLC-DAD-TOF/MS methods Food Chem. 2012, 135, 2366-2371 10.1016/j.foodchem.2012.07.042
14. López-Cobo, A.; Gómez-Caravaca, A. M.; Cerretani, L.; Segura-Carretero, A.; Fernández-Gutiérrez, A. Distribution of phenolic compounds and other polar compounds in the tuber of Solanum tuberosum L. by HPLC-DAD-q-TOF and study of their antioxidant activity J. Food Compos. Anal. 2014, 36, 1-11 10.1016/j.jfca.2014.04.009
15. Talhaoui, N.; Gómez-Caravaca, A. M.; León, L.; De la Rosa, R.; Segura-Carretero, A.; Fernández-Gutiérrez, A. Determination of phenolic compounds of 'Sikitita' olive leaves by HPLC-DAD-TOF-MS. Comparison with its parents 'Arbequina' and 'Picual' olive leaves LWT-Food Sci. Technol. 2014, 58, 28-34 10.1016/j.lwt.2014.03.014
16. Gonzales, G. B.; Raes, K.; Vanhoutte, H.; Coelus, S.; Smagghe, G.; Van Camp, J. Liquid chromatography-mass spectrometry coupled with multivariate analysis for the characterization and discrimination of extractable and nonextractable polyphenols and glucosinolates from red cabbage and Brussels sprout waste streams J. Chromatogr. A 2015, 1402, 60-70 10.1016/j.chroma.2015.05.009
17. Fabre, N.; Rustan, I.; de Hoffmann, E.; Quetin-Leclercq, J. Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry J. Am. Soc. Mass Spectrom. 2001, 12, 707-715 10.1016/S1044-0305(01)00226-4
18. Plumb, R. S.; Johnson, K. A.; Rainville, P.; Smith, B. W.; Wilson, I. D.; Castro-Perez, J. M.; Nicholson, J. K. UPLC/MSE; a new approach for generating molecular fragment information for biomarker structure elucidation Rapid Commun. Mass Spectrom. 2006, 20, 1989-1994 10.1002/rcm.2550
19. Wu, T.; Yan, J.; Liu, R.; Marcone, M. F.; Aisa, H. A.; Tsao, R. Optimization of microwave-assisted extraction of phenolics from potato and its downstream waste using orthogonal array design Food Chem. 2012, 133, 1292-1298 10.1016/j.foodchem.2011.08.002
20. Chaovanalikit, A.; Wrolstad, R. E. Total Anthocyanins and Total Phenolics of Fresh and Processed Cherries and Their Antioxidant Properties J. Food Sci. 2004, 69, FCT67-FCT72 10.1111/j.1365-2621.2004.tb17858.x
21. Donno, D.; Beccaro, G. L.; Mellano, M. G.; Cerutti, A. K.; Bounous, G. Goji berry fruit (Lycium spp.): antioxidant compound fingerprint and bioactivity evaluation J. Funct. Foods 2015, 18 (Part B) 1070-1085 10.1016/j.jff.2014.05.020
22. Pertuzatti, P. B.; Barcia, M. T.; Rodrigues, D.; da Cruz, P. N.; Hermosín-Gutiérrez, I.; Smith, R.; Godoy, H. T. Antioxidant activity of hydrophilic and lipophilic extracts of Brazilian blueberries Food Chem. 2014, 164, 81-88 10.1016/j.foodchem.2014.04.114
23. García-Salas, P.; Gómez-Caravaca, A. M.; Morales-Soto, A.; Segura-Carretero, A.; Fernández-Gutiérrez, A. Identification and quantification of phenolic compounds in diverse cultivars of eggplant grown in different seasons by high-performance liquid chromatography coupled to diode array detector and electrospray-quadrupole-time of flight-mass spectrometry Food Res. Int. 2014, 57, 114-122 10.1016/j.foodres.2014.01.032
24. Oszmiański, J.; Wojdyło, A.; Gorzelany, J.; Kapusta, I. Identification and characterization of low molecular weight polyphenols in berry leaf extracts by HPLC-DAD and LC-ESI/MS J. Agric. Food Chem. 2011, 59, 12830-12835 10.1021/jf203052j
25. Narváez-Cuenca, C.-E.; Vincken, J.-P.; Zheng, C.; Gruppen, H. Diversity of (dihydro) hydroxycinnamic acid conjugates in Colombian potato tubers Food Chem. 2013, 139, 1087-1097 10.1016/j.foodchem.2013.02.018
26. Cho, A.-S.; Jeon, S.-M.; Kim, M.-J.; Yeo, J.; Seo, K.-I.; Choi, M.-S.; Lee, M.-K. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice Food Chem. Toxicol. 2010, 48, 937-943 10.1016/j.fct.2010.01.003
27. Ong, K. W.; Hsu, A.; Tan, B. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes PLoS One 2012, 7, e32718 10.1371/journal.pone.0032718
28. Wu, S.-B.; Meyer, R. S.; Whitaker, B. D.; Litt, A.; Kennelly, E. J. A new liquid chromatography-mass spectrometry-based strategy to integrate chemistry, morphology, and evolution of eggplant (Solanum) species J. Chromatogr. A 2013, 1314, 154-172 10.1016/j.chroma.2013.09.017
29. Shakya, R.; Navarre, D. A. Rapid screening of ascorbic acid, glycoalkaloids, and phenolics in potato using high-performance liquid chromatography J. Agric. Food Chem. 2006, 54, 5253-5260 10.1021/jf0605300
30. Muroi, A.; Ishihara, A.; Tanaka, C.; Ishizuka, A.; Takabayashi, J.; Miyoshi, H.; Nishioka, T. Accumulation of hydroxycinnamic acid amides induced by pathogen infection and identification of agmatine coumaroyltransferase in Arabidopsis thaliana Planta 2009, 230, 517-527 10.1007/s00425-009-0960-0
31. Abdennacer, B.; Karim, M.; Yassine, M. r.; Nesrine, R.; Mouna, D.; Mohamed, B. Determination of phytochemicals and antioxidant activity of methanol extracts obtained from the fruit and leaves of Tunisian Lycium intricatum Boiss Food Chem. 2015, 174, 577-584 10.1016/j.foodchem.2014.11.114
32. Sun, J.; Song, Y.-L.; Zhang, J.; Huang, Z.; Huo, H.-X.; Zheng, J.; Zhang, Q.; Zhao, Y.-F.; Li, J.; Tu, P.-F. Characterization and Quantitative Analysis of Phenylpropanoid Amides in Eggplant (Solanum melongena L.) by High Performance Liquid Chromatography Coupled with Diode Array Detection and Hybrid Ion Trap Time-of-Flight Mass Spectrometry J. Agric. Food Chem. 2015, 63, 3426-3436 10.1021/acs.jafc.5b00023
33. Hvattum, E. Determination of phenolic compounds in rose hip (Rosa canina) using liquid chromatography coupled to electrospray ionisation tandem mass spectrometry and diode-array detection Rapid Commun. Mass Spectrom. 2002, 16, 655-662 10.1002/rcm.622
34. Galati, E. M.; Mondello, M. R.; Giuffrida, D.; Dugo, G.; Miceli, N.; Pergolizzi, S.; Taviano, M. F. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) Mill. fruit juice: antioxidant and antiulcerogenic activity J. Agric. Food Chem. 2003, 51, 4903-4908 10.1021/jf030123d
35. Downey, M. O.; Rochfort, S. Simultaneous separation by reversed-phase high-performance liquid chromatography and mass spectral identification of anthocyanins and flavonols in Shiraz grape skin J. Chromatogr. A 2008, 1201, 43-47 10.1016/j.chroma.2008.06.002
36. Song, H.; Wu, T.; Xu, D.; Chu, Q.; Lin, D.; Zheng, X. Dietary sweet cherry anthocyanins attenuates diet-induced hepatic steatosis by improving hepatic lipid metabolism in mice Nutrition 2016, 10.1016/j.nut.2016.01.007
37. Prosperini, A.; Juan-García, A.; Font, G.; Ruiz, M. Reactive oxygen species involvement in apoptosis and mitochondrial damage in Caco-2 cells induced by enniatins A, A 1, B and B 1 Toxicol. Lett. 2013, 222, 36-44 10.1016/j.toxlet.2013.07.009
38. Shi, Y.; Kovacs-Nolan, J.; Jiang, B.; Tsao, R.; Mine, Y. Antioxidant activity of enzymatic hydrolysates from eggshell membrane proteins and its protective capacity in human intestinal epithelial Caco-2 cells J. Funct. Foods 2014, 10, 35-45 10.1016/j.jff.2014.05.004