Protective effect of Lycium ruthenicum Murr. Against radiation injury in mice

International Journal of Environmental Research and Public Health

Volumn 12, Issue 7, 2015, Pages 8332-8347

  Duan, Yabin ^a   Chen, Fan ^a   Yao, Xingchen ^a   Zhu, Junbo ^a   Wang, Cai ^a   Zhang, Juanling ^a   Li, Xiangyang ^a  

^a QINGHAI UNIVERSITY   (China)

Author keywords

Apoptosis; Hematopoietic; Lycium ruthenicum murr; Radioprotection

Indexed keywords

AMIFOSTINE; CASPASE 3; CASPASE 6; DNA; LYCIUM EXTRACT; LYCIUM RUTHENICUM EXTRACT; PROANTHOCYANIDIN; PROANTHOCYANIDIN DERIVATIVE; PROTEIN P53; UNCLASSIFIED DRUG; CASP3 PROTEIN, MOUSE; CASP6 PROTEIN, MOUSE; RADIOPROTECTIVE AGENT;

ANGIOSPERM; INJURY; IRRADIATION; MEDICINAL PLANT; PLANT EXTRACT; RODENT;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DNA CONTENT; DRUG DOSE COMPARISON; DRUG MEGADOSE; ERYTHROCYTE COUNT; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; LYCIUM; LYCIUM RUTHENICUM; MALE; MOUSE; NONHUMAN; PROTEIN CONTENT; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; SPLEEN; THYMUS; X RAY; ANIMAL; BLOOD; CHEMISTRY; METABOLISM; PHYTOTHERAPY; RADIATION INJURIES, EXPERIMENTAL; RADIATION RESPONSE; WHOLE BODY RADIATION;

LYCIUM RUTHENICUM; MUS;

ANIMALS; CASPASE 3; CASPASE 6; LYCIUM; MICE; PHYTOTHERAPY; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; SPLEEN; TUMOR SUPPRESSOR PROTEIN P53; WHOLE-BODY IRRADIATION; X-RAYS;

EID: 84937510879     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph120708332     Document Type: Article

References (32)

1. Brizel, D.M.; Wasserman, T.H.; Henke, M.; Strnad, V.; Rudat, V.; Monnier, A.; Eschwege, F.; Zhang, J.; Russell, L.; Oster, W.; et al. Phase III randomized trial of Amifostine as a radioprotector in head and neck cancer. J. Clin. Oncol. 2000, 18, 3339–3345.
2. Koukourakis, M.I. Amifostine in clinical oncology: Current use and future applications. Anti-Cancer Drugs 2002, 13, 181–209.
3. Ghielmini, M.; van der Bosch, S.; Bosshard, M.; Pampallona, S.; Gabutti, L.; Egger, H.P.; Kiess, M.; Cavalli, F.; Sessa, C. Phase I-II study of escalating doses of Amifostine combined with high-dose cyclophosphamide. Cancer Chemother. Pharmacol. 2001, 47, 532–536.
4. Koukourakis, M.I.; Kyrias, G.; Kakolyris, S.; Kouroussis, C.; Frangiadaki, C.; Giatromanolaki, A.; Retalis, G.; Georgoulias, V. Subcutaneous administration of Amifostine during fractionated radiotherapy: A randomized phase II study. J. Clin. Oncol. 2000, 18, 2226–2233.
5. Veerasarn, V.; Phromratanapongse, P.; Suntornpong, N.; Lorvidhaya, V.; Sukthomya, V.; Chitapanarux, I.; Tesavibul, C.; Swangsilpa, T.; Khorprasert, C.; Shotelersuk, K.; et al. Effect of Amifostine to prevent radiotherapy-induced acute and late toxicity in head and neck cancer patients who had normal or mild imparied salivary gland function. J. Med. Assoc. Thail. 2006, 89, 2056–2067.
6. Chen, Y.Z.; Lin, F.; Zhuang, G.B.; Ren, Y.; Li, P.P. Protective effect of Renshen Yangrong decoction on bone marrow against radiation injury in mouse. Chin. J. Integr. Med. 2011, 17, 453–458. (In Chinese)
7. Fan, Z.L.; Wang, Z.Y.; Zuo, L.L.; Tian, S.-Q. Protective effect of Anthocyanins from lingonberry on radiation-induced damages. Int. J. Environ. Res. Public Health 2012, 9, 4732–4743.
8. Xu, P.; Jia, J.Q.; Jiang, E.J.; Kang, L.P.; Wu, K.L. Protective effect of an extract of Guipi pill against radiation-induced damages in mice. Chin. J. Integr. Med. 2012, 18, 490–495.
9. Dimaer, D. Jing Zhu Ben Cao; Sichuan science and technology publishing house: Chengdu, China, 1986; pp. 438–440. (In Chinese)
10. Lv, X.; Wang, C.; Cheng, Y.; Huang, L.; Wang, Z. Isolation and structural characterization of a polysaccharide LRP4-A from Lycium ruthenicum Murr. Carbohydr. Res. 2013, 365, 20–25.
11. Ou, Y.F.; Ji, T.F.; Su, Y.L.; Li, J.; Liu, H. Chemcial constituents of the fruits of Lycium ruthenicum. Zhong Yao Cai 2012, 35, 1599–1601. (In Chinese)
12. Zheng, J.; Ding, C.X.; Wang, L.S.; Lia, G.; Shia, J.; Li, H.; Wanga, H.; Suoa, Y. Anthocyanins composition and antioxidant activity of wild Lycium ruthenicum Murr. from Qinghai-Tibet Plateau. Food Chem. 2011, 126, 859–865.
13. Li, J.; Yuan, H.; Ceng, X.C.; Han, B.; Shi, D.H. Toxicological assessment of pigment of Lycium ruthenicum Murr. Food Sci. 2007, 28, 470–474. (In Chinese)
14. Liu, Z.G.; Dang, J.; Wang, Q.L.; Yu, M.; Jiang, L.; Mei, L.; Shao, Y.; Tao, Y. Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity. Int. J. Biol. Macromol. 2013, 61, 127–134.
15. Peng, Q.; Liu, H.; Shi, S.; Li, M. Lycium ruthenicum polysaccharide attenuates inflammation through inhibiting TLR4/NFκB signaling pathway. Int. J. Biol. Macromol. 2014, 67, 330–335.
16. Song, J.L.; Gao, Y.; Xu, J. Protective effects of methanolic extract from fruits of Lycium ruthenicum Murr. on 2,2′-azobis(2-amidinopropane) dihydrochloride-induced oxidative stress in LLC-PK1 cells. Pharmacogn. Mag. 2014, 10, 522–528.
17. Marusyk, A.; Casás-Selves, M.; Henry, C.J.; Zaberezhnyy, V.; Klawitter, J.; Christians, U.; DeGregori, J. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res. 2009, 69, 7262–7269.
18. Song, J.Y.; Yang, H.O.; Shim, J.Y.; Yeon-Ahn, J.; Han, Y.S.; Jung, I.S.; Yun, Y.S. Radiation protective effect of an extract from Chelidonium majus. Int. J. Hematol. 2003, 78, 226–232.
19. Gapeyev, A.B.; Aripovsky, A.V.; Kulagina, T.P. Modifying effects of low-intensity extremely high-frequency electromagnetic radiation on content and composition of fatty acids in thymus of mice exposed to X-rays. Int. J. Radiat. Biol. 2014, 27, 1–26.
20. Johnke, R.M.; Sattler, J.A.; Allison, R.R. Radioprotective agents for radiation therapy: Future trends. Future Oncol. 2014, 10, 2345–2357.
21. Bhilwade, H.N.; Jayakumar, S.; Chaubey R.C. Age-dependent changes in spontaneous frequency of micronucleated erythrocytes in bone marrow and DNA damage in peripheral blood of Swiss mice. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2014, 770, 80–84.
22. Carsten, R.E.; Bachand, A.M.; Bailey, S.M.; Ullrich, R.L. Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells. Radiati. Res. 2008, 169, 633–638.
23. Lutz, A.; Sanwald, J.; Thomas, M.; Feuer, R.; Sawodny, O.; Ederer, M.; Borner, C.; Humar, M.; Merfort, I. Interleukin-1β Enhances FasL-Induced Capase-3/-7 Activity without Increase Apoptosis in Primary Mouse Hepatocytes. PLoS ONE 2014, 9, e115603.
24. Vila-Petroff, M.; Salas, M.A.; Said, M.; Valverde, C.A.; Sapia, L.; Portiansky, E.; Hajjar, R.J.; Kranias, E.G.; Mundiña-Weilenmann, C.; Mattiazzi, A.; et al. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovasc. Res. 2007, 73, 689–698.
25. Choi, H.N.; Chung, M.J.; Park, J.K.; Park, Y.I. Neuroprotective Effects of N-Acetylglucosamine against Hydrogen Peroxide-induced Apoptosis in Human Neuronal SK-N-SH Cells by Inhibiting the Activation of Caspase-3, PARP and p38. Food Sci. Biotechnol. 2013, 22, 853–858.
26. Napso, T.; Fares, F. Zebularine induces prolonged apoptosis effects via the caspase-3/PARP pathway in head and neck cancer cells. Int. J. Oncol. 2014, 44, 1971–1979.
27. Rouleau, M.; Patel, A.; Hendzel, M.J.; Kaufmann, S.H.; Poirier, G.G. PARP inhibition: PARP1 and beyond. Nat. Rev. Cancer 2010, 10, 293–301.
28. Ferraris, D.V. Evolution of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J. Med. Chem. 2010, 53, 4561–4584.
29. Faleiro, L.; Kobayashi, R.; Fearnhead, H.; Lazebnik Y. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J. 1997, 16, 2271–2281.
30. Ilmarinen, S.P.; Moilanen, E.; Kankaanranta, H. Nitric oxide induces apoptosis in GM-CSF-treated eosinophils via caspase-6-dependent lamin and DNA fragmentation. Pulm. Pharmacol. Ther. 2014, 23, 365–371.
31. Majsterek, I.; Gloc, E.; Blasiak, J.; Reiter, R.J. A comparison of the action of Amifostine and melatonin on DNA- damaging effects and apoptosis induced by idarubicin in normal and cancer cells. J. Pineal Res. 2005, 38, 254–263.
32. Ormsby, R.J.; Lawrence, M.D.; Blyth, B.J.; Bexis, K.; Bezak, E.; Murley, J.S.; Grdina, D.J.; Sykes, P.J. Protection from radiation-induced apoptosis by the radioprotector Amifostine (WR-2721) is radiation does dependent. Cell Biol. Toxicol. 2014, 30, 55–66.