Aerosol-based detectors for liquid chromatography

Journal of Chromatography A

Volumn 1421, Issue , 2015, Pages 68-81

  Magnusson, Lars Erik ^a   Risley, Donald S ^a   Koropchak, John A ^b  

^a ELI LILLY AND COMPANY   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Aerosol based detectors; Liquid chromatography detectors; Universal detectors

Indexed keywords

AEROSOLS; CHROMATOGRAPHY; LIGHT SCATTERING; LIQUIDS;

ANALYTES; CHARGED AEROSOL DETECTION; COMPARATIVE EVALUATIONS; CONDENSATION NUCLEATION; EVAPORATIVE LIGHT SCATTERING DETECTION; LIGHT-SCATTERING DETECTION; OPERATING PRINCIPLES;

LIQUID CHROMATOGRAPHY;

AZELAIC ACID; BACITRACIN; CARBOHYDRATE; CATECHOLAMINE; EXCIPIENT; FLIBANSERIN; GENTAMICIN; GLUCOSAMINE; HERBICIDE; IBANDRONIC ACID; KANAMYCIN; MIDECAMYCIN; NEOMYCIN; POLYMER; SPECTINOMYCIN; TADALAFIL; AEROSOL;

AEROSOL; AEROSOL BASED DETECTOR; AEROSOL PARTICLE FILTRATION; AMINO ACID ANALYSIS; ANALYTICAL EQUIPMENT; CHARGED AEROSOL DETECTION; CONDENSATION NUCLEATION LIGHT SCATTERING DETECTION; DRUG DETERMINATION; DRUG FORMULATION; DRUG IMPURITY; EVAPORATIVE LIGHT SCATTERING DETECTION; FILTRATION; FOOD ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIGHT SCATTERING; LIMIT OF DETECTION; LIPID ANALYSIS; LIQUID CHROMATOGRAPHY; MEASUREMENT PRECISION; NANO QUANTITY ANALYTE DETECTOR; PRIORITY JOURNAL; REVIEW; SIGNAL NOISE RATIO; DEVICES; LIGHT; PROCEDURES; RADIATION SCATTERING;

AEROSOLS; CHROMATOGRAPHY, LIQUID; LIGHT; SCATTERING, RADIATION;

EID: 84960498585     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2015.07.045     Document Type: Review

References (126)

1. Brown P.R. High-performance liquid chromatography past developments, present status, and future trends. Anal. Chem. 1990, 62:995A-1008A.
2. Charlesworth J.M. Evaporative analyzer as a mass detector for liquid chromatography. Anal. Chem. 1978, 50:1414-1420.
3. Allen L.B., Koropchak J.A. Condensation nucleation light scattering: a new approach to development of high-sensitivity, universal detectors for separations. Anal. Chem. 1993, 65:841-844.
4. Dixon R.W., Peterson D.S. Development and testing of a detection method for liquid chromatography based on aerosol charging. Anal. Chem. 2002, 74:2930-2937.
5. Koropchak J.A., Magnusson L.-E., Heybroek M., Sadain S., Yang X., Anisimov M.P. Fundamental aspects of aerosol-based light-scattering detectors for separations. Advances in Chromatography 2000, vol. 40:275-314. Marcel Dekker, New York, (chapter 5).
6. Dreux M., Lafosse M., Morin-Allory L. The evaporative light scattering detector. A universal instrument for non-volatile solutes in LC and SFC. LC-GC Int. 1996, 9:148-156.
7. Nukiyama S., Tanasawa Y. Experiment on atomization of liquids. Trans. Soc. Mech. Eng. Jpn. 1938, 4:86-93.
8. Ford D.L., Kennard W. Evaporative analyzer. J. Oil Col. Chem. Assoc. 1966, 49:299-313.
9. Cobb Z., Barret D., Shaw P., Meehan E., Watkins J., O'Donohue S., Wrench N. Evaporative light-scattering detection coupled to microcolumn liquid chromatography for the analysis of underivatized amino acids: sensitivity, linearity of response and comparisons with UV absorbance detection. J. Microcol. Sep. 2001, 13:169-175.
10. Shock D., Dennis G.R., Guiochon G., Dasgupta P.K., Shalliker R.A. Anomalies in evaporative light scattering detection. Anal. Chim. Acta 2011, 703:245-259.
11. Gaudin K., Baillet A., Chaminade P. Application of a xenon arc lamp as a light source for evaporative light scattering detection. Anal. Bioanal. Chem. 2006, 384:1302-1307.
12. Mefoulas N., Koupparis M. Enhancement of evaporative light scattering detection in high-performance liquid chromatographic determination of neomycin based on highly volatile mobile phase, high-molecular-mass ion-pairing reagents and controlled peak shape. J. Chromatogr. A 2004, 1057:125-131.
13. Deschamps F.S., Gaudin K., Lesellier E., Tchapla A., Ferrier D., Baillet A., Chaminade P. Response enhancement for the evaporative light scattering detection for the analysis of lipid classes and molecular species. Chromatographia 2001, 54(9/10):607-611.
14. Roy S., Gaudin K., Germain D.P., Baillet A., Prognon P., Chaminade P. Optimisation of the separation of four major neutral glycosphingolipids: application to a rapid and simple detection of urinary globotriaosylceramide in Fabry disease. J. Chromatogr. B 2004, 805:331-337.
15. Almeling S., Holzgrabe U. Use of evaporative light scattering detection for the quality control of drug substances: influence of different liquid chromatographic and evaporative light scattering detector parameters on the appearance of spike peaks. J. Chromatogr. A 2010, 1217:2163-2170.
16. Robinson J.L., Tsimido M., Macrae R.J. Evaluation of the mass detector for quantitative detection of triglycerides and fatty acid methyl esters. J. Chromatogr. 1985, 324:35-51.
17. Asmus P.A., Landis J.B. Analysis of steroids in bulk pharmaceuticals by liquid chromatography with light-scattering detection. J. Chromatogr. 1984, 316:461-472.
18. Mathews B.T., Higginson P.D., Lyons R., Mithcell J.C., Sach N.W., Snowden M.J., Taylor M.R., Wright A.G. Improving quantitative measurements for the evaporative light scattering detector. Chromatographia 2004, 60(December (11/12)):625-633.
19. Galanakis E.G., Megoulas N.C., Solich P., Koupparis M.A. Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection. J. Pharm. Biomed. Anal. 2006, 40:1114-1120.
20. Macko T., Pasch H., Denayer J.F. Adsorption of polypropylene from dilute solutions on a zeolite column packing. J. Sep. Sci. 2005, 28:59-64.
21. Albrecht A., Brull R., Macko T., Pasch H. Separation of ethylene-vinyl acetate copolymers by high-temperature gradient liquid chromatography. Macromolecules 2007, 40:5545-5551.
22. Li X., Monsuur F., Denoulet B., Dobrak A., Vandezande P., Vankelecom I.F.J. Evaporative light scattering detector: toward a general molecular weight cutoff characterization of nanofiltration membranes. Anal. Chem. 2009, 81:1801-1809.
23. Mitchell C.R., Bao Y., Benz N.J., Zhang S. Comparison of the sensitivity of evaporative universal detectors and LC/MS in the HILIC and the reversed-phase HPLC modes. J. Chromatogr. B 2009, 877:4133-4139.
24. Webster G.K., Jensen J.S., Diaz A.R. An investigation into detector limitations using evaporative light-scattering detectors for pharmaceutical applications. J. Chromatogr. Sci. 2004, 42(9):484-490.
25. Van Nederkassel A.M., Vijverman V., Massart D.L., Vaner Heyden Y. Development of Ginkgo biloba fingerprint chromatogram with UV and evaporative light scattering detection and optimization of the evaporative light scattering detector operating conditions. J. Chromatogr. A 2005, 1085:230-239.
26. Guillarme D., Rudaz S., Schelling C., Dreux M., Veuthey J.L. Micro liquid chromatography coupled with evaporative light scattering detector at ambient and high temperature: optimization of the nebulization cell geometry. J. Chromatogr. A 2008, 1192:103-112.
27. Karatapanis A.E., Fiamegos Y.C., Sakkas V.A., Stalikas C.D. Effect of chromatographic parameter and detector settings on the response of HILIC-evaporative light-scattering detection system using experimental design approach and multicriteria optimization methodology. Talanta 2011, 83:1126-1133.
28. Villiers A., Gorecki T., Lynen F., Szucs R., Sandra P. Improving the universal response of evaporative light scattering detection by mobile phase compensation. J. Chromatogr. A 2007, 1161:183-191.
29. Walfish S., Aruda W.O., Krull I.S. Review and optimization of linearity and precision in quantitative HPLC-ELSD with chemometrics. LC-GC North Am. 2008, (October (1)):1032-1042.
30. Mefoulas N.C., Kourpparis M.A. Twenty years of evaporative light scattering detection. Crit. Rev. Anal. Chem. 2005, 35:301-316.
31. Kohler M., Haerdi W., Christen P., Veuthey J.-L. The evaporative light scattering detector: some applications in pharmaceutical analysis. Trends Anal. Chem. 1997, 16(8):475-484.
32. Restuccia D., Spizzirri U.G., Puoci F., Cirrillo G., Vinci G., Picci N. Determination of phospholipids in food samples. Food Rev. Int. 2012, 28:1-46.
33. Dvorackova E., Snoblova M., Hrdlicka P. Carbohydrate analysis: from sample preparation to HPLC on different stationary phases coupled with evaporative light-scattering detection. J. Sep. Sci. 2014, 37:323-337.
34. Holzgrabe U., Brinz D., Weber C., Almeling S. Use of evaporative light scattering detection (ELSD) for the quality control of drug substances. Chromatography: Types, Techniques and Methods 2010, 483-496. Nova Publishers Inc., New York. T.J. Quintin (Ed.).
35. Alvarez J.G. Evaporative light scattering detection. Encyclopedia of Chromatography 2010, 816-817. 3rd ed. J. Cazes (Ed.).
36. Scheidl C.O.R., Menzinger F., Maier E.J., Capek E., Scheidl O., Huck C.W. Simultaneous quantification of neomycin and bacitracin by LC-ELSD. Chromatographia 2009, 69(11/12):1181-1188.
37. Megoulas N.C., Koupparis M.A. Development and validation of a novel LC/ELSD method for the quantitation of gentamicin sulfate components in pharmaceuticals. J. Pharm. Biomed. Anal. 2004, 36:73-79.
38. Manoj Babu M.K. Simultaneous separation and quantitation of four antiepileptic drugs - a study with potential for use in patient drug level monitoring. J. Pharm. Biomed. Anal. 2004, 34(2):315-324.
39. Hewitt D., Zhang R., Kao Y.-H. Quantitation of polysorbate 20 in protein solutions using mixed-mode chromatography and evaporative light scattering detection. J. Chromatogr. A 2008, 1215:156-160.
40. Nair L.M., Stephens N.V., Vincent S., Raghavan N., Sand P.J. Determination of polysorbate 80 in parenteral formulations by high-performance liquid chromatography and evaporative light scattering detection. J. Chromatogr. A 2003, 1012:81-86.
41. Han S., Karlowicz-Bodalska K., Szura D., Ozimek L., Musial W. Application of HPLC with ELSD detection for the assessment of azelaic acid impurities in liposomal formulation. Sci. World J. 2013, 564962:1-8.
42. Jian Y., Xie A. Determination of ibandronate and its degradation products by ion-pair RP LC with evaporative light-scattering detection. Chromatographia 2005, 62(5/6):257-261.
43. Liu Y., Hu C. RP-HPLC determination of midecamycin and related impurities. Chromatographia 2003, 57(3/4):143-146.
44. Wang M.-J., Hu C. Analysis of spectinomycin by HPLC with evaporative light-scattering detection. Chromatographia 2006, 63(5/6):255-260.
45. Zhou J., Zhang L., Wang Y., Yan C. HPLC-ELSD analysis of spectinomycin dihydrochloride and its impurities. J. Sep. Sci. 2011, 34:1811-1819.
46. Peterson J.A., Risley D.S. Validation of an HPLC method for the determination of sodium in LY239111 sodium, a novel LTB4 receptor antagonist, using evaporative light scattering detection. J. Liq. Chromatogr. 1995, 18:331-338.
47. Risley D.S., Peterson J.A., Griffiths K., McCarthy S. An alternative method for the determination of chloride in pharmaceutical drug substances using HPLC and evaporative light-scattering detection. LC-GC N. Am. 1996, 14:1040-1047.
48. Risley D.S., Pack B.W. Simultaneous determination of positive and negative counterions using a hydrophilic interaction chromatography method. LC-GC N. Am. 2006, 24:776-785.
49. Zhang T., Nguyen D., Franco P. Use of evaporative light scattering detector in the detection and quantification of enantiomeric mixtures by HPLC. J. Sep. Sci. 2006, 29:1517-1524.
50. Forget R., Spagnoli S. Excipient quantitation and drug distribution during formulation optimization. J. Pharm. Biomed. Anal. 2006, 41:1051-1055.
51. Torres C.F., Vazquez L., Senorans J., Reglero G. Study of the analysis of alkoxyglycerols and other non-polar lipids by liquid chromatography coupled with evaporative light scattering detector. J. Chromatogr. A 2005, 1078:28-34.
52. Schaefer A., Kuchler T., Simat T.J., Steinhart H. Migration of lubricants from food packagings: screening for lipid classes and quantitative estimation using normal-phase liquid chromatographic separation with evaporative light scattering detection. J. Chromatogr. A 2003, 1017:107-116.
53. Graeve M., Janssen D. Improved separation and quantification of neutral and polar lipid classes by HPLC-ELSD using a monolithic silica phase: application to exceptional marine lipids. J. Chromatogr. B 2009, 877:1815-1819.
54. Rodriguez-Alcala L.M., Fontecha J. Major lipid classes separation of buttermilk, and cows, goats and ewes milk by high performance liquid chromatography with an evaporative light scattering detector focused on the phospholipid fraction. J. Chromatogr. A 2010, 1217:3063-3066.
55. Rombaut R., Dewettinck K., Van Camp J. Phospho- and sphingolipid content of selected dairy products as determined by HPLC coupled to an evaporative light scattering detector (HPLC-ELSD). J. Food Comp. Anal. 2007, 20:308-312.
56. Nogueira L.C., Silva F., Ferreira I., Trugo L.C. Separation and quantification of beer carbohydrates by high-performance liquid chromatography with evaporative light scattering detection. J. Chromatogr. A 2005, 1065:207-210.
57. Wei Y., Ding M.-Y. Analysis of carbohydrates in drinks by high-performance liquid chromatography with a dynamically modified amino column and evaporative light scattering detection. J. Chromatogr. A 2000, 904:113-117.
58. Shanmugavelan P., Kim S.Y., Kim J.B., Kim H.W., Cho S.M., Kim S.N., Kim S.Y., Cho Y.S., Kim H.R. Evaluation of sugar content and composition in commonly consumed Korean vegetables, fruits, cereals, seed plants, and leave by HPLC-ELSD. Carbohydr. Res. 2013, 380:112-117.
59. Ma C., Sun Z., Chen C., Zhang L., Zhu S. Simultaneous separation and determination of fructose, sorbitol, glucose and sucrose in fruits by HPLC-ELSD. Food Chem. 2014, 145:784-788.
60. Karlsson G., Winge S., Sandberg H. Separation of monosaccharides by hydrophilic interaction chromatography with evaporative light scattering detection. J. Chromatogr. A 2005, 1092:246-249.
61. Bhandari P., Kumar N., Singh B., Kaul V.K. Simultaneous determination of sugars and picrosides in Picrorhiza species using ultrasonic extraction and high-performance liquid chromatography with evaporative light scattering detection. J. Chromatogr. A 2008, 1194:257-261.
62. Olšovská J., Kameník Z., Cajthamla T. Hyphenated ultra high-performance liquid chromatography-nano quantity analyte detector technique for determination of compounds with low UV absorption. J. Chromatogr. A 2009, 1216:5774-5778.
63. Koropchak J.A., Sadain S., Yang X., Magnusson L.-E., Heybroek M., Anisimov M., Kaufman S.L. Nanoparticle detection technology for chemical analysis. Anal. Chem. 1999, 71:386A-394A.
64. D.R. Oberreit, F.R. Quant, D.B. Blackford, Measuring analyte concentrations in liquids, US Patent Application (2008), US 2008/0137065 A1.
65. S.V. Hering, M.R. Stolzenburg, Continuous, laminar flow water-based particle condensation device and method, International Patent (2003), WO 03/065005 A2.
66. Hering S.V., Stolzenburg M.R. A method for particle size amplification by water condensation in a laminar, thermally diffusive flow. Aerosol Sci. Technol. 2005, 39:428-436.
67. Magnusson L.-E., Koropchak J.A., Anisimov M.P., Poznjakovskiy V.M., Fernandez de la Mora J. Correlations for vapor nucleating critical embryo parameters. J. Phys. Chem. Ref. Data 2003, 32:1387-1410.
68. Magnusson L.-E. Fundamental advances and applications of condensation nucleation light scattering detection for capillary electrophoresis 2002, (Ph.D. dissertation), Southern Illinois University.
69. Petäjä T., Mordas G., Manninen H., Aalto P.P., Hämeri K., Kulmala M. Detection efficiency of a water-based TSI condensation particle counter 3785. Aerosol Sci. Technol. 2006, 40:1090-1097.
70. Kupc A., Bischof O., Tritscher T., Beeston M., Krinke T., Wagner P.E. Laboratory characterization of a new nano-water-based CPC 3788 and performance comparison to an ultrafine butanol-based CPC 3776. Aerosol Sci. Technol. 2013, 47:183-191.
71. Magnusson L.-E., Anisimov M.P., Koropchak J.A. Evidence for sub-3 nanometer neutralized particle detection using glycerol as a condensing fluid. J. Aerosol Sci. 2010, 41:637-654.
72. Bartz H., Fissan H., Helsper C., Kousaka Y., Okuyama K., Fukushima N., Keady P.B., Kerrigan S., Fruin S.A., McMurry P.H., Pui D.Y.H., Stolzenburg M.R. Response characteristics for four different condensation nucleus counters to particles in the 3-50 nm diameter range. J. Aerosol Sci. 1985, 16:443-456.
73. 2, and naphthalene. J. Colloid Interface Sci. 1998, 198:354-367.
74. Porstendörfer J., Scheibel H.G., Pohl F.G., Preining O., Reischl G., Wagner P.E. Heterogeneous nucleation of water vapor on monodispersed Ag and NaCl particles with diameters between 6 and 18 nm. Aerosol Sci. Technol. 1985, 4:65-79.
75. Hering S.V., Stolzenburg M.R., Quant F.R., Oberreit D.R., Keady P.B. A laminar-flow, water-based condensation particle counter (WCPC). Aerosol Sci. Technol. 2005, 39:659-672.
76. Liu W., Kaufman S.L., Osmondson B.L., Sem G.J., Quant F.R., Oberreit D.R. Water-based condensation particle counters for environmental monitoring of ultrafine particles. J. Air Waste Manage. Assoc. 2006, 56:444-455.
77. Mordas G., Manninen H.E., Petäjä T., Aalto P.P., Hämeri K., Kulmala M. On operation of the ultra-fine water-based CPC TSI 3786 and comparison with other TSI Models (TSI 3776, TSI 3772, TSI 3025, TSI 3010, TSI 3007). Aerosol Sci. Technol. 2008, 42:152-158.
78. Biswas S., Fine P.M., Geller M.D., Hering S.V., Sioutas C. Performance evaluation of a recently developed water-based condensation particle counter. Aerosol Sci. Technol. 2005, 39:419-427.
79. Winkler P.M., Hienola A., Steiner G., Hill G., Vrtala A., Reischl G.P., Kulmala M., Wagner P.E. Effects of seed particle size and composition on heterogeneous nucleation of n-nonane. Atmos. Res. 2008, 90:187-194.
80. Chemmalil L., Suravajjala S., See K., Jordan E., Furtado M., Sun C., Hosselet S. A novel approach for quantitation of nonderivatized sialic acid in protein therapeutics using hydrophilic interaction chromatographic separation and nano quantity analyte detection. J. Pharm. Sci. 2015, 104:15-24.
81. Fekete S., Ganzler K., Fekete J. Simultaneous determination of polysorbate 20 and unbound polyethylene-glycol in protein solutions using new core-shell reversed phase column and condensation nucleation light scattering detection. J. Chromatogr. A 2010, 1217:6258-6266.
82. Wang J.-F., Yang H.-X., Zhu L., Yin L.-H. Determination of kanamycin sulfate injection by HPLC-NQAD and HPLC-ELSD. Yaowu Fenxi Zazhi 2014, 34:644-648.
83. Cintrón J.M., Risley D.S. Hydrophilic interaction chromatography with aerosol-based detectors (ELSD, CAD, NQAD) for polar compounds lacking a UV chromophore in an intravenous formulation. J. Pharm. Biomed. Anal. 2013, 78-79:14-18.
84. Risley D.S., Magnusson L.-E., Morow P.R., Aburub A. Analysis of magnesium from magnesium stearate in pharmaceutical tablet formulations using hydrophilic interaction liquid chromatography with nano quantity analyte detection. J. Pharm. Biomed. Anal. 2013, 78-79:112-117.
85. Cohen R.D., Liu Y., Gong X. Analysis of volatile bases by high performance liquid chromatography with aerosol-based detection. J. Chromatogr. A 2012, 1229:172-179.
86. Hutchinson J.P., Li J., Farrell W., Groeber E., Szucs R., Dicinoskia G., Haddad P.R. Comparison of the response of four aerosol detectors used with ultra high pressure liquid chromatography. J. Chromatogr. A 2011, 1218:1646-1655.
87. Holzgrabe U., Nap C.-J., Beyer T., Almeling S. Alternatives to amino acid analysis for the purity control of pharmaceutical grade l-alanine. J. Sep. Sci. 2010, 33:2402-2410.
88. Almeling S. The use of aerosol-based detection systems in the quality control of drug substances 2011, (Ph.D. dissertation), Julius-Maximilians-Universität, Würzburg.
89. Holzgrabe U., Nap C.-J., Almeling S. Control of impurities in l-aspartic acid and l-alanine by high-performance liquid chromatography coupled with a corona charged aerosol detector. J. Chromatogr. A 2010, 1217:294-301.
90. Lu Q. Development and evaluation of a prototype commercial condensation nucleation light scattering detector for HPLC and a corona discharge neutralizer for electrospray aerosols used with condensation nucleation light scattering detection 2004, (Ph.D. dissertation), Southern Illinois University.
91. Chen Q.-Y., Xu J.-Z., Xia J.-M., Zhong T.-H., Xu C. Determination of glucosamine compounds by HPLC-nano-quantity analyte detector. Xiamen Daxue Xuebao, Ziran Kexueban Journal of Xiamen University (Nat. Sci.) 2012, 51:1043-1046.
92. Beppu F., Nagai T., Yoshinaga K., Mizobe H., Kojima K., Gotoh N. Quantification of triacylglycerol molecular species in cocoa butter using high-performance liquid chromatography equipped with nano quantity analyte detector. J. Oleo Sci. 2013, 10:789-794.
93. Cai X.-J., Xu J.-Z., Huang H.-N., Xia J.-M., Chen Q.-Y., Xu C. Determination of d-xylose by HPLC with nano quantity analyte detector. Shipin Kexue (Beijing, China) 2013, 34:179-181.
94. Wang Q., Sadain S., Koropchak J.A. Investigation of the condensation nucleation light scattering detector (CNLSD) for carbohydrates with ion-exchange and hydrophilic interaction separations. Am. Biotechnol. Lab. 2001, 19:22-24.
95. Wang Q. Development of CNLSD for detection of carbohydrates after liquid-phase separations 2002, (Ph.D. dissertation), Southern Illinois University.
96. You J., Koropchak J.A. Condensation nucleation light scattering detection with ion chromatography for direct determination of glyphosate and its metabolite in water. J. Chromatogr. A 2003, 989:231-238.
97. Gamache P.H., McCarthy R.S., Freeto S.M., Asa D.J., Woodcock M.J., Laws K., Cole R.O. HPLC analysis of non-volatile analytes using charged aerosol detection. LC-GC Eur. 2005, 18:345-354.
98. Ligor M., Studzinska S., Horna A., Buszewski B. Corona-charged aerosol detection: an analytical approach. Crit. Rev. Anal. Chem. 2013, 43:64-78.
99. Vehovec T., Obreza A. Review of operating principle and applications of the charged aerosol detector. J. Chromatogr. A 2010, 1217:1549-1556.
100. Almeling S., Ilko D., Holzgrabe U. Charged aerosol detection in pharmaceutical analysis. J. Pharm. Biomed. Anal. 2012, 69:50-63.
101. Dixon R.W. Aerosol-based detectors for liquid chromatography: do they have a role in bioanalysis?. Bioanalysis 2009, 1(8):1389-1392.
102. S.L. Kaufman, Evaporative electrical detector, United States Patent 6,568,245 (2003).
103. Vervoort N., Daemen D., Torok G. Performance evaluation of evaporative light scattering detection and charged aerosol detection in reversed phase liquid chromatography. J. Chromatogr. A 2008, 1189:92-100.
104. A.D. Yim, P.H. Gamache, R.S. McCarthy, Nebulizer for charged aerosol detection (CAD) system, United States Patent Application 0352411 A1 (2014).
105. Stojanovic A., Lammerhofer M., Kogelnig D., Schiesel S., Sturm M., Galanski M., Krachler R., Keppler B., Lindner W. Analysis of quaternary ammonium and phosphonium ionic liquids by reversed-phase high-performance liquid chromatography with charged aerosol detection and unified calibration. J. Chromatogr. A 2008, 1209:179-187.
106. Matsuyama S., Orihara Y., Kinugasa S., Ohtani H. Effects of densities of brominated flame retardants on the detection response for HPLC analysis with a corona-charged aerosol detector. Anal. Sci. 2015, 31:61-65.
107. Nukiyama S., Tanasawa Y. An experiment on the atomization of liquid. IV. The effect of the properties of liquid on the size of drops. Trans. Soc. Mech. Eng. Jpn. 1939, 5:68-75.
108. Gorecki T., Lynen F., Szucs R., Sandra P. Universal response in liquid chromatography using charged aerosol detection. Anal. Chem. 2006, 78:3186-3192.
109. Khandagale M.M., Hilder E., Shellie R.A., Haddad P.R. Assessment of the complementarity of temperature and flow-rate for response normalisation of aerosol-based detectors. J. Chromatogr. A 2014, 1356:180-187.
110. Moreau R.A. The analysis of lipids via HPLC with a charged aerosol detector. Lipids 2006, 41:727-734.
111. Schiesel S., Lammerhofer M., Lindner W. Comprehensive impurity profiling of nutritional infusion solutions by multidimensional off-line reversed-phase liquid chromatography × hydrophilic interaction chromatography-ion trap mass-spectrometry and charged aerosol detection with universal calibration. J. Chromatogr. A 2012, 1259:100-110.
112. Wang R., Wang X., Paulino J., Alquier L. Evaluation of charged aerosol detector for purity assessment of protein. J. Chromatogr. A 2013, 1283:116-121.
113. Zhang K., Li Y., Tsang M., Chetwyn N.P. Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection. J. Sep. Sci. 2013, 36:2986-2992.
114. Wahl O., Holzgrabe U. Impurity profiling of carbocisteine by HPLC-CAD, qNMR and UV/vis spectroscopy. J. Pharm. Biomed. Anal. 2014, 95:1-10.
115. Khoomrung S., Chumnanpuen P., Jansa-Ard S., Stahlman M., Nookaew I., Boren J., Nielsen J. Rapid quantification of yeast lipid using microwave-assisted total lipid extraction and HPLC-CAD. Anal. Chem. 2013, 85:4912-4919.
116. Marquez-Sillero I., Cardenas S., Valcarcel M. Determination of water-soluble vitamins in infant milk and dietary supplement using a liquid chromatography on-line coupled to a corona-charged aerosol detector. J. Chromatogr. A 2013, 1313:253-258.
117. Plaza M., Kaiuki J., Turner C. Quantification of individual phenolic compounds' contribution to antioxidant capacity in apple: a novel analytical tool based on liquid chromatography with diode array, electrochemical, and charged aerosol detection. J. Agric. Food Chem. 2014, 62:409-418.
118. Li J., Hu D., Zong W., Lv G., Zhao J., Li S. Determination of inulin-type fructooligosaccharides in edible plants by high-performance liquid chromatography with charged aerosol detector. J. Agric. Food Chem. 2014, 62:7707-7713.
119. Nair L.M., Werling J.O. Aerosol based detectors for the investigation of phospholipid hydrolysis in a pharmaceutical suspension formulation. J. Pharm. Biomed. Anal. 2009, 49:95-99.
120. Poplawska M., Blazewicz A., Zolek P., Fijalek Z. Determination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector. J. Pharm. Biomed. Anal. 2014, 94:45-53.
121. Kou D., Manius G., Zhan S., Chokshi H.P. Size exclusion chromatography with corona charged aerosol detector for the analysis of polyethylene glycol polymer. J. Chromatogr. A 2009, 1216:5424-5428.
122. Park E.J., Choo H., Kim S.W., Na D.H. Chromatographic methods for characterization of poly (ethylene glycol)-modified polyamidoamine dendrimers. Anal. Biochem. 2014, 449:42-44.
123. Flagan R.C. History of electrical aerosol measurements. Aerosol Sci. Technol. 1998, 28:301-380.
124. Kuang C., Chen M., McMurry P.H., Wang J. Modification of laminar flow ultrafine condensation particle counters for the enhanced detection of 1 nm condensation nuclei. Aerosol Sci. Technol. 2012, 46:309-315.
125. Gamero-Castano M., Fernandez de la Mora J. A condensation nucleus counter (CNC) sensitive to singly charged sub-nanometer particles. J. Aerosol Sci. 2000, 31:757-772.
126. Sipila M., Berndt T., Petaja T., Brus D., Vanhanen J., Stratman F., Patokoski J., Mauldin R.L., Hyvarinen A.-P., Lihaveinen H., Kulmala M. The role of sulfuric acid in atmospheric nucleation. Science 2010, 327:1243-1246.