An investigation into detector limitations using evaporative light-scattering detectors for pharmaceutical applications

Journal of Chromatographic Science

Volumn 42, Issue 9, 2004, Pages 484-490

  Webster, Gregory K ^a   Jensen, James S ^a   Diaz, Angel R ^b  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 3 HYDROXYBUTYRIC ACID; ANTICONVULSIVE AGENT; CYCLOHEXIMIDE; DIMETHADIONE; ETHOSUXIMIDE; MALTOSE; PARTHENOLIDE; SUCCINIMIDE; TRIMETHADIONE; UREA; VIGABATRIN;

ANALYTIC METHOD; ARTICLE; CHROMATOPHORE; DRUG INDUSTRY; EVALUATION; EVAPORATION; EVAPORATIVE LIGHT SCATTERING DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT ABSORPTION; LIGHT SCATTERING; MELTING POINT; MOLECULAR WEIGHT; NEBULIZER; PARAMETER; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; TECHNIQUE; TECHNOLOGY; TEMPERATURE DEPENDENCE; ULTRAVIOLET RADIATION; VOLATILIZATION;

EID: 8844242479     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/42.9.484     Document Type: Article

References (14)

1. ICH Committee. "Guideline on the validation of analytical procedures: methodology". International Conference on Harmonization of Technical Requirements for the Registration of Drugs for Human Use, Geneva, Switzerland, May 9, 1997.
2. R. Gatti, R. Giotti, D. Bonazzi, and V. Cavrini. A comparative evaluation of three detectors in the HPLC analysis of sodium fusidate. IL Farmaco 51(2): 115-19 (1996).
3. M. Kohler, W. Haerdi, P. Christen, and J.L. Veuthey. The evaporative light scattering detector: some applications in pharmaceutical analysis. Trends Anal. Chem. 16(8): 475-84 (1997).
4. S. Cardenas, M. Gallego, and M. Valcarcel. Evaporative light scattering detector: a new tool for screening purposes. Anal. Chim. Acta 402: 1-5 (1999).
5. F.S. Deschamps, K. Gaudin, E. Lesellier, A. Tchapla, D. Ferrier, A. Baillet, and P. Chaminade. Response enhancement for the evaporative light scattering detection for the analysis of underivatized amino acids. Chromatographic 54(9-10): 607-11 (2001).
6. K. Petritis, C. Elfakir, and M. Dreux. A comparative study of commercial liquid chromatographic detectors for the analysis of underivatized amino acids. J. Chromatogr. A 961: 9-21 (2002).
7. T.H. Mourey and L.E. Oppenheimer. Principles of operation of an evaporative light scattering detectors for liquid chromatography. Anal. Chem. 56: 2427-34 (1984).
8. J.N. Alexander. Evaporative light scattering detection for microcolumn liquid chromatography. J. Microcol. Sep. 10(6): 491-502 (1998).
9. M.B.O. Anderson and L.G. Blomberg. A miniaturized evaporative light scattering detector for application with packed microcolumn high-performance liquid chromatography. J. Microcol. Sep.10(3): 249-54 (1998).
10. F. Mancini, E. Miniati, and L. Montanari. Performance of some evaporative light scattering detectors (ELSD) in the analysis of triglycerides and phospholipids. Ital. J. Food Sci. 9(4): 323-35 (1997).
11. F.S. Deschamps, A. Baillet, and P. Chaminade. Mechanism of response enhancement in evaporative light scattering detection with the addition of triethylamine and formic acid. Analyst 127: 35-41 (2002).
12. C.S. Young and J.W. Dolan. Success with evaporative light-scattering detection. LC-GC 21(2): 120-28 (2003).
13. J.M, Charlesworth. Evaporative analyzer as mass detector for liquid chromatography. Anal. Chem. 50(11): 1414-20 (1978).
14. G.K. Webster and A.R. Diaz. "Evaluation of evaporative light scattering detection as a bridge to LC-MS for quality control". 2002 AAPS National Meeting, Toronto, Canada, November, 2002.