Simultaneous determination of polysorbate 20 and unbound polyethylene-glycol in protein solutions using new core-shell reversed phase column and condensation nucleation light scattering detection

Journal of Chromatography A

Volumn 1217, Issue 40, 2010, Pages 6258-6266

  Fekete, Szabolcs ^a   Ganzler, Katalin ^a   Fekete, Jeno ^b  

^a GEDEON RICHTER LTD   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

CNLSD; Fast chromatography; Kinetex; NQAD; PEG; Tween 20

Indexed keywords

CNLSD; FAST CHROMATOGRAPHY; KINETEX; NQAD; PEG; TWEEN-20;

CONDENSATION; DRUG PRODUCTS PLANTS; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; LIQUIDS; METHANOL; NUCLEATION; POLYETHYLENE OXIDES; POLYETHYLENES; PROTEINS; REFRACTION; THERMOPLASTICS;

POLYETHYLENE GLYCOLS;

ACETONITRILE; MACROGOL; METHANOL; POLYSORBATE 20; TRIFLUOROACETIC ACID;

ACCURACY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG INDUSTRY; EVAPORATION; GOOD MANUFACTURING PRACTICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYMERIZATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; LIGHT; LINEAR MODELS; POLYETHYLENE GLYCOLS; POLYSORBATES; PROTEINS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPERATURE;

EID: 77956652295     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.08.028     Document Type: Article

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