Comprehensive impurity profiling of nutritional infusion solutions by multidimensional off-line reversed-phase liquid chromatography×hydrophilic interaction chromatography-ion trap mass-spectrometry and charged aerosol detection with universal calibration

Journal of Chromatography A

Volumn 1259, Issue , 2012, Pages 100-110

  Schiesel, Simone ^a   Lämmerhofer, Michael ^a,b   Lindner, Wolfgang ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Amino acids; Charged aerosol detector; Impurity profiling; Off line two dimensional liquid chromatography; Peptides; Unified calibration function

Indexed keywords

CHARGED AEROSOL DETECTION; CHARGED AEROSOL DETECTORS; COMPLEMENTARY DETECTION; COMPLEX SAMPLES; CONDENSATION PRODUCT; CROSS VALIDATION; DETECTOR RESPONSE; DI-PEPTIDES; DIKETOPIPERAZINES; HPLC-MS/MS; HYDROPHILIC INTERACTION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IMPURITY PROFILE; IMPURITY PROFILING; ION-TRAP MASS SPECTROMETRY; MULTIDIMENSIONAL ANALYSIS; NON-VOLATILE COMPOUNDS; PHARMACEUTICAL DRUG FORMULATIONS; PRECURSOR COMPOUNDS; PYROGLUTAMIC ACIDS; REVERSED-PHASE LIQUID CHROMATOGRAPHY; TETRA PEPTIDE; TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY; UNIFIED CALIBRATION; UNIVERSAL CALIBRATION;

AMINO ACIDS; ATMOSPHERIC AEROSOLS; CALIBRATION; IMPURITIES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES; STANDARDS; TWO DIMENSIONAL; VOLATILE ORGANIC COMPOUNDS;

DETECTORS;

DIPEPTIDE; GLUTAMIC ACID DERIVATIVE; INFUSION FLUID; PIPERAZINEDIONE; POLYGLUTAMIC ACID; TETRAPEPTIDE; TRIPEPTIDE; VOLATILE AGENT;

AEROSOL; ANALYZER; ARTICLE; CALIBRATION; CLASSIFICATION; DRUG IMPURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; MASS SPECTROMETRY; PARENTERAL NUTRITION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; STANDARDIZATION; VALIDATION PROCESS;

AEROSOLS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG CONTAMINATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MASS SPECTROMETRY; OLIGOPEPTIDES; PHARMACEUTICAL SOLUTIONS; REPRODUCIBILITY OF RESULTS;

EID: 84866330083     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.01.009     Document Type: Article

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