Excipient quantitation and drug distribution during formulation optimization

Journal of Pharmaceutical and Biomedical Analysis

Volumn 41, Issue 3, 2006, Pages 1051-1055

  Forget, Robert ^a   Spagnoli, Suzanne ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

ELSD; Excipient quantitation; Formulation optimization; HPLC; Mannitol; RID

Indexed keywords

EXCIPIENT; MANNITOL;

AIRFLOW; ANALYTIC METHOD; ARTICLE; CHROMATOPHORE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; FILTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REFRACTION INDEX; REPRODUCIBILITY; ULTRAVIOLET RADIATION; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; ULTRAVIOLET SPECTROPHOTOMETRY;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCIPIENTS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33746489548     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.01.039     Document Type: Article

References (6)

1. Dionex Corporation, Quantitation of Carbohydrates and Glycols in Pharmaceuticals, Application Note 117.
2. Bao Y., Silva T.M., Guerrant R.L., Lima A.M., and Fox J.W. J. Chromatogr. B: Biomed. Appl. 685 (1996) 105-112
3. Kiyoshima A., Kudo K., Nishida N., and Ikeda N. Forensic Sci. Int. 125 (2002) 127-133 (7)
4. Kiyoshima A., Kudo K., Hino Y., and Ikeda N. Chromatogr. B: Biomed. Sci. Appl. 758 (2001) 103-108
5. Young C.S., and Nolan J.W. LC-GC 21 (2003) 120-128
6. Young C.S., and Nolan J.W. LC-GC 22 (2004) 244-250