Control of impurities in l-aspartic acid and l-alanine by high-performance liquid chromatography coupled with a corona charged aerosol detector

Journal of Chromatography A

Volumn 1217, Issue 3, 2010, Pages 294-301

  Holzgrabe, Ulrike ^a   Nap, Cees Jan ^b   Almeling, Stefan ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b European Directorate for the Quality of Medicines and Health Care   (France)

Author keywords

Alanine; Aspartic acid; Charged aerosol detector (CAD); Evaporative light scattering detector (ELSD); High performance liquid chromatography (HPLC); Impurities control

Indexed keywords

ASPARTIC ACID; ASPARTIC ACIDS; CHARGED AEROSOLS; EVAPORATIVE LIGHT SCATTERING DETECTORS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC);

AMINES; AMINO ACIDS; ATMOSPHERIC AEROSOLS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DETECTORS; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IMPURITIES; LIGHT SCATTERING; LIQUIDS; ORGANIC ACIDS; QUALITY FUNCTION DEPLOYMENT; REFRACTION; SCATTERING; TOTAL QUALITY MANAGEMENT;

QUALITY CONTROL;

ALANINE; AMINO ACID; ASPARTIC ACID; CARBOXYLIC ACID; CITRIC ACID; FUMARIC ACID; GLUTAMIC ACID; GLUTAMINE; MALEIC ACID; MALIC ACID; SUCCINIC ACID;

AMINO ACID ANALYSIS; ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ARTICLE; CHARGED AEROSOL DETECTION; CHEMICAL REACTION; CONTROLLED STUDY; DERIVATIZATION; EVAPORATIVE LIGHT SCATTERING DETECTOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; ION PAIR CHROMATOGRAPHY; ION PAIR EXTRACTION; PRIORITY JOURNAL; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY; VOLATILIZATION;

AEROSOLS; ALANINE; ASPARTIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; LIGHT; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SENSITIVITY AND SPECIFICITY;

EID: 72449168034     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.11.036     Document Type: Article

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