HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction

Cardiovascular Research

Volumn 109, Issue 1, 2016, Pages 115-130

  Labrousse Arias, David ^a   Castillo González, Raquel ^a   Rogers, Natasha M ^b   Torres Capelli, Mar ^a   Barreira, Bianca ^c   Aragonés, Julián ^a   Cogolludo, Ángel ^c,d   Isenberg, Jeffrey S ^b   Calzada, María J ^a  

^a AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Endothelial cells; Fibroblasts; HIF 2a; Hypoxia; Pulmonary arterial hypertension; Pulmonary artery; Smooth muscle cells; Thrombospondin 1

Indexed keywords

ACETYLCHOLINE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; KV CHANNEL INTERACTING PROTEIN; THROMBOSPONDIN 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; POTASSIUM CHANNEL KV1.5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL MIGRATION; CONTROLLED STUDY; FIBROBLAST; HYPOXIA; LUNG BLOOD VESSEL; LUNG VASOCONSTRICTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PULMONARY ARTERY; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; VASODILATATION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL HYPOXIA; CELL MOTION; DNA RESPONSIVE ELEMENT; GENETICS; PHYSIOLOGY; PROMOTER REGION; VASCULAR REMODELING; VASOCONSTRICTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL MOVEMENT; CELLS, CULTURED; KV1.5 POTASSIUM CHANNEL; MALE; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; THROMBOSPONDIN 1; VASCULAR REMODELING; VASOCONSTRICTION;

EID: 84959894127     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv243     Document Type: Article

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