Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes

American Journal of Respiratory Cell and Molecular Biology

Volumn 31, Issue 3, 2004, Pages 337-343

  Hong, Zhigang ^b   Weir, E Kenneth ^b   Nelson, Daniel P ^b   Olschewski, Andrea ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; CALCIUM ION; MEMBRANE PROTEIN; MESSENGER RNA; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HYPOXIA; MALE; MUSCLE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALTITUDE SICKNESS; ANIMALS; ANOXIA; ANTIBODIES; BRONCHOCONSTRICTION; CALCIUM; CALCIUM SIGNALING; CELL MEMBRANE; DELAYED RECTIFIER POTASSIUM CHANNELS; DOWN-REGULATION; HYPERTENSION, PULMONARY; KV1.2 POTASSIUM CHANNEL; KV1.5 POTASSIUM CHANNEL; MALE; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PULMONARY ARTERY; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SHAB POTASSIUM CHANNELS;

ANIMALIA;

EID: 4444367046     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2003-0386OC     Document Type: Article

References (32)

1. 2 in type I chemoreceptor cells. Science 241:580-582.
2. Post, J. M., J. R. Hume, S. L. Archer, and E. K. Weir. 1992. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol. 262:C882-C890.
3. Weir, E. K., and S. L. Archer. 1995. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J. 9:183-189.
4. i in pulmonary arterial myocytes. Circ. Res. 77:370-378.
5. Archer, S. L., J. M. Huang, H. L. Reeve, V. Hampl, S. Tolarova, E. Michelakis, and E. K. Weir. 1996. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ. Res. 78:431-442.
6. 2-sensing potassium current. Br. J. Pharmacol. 120:1461-1470.
7. Hille, B. 2001. Potassium Channels and Chloride Channels: Ion Channels of Excitable Membranes. 3rd ed. Sinauer Associates Inc., Sunderland. 131-167.
8. + channel α subunits in pulmonary artery smooth muscle cells. J. Clin. Invest. 100:2347-2353.
9. + channels expressed in the pulmonary vasculature. Circ. Res. 85:489-497.
10. + channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J. Clin. Invest. 101:2319-2330.
11. + channel in oxygen-sensitive pulmonary artery myocytes. EMBO J. 16:6615-6625.
12. Osipenko, O. N., R. J. Tate, and A. M. Gurney. 2000. Potential role for kv3.1b channels as oxygen sensors. Circ. Res. 86:534-540.
13. Osipenko, O. N., D. Alexander, M. R. MacLean, and A. M. Gurney. 1998. Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle. Br. J. Pharmacol. 124:1335-1337.
14. i, and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am. J. Physiol. 279:L884-L894.
15. + current in rat pulmonary artery muscle cells. Am. J. Physiol. 266:H365-H370.
16. + currents in pulmonary arterial myocytes. Am. J. Physiol. 277:L431-L439.
17. Reeve, H. L., E. Michelakis, D. Nelson, E. K. Weir, and S. L. Archer. 2001. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J. Appl. Physiol. 90:2249-2256.
18. Platoshyn, O., Y. Yu, V. A. Golovina, S. S. McDaniel, S. Krick, L. Li, J. Y. Wang, L. J. Rubin, and J. X. Yuan. 2001. Chronic hypoxia decreases K(v) channel expression and function in pulmonary artery myocytes. Am. J. Physiol. 280:L801-LS12.
19. + channels. Am. J. Physiol. 281:L1-12.
20. Hong, Z. G., A. J. Olschewski, and E. K. Weir. 2001 Effects of sub-acute hypoxia on expression of potassium channels in rat intrapulmonary arteries. Circulation 104:1917.
21. Eckhart, A. D., Z. Zhu, W. J. Arendshorst, and J. E. Faber. 1996. Oxygen modulates α 1B-adrenergic receptor gene expression by arterial but not venous vascular smooth muscle. Am. J. Physiol. 271:H1599-H1608.
22. Prabhakar, N. R., S. F. Pieramici, D. R. Premkumar, G. K. Kumar, and R. N. Kalaria. 1996. Activation of nitric oxide synthase gene, expression by hypoxia in central and peripheral neurons. Brain Res. 43:341-346.
23. i to hypoxia in pulmonary arterial smooth muscle. Am. J. Physiol. 283:L1143-L1150.
24. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:85-100.
25. Hogg, D. S., A. R. L. Davies, G. McMurray, and R. Z. Kozlowski. 2002. K(V)2.1 channels mediate hypoxic inhibition of I(KV) in native pulmonary arterial smooth muscle cells of the rat. Cardiovasc. Res. 55:349-360.
26. Wang, G. X., W. J. Hatton, G. L. Wang, J. Zhong, I. Yamboliev, D. Duan, and J. R. Hume. 2003. Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells. Am. J. Physiol. 285:H1453-H1463.
27. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
28. v channels in hypoxic hypertensive rat pulmonary artery myocytes. Am. J. Physiol. 277:H363-H370.
29. + channels: regulation in human pulmonary vascular smooth muscle cells. Am. J. Physiol. 272:C1271-C1278.
30. Sweeney, M., and J. X. Yuan. 2000. Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels. Respir. Res. 1:40-48.
31. Maggiorini, M., C. Melot, S. Pierre, F. Pfeiffer, I. Greve, C. Sartori, M. Lepori, M. Hauser, U. Scherrer, and R. Naeije. 2001. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 103:2078-2083.
32. Michelakis, E. D., E. K. Weir, X. Wu, A. Nsair, R. Waite, K. Hashimoto, L. Puttagunta, H. G. Knaus, and S. L. Archer. 2001. Potassium channels regulate tone in rat pulmonary veins. Am. J. Physiol. 280:L1138-L1147.