Compensatory vasodilatation during hypoxic exercise: Mechanisms responsible for matching oxygen supply to demand

Journal of Physiology

Volumn 590, Issue 24, 2012, Pages 6321-6326

  Casey, Darren P ^a,b   Joyner, Michael J ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANAEROBIC EXERCISE; ARM EXERCISE; BLOOD FLOW; BLOOD OXYGEN TENSION; BLOOD VESSEL FUNCTION; ENDURANCE TRAINING; EXERCISE INTENSITY; HEART OUTPUT; HUMAN; HYPEREMIA; MUSCLE MASS; MUSCLE METABOLISM; OXYGEN CONSUMPTION; OXYGEN SUPPLY; PRIORITY JOURNAL; REVIEW; SKELETAL MUSCLE; SYMPATHETIC NERVE; VASOCONSTRICTION; VASODILATATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; EXERCISE; HUMANS; HYPEREMIA; MUSCLE CONTRACTION; MUSCLE, SKELETAL; OXYGEN; OXYGEN CONSUMPTION; VASOCONSTRICTION; VASODILATION;

EID: 84871067431     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.242396     Document Type: Review

References (42)

1. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
2. Armstrong RB & Laughlin MH (1985). Rat muscle blood flows during high-speed locomotion. J Appl Physiol 59, 1322-1328.
3. Bryan PT & Marshall JM (1999a). Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. J Physiol 514, 151-162.
4. Bryan PT & Marshall JM (1999b). Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia. J Physiol 514, 163-175.
5. Calbet JA (2000). Oxygen tension and content in the regulation of limb blood flow. Acta physiol Scand 168, 465-472.
6. Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD & Saltin B (2003). Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284, R291-303.
7. Calbet JA, Radegran G, Boushel R & Saltin B (2009a). On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass. J Physiol 587, 477-490.
8. Calbet JA, Robach P & Lundby C (2009b). The exercising heart at altitude. Cell Mol Life Sci 66, 3601-3613.
9. Casey DP, Curry TB, Wilkins BW & Joyner MJ (2011). Nitric oxide-mediated vasodilation becomes independent of β-adrenergic receptor activation with increased intensity of hypoxic exercise. J Appl Physiol 110, 687-694.
10. Casey DP & Joyner MJ (2011). Contribution of adenosine to compensatory dilation in hypoperfused contracting human muscles is independent of nitric oxide. J Appl Physiol 110, 1181-1189.
11. Casey DP, Madery BD, Curry TB, Eisenach JH, Wilkins BW & Joyner MJ (2010). Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise. J Physiol 588, 373-385.
12. Casey DP, Madery BD, Pike TL, Eisenach JH, Dietz NM, Joyner MJ & Wilkins BW (2009). Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise. J Appl Physiol 107, 1128-1137.
13. Clifford PS (2007). Skeletal muscle vasodilatation at the onset of exercise. J Physiol 583, 825-833.
14. Dinenno FA & Joyner MJ (2003). Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory J Physiol 553, 281-292.
15. Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH & Sprague RS (2009). Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology 24, 107-116.
16. Gonzalez-Alonso J, Olsen DB & Saltin B (2002). Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP. Circ Res 91, 1046-1055.
17. Gonzalez-Alonso J, Richardson RS & Saltin B (2001). Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen. J Physiol 530, 331-341.
18. Hanada A, Sander M & Gonzalez-Alonso J (2003). Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise. J Physiol 551, 635-647.
19. Heinonen IH, Kemppainen J, Kaskinoro K, Peltonen JE, Borra R, Lindroos M, Oikonen V, Nuutila P, Knuuti J, Boushel R & Kalliokoski KK (2010). Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia. Am J Physiol Regul Interg Comp Physiol 299, R72-79.
20. Heistad DD, Abboud FM, Mark AL & Schmid PG (1975). Effect of hypoxemia on responses to norepinephrine and angiotensin in coronary and muscular vessels. J Pharmacol Exp Ther 193, 941-950.
21. Heistad DD & Wheeler RC (1970). Effect of acute hypoxia on vascular responsiveness in man. I. Responsiveness to lower body negative pressure and ice on the forehead. II. Responses to norepinephrine and angiotensin. 3. Effect of hypoxia and hypocapnia. J Clin Invest 49, 1252-1265.
22. 2 on cardiopulmonary and metabolic responses to exercise in man. J Appl Physiol 24, 336-347.
23. Joyner MJ & Wilkins BW (2007). Exercise hyperaemia: is anything obligatory but the hyperaemia J Physiol 583, 855-860.
24. Kooijman M, Thijssen DH, de Groot PC, Bleeker MW, van Kuppevelt HJ, Green DJ, Rongen GA, Smits P & Hopman MT (2008). Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans. J Physiol 586, 1137-1145.
25. Laxson DD, Homans DC & Bache RJ (1993). Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise. Am J Physiol Heart Circ Physiol 265, H1471-1477.
26. Leuenberger UA, Johnson D, Loomis J, Gray KS & MacLean DA (2008). Venous but not skeletal muscle interstitial nitric oxide is increased during hypobaric hypoxia. Eur J Appl Physiol 102, 457-461.
27. Lundby C, Sander M, van Hall G, Saltin B & Calbet JA (2006). Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives. J Physiol 573, 535-547.
28. Mortensen SP, Damsgaard R, Dawson EA, Secher NH & Gonzalez-Alonso J (2008). Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and during high-intensity whole-body exercise in humans. J Physiol 586, 2621-2635.
29. Mortensen SP, Gonzalez-Alonso J, Damsgaard R, Saltin B & Hellsten Y (2007). Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg. J Physiol 581, 853-861.
30. Mortensen SP, Nyberg M, Thaning P, Saltin B & Hellsten Y (2009). Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. Hypertension 53, 993-999.
31. Mortensen SP, Thaning P, Nyberg M, Saltin B & Hellsten Y (2011). Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique. J Physiol 589, 1847-1857.
32. Musch TI (1988). Skeletal muscle blood flow in exercising dogs. Med Sci Sports Exerc 20, S104-108.
33. Pohl U & Busse R (1989). Hypoxia stimulates release of endothelium-derived relaxant factor. Am J Physiol Heart Circ Physiol 256, H1595-1600.
34. Remensnyder JP, Mitchell JH & Sarnoff SJ (1962). Functional sympatholysis during muscular activity. Observations on influence of carotid sinus on oxygen uptake. Circ Res 11, 370-380.
35. 2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am J Physiol Heart Circ Physiol 276, H438-445.
36. Shepherd JT (1983). Circulation to skeletal muscle. In Handbook of Physiology, section 2, The Cardiovascular System, vol. 3, Peripheral Circulation and Organ Blood Flow, ed. Shepherd JT & Abboud FM, pp. 319-370. American Physiological Society, Bethesda
37. Stamler J, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP & Loscalzo J (1989). N-Acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res 65, 789-795.
38. Stenberg J, Ekblom B & Messin R (1966). Hemodynamic response to work at simulated altitude, 4, 000 m. J Appl Physiol 21, 1589-1594.
39. Vogel JA & Gleser MA (1972). Effect of carbon monoxide on oxygen transport during exercise. J Appl Physiol 32, 234-239.
40. Weisbrod CJ, Minson CT, Joyner MJ & Halliwill JR (2001). Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. J Physiol 537, 613-621.
41. Wilkins BW, Pike TL, Martin EA, Curry TB, Ceridon ML & Joyner MJ (2008). Exercise intensity-dependent contribution of beta-adrenergic receptor-mediated vasodilatation in hypoxic humans. J Physiol 586, 1195-1205.
42. Wilkins BW, Schrage WG, Liu Z, Hancock KC & Joyner MJ (2006). Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle. J Appl Physiol 101, 1343-1350.