The de-adhesive activity of matricellular proteins: Is intermediate cell adhesion an adaptive state?

Journal of Clinical Investigation

Volumn 107, Issue 7, 2001, Pages 785-790

  Murphy Ullrich, J E ^a  

^a Biomedical Research Building II   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA ACTININ; INTEGRIN; MATRIX PROTEIN; OSTEONECTIN; TALIN; TENASCIN; THROMBOSPONDIN 1; VINCULIN;

ANIMAL CELL; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0035058769     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12609     Document Type: Review

References (36)

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2. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1
3. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases rac and cdc42
4. Tenascin-C suppresses Rho activation
5. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
6. Cell nucleus in context
7. Integrins, adhesion, and apoptosis
8. Geometric control of cell life and death
9. Integrins and anoikis
10. Bidirectional signaling between the cytoskeleton and integrins
11. Signaling of de-adhesion in cellular regulation and motility
12. Thrombospondin modulates focal adhesions in endothelial cells
13. Thrombospondin signaling of focal adhesion disassembly requires activation of phosphoinositide 3-kinase
14. 3 binding to alpha-actinin
15. Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin
16. SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the calcium-binding EF-hand
17. Heparin-binding peptides from thrombospondin-1 and 2 contain focal adhesion-labilizing activity
18. Matricellular proteins as modulators of cell-matrix interactions: Adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2
19. The expression of tenascin-C with the AD1 variable repeat in embryonic tissues, cell lines and tumors in various vertebrate species
20. Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II
21. Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin
22. Plasma membrane caveolae mediate the efflux of cellular free cholesterol
23. 2+ handling
24. Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly
25. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins
26. SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway
27. Mathematical model for the effects of adhesion and mechanics on cell migration speed
28. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
29. Adhesion in cell migration
30. The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells
31. SPARC, a matricellular glycoprotein with important biological functions
32. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
33. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
34. Cellular tensegrity: Defining new rules of biological design that govern the cytoskeleton