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Volumn 16, Issue 3, 2016, Pages 131-144

Antitumour actions of interferons: Implications for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INTERFERON; ANTINEOPLASTIC AGENT;

EID: 84959531327     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc.2016.14     Document Type: Review
Times cited : (673)

References (222)
  • 2
    • 77955880854 scopus 로고    scopus 로고
    • Interferon-γ: A new addition to an old family
    • Donnelly, R. P., & Kotenko, S. V. Interferon-γ: a new addition to an old family. J. Interferon Cytokine Res. 30, 555-564 (2010
    • (2010) J. Interferon Cytokine Res , vol.30 , pp. 555-564
    • Donnelly, R.P.1    Kotenko, S.V.2
  • 3
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. Interferon-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75, 163-189 (2004
    • (2004) J. Leukoc. Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 4
    • 0037243222 scopus 로고    scopus 로고
    • IFN-γs mediate antiviral protection through a distinct class II cytokine receptor complex
    • Kotenko, S. V., et al. IFN-γs mediate antiviral protection through a distinct class II cytokine receptor complex. Nat. Immunol. 4, 69-77 (2003
    • (2003) Nat. Immunol , vol.4 , pp. 69-77
    • Kotenko, S.V.1
  • 5
    • 0033561762 scopus 로고    scopus 로고
    • Differential cytokine and chemokine gene expression by human NK cells following activation with IL 18 or IL 15 in combination with IL 12: Implications for the innate immune response
    • Fehniger, T. A., et al. Differential cytokine and chemokine gene expression by human NK cells following activation with IL 18 or IL 15 in combination with IL 12: implications for the innate immune response. J. Immunol. 162, 4511-4520 (1999
    • (1999) J. Immunol , vol.162 , pp. 4511-4520
    • Fehniger, T.A.1
  • 6
    • 0027491655 scopus 로고
    • Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
    • Seder, R. A., Gazzinelli, R., Sher, A., & Paul, W. E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl Acad. Sci. USA 90, 10188-10192 (1993
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 7
    • 84857415635 scopus 로고    scopus 로고
    • Constitutive type i interferon modulates homeostatic balance through tonic signaling
    • Gough, D. J., Messina, N. L., Clarke, C. J., Johnstone, R. W., & Levy, D. E. Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity 36, 166-174 (2012
    • (2012) Immunity , vol.36 , pp. 166-174
    • Gough, D.J.1    Messina, N.L.2    Clarke, C.J.3    Johnstone, R.W.4    Levy, D.E.5
  • 8
    • 0028864798 scopus 로고
    • A null mutation in the gene encoding a type i interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses
    • Hwang, S. Y., et al. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc. Natl Acad. Sci. USA 92, 11284-11288 (1995
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 11284-11288
    • Hwang, S.Y.1
  • 9
    • 0035955680 scopus 로고    scopus 로고
    • Interferon-?, a novel type i interferon expressed in human keratinocytes
    • LaFleur, D. W., et al. Interferon-?, a novel type I interferon expressed in human keratinocytes. J. Biol. Chem. 276, 39765-39771 (2001
    • (2001) J. Biol. Chem , vol.276 , pp. 39765-39771
    • LaFleur, D.W.1
  • 10
    • 24044533884 scopus 로고    scopus 로고
    • IFN-limitin: A member of type i IFN with mild lympho-myelosuppression
    • Oritani, K., & Kanakura, Y. IFN-/limitin: a member of type I IFN with mild lympho-myelosuppression. J. Cell. Mol. Med. 9, 244-254 (2005
    • (2005) J. Cell. Mol. Med , vol.9 , pp. 244-254
    • Oritani, K.1    Kanakura, Y.2
  • 11
    • 84874396777 scopus 로고    scopus 로고
    • Interferon-protects the female reproductive tract from viral and bacterial infection
    • Fung, K. Y., et al. Interferon-protects the female reproductive tract from viral and bacterial infection. Science 339, 1088-1092 (2013
    • (2013) Science , vol.339 , pp. 1088-1092
    • Fung, K.Y.1
  • 12
    • 0028820423 scopus 로고
    • Mutant U5A cells are complemented by an interferon-αβ receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster
    • Lutfalla, G., et al. Mutant U5A cells are complemented by an interferon-αβ receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14, 5100-5108 (1995
    • (1995) EMBO J. , vol.14 , pp. 5100-5108
    • Lutfalla, G.1
  • 13
    • 0030765360 scopus 로고    scopus 로고
    • Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type i interferon receptor
    • Owczarek, C. M., et al. Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. J. Biol. Chem. 272, 23865-23870 (1997
    • (1997) IFNAR 2. J. Biol. Chem , vol.272 , pp. 23865-23870
    • Owczarek, C.M.1
  • 14
    • 21644484845 scopus 로고    scopus 로고
    • The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-Apoptotic effect of IFNα on pleomorphic sarcoma cells
    • Gazziola, C., et al. The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-Apoptotic effect of IFNα on pleomorphic sarcoma cells. Int. J. Oncol. 26, 129-140 (2005
    • (2005) Int. J. Oncol , vol.26 , pp. 129-140
    • Gazziola, C.1
  • 15
    • 0026618659 scopus 로고
    • Soluble interferon-α receptor molecules are present in body fluids
    • Novick, D., Cohen, B., & Rubinstein, M. Soluble interferon-α receptor molecules are present in body fluids. FEBS Lett. 314, 445-448 (1992
    • (1992) FEBS Lett , vol.314 , pp. 445-448
    • Novick, D.1    Cohen, B.2    Rubinstein, M.3
  • 16
    • 0345098447 scopus 로고    scopus 로고
    • Free interferon-α/β receptors in the circulation of patients with adenocarcinoma
    • Ambrus, J. L. Sr, et al. Free interferon-α/β receptors in the circulation of patients with adenocarcinoma. Cancer 98, 2730-2733 (2003
    • (2003) Cancer , vol.98 , pp. 2730-2733
    • Ambrus, J.L.1
  • 17
    • 0034122598 scopus 로고    scopus 로고
    • An investigation of serum soluble interferon receptor levels in patients with renal cell carcinoma
    • Iseda, T., Yokoyama, M., Kanayana, H., Oomoto, Y., & Kagawa, S [An investigation of serum soluble interferon receptor levels in patients with renal cell carcinoma]. Nihon Hinyokika Gakkai Zasshi 91, 514-519 (2000
    • (2000) Nihon Hinyokika Gakkai Zasshi , vol.91 , pp. 514-519
    • Iseda, T.1    Yokoyama, M.2    Kanayana, H.3    Oomoto, Y.4    Kagawa, S.5
  • 18
    • 84899538452 scopus 로고    scopus 로고
    • Soluble IFN receptor potentiates in vivo type i IFN signaling and exacerbates TLR4 mediated septic shock
    • Samarajiwa, S. A., et al. Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4 mediated septic shock. J. Immunol. 192, 4425-4435 (2014
    • (2014) J. Immunol , vol.192 , pp. 4425-4435
    • Samarajiwa, S.A.1
  • 19
    • 0035863894 scopus 로고    scopus 로고
    • The soluble murine type i interferon receptor Ifnar 2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties
    • Hardy, M. P., et al. The soluble murine type I interferon receptor Ifnar 2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties. Blood 97, 473-482 (2001
    • (2001) Blood , vol.97 , pp. 473-482
    • Hardy, M.P.1
  • 20
    • 84883146392 scopus 로고    scopus 로고
    • Structural basis of a unique interferon-βsignaling axis mediated via the receptor IFNAR1
    • de Weerd, N. A., et al. Structural basis of a unique interferon-βsignaling axis mediated via the receptor IFNAR1. Nat. Immunol. 14, 901-907 (2013
    • (2013) Nat. Immunol , vol.14 , pp. 901-907
    • De Weerd, N.A.1
  • 21
    • 0027742729 scopus 로고
    • Interferon-induced nuclear signalling by Jak protein tyrosine kinases
    • Silvennoinen, O., Ihle, J. N., Schlessinger, J., & Levy, D. E. Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature 366, 583-585 (1993
    • (1993) Nature , vol.366 , pp. 583-585
    • Silvennoinen, O.1    Ihle, J.N.2    Schlessinger, J.3    Levy, D.E.4
  • 22
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type I-And type II interferon-mediated signalling
    • Platanias, L. C. Mechanisms of type I-And type II interferon-mediated signalling. Nat. Rev. Immunol. 5, 375-386 (2005
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 23
    • 78651481470 scopus 로고    scopus 로고
    • The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins
    • Cheon, H., Yang, J., & Stark, G. R. The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J. Interferon Cytokine Res. 31, 33-40 (2011
    • (2011) J. Interferon Cytokine Res , vol.31 , pp. 33-40
    • Cheon, H.1    Yang, J.2    Stark, G.R.3
  • 24
    • 77955501765 scopus 로고    scopus 로고
    • Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: Correlation of resistance with IFN-stimulated gene expression
    • Luszczek, W., Cheriyath, V., Mekhail, T. M., & Borden, E. C. Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression. Mol. Cancer Ther. 9, 2309-2321 (2010
    • (2010) Mol. Cancer Ther , vol.9 , pp. 2309-2321
    • Luszczek, W.1    Cheriyath, V.2    Mekhail, T.M.3    Borden, E.C.4
  • 26
    • 78651496241 scopus 로고    scopus 로고
    • Toll-like receptors as interferon-regulated genes and their role in disease
    • Khoo, J. J., Forster, S., & Mansell, A. Toll-like receptors as interferon-regulated genes and their role in disease. J. Interferon Cytokine Res. 31, 13-25 (2011
    • (2011) J. Interferon Cytokine Res , vol.31 , pp. 13-25
    • Khoo, J.J.1    Forster, S.2    Mansell, A.3
  • 27
    • 84924265294 scopus 로고    scopus 로고
    • Dynamic control of type i IFN signalling by an integrated network of negative regulators
    • Porritt, R. A., & Hertzog, P. J. Dynamic control of type I IFN signalling by an integrated network of negative regulators. Trends Immunol. 36, 150-160 (2015
    • (2015) Trends Immunol , vol.36 , pp. 150-160
    • Porritt, R.A.1    Hertzog, P.J.2
  • 28
    • 0018072436 scopus 로고
    • Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast
    • Balkwill, F., Watling, D., & Taylor-Papadimitriou, J. Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast. Int. J. Cancer 22, 258-265 (1978
    • (1978) Int. J. Cancer , vol.22 , pp. 258-265
    • Balkwill, F.1    Watling, D.2    Taylor-Papadimitriou, J.3
  • 29
    • 0030609969 scopus 로고    scopus 로고
    • IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells
    • Hobeika, A. C., Subramaniam, P. S., & Johnson, H. M. IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. Oncogene 14, 1165-1170 (1997
    • (1997) Oncogene , vol.14 , pp. 1165-1170
    • Hobeika, A.C.1    Subramaniam, P.S.2    Johnson, H.M.3
  • 30
    • 77952955507 scopus 로고    scopus 로고
    • Interferon-α targets JAK2V617F positive hematopoietic progenitor cells and acts through the p38 MAPK pathway
    • Lu, M., et al. Interferon-α targets JAK2V617F positive hematopoietic progenitor cells and acts through the p38 MAPK pathway. Exp. Hematol. 38, 472-480 (2010
    • (2010) Exp. Hematol , vol.38 , pp. 472-480
    • Lu, M.1
  • 31
    • 0032806841 scopus 로고    scopus 로고
    • CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors
    • Platanias, L. C., et al. CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors. Exp. Hematol. 27, 1315-1321 (1999
    • (1999) Exp. Hematol , vol.27 , pp. 1315-1321
    • Platanias, L.C.1
  • 32
    • 0027170176 scopus 로고
    • RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat 1 fibroblasts
    • Cook, S. J., Rubinfeld, B., Albert, I., & McCormick, F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat 1 fibroblasts. EMBO J. 12, 3475-3485 (1993
    • (1993) EMBO J. , vol.12 , pp. 3475-3485
    • Cook, S.J.1    Rubinfeld, B.2    Albert, I.3    McCormick, F.4
  • 33
    • 84895549289 scopus 로고    scopus 로고
    • Crk at the quarter century mark: Perspectives in signaling and cancer
    • Kumar, S., Fajardo, J. E., Birge, R. B., & Sriram, G. Crk at the quarter century mark: perspectives in signaling and cancer. J. Cell. Biochem. 115, 819-825 (2013
    • (2013) J. Cell. Biochem , vol.115 , pp. 819-825
    • Kumar, S.1    Fajardo, J.E.2    Birge, R.B.3    Sriram, G.4
  • 34
    • 84860621179 scopus 로고    scopus 로고
    • Crk adaptor proteins act as key signaling integrators for breast tumorigenesis
    • Fathers, K. E., et al. Crk adaptor proteins act as key signaling integrators for breast tumorigenesis. Breast Cancer Res. 14, R74 (2012
    • (2012) Breast Cancer Res , vol.14 , pp. R74
    • Fathers, K.E.1
  • 35
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda, S., & Debatin, K. M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25, 4798-4811 (2006
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 36
    • 0037075172 scopus 로고    scopus 로고
    • Mechanisms of Interferon-Alpha induced apoptosis in malignant cells
    • Thyrell, L., et al. Mechanisms of Interferon-Alpha induced apoptosis in malignant cells. Oncogene 21, 1251-1262 (2002
    • (2002) Oncogene , vol.21 , pp. 1251-1262
    • Thyrell, L.1
  • 37
    • 0141816850 scopus 로고    scopus 로고
    • Stat1 dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells
    • Choi, E. A., et al. Stat1 dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells. Cancer Res. 63, 5299-5307 (2003
    • (2003) Cancer Res , vol.63 , pp. 5299-5307
    • Choi, E.A.1
  • 38
    • 84878958382 scopus 로고    scopus 로고
    • Synergy between RA and TLR3 promotes type i IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells
    • Bernardo, A. R., Cosgaya, J. M., Aranda, A., & Jimenez-Lara, A. M. Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells. Cell Death Dis. 4, e479 (2013
    • (2013) Cell Death Dis , vol.4 , pp. e479
    • Bernardo, A.R.1    Cosgaya, J.M.2    Aranda, A.3    Jimenez-Lara, A.M.4
  • 39
    • 84873871853 scopus 로고    scopus 로고
    • Type i interferons induce apoptosis by balancing cFLIP and caspase 8 independent of death ligands
    • Apelbaum, A., Yarden, G., Warszawski, S., Harari, D., & Schreiber, G. Type I interferons induce apoptosis by balancing cFLIP and caspase 8 independent of death ligands. Mol. Cell. Biol. 33, 800-814 (2013
    • (2013) Mol. Cell. Biol , vol.33 , pp. 800-814
    • Apelbaum, A.1    Yarden, G.2    Warszawski, S.3    Harari, D.4    Schreiber, G.5
  • 40
    • 0037790592 scopus 로고    scopus 로고
    • Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
    • Chawla-Sarkar, M., et al. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8, 237-249 (2003
    • (2003) Apoptosis , vol.8 , pp. 237-249
    • Chawla-Sarkar, M.1
  • 41
    • 11144240264 scopus 로고    scopus 로고
    • Inverse interference: How viruses fight the interferon system
    • Weber, F., Kochs, G., & Haller, O. Inverse interference: how viruses fight the interferon system. Viral Immunol. 17, 498-515 (2004
    • (2004) Viral Immunol , vol.17 , pp. 498-515
    • Weber, F.1    Kochs, G.2    Haller, O.3
  • 43
    • 3042859189 scopus 로고    scopus 로고
    • Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors
    • Wagner, T. C., et al. Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors. Int. J. Cancer 111, 32-42 (2004
    • (2004) Int. J. Cancer , vol.111 , pp. 32-42
    • Wagner, T.C.1
  • 44
    • 79961163823 scopus 로고    scopus 로고
    • Stochastic receptor expression determines cell fate upon interferon treatment
    • Levin, D., Harari, D., & Schreiber, G. Stochastic receptor expression determines cell fate upon interferon treatment. Mol. Cell. Biol. 31, 3252-3266 (2011
    • (2011) Mol. Cell. Biol , vol.31 , pp. 3252-3266
    • Levin, D.1    Harari, D.2    Schreiber, G.3
  • 45
    • 84883741732 scopus 로고    scopus 로고
    • Anti-Tumorigenic effects of Type 1 interferon are subdued by integrated stress responses
    • Bhattacharya, S., et al. Anti-Tumorigenic effects of Type 1 interferon are subdued by integrated stress responses. Oncogene 32, 4214-4221 (2013
    • (2013) Oncogene , vol.32 , pp. 4214-4221
    • Bhattacharya, S.1
  • 46
    • 0029799912 scopus 로고    scopus 로고
    • Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon ?
    • Bromberg, J. F., Horvath, C. M., Wen, Z., Schreiber, R. D., & Darnell, J. E. Jr. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon ?. Proc. Natl Acad. Sci. USA 93, 7673-7678 (1996
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 7673-7678
    • Bromberg, J.F.1    Horvath, C.M.2    Wen, Z.3    Schreiber, R.D.4    Darnell, J.E.5
  • 47
    • 0034658690 scopus 로고    scopus 로고
    • Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
    • Levy, D. E., & Gilliland, D. G. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 19, 2505-2510 (2000
    • (2000) Oncogene , vol.19 , pp. 2505-2510
    • Levy, D.E.1    Gilliland, D.G.2
  • 48
    • 0018907030 scopus 로고
    • Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice
    • Balkwill, F., Taylor-Papadimitriou, J., Fantes, K. H., & Sebesteny, A. Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice. Eur. J. Cancer 16, 569-573 (1980
    • (1980) Eur. J. Cancer , vol.16 , pp. 569-573
    • Balkwill, F.1    Taylor-Papadimitriou, J.2    Fantes, K.H.3    Sebesteny, A.4
  • 49
    • 0020377792 scopus 로고
    • Comparative antiproliferative activity in vitro of natural interferons α and β for diploid and transformed human cells
    • Borden, E. C., Hogan, T. F., & Voelkel, J. G. Comparative antiproliferative activity in vitro of natural interferons α and β for diploid and transformed human cells. Cancer Res. 42, 4948-4953 (1982
    • (1982) Cancer Res , vol.42 , pp. 4948-4953
    • Borden, E.C.1    Hogan, T.F.2    Voelkel, J.G.3
  • 50
    • 84876100198 scopus 로고    scopus 로고
    • Hope and fear for interferon: The receptor-centric outlook on the future of interferon therapy
    • Fuchs, S. Y. Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy. J. Interferon Cytokine Res. 33, 211-225 (2013
    • (2013) J. Interferon Cytokine Res , vol.33 , pp. 211-225
    • Fuchs, S.Y.1
  • 51
    • 84899755904 scopus 로고    scopus 로고
    • Interferons and their stimulated genes in the tumor microenvironment
    • Cheon, H., Borden, E. C., & Stark, G. R. Interferons and their stimulated genes in the tumor microenvironment. Semin. Oncol. 41, 156-173 (2014
    • (2014) Semin. Oncol , vol.41 , pp. 156-173
    • Cheon, H.1    Borden, E.C.2    Stark, G.R.3
  • 52
    • 84965092294 scopus 로고
    • Cancer a biological approach i the processes of control
    • Burnet, M. Cancer: a biological approach. I. The processes of control. Br. Med. J. 1, 779-786 (1957
    • (1957) Br. Med. J. , vol.1 , pp. 779-786
    • Burnet, M.1
  • 53
    • 84991131571 scopus 로고
    • Immunological surveillance in neoplasia
    • Burnet, F. M. Immunological surveillance in neoplasia. Transplant. Rev. 7, 3-25 (1971
    • (1971) Transplant. Rev , vol.7 , pp. 3-25
    • Burnet, F.M.1
  • 55
    • 0015510799 scopus 로고
    • Mechanism of the antitumour effect of interferon in mice
    • Gresser, I., Maury, C., & Brouty-Boye, D. Mechanism of the antitumour effect of interferon in mice. Nature 239, 167-168 (1972
    • (1972) Nature , vol.239 , pp. 167-168
    • Gresser, I.1    Maury, C.2    Brouty-Boye, D.3
  • 56
    • 22144465860 scopus 로고    scopus 로고
    • A critical function for type i interferons in cancer immunoediting
    • Dunn, G. P., et al. A critical function for type I interferons in cancer immunoediting. Nat. Immunol. 6, 722-729 (2005
    • (2005) Nat. Immunol , vol.6 , pp. 722-729
    • Dunn, G.P.1
  • 57
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu, Y. J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23, 275-306 (2005
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 58
    • 40549143697 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice
    • Liu, C., et al. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J. Clin. Invest. 118, 1165-1175 (2008
    • (2008) J. Clin. Invest , vol.118 , pp. 1165-1175
    • Liu, C.1
  • 59
    • 9444265268 scopus 로고    scopus 로고
    • Dendritic cell infiltration and prognosis of early stage breast cancer
    • Treilleux, I., et al. Dendritic cell infiltration and prognosis of early stage breast cancer. Clin. Cancer Res. 10, 7466-7474 (2004
    • (2004) Clin. Cancer Res , vol.10 , pp. 7466-7474
    • Treilleux, I.1
  • 60
    • 84867520423 scopus 로고    scopus 로고
    • Impaired IFN-α production by plasmacytoid dendritic cells favors regulatory T cell expansion that may contribute to breast cancer progression
    • Sisirak, V., et al. Impaired IFN-α production by plasmacytoid dendritic cells favors regulatory T cell expansion that may contribute to breast cancer progression. Cancer Res. 72, 5188-5197 (2012
    • (2012) Cancer Res , vol.72 , pp. 5188-5197
    • Sisirak, V.1
  • 61
    • 84864654660 scopus 로고    scopus 로고
    • Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
    • Bidwell, B. N., et al. Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat. Med. 18, 1224-1231 (2012
    • (2012) Nat. Med , vol.18 , pp. 1224-1231
    • Bidwell, B.N.1
  • 62
    • 0021153534 scopus 로고
    • Enhanced expression of surface tumor-Associated antigens on human breast and colon tumor cells after recombinant human leukocyte α-interferon treatment
    • Greiner, J. W., et al. Enhanced expression of surface tumor-Associated antigens on human breast and colon tumor cells after recombinant human leukocyte α-interferon treatment. Cancer Res. 44, 3208-3214 (1984
    • (1984) Cancer Res , vol.44 , pp. 3208-3214
    • Greiner, J.W.1
  • 63
    • 0024320073 scopus 로고
    • Differential induction by interferons of major histocompatibility complex-encoded and non-major histocompatibility complex-encoded antigens in human breast and ovarian carcinoma cell lines
    • Boyer, C. M., et al. Differential induction by interferons of major histocompatibility complex-encoded and non-major histocompatibility complex-encoded antigens in human breast and ovarian carcinoma cell lines. Cancer Res. 49, 2928-2934 (1989
    • (1989) Cancer Res , vol.49 , pp. 2928-2934
    • Boyer, C.M.1
  • 64
    • 84892147411 scopus 로고    scopus 로고
    • Type i interferons as stimulators of DC mediated cross-priming: Impact on anti-Tumor response
    • Schiavoni, G., Mattei, F., & Gabriele, L. Type I interferons as stimulators of DC mediated cross-priming: impact on anti-Tumor response. Front. Immunol. 4, 483 (2013
    • (2013) Front. Immunol , vol.4 , pp. 483
    • Schiavoni, G.1    Mattei, F.2    Gabriele, L.3
  • 66
    • 77953541634 scopus 로고    scopus 로고
    • Inflammatory cytokines as a third signal for T cell activation
    • Curtsinger, J. M., & Mescher, M. F. Inflammatory cytokines as a third signal for T cell activation. Curr. Opin. Immunol. 22, 333-340 (2010
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 333-340
    • Curtsinger, J.M.1    Mescher, M.F.2
  • 67
    • 80355136945 scopus 로고    scopus 로고
    • Host type i IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells
    • Fuertes, M. B., et al. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells. J. Exp. Med. 208, 2005-2016 (2011
    • (2011) J. Exp. Med , vol.208 , pp. 2005-2016
    • Fuertes, M.B.1
  • 68
    • 77953375467 scopus 로고    scopus 로고
    • APC activation by IFN-Alpha decreases regulatory T cell and enhances Th cell functions
    • Pace, L., et al. APC activation by IFN-Alpha decreases regulatory T cell and enhances Th cell functions. J. Immunol. 184, 5969-5979 (2010
    • (2010) J. Immunol , vol.184 , pp. 5969-5979
    • Pace, L.1
  • 69
    • 84899746524 scopus 로고    scopus 로고
    • Type i interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection
    • Srivastava, S., Koch, M. A., Pepper, M., & Campbell, D. J. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J. Exp. Med. 211, 961-974 (2014
    • (2014) J. Exp. Med , vol.211 , pp. 961-974
    • Srivastava, S.1    Koch, M.A.2    Pepper, M.3    Campbell, D.J.4
  • 70
    • 79953300942 scopus 로고    scopus 로고
    • CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice
    • Zoglmeier, C., et al. CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice. Clin. Cancer Res. 17, 1765-1775 (2011
    • (2011) Clin. Cancer Res , vol.17 , pp. 1765-1775
    • Zoglmeier, C.1
  • 71
    • 84862318552 scopus 로고    scopus 로고
    • Regulatory T cells increase in breast cancer and in stage IV breast cancer
    • Wang, Z. K., et al. Regulatory T cells increase in breast cancer and in stage IV breast cancer. Cancer Immunol. Immunother. 61, 911-916 (2012
    • (2012) Cancer Immunol. Immunother , vol.61 , pp. 911-916
    • Wang, Z.K.1
  • 73
    • 67449088117 scopus 로고    scopus 로고
    • Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-Associated macrophages
    • Duluc, D., et al. Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-Associated macrophages. Int. J. Cancer 125, 367-373 (2009
    • (2009) Int. J. Cancer , vol.125 , pp. 367-373
    • Duluc, D.1
  • 74
    • 12244280810 scopus 로고    scopus 로고
    • Low-dose IFN-γ induces tumor MHC expression in metastatic malignant melanoma
    • Propper, D. J., et al. Low-dose IFN-γ induces tumor MHC expression in metastatic malignant melanoma. Clin. Cancer Res. 9, 84-92 (2003
    • (2003) Clin. Cancer Res , vol.9 , pp. 84-92
    • Propper, D.J.1
  • 76
    • 4444355857 scopus 로고    scopus 로고
    • Interferon-β enhances monocyte and dendritic cell expression of B7 H1 (PD L1), a strong inhibitor of autologous T cell activation: Relevance for the immune modulatory effect in multiple sclerosis
    • Schreiner, B., et al. Interferon-β enhances monocyte and dendritic cell expression of B7 H1 (PD L1), a strong inhibitor of autologous T cell activation: relevance for the immune modulatory effect in multiple sclerosis. J. Neuroimmunol. 155, 172-182 (2004
    • (2004) J. Neuroimmunol , vol.155 , pp. 172-182
    • Schreiner, B.1
  • 77
    • 0036549835 scopus 로고    scopus 로고
    • Expression and regulation of the PD L1 immunoinhibitory molecule on microvascular endothelial cells
    • Eppihimer, M. J., et al. Expression and regulation of the PD L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation 9, 133-145 (2002
    • (2002) Microcirculation , vol.9 , pp. 133-145
    • Eppihimer, M.J.1
  • 78
    • 0035423390 scopus 로고    scopus 로고
    • IL 15 is expressed by dendritic cells in response to type i IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation
    • Mattei, F., Schiavoni, G., Belardelli, F., & Tough, D. F. IL 15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 167, 1179-1187 (2001
    • (2001) J. Immunol , vol.167 , pp. 1179-1187
    • Mattei, F.1    Schiavoni, G.2    Belardelli, F.3    Tough, D.F.4
  • 79
    • 84924368722 scopus 로고    scopus 로고
    • Soluble interleukin 15 complexes are generated in vivo by type i interferon dependent and independent pathways
    • Anthony, S. M., Howard, M. E., Hailemichael, Y., Overwijk, W. W., & Schluns, K. S. Soluble interleukin 15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS ONE 10, e0120274 (2015
    • (2015) PLoS ONE , vol.10 , pp. e0120274
    • Anthony, S.M.1    Howard, M.E.2    Hailemichael, Y.3    Overwijk, W.W.4    Schluns, K.S.5
  • 80
    • 5444239242 scopus 로고    scopus 로고
    • Coordinate expression and trans presentation of interleukin (IL)-15Rα and IL 15 supports natural killer cell and memory CD8+ T cell homeostasis
    • Burkett, P. R., et al. Coordinate expression and trans presentation of interleukin (IL)-15Rα and IL 15 supports natural killer cell and memory CD8+ T cell homeostasis. J. Exp. Med. 200, 825-834 (2004
    • (2004) J. Exp. Med , vol.200 , pp. 825-834
    • Burkett, P.R.1
  • 81
    • 84907377182 scopus 로고    scopus 로고
    • Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells
    • Sathe, P., et al. Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells. Nat. Commun. 5, 4539 (2014
    • (2014) Nat. Commun , vol.5 , pp. 4539
    • Sathe, P.1
  • 82
    • 84961554501 scopus 로고    scopus 로고
    • The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: Implications for cancer therapy
    • Waldmann, T. A. The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy. Cancer Immunol. Res. 3, 219-227 (2015
    • (2015) Cancer Immunol. Res , vol.3 , pp. 219-227
    • Waldmann, T.A.1
  • 83
    • 0037108345 scopus 로고    scopus 로고
    • Coordinated and distinct roles for IFN-αβ IL 12 and IL 15 regulation of NK cell responses to viral infection
    • Nguyen, K. B., et al. Coordinated and distinct roles for IFN-αβ, IL 12, and IL 15 regulation of NK cell responses to viral infection. J. Immunol. 169, 4279-4287 (2002
    • (2002) J. Immunol , vol.169 , pp. 4279-4287
    • Nguyen, K.B.1
  • 84
    • 0019595206 scopus 로고
    • Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon
    • Herberman, R. B., Ortaldo, J. R., Rubinstein, M., & Pestka, S. Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon. J. Clin. Immunol. 1, 149-153 (1981
    • (1981) J. Clin. Immunol , vol.1 , pp. 149-153
    • Herberman, R.B.1    Ortaldo, J.R.2    Rubinstein, M.3    Pestka, S.4
  • 85
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-A proposal for uniform nomenclature
    • Spits, H., et al. Innate lymphoid cells-A proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 145-149
    • Spits, H.1
  • 86
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier, L. L. NK cell recognition. Annu. Rev. Immunol. 23, 225-274 (2005
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 87
    • 84883358274 scopus 로고    scopus 로고
    • NK cells sense tumors, course of disease and treatments: Consequences for NK based therapies
    • Fregni, G., Perier, A., Avril, M. F., & Caignard, A. NK cells sense tumors, course of disease and treatments: consequences for NK based therapies. Oncoimmunology 1, 38-47 (2012
    • (2012) Oncoimmunology , vol.1 , pp. 38-47
    • Fregni, G.1    Perier, A.2    Avril, M.F.3    Caignard, A.4
  • 88
    • 34250203538 scopus 로고    scopus 로고
    • Type i IFN contributes to NK cell homeostasis, activation, and antitumor function
    • Swann, J. B., et al. Type I IFN contributes to NK cell homeostasis, activation, and antitumor function. J. Immunol. 178, 7540-7549 (2007
    • (2007) J. Immunol , vol.178 , pp. 7540-7549
    • Swann, J.B.1
  • 89
    • 0021070204 scopus 로고
    • Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors
    • Gresser, I., Belardelli, F., Maury, C., Maunoury, M. T., & Tovey, M. G. Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors. J. Exp. Med. 158, 2095-2107 (1983
    • (1983) J. Exp. Med , vol.158 , pp. 2095-2107
    • Gresser, I.1    Belardelli, F.2    Maury, C.3    Maunoury, M.T.4    Tovey, M.G.5
  • 90
    • 0345686775 scopus 로고    scopus 로고
    • Critical roles for IFN-β in lymphoid development, myelopoiesis, and tumor development: Links to tumor necrosis factor alpha
    • Deonarain, R., et al. Critical roles for IFN-β in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha. Proc. Natl Acad. Sci. USA 100, 13453-13458 (2003
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13453-13458
    • Deonarain, R.1
  • 91
    • 84898910134 scopus 로고    scopus 로고
    • The tumor suppressor function of STAT1 in breast cancer
    • Koromilas, A. E., & Sexl, V. The tumor suppressor function of STAT1 in breast cancer. JAKSTAT 2, e23353 (2013
    • (2013) JAKSTAT , vol.2 , pp. e23353
    • Koromilas, A.E.1    Sexl, V.2
  • 92
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon ?-dependent tumor surveillance system in immunocompetent mice
    • Kaplan, D. H., et al. Demonstration of an interferon ?-dependent tumor surveillance system in immunocompetent mice. Proc. Natl Acad. Sci. USA 95, 7556-7561 (1998
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1
  • 93
    • 80155157544 scopus 로고    scopus 로고
    • Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis
    • Bi, X., et al. Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis. Breast Cancer Res. 13, R111 (2011
    • (2011) Breast Cancer Res , vol.13 , pp. R111
    • Bi, X.1
  • 94
    • 0030712998 scopus 로고    scopus 로고
    • Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48 ISGF3?
    • Wong, L. H., et al. Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48 ISGF3?. J. Biol. Chem. 272, 28779-28785 (1997
    • (1997) J. Biol. Chem , vol.272 , pp. 28779-28785
    • Wong, L.H.1
  • 95
    • 0034584605 scopus 로고    scopus 로고
    • Chronic myeloid leukemia cells resistant to interferon-α lack STAT1 expression
    • Landolfo, S., et al. Chronic myeloid leukemia cells resistant to interferon-α lack STAT1 expression. Hematol. J. 1, 7-14 (2000
    • (2000) Hematol. J. , vol.1 , pp. 7-14
    • Landolfo, S.1
  • 96
    • 80755168367 scopus 로고    scopus 로고
    • Interferon-signaling pathway: Associations with colon and rectal cancer risk and subsequent survival
    • Slattery, M. L., Lundgreen, A., Bondurant, K. L., & Wolff, R. K. Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. Carcinogenesis 32, 1660-1667 (2011
    • (2011) Carcinogenesis , vol.32 , pp. 1660-1667
    • Slattery, M.L.1    Lundgreen, A.2    Bondurant, K.L.3    Wolff, R.K.4
  • 97
    • 84929023079 scopus 로고    scopus 로고
    • Investigations of interferon-γ for the treatment of cancer
    • Stiff, A., & Carson, W. III. Investigations of interferon-γ for the treatment of cancer. J. Innate Immun. 7, 243-250 (2015
    • (2015) J. Innate Immun , vol.7 , pp. 243-250
    • Stiff, A.1    Carson, W.2
  • 99
    • 0036793979 scopus 로고    scopus 로고
    • Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer
    • Widschwendter, A., et al. Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer. Clin. Cancer Res. 8, 3065-3074 (2002
    • (2002) Clin. Cancer Res , vol.8 , pp. 3065-3074
    • Widschwendter, A.1
  • 100
    • 84898462512 scopus 로고    scopus 로고
    • Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis
    • Sun, Y., Yang, S., Sun, N., & Chen, J. Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis. Pancreas 43, 619-623 (2014
    • (2014) Pancreas , vol.43 , pp. 619-623
    • Sun, Y.1    Yang, S.2    Sun, N.3    Chen, J.4
  • 101
    • 78149473710 scopus 로고    scopus 로고
    • Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus
    • Ahtiainen, L., et al. Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus. PLoS ONE 5, e13859 (2010
    • (2010) PLoS ONE , vol.5 , pp. e13859
    • Ahtiainen, L.1
  • 102
    • 84876107973 scopus 로고    scopus 로고
    • Interferons and their antitumor properties
    • Platanias, L. C. Interferons and their antitumor properties. J. Interferon Cytokine Res. 33, 143-144 (2013
    • (2013) J. Interferon Cytokine Res , vol.33 , pp. 143-144
    • Platanias, L.C.1
  • 103
    • 84876138022 scopus 로고    scopus 로고
    • Biological rationale and clinical use of interferon in the classical BCR-ABL-negative myeloproliferative neoplasms
    • Stein, B. L., & Tiu, R. V. Biological rationale and clinical use of interferon in the classical BCR-ABL-negative myeloproliferative neoplasms. J. Interferon Cytokine Res. 33, 145-153 (2013
    • (2013) J. Interferon Cytokine Res , vol.33 , pp. 145-153
    • Stein, B.L.1    Tiu, R.V.2
  • 104
    • 79955509835 scopus 로고    scopus 로고
    • Direct effects of type i interferons on cells of the immune system
    • Hervas-Stubbs, S., et al. Direct effects of type I interferons on cells of the immune system. Clin. Cancer Res. 17, 2619-2627 (2011
    • (2011) Clin. Cancer Res , vol.17 , pp. 2619-2627
    • Hervas-Stubbs, S.1
  • 105
    • 84876100195 scopus 로고    scopus 로고
    • Re emergence of interferon-α in the treatment of chronic myeloid leukemia
    • Talpaz, M., Hehlmann, R., Quintas-Cardama, A., Mercer, J., & Cortes, J. Re emergence of interferon-α in the treatment of chronic myeloid leukemia. Leukemia 27, 803-812 (2013
    • (2013) Leukemia , vol.27 , pp. 803-812
    • Talpaz, M.1    Hehlmann, R.2    Quintas-Cardama, A.3    Mercer, J.4    Cortes, J.5
  • 106
    • 84903388549 scopus 로고    scopus 로고
    • Interferon α for the adjuvant treatment of melanoma: Review of international literature and practical recommendations from an expert panel on the use of interferon
    • Ascierto, P. A., et al. Interferon α for the adjuvant treatment of melanoma: review of international literature and practical recommendations from an expert panel on the use of interferon. J. Chemother. 26, 193-201 (2014
    • (2014) J. Chemother , vol.26 , pp. 193-201
    • Ascierto, P.A.1
  • 107
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alfa 2b significantly prolongs relapse-free and overall survival compared with the GM2 KLH/QS 21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801
    • Kirkwood, J. M., et al. High-dose interferon alfa 2b significantly prolongs relapse-free and overall survival compared with the GM2 KLH/QS 21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. J. Clin. Oncol. 19, 2370-2380 (2001
    • (2001) J. Clin. Oncol , vol.19 , pp. 2370-2380
    • Kirkwood, J.M.1
  • 108
    • 77950576363 scopus 로고    scopus 로고
    • Interferon α adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-Analysis
    • Mocellin, S., Pasquali, S., Rossi, C. R., & Nitti, D. Interferon α adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-Analysis. J. Natl Cancer Inst. 102, 493-501 (2010
    • (2010) J. Natl Cancer Inst , vol.102 , pp. 493-501
    • Mocellin, S.1    Pasquali, S.2    Rossi, C.R.3    Nitti, D.4
  • 109
    • 77957961248 scopus 로고    scopus 로고
    • The anticancer face of interferon α (IFN-α): From biology to clinical results, with a focus on melanoma
    • Pasquali, S., & Mocellin, S. The anticancer face of interferon α (IFN-α): from biology to clinical results, with a focus on melanoma. Curr. Med. Chem. 17, 3327-3336 (2010
    • (2010) Curr. Med. Chem , vol.17 , pp. 3327-3336
    • Pasquali, S.1    Mocellin, S.2
  • 110
    • 84929946426 scopus 로고    scopus 로고
    • Long-Term outcomes and prognostic factors of high-risk malignant melanoma patients after surgery and adjuvant high-dose interferon treatment: A single-center experience
    • Akman, T., et al. Long-Term outcomes and prognostic factors of high-risk malignant melanoma patients after surgery and adjuvant high-dose interferon treatment: a single-center experience. Chemotherapy 60, 228-238 (2014
    • (2014) Chemotherapy , vol.60 , pp. 228-238
    • Akman, T.1
  • 111
    • 0035253368 scopus 로고    scopus 로고
    • Patient preferences for adjuvant interferon α 2b treatment
    • Kilbridge, K. L., et al. Patient preferences for adjuvant interferon α 2b treatment. J. Clin. Oncol. 19, 812-823 (2001
    • (2001) J. Clin. Oncol , vol.19 , pp. 812-823
    • Kilbridge, K.L.1
  • 112
    • 0034490207 scopus 로고    scopus 로고
    • White blood cell count: A prognostic factor and possible subset indicator of optimal treatment with low-dose adjuvant interferon in primary melanoma
    • de La Salmoniere, P., Grob, J. J., Dreno, B., Delaunay, M., & Chastang, C. White blood cell count: a prognostic factor and possible subset indicator of optimal treatment with low-dose adjuvant interferon in primary melanoma. Clin. Cancer Res. 6, 4713-4718 (2000
    • (2000) Clin. Cancer Res , vol.6 , pp. 4713-4718
    • De La Salmoniere, P.1    Grob, J.J.2    Dreno, B.3    Delaunay, M.4    Chastang, C.5
  • 113
    • 0026562566 scopus 로고
    • Anti-Tumor and immunomodulatory activity of intraperitoneal IFN-γ in ovarian carcinoma patients with minimal residual tumor after chemotherapy
    • Colombo, N., et al. Anti-Tumor and immunomodulatory activity of intraperitoneal IFN-γ in ovarian carcinoma patients with minimal residual tumor after chemotherapy. Int. J. Cancer 51, 42-46 (1992
    • (1992) Int. J. Cancer , vol.51 , pp. 42-46
    • Colombo, N.1
  • 114
    • 51549092094 scopus 로고    scopus 로고
    • The impact of PEGylation on biological therapies
    • Veronese, F. M., & Mero, A. The impact of PEGylation on biological therapies. BioDrugs 22, 315-329 (2008
    • (2008) BioDrugs , vol.22 , pp. 315-329
    • Veronese, F.M.1    Mero, A.2
  • 115
    • 84902159056 scopus 로고    scopus 로고
    • Peginterferon α in the treatment of chronic hepatitis B
    • Tseng, T. C., Kao, J. H., & Chen, D. S. Peginterferon α in the treatment of chronic hepatitis B. Expert Opin. Biol. Ther. 14, 995-1006 (2014
    • (2014) Expert Opin. Biol. Ther , vol.14 , pp. 995-1006
    • Tseng, T.C.1    Kao, J.H.2    Chen, D.S.3
  • 116
    • 84875043423 scopus 로고    scopus 로고
    • Efficacy and safety of pegylated interferon alfa 2a or alfa 2b plus ribavirin for the treatment of chronic hepatitis C in children and adolescents: A systematic review and meta-Analysis
    • Druyts, E., et al. Efficacy and safety of pegylated interferon alfa 2a or alfa 2b plus ribavirin for the treatment of chronic hepatitis C in children and adolescents: a systematic review and meta-Analysis. Clin. Infect. Dis. 56, 961-967 (2013
    • (2013) Clin. Infect. Dis , vol.56 , pp. 961-967
    • Druyts, E.1
  • 117
    • 46749103710 scopus 로고    scopus 로고
    • Adjuvant therapy with pegylated interferon alfa 2b versus observation alone in resected stage III melanoma: Final results of EORTC 18991, a randomised phase III trial
    • Eggermont, A. M., et al. Adjuvant therapy with pegylated interferon alfa 2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial. Lancet 372, 117-126 (2008
    • (2008) Lancet , vol.372 , pp. 117-126
    • Eggermont, A.M.1
  • 118
    • 84869212118 scopus 로고    scopus 로고
    • Long-Term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa 2b versus observation in resected stage III melanoma
    • Eggermont, A. M., et al. Long-Term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa 2b versus observation in resected stage III melanoma. J. Clin. Oncol. 30, 3810-3818 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 3810-3818
    • Eggermont, A.M.1
  • 119
    • 84863793064 scopus 로고    scopus 로고
    • Management of pegylated interferon α toxicity in adjuvant therapy of melanoma
    • Daud, A., et al. Management of pegylated interferon α toxicity in adjuvant therapy of melanoma. Expert Opin. Biol. Ther. 12, 1087-1099 (2012
    • (2012) Expert Opin. Biol. Ther , vol.12 , pp. 1087-1099
    • Daud, A.1
  • 120
    • 84871920160 scopus 로고    scopus 로고
    • Real-life experience with pegylated interferon and conventional interferon in adjuvant melanoma therapy
    • Rozati, S., Naef, L., Levesque, M. P., French, L. E., & Dummer, R. Real-life experience with pegylated interferon and conventional interferon in adjuvant melanoma therapy. J. Immunother. 36, 52-56 (2013
    • (2013) J. Immunother , vol.36 , pp. 52-56
    • Rozati, S.1    Naef, L.2    Levesque, M.P.3    French, L.E.4    Dummer, R.5
  • 121
    • 84869210903 scopus 로고    scopus 로고
    • How much of a good thing? What duration for interferon alfa 2b adjuvant therapy
    • Tarhini, A. A., & Kirkwood, J. M. How much of a good thing? What duration for interferon alfa 2b adjuvant therapy? J. Clin. Oncol. 30, 3773-3776 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 3773-3776
    • Tarhini, A.A.1    Kirkwood, J.M.2
  • 122
    • 84906871563 scopus 로고    scopus 로고
    • Trial Watch: Toll-like receptor agonists in oncological indications
    • Aranda, F., et al. Trial Watch: Toll-like receptor agonists in oncological indications. Oncoimmunology 3, e29179 (2014
    • (2014) Oncoimmunology , vol.3 , pp. e29179
    • Aranda, F.1
  • 123
    • 84905503992 scopus 로고    scopus 로고
    • Safety of Toll-like receptor 9 agonists: A systematic review and meta-Analysis
    • Qin, M., Li, Y., Yang, X., & Wu, H. Safety of Toll-like receptor 9 agonists: a systematic review and meta-Analysis. Immunopharmacol. Immunotoxicol. 36, 251-260 (2014
    • (2014) Immunopharmacol. Immunotoxicol , vol.36 , pp. 251-260
    • Qin, M.1    Li, Y.2    Yang, X.3    Wu, H.4
  • 124
    • 84905124472 scopus 로고    scopus 로고
    • Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors
    • Hartman, L. L., et al. Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors. J. Pediatr. Hematol. Oncol. 36, 451-457 (2014
    • (2014) J. Pediatr. Hematol. Oncol , vol.36 , pp. 451-457
    • Hartman, L.L.1
  • 125
    • 40149085707 scopus 로고    scopus 로고
    • Phase III trial of adjuvant 5 fluorouracil and adriamycin versus 5 fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (polyA: U) for locally advanced gastric cancer after curative surgery: Final results of 15 year follow up
    • Jeung, H. C., et al. Phase III trial of adjuvant 5 fluorouracil and adriamycin versus 5 fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (polyA: U) for locally advanced gastric cancer after curative surgery: final results of 15 year follow up. Ann. Oncol. 19, 520-526 (2008
    • (2008) Ann. Oncol , vol.19 , pp. 520-526
    • Jeung, H.C.1
  • 126
    • 0019785549 scopus 로고
    • Randomized trial of standard therapy with or without poly I: C in patients with superficial bladder cancer
    • Kemeny, N., et al. Randomized trial of standard therapy with or without poly I: C in patients with superficial bladder cancer. Cancer 48, 2154-2157 (1981
    • (1981) Cancer , vol.48 , pp. 2154-2157
    • Kemeny, N.1
  • 127
    • 0018824574 scopus 로고
    • Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma
    • Gutterman, J. U., et al. Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann. Intern. Med. 93, 399-406 (1980
    • (1980) Ann. Intern. Med , vol.93 , pp. 399-406
    • Gutterman, J.U.1
  • 128
    • 0019965549 scopus 로고
    • Leukocyte-derived interferon (alpha) in human breast carcinoma the American cancer society phase II trial
    • Borden, E. C., et al. Leukocyte-derived interferon (alpha) in human breast carcinoma. The American Cancer Society phase II trial. Ann. Intern. Med. 97, 1-6 (1982
    • (1982) Ann. Intern. Med , vol.97 , pp. 1-6
    • Borden, E.C.1
  • 129
    • 84910491603 scopus 로고
    • A multiple-dose phase i trial of recombinant leukocyte A interferon in cancer patients
    • Sherwin, S. A., et al. A multiple-dose phase I trial of recombinant leukocyte A interferon in cancer patients. JAMA 248, 2461-2466 (1982
    • (1982) JAMA , vol.248 , pp. 2461-2466
    • Sherwin, S.A.1
  • 130
    • 0020567845 scopus 로고
    • Recombinant leukocyte A interferon in advanced breast cancer Results of a phase II efficacy trial
    • Sherwin, S. A., et al. Recombinant leukocyte A interferon in advanced breast cancer. Results of a phase II efficacy trial. Ann. Intern. Med. 98, 598-602 (1983
    • (1983) Ann. Intern. Med , vol.98 , pp. 598-602
    • Sherwin, S.A.1
  • 131
    • 0021226287 scopus 로고
    • A phase II study of recombinant alpha interferon in patients with recurrent or metastatic breast cancer
    • Muss, H. B., et al. A phase II study of recombinant alpha interferon in patients with recurrent or metastatic breast cancer. J. Clin. Oncol. 2, 1012-1016 (1984
    • (1984) J. Clin. Oncol , vol.2 , pp. 1012-1016
    • Muss, H.B.1
  • 133
    • 0021959962 scopus 로고
    • Recombinant DNA human interferon alpha 2 in advanced breast cancer: A phase 2 trial
    • Padmanabhan, N., Balkwill, F. R., Bodmer, J. G., & Rubens, R. D. Recombinant DNA human interferon alpha 2 in advanced breast cancer: a phase 2 trial. Br. J. Cancer 51, 55-60 (1985
    • (1985) Br. J. Cancer , vol.51 , pp. 55-60
    • Padmanabhan, N.1    Balkwill, F.R.2    Bodmer, J.G.3    Rubens, R.D.4
  • 134
    • 0021241362 scopus 로고
    • Collaborative phase I-II study of recombinant DNA-produced leukocyte interferon (clone A) in metastatic breast cancer, malignant lymphoma, and multiple myeloma
    • Quesada, J. R., et al. Collaborative phase I-II study of recombinant DNA-produced leukocyte interferon (clone A) in metastatic breast cancer, malignant lymphoma, and multiple myeloma. Am. J. Med. 77, 427-432 (1984
    • (1984) Am. J. Med , vol.77 , pp. 427-432
    • Quesada, J.R.1
  • 135
    • 0020452022 scopus 로고
    • Administration of fibroblast interferon to patients with advanced breast cancer: Possible effects on skin metastasis and on hormone receptors
    • Pouillart, P., et al. Administration of fibroblast interferon to patients with advanced breast cancer: possible effects on skin metastasis and on hormone receptors. Eur. J. Cancer Clin. Oncol. 18, 929-935 (1982
    • (1982) Eur. J. Cancer Clin. Oncol , vol.18 , pp. 929-935
    • Pouillart, P.1
  • 136
    • 0020314723 scopus 로고
    • Clinical and immunological study of beta interferon by intramuscular route in patients with metastatic breast cancer
    • Quesada, J. R., Gutterman, J. U., & Hersh, E. M. Clinical and immunological study of beta interferon by intramuscular route in patients with metastatic breast cancer. J. Interferon Res. 2, 593-599 (1982
    • (1982) J. Interferon Res , vol.2 , pp. 593-599
    • Quesada, J.R.1    Gutterman, J.U.2    Hersh, E.M.3
  • 138
    • 0022539286 scopus 로고
    • A randomized trial of low doses of alpha interferon in patients with breast cancer
    • Laszlo, J., Hood, L., Cox, E., & Goodwin, B. A randomized trial of low doses of alpha interferon in patients with breast cancer. J. Biol. Response Mod. 5, 206-210 (1986
    • (1986) J. Biol. Response Mod , vol.5 , pp. 206-210
    • Laszlo, J.1    Hood, L.2    Cox, E.3    Goodwin, B.4
  • 139
    • 0027507868 scopus 로고
    • Lymphoblastoid interferon in advanced breast cancer: A phase II study
    • Naso, C., et al. Lymphoblastoid interferon in advanced breast cancer: a phase II study. J. Chemother. 5, 258-261 (1993
    • (1993) J. Chemother , vol.5 , pp. 258-261
    • Naso, C.1
  • 140
    • 0021858476 scopus 로고
    • Phase II trial of alpha-lymphoblastoid interferon given weekly as treatment of advanced breast cancer
    • Sarna, G. P., & Figlin, R. A. Phase II trial of alpha-lymphoblastoid interferon given weekly as treatment of advanced breast cancer. Cancer Treat. Rep. 69, 547-549 (1985
    • (1985) Cancer Treat. Rep , vol.69 , pp. 547-549
    • Sarna, G.P.1    Figlin, R.A.2
  • 141
    • 0023117170 scopus 로고
    • Recombinant human interferon alpha increases oestrogen receptor expression in human breast cancer cells (ZR 75 1) and sensitizes them to the anti-proliferative effects of tamoxifen
    • van den Berg, H. W., Leahey, W. J., Lynch, M., Clarke, R., & Nelson, J. Recombinant human interferon alpha increases oestrogen receptor expression in human breast cancer cells (ZR 75 1) and sensitizes them to the anti-proliferative effects of tamoxifen. Br. J. Cancer 55, 255-257 (1987
    • (1987) Br. J. Cancer , vol.55 , pp. 255-257
    • Van Den Berg, H.W.1    Leahey, W.J.2    Lynch, M.3    Clarke, R.4    Nelson, J.5
  • 142
    • 0027095887 scopus 로고
    • Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells
    • Sica, G., et al. Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells. Anticancer Res. 12, 2061-2064 (1992
    • (1992) Anticancer Res , vol.12 , pp. 2061-2064
    • Sica, G.1
  • 143
    • 0023232206 scopus 로고
    • Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells
    • Sica, G., Natoli, V., Stella, C., & Del Bianco, S. Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells. Cancer 60, 2419-2423 (1987
    • (1987) Cancer , vol.60 , pp. 2419-2423
    • Sica, G.1    Natoli, V.2    Stella, C.3    Del Bianco, S.4
  • 144
    • 0027328252 scopus 로고
    • Interferon plus tamoxifen treatment for advanced breast cancer: In vivo biologic effects of two growth modulators
    • Seymour, L., & Bezwoda, W. R. Interferon plus tamoxifen treatment for advanced breast cancer: in vivo biologic effects of two growth modulators. Br. J. Cancer 68, 352-356 (1993
    • (1993) Br. J. Cancer , vol.68 , pp. 352-356
    • Seymour, L.1    Bezwoda, W.R.2
  • 145
    • 0027498188 scopus 로고
    • Steroid receptor enhancement by natural interferon-beta in advanced breast cancer
    • Sica, G., et al. Steroid receptor enhancement by natural interferon-beta in advanced breast cancer. Eur. J. Cancer 29A, 329-333 (1993
    • (1993) Eur. J. Cancer , vol.29 A , pp. 329-333
    • Sica, G.1
  • 146
    • 0028990097 scopus 로고
    • In vivo effect induced by interferon beta on steroid receptor status, cell kinetics and DNA ploidy in operable breast cancer patients
    • Di Martino, L., Demontis, B., Saccani Iotti, G., & Murenu, G. In vivo effect induced by interferon beta on steroid receptor status, cell kinetics and DNA ploidy in operable breast cancer patients. Anticancer Res. 15, 537-541 (1995
    • (1995) Anticancer Res , vol.15 , pp. 537-541
    • Di Martino, L.1    Demontis, B.2    Saccani Iotti, G.3    Murenu, G.4
  • 147
    • 0032993907 scopus 로고    scopus 로고
    • Effect of interferon alpha 2a on hormone receptor status in patients with advanced breast cancer
    • Kornek, G., et al. Effect of interferon alpha 2a on hormone receptor status in patients with advanced breast cancer. Cancer Invest. 17, 189-194 (1999
    • (1999) Cancer Invest , vol.17 , pp. 189-194
    • Kornek, G.1
  • 148
    • 0029620462 scopus 로고
    • Natural interferon-beta and tamoxifen in hormone-resistant patients with advanced breast cancer
    • Buzzi, E., et al. Natural interferon-beta and tamoxifen in hormone-resistant patients with advanced breast cancer. Anticancer Res. 15, 2187-2190 (1995
    • (1995) Anticancer Res , vol.15 , pp. 2187-2190
    • Buzzi, E.1
  • 149
    • 0026782798 scopus 로고
    • Combination of beta-interferon and tamoxifen as a new way to overcome clinical resistance to tamoxifen in advanced breast cancer
    • Buzzi, F., et al. Combination of beta-interferon and tamoxifen as a new way to overcome clinical resistance to tamoxifen in advanced breast cancer. Anticancer Res. 12, 869-871 (1992
    • (1992) Anticancer Res , vol.12 , pp. 869-871
    • Buzzi, F.1
  • 150
    • 0026348833 scopus 로고
    • Tamoxifen and alpha interferon in advanced breast cancer
    • Miglietta, L., et al. Tamoxifen and alpha interferon in advanced breast cancer. J. Chemother. 3, 383-386 (1991
    • (1991) J. Chemother , vol.3 , pp. 383-386
    • Miglietta, L.1
  • 151
    • 0025873825 scopus 로고
    • Phase II evaluation of interferon added to tamoxifen in the treatment of metastatic breast cancer
    • Macheledt, J. E., et al. Phase II evaluation of interferon added to tamoxifen in the treatment of metastatic breast cancer. Breast Cancer Res. Treat. 18, 165-170 (1991
    • (1991) Breast Cancer Res. Treat , vol.18 , pp. 165-170
    • MacHeledt, J.E.1
  • 152
    • 0029813179 scopus 로고    scopus 로고
    • Tamoxifen and interferon-beta for the treatment of metastatic breast cancer
    • Repetto, L., et al. Tamoxifen and interferon-beta for the treatment of metastatic breast cancer. Breast Cancer Res. Treat. 39, 235-238 (1996
    • (1996) Breast Cancer Res. Treat , vol.39 , pp. 235-238
    • Repetto, L.1
  • 153
    • 0032468321 scopus 로고    scopus 로고
    • Changes in cytokine production of breast cancer patients treated with interferons
    • Barak, V., et al. Changes in cytokine production of breast cancer patients treated with interferons. Cytokine 10, 977-983 (1998
    • (1998) Cytokine , vol.10 , pp. 977-983
    • Barak, V.1
  • 154
    • 0030021869 scopus 로고    scopus 로고
    • Combined effects of 13 cis-retinoic acid, tamoxifen and interferon on the growth of human breast cancer cells
    • Lama, G., Angelucci, C., Recchia, F., & Sica, G. Combined effects of 13 cis-retinoic acid, tamoxifen and interferon on the growth of human breast cancer cells. Cancer Lett. 100, 181-189 (1996
    • (1996) Cancer Lett , vol.100 , pp. 181-189
    • Lama, G.1    Angelucci, C.2    Recchia, F.3    Sica, G.4
  • 155
    • 0031732404 scopus 로고    scopus 로고
    • Beta-interferon, retinoids and tamoxifen combination in advanced breast cancer
    • Recchia, F., et al. Beta-interferon, retinoids and tamoxifen combination in advanced breast cancer. Clin. Ter. 149, 203-208 (1998
    • (1998) Clin. Ter , vol.149 , pp. 203-208
    • Recchia, F.1
  • 156
    • 67449098967 scopus 로고    scopus 로고
    • Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-Term follow up of a phase II study
    • Recchia, F., et al. Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: long-Term follow up of a phase II study. Oncol. Rep. 21, 1011-1016 (2009
    • (2009) Oncol. Rep , vol.21 , pp. 1011-1016
    • Recchia, F.1
  • 157
    • 0029164679 scopus 로고
    • Interferon-beta, retinoids, and tamoxifen in the treatment of metastatic breast cancer: A phase II study
    • Recchia, F., et al. Interferon-beta, retinoids, and tamoxifen in the treatment of metastatic breast cancer: a phase II study. J. Interferon Cytokine Res. 15, 605-610 (1995
    • (1995) J. Interferon Cytokine Res , vol.15 , pp. 605-610
    • Recchia, F.1
  • 158
    • 41749108460 scopus 로고    scopus 로고
    • Tamoxifen versus tamoxifen plus 13 cis-retinoic acid versus tamoxifen plus interferon alpha 2a as first-line endocrine treatments in advanced breast cancer: Updated results of a phase II, prospective, randomised multicentre trial
    • Chiesa, M. D., et al. Tamoxifen versus tamoxifen plus 13 cis-retinoic acid versus tamoxifen plus interferon alpha 2a as first-line endocrine treatments in advanced breast cancer: updated results of a phase II, prospective, randomised multicentre trial. Acta Biomed. 78, 204-209 (2007
    • (2007) Acta Biomed , vol.78 , pp. 204-209
    • Chiesa, M.D.1
  • 159
    • 84924240604 scopus 로고    scopus 로고
    • The molecular basis for functional plasticity in type i interferon signaling
    • Schreiber, G., & Piehler, J. The molecular basis for functional plasticity in type I interferon signaling. Trends Immunol. 36, 139-149 (2015
    • (2015) Trends Immunol , vol.36 , pp. 139-149
    • Schreiber, G.1    Piehler, J.2
  • 160
    • 0023236798 scopus 로고
    • Overview of preclinical and clinical studies of interferon alfa 2b in combination with cytotoxic drugs
    • Suppl
    • Welander, C. E. Overview of preclinical and clinical studies of interferon alfa 2b in combination with cytotoxic drugs. Invest. New Drugs 5 (Suppl.), S47-S59 (1987
    • (1987) Invest. New Drugs , vol.5 , pp. S47-S59
    • Welander, C.E.1
  • 161
    • 0025312580 scopus 로고
    • Cisplatin and recombinant alpha interferon in advanced breast cancer
    • Pronzato, P., et al. Cisplatin and recombinant alpha interferon in advanced breast cancer. Ann. Oncol. 1, 150-151 (1990
    • (1990) Ann. Oncol , vol.1 , pp. 150-151
    • Pronzato, P.1
  • 162
    • 0029558890 scopus 로고
    • Phase II study of recombinant alpha-interferon (rIFN alpha) and continuous-infusion 5 fluorouracil in metastatic breast cancer
    • Walters, R. S., Theriault, R. L., Booser, D. J., Esparza, L., & Hortobagyi, G. N. Phase II study of recombinant alpha-interferon (rIFN alpha) and continuous-infusion 5 fluorouracil in metastatic breast cancer. J. Immunother. Emphasis Tumor Immunol. 18, 185-187 (1995
    • (1995) J. Immunother. Emphasis Tumor Immunol , vol.18 , pp. 185-187
    • Walters, R.S.1    Theriault, R.L.2    Booser, D.J.3    Esparza, L.4    Hortobagyi, G.N.5
  • 163
    • 0028999807 scopus 로고
    • Phase II study of high-dose epirubicin, lonidamine, alpha 2b interferon in advanced breast cancer
    • Iaffaioli, R. V., et al. Phase II study of high-dose epirubicin, lonidamine, alpha 2b interferon in advanced breast cancer. Breast Cancer Res. Treat. 35, 243-248 (1995
    • (1995) Breast Cancer Res. Treat , vol.35 , pp. 243-248
    • Iaffaioli, R.V.1
  • 164
    • 0026825467 scopus 로고
    • Combination biotherapy utilizing interleukin 2 and alpha interferon in patients with advanced cancer: A National Biotherapy Study Group Trial
    • Oldham, R. K., Blumenschein, G., Schwartzberg, L., Birch, R., & Arnold, J. Combination biotherapy utilizing interleukin 2 and alpha interferon in patients with advanced cancer: a National Biotherapy Study Group Trial. Mol. Biother. 4, 4-9 (1992
    • (1992) Mol. Biother , vol.4 , pp. 4-9
    • Oldham, R.K.1    Blumenschein, G.2    Schwartzberg, L.3    Birch, R.4    Arnold, J.5
  • 166
    • 1042279666 scopus 로고    scopus 로고
    • Subcutaneously administered recombinant human interleukin 2 and interferon alfa 2a for advanced breast cancer: A phase II study of the Cancer and Leukemia Group B (CALGB 9041
    • Kimmick, G., et al. Subcutaneously administered recombinant human interleukin 2 and interferon alfa 2a for advanced breast cancer: a phase II study of the Cancer and Leukemia Group B (CALGB 9041). Invest. New Drugs 22, 83-89 (2004
    • (2004) Invest. New Drugs , vol.22 , pp. 83-89
    • Kimmick, G.1
  • 167
    • 0026848579 scopus 로고
    • Early phase II study of interferon-Alpha and tumor necrosis factor-Alpha combination in patients with advanced cancer
    • Orita, K., Fuchimoto, S., Kurimoto, M., Ando, S., & Minowada, J. Early phase II study of interferon-Alpha and tumor necrosis factor-Alpha combination in patients with advanced cancer. Acta Med. Okayama 46, 103-112 (1992
    • (1992) Acta Med. Okayama , vol.46 , pp. 103-112
    • Orita, K.1    Fuchimoto, S.2    Kurimoto, M.3    Ando, S.4    Minowada, J.5
  • 168
    • 17844378586 scopus 로고    scopus 로고
    • Beta-interferon and interleukin 2 prolong more than three times the survival of 26 consecutive endocrine dependent breast cancer patients with distant metastases: An exploratory trial
    • Nicolini, A., & Carpi, A. Beta-interferon and interleukin 2 prolong more than three times the survival of 26 consecutive endocrine dependent breast cancer patients with distant metastases: an exploratory trial. Biomed. Pharmacother. 59, 253-263 (2005
    • (2005) Biomed. Pharmacother , vol.59 , pp. 253-263
    • Nicolini, A.1    Carpi, A.2
  • 169
    • 17844388569 scopus 로고    scopus 로고
    • An immunotherapy schedule in endocrine-dependent metastatic breast cancer: Correlation between clinical course and immunologic parameters
    • Nicolini, A., Carpi, A., & Rossi, G. An immunotherapy schedule in endocrine-dependent metastatic breast cancer: correlation between clinical course and immunologic parameters. J. Immunother. 28, 276-279 (2005
    • (2005) J. Immunother , vol.28 , pp. 276-279
    • Nicolini, A.1    Carpi, A.2    Rossi, G.3
  • 170
    • 34247626802 scopus 로고    scopus 로고
    • Relationship of cellular immunity, cytokines and CRP with clinical course in breast cancer patients with endocrine-dependent distant metastases treated with immunotherapy
    • Nicolini, A., Carpi, A., & Rossi, G. Relationship of cellular immunity, cytokines and CRP with clinical course in breast cancer patients with endocrine-dependent distant metastases treated with immunotherapy. Cancer Lett. 251, 330-338 (2007
    • (2007) Cancer Lett , vol.251 , pp. 330-338
    • Nicolini, A.1    Carpi, A.2    Rossi, G.3
  • 171
    • 0022390063 scopus 로고
    • A phase i clinical tolerance study of polyadenylic-polyuridylic acid in cancer patients
    • Ducret, J. P., et al. A phase I clinical tolerance study of polyadenylic-polyuridylic acid in cancer patients. J. Biol. Response Mod. 4, 129-133 (1985
    • (1985) J. Biol. Response Mod , vol.4 , pp. 129-133
    • Ducret, J.P.1
  • 172
    • 0018828863 scopus 로고
    • Adjuvant treatment with polyadenylic-polyuridylic acid (Polya. Polyu) in operable breast cancer
    • Lacour, J., et al. Adjuvant treatment with polyadenylic-polyuridylic acid (Polya. Polyu) in operable breast cancer. Lancet 2, 161-164 (1980
    • (1980) Lancet , vol.2 , pp. 161-164
    • Lacour, J.1
  • 173
    • 0022406787 scopus 로고
    • Clinical trials using polyadenylic-polyuridylic acid as an adjuvant to surgery in treating different human tumors
    • Lacour, J. Clinical trials using polyadenylic-polyuridylic acid as an adjuvant to surgery in treating different human tumors. J. Biol. Response Mod. 4, 538-543 (1985
    • (1985) J. Biol. Response Mod , vol.4 , pp. 538-543
    • Lacour, J.1
  • 174
    • 0021264516 scopus 로고
    • Adjuvant treatment with polyadenylic-polyuridylic acid in operable breast cancer: Updated results of a randomised trial
    • Lacour, J., et al. Adjuvant treatment with polyadenylic-polyuridylic acid in operable breast cancer: updated results of a randomised trial. Br. Med. J. (Clin. Res. Ed.) 288, 589-592 (1984
    • (1984) Br. Med. J. (Clin. Res. Ed. , vol.288 , pp. 589-592
    • Lacour, J.1
  • 175
    • 0034541497 scopus 로고    scopus 로고
    • Polyadenylic-polyuridylic acid plus locoregional radiotherapy versus chemotherapy with CMF in operable breast cancer: A 14 year follow up analysis of a randomized trial of the federation nationale des centres de lutte contre le cancer (fnclcc
    • Laplanche, A., et al. Polyadenylic-polyuridylic acid plus locoregional radiotherapy versus chemotherapy with CMF in operable breast cancer: a 14 year follow up analysis of a randomized trial of the Federation Nationale des Centres de Lutte contre le Cancer (FNCLCC). Breast Cancer Res. Treat. 64, 189-191 (2000
    • (2000) Breast Cancer Res. Treat , vol.64 , pp. 189-191
    • Laplanche, A.1
  • 176
    • 79952212690 scopus 로고    scopus 로고
    • TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer
    • Salaun, B., et al. TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer. Cancer Res. 71, 1607-1614 (2011
    • (2011) Cancer Res , vol.71 , pp. 1607-1614
    • Salaun, B.1
  • 177
    • 84905160299 scopus 로고    scopus 로고
    • Circulating tumor cells predict survival in early average-To high risk breast cancer patients
    • Rack, B., et al. Circulating tumor cells predict survival in early average-To high risk breast cancer patients. J. Natl Cancer Inst. 106, dju066 (2014
    • (2014) J. Natl Cancer Inst , vol.106 , pp. dju066
    • Rack, B.1
  • 178
    • 84909629677 scopus 로고    scopus 로고
    • Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination
    • Giuliano, M., et al. Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination. Breast Cancer Res. 16, 440 (2014
    • (2014) Breast Cancer Res , vol.16 , pp. 440
    • Giuliano, M.1
  • 179
    • 23944466427 scopus 로고    scopus 로고
    • A pooled analysis of bone marrow micrometastasis in breast cancer
    • Braun, S., et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N. Engl. J. Med. 353, 793-802 (2005
    • (2005) N. Engl. J. Med , vol.353 , pp. 793-802
    • Braun, S.1
  • 180
    • 0031962552 scopus 로고    scopus 로고
    • Interferon-Alpha resistance in a cutaneous T cell lymphoma cell line is associated with lack of STAT1 expression
    • Sun, W. H., et al. Interferon-Alpha resistance in a cutaneous T cell lymphoma cell line is associated with lack of STAT1 expression. Blood 91, 570-576 (1998
    • (1998) Blood , vol.91 , pp. 570-576
    • Sun, W.H.1
  • 181
    • 84913586780 scopus 로고    scopus 로고
    • Cancer cell-Autonomous contribution of type i interferon signaling to the efficacy of chemotherapy
    • Sistigu, A., et al. Cancer cell-Autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat. Med. 20, 1301-1309 (2014
    • (2014) Nat. Med , vol.20 , pp. 1301-1309
    • Sistigu, A.1
  • 182
    • 77955894773 scopus 로고    scopus 로고
    • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    • Berry, M. P., et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466, 973-977 (2010
    • (2010) Nature , vol.466 , pp. 973-977
    • Berry, M.P.1
  • 183
    • 84901641596 scopus 로고    scopus 로고
    • Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type i and type II interferon signatures
    • Chiche, L., et al. Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures. Arthritis Rheumatol. 66, 1583-1595 (2014
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1583-1595
    • Chiche, L.1
  • 184
    • 0036269757 scopus 로고    scopus 로고
    • Cancer immunotherapy: The interferon-Alpha experience
    • Kirkwood, J. Cancer immunotherapy: the interferon-Alpha experience. Semin. Oncol. 29, 18-26 (2002
    • (2002) Semin. Oncol , vol.29 , pp. 18-26
    • Kirkwood, J.1
  • 185
    • 79960426821 scopus 로고    scopus 로고
    • Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors
    • Mattarollo, S. R., et al. Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors. Cancer Res. 71, 4809-4820 (2011
    • (2011) Cancer Res , vol.71 , pp. 4809-4820
    • Mattarollo, S.R.1
  • 186
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance
    • Zitvogel, L., Galluzzi, L., Smyth, M. J., & Kroemer, G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 39, 74-88 (2013
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 187
    • 79955570584 scopus 로고    scopus 로고
    • Anti-ErbB 2 mAb therapy requires type i and II interferons and synergizes with anti PD 1 or anti CD137 mAb therapy
    • Stagg, J., et al. Anti-ErbB 2 mAb therapy requires type I and II interferons and synergizes with anti PD 1 or anti CD137 mAb therapy. Proc. Natl Acad. Sci. USA 108, 7142-7147 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7142-7147
    • Stagg, J.1
  • 188
    • 84885700363 scopus 로고    scopus 로고
    • Lapatinib and doxorubicin enhance the Stat1 dependent antitumor immune response
    • Hannesdottir, L., et al. Lapatinib and doxorubicin enhance the Stat1 dependent antitumor immune response. Eur. J. Immunol. 43, 2718-2729 (2013
    • (2013) Eur. J. Immunol , vol.43 , pp. 2718-2729
    • Hannesdottir, L.1
  • 189
    • 84885034623 scopus 로고    scopus 로고
    • The emerging role of immunosurveillance in dictating metastatic spread in breast cancer
    • Slaney, C. Y., Rautela, J., & Parker, B. S. The emerging role of immunosurveillance in dictating metastatic spread in breast cancer. Cancer Res. 73, 5852-5857 (2013
    • (2013) Cancer Res , vol.73 , pp. 5852-5857
    • Slaney, C.Y.1    Rautela, J.2    Parker, B.S.3
  • 190
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • Formenti, S. C., & Demaria, S. Systemic effects of local radiotherapy. Lancet Oncol. 10, 718-726 (2009
    • (2009) Lancet Oncol , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 191
    • 84905730032 scopus 로고    scopus 로고
    • The optimal partnership of radiation and immunotherapy: From preclinical studies to clinical translation
    • Demaria, S., Pilones, K. A., Vanpouille-Box, C., Golden, E. B., & Formenti, S. C. The optimal partnership of radiation and immunotherapy: from preclinical studies to clinical translation. Radiat. Res. 182, 170-181 (2014
    • (2014) Radiat. Res , vol.182 , pp. 170-181
    • Demaria, S.1    Pilones, K.A.2    Vanpouille-Box, C.3    Golden, E.B.4    Formenti, S.C.5
  • 192
    • 84927574518 scopus 로고    scopus 로고
    • Immune modulation for cancer therapy
    • Naidoo, J., Page, D. B., & Wolchok, J. D. Immune modulation for cancer therapy. Br. J. Cancer 111, 2214-2219 (2014
    • (2014) Br. J. Cancer , vol.111 , pp. 2214-2219
    • Naidoo, J.1    Page, D.B.2    Wolchok, J.D.3
  • 194
    • 84870239310 scopus 로고    scopus 로고
    • Immunogenic cell death and DAMPs in cancer therapy
    • Krysko, D. V., et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860-875 (2012
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 860-875
    • Krysko, D.V.1
  • 195
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL 1β dependent adaptive immunity against tumors
    • Ghiringhelli, F., et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL 1β dependent adaptive immunity against tumors. Nat. Med. 15, 1170-1178 (2009
    • (2009) Nat. Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1
  • 196
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • Obeid, M., et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13, 54-61 (2007
    • (2007) Nat. Med , vol.13 , pp. 54-61
    • Obeid, M.1
  • 197
    • 79551523389 scopus 로고    scopus 로고
    • Cyclophosphamide synergizes with type i interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
    • Schiavoni, G., et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res. 71, 768-778 (2011
    • (2011) Cancer Res , vol.71 , pp. 768-778
    • Schiavoni, G.1
  • 198
    • 84866508637 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer
    • Yamaguchi, R., et al. Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer. Hum. Pathol. 43, 1688-1694 (2012
    • (2012) Hum. Pathol , vol.43 , pp. 1688-1694
    • Yamaguchi, R.1
  • 199
    • 84890280749 scopus 로고    scopus 로고
    • Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-Antigen-Targeting anticancer vaccination
    • Litterman, A. J., Dudek, A. Z., & Largaespada, D. A. Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-Antigen-Targeting anticancer vaccination. Oncoimmunology 2, e26294 (2013
    • (2013) Oncoimmunology , vol.2 , pp. e26294
    • Litterman, A.J.1    Dudek, A.Z.2    Largaespada, D.A.3
  • 200
    • 84862557227 scopus 로고    scopus 로고
    • CD20+ tumor-infiltrating lymphocytes have an atypical CD27-memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer
    • Nielsen, J. S., et al. CD20+ tumor-infiltrating lymphocytes have an atypical CD27-memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer. Clin. Cancer Res. 18, 3281-3292 (2012
    • (2012) Clin. Cancer Res , vol.18 , pp. 3281-3292
    • Nielsen, J.S.1
  • 201
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • de Visser, K. E., Korets, L. V., & Coussens, L. M. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7, 411-423 (2005
    • (2005) Cancer Cell , vol.7 , pp. 411-423
    • De Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3
  • 202
    • 79956131523 scopus 로고    scopus 로고
    • Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T regulatory cells
    • Olkhanud, P. B., et al. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T regulatory cells. Cancer Res. 71, 3505-3515 (2011
    • (2011) Cancer Res , vol.71 , pp. 3505-3515
    • Olkhanud, P.B.1
  • 203
    • 33646387194 scopus 로고    scopus 로고
    • Type i IFN-mediated enhancement of anti-leukemic cytotoxicity of ?δ T cells expanded from peripheral blood cells by stimulation with zoledronate
    • Watanabe, N., et al. Type I IFN-mediated enhancement of anti-leukemic cytotoxicity of ?δ T cells expanded from peripheral blood cells by stimulation with zoledronate. Cytotherapy 8, 118-129 (2006
    • (2006) Cytotherapy , vol.8 , pp. 118-129
    • Watanabe, N.1
  • 204
    • 84884798380 scopus 로고    scopus 로고
    • Interferon-Alpha suppresses cAMP to disarm human regulatory T cells
    • Bacher, N., et al. Interferon-Alpha suppresses cAMP to disarm human regulatory T cells. Cancer Res. 73, 5647-5656 (2013
    • (2013) Cancer Res , vol.73 , pp. 5647-5656
    • Bacher, N.1
  • 205
    • 0036206908 scopus 로고    scopus 로고
    • IFN-Alpha/beta enhances BCR-dependent B cell responses
    • Braun, D., Caramalho, I., & Demengeot, J. IFN-Alpha/beta enhances BCR-dependent B cell responses. Int. Immunol. 14, 411-419 (2002
    • (2002) Int. Immunol , vol.14 , pp. 411-419
    • Braun, D.1    Caramalho, I.2    Demengeot, J.3
  • 206
    • 32044460431 scopus 로고    scopus 로고
    • Cutting edge: Enhancement of antibody responses through direct stimulation of B and T cells by Type i IFN
    • Le Bon, A., et al. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by Type I IFN. J. Immunol. 176, 2074-2078 (2006
    • (2006) J. Immunol , vol.176 , pp. 2074-2078
    • Le Bon, A.1
  • 207
    • 77954403513 scopus 로고    scopus 로고
    • Type i IFN enhances follicular B cell contribution to the T cell-independent antibody response
    • Swanson, C. L., et al. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J. Exp. Med. 207, 1485-1500 (2010
    • (2010) J. Exp. Med , vol.207 , pp. 1485-1500
    • Swanson, C.L.1
  • 209
    • 59849122968 scopus 로고    scopus 로고
    • Cutting edge: Down-regulation of MHC class i related chain A on tumor cells by IFN-gamma-induced microRNA
    • Yadav, D., Ngolab, J., Lim, R. S., Krishnamurthy, S., & Bui, J. D. Cutting edge: down-regulation of MHC class I related chain A on tumor cells by IFN-gamma-induced microRNA. J. Immunol. 182, 39-43 (2009
    • (2009) J. Immunol , vol.182 , pp. 39-43
    • Yadav, D.1    Ngolab, J.2    Lim, R.S.3    Krishnamurthy, S.4    Bui, J.D.5
  • 210
    • 0022178901 scopus 로고
    • YAC 1 MHC class i variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage
    • Piontek, G. E., et al. YAC 1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage. J. Immunol. 135, 4281-4288 (1985
    • (1985) J. Immunol , vol.135 , pp. 4281-4288
    • Piontek, G.E.1
  • 211
    • 0942276768 scopus 로고    scopus 로고
    • Modulation of major histocompatibility complex Class i molecules and major histocompatibility complex-bound immunogenic peptides induced by interferon-Alpha and interferon-gamma treatment of human glioblastoma multiforme
    • Yang, I., et al. Modulation of major histocompatibility complex Class I molecules and major histocompatibility complex-bound immunogenic peptides induced by interferon-Alpha and interferon-gamma treatment of human glioblastoma multiforme. J. Neurosurg. 100, 310-319 (2004
    • (2004) J. Neurosurg , vol.100 , pp. 310-319
    • Yang, I.1
  • 212
    • 0021638195 scopus 로고
    • Interferon induces natural killer cell blastogenesis in vivo
    • Biron, C. A., Sonnenfeld, G., & Welsh, R. M. Interferon induces natural killer cell blastogenesis in vivo. J. Leukoc. Biol. 35, 31-37 (1984
    • (1984) J. Leukoc. Biol , vol.35 , pp. 31-37
    • Biron, C.A.1    Sonnenfeld, G.2    Welsh, R.M.3
  • 213
    • 0033081259 scopus 로고    scopus 로고
    • Type i interferons keep activated T cells alive
    • Marrack, P., Kappler, J., & Mitchell, T. Type I interferons keep activated T cells alive. J. Exp. Med. 189, 521-530 (1999
    • (1999) J. Exp. Med , vol.189 , pp. 521-530
    • Marrack, P.1    Kappler, J.2    Mitchell, T.3
  • 214
    • 0027433104 scopus 로고
    • Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells
    • Brinkmann, V., Geiger, T., Alkan, S., & Heusser, C. H. Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells. J. Exp. Med. 178, 1655-1663 (1993
    • (1993) J. Exp. Med , vol.178 , pp. 1655-1663
    • Brinkmann, V.1    Geiger, T.2    Alkan, S.3    Heusser, C.H.4
  • 215
    • 0032076635 scopus 로고    scopus 로고
    • Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL 15
    • Zhang, X., Sun, S., Hwang, I., Tough, D F., & Sprent, J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL 15. Immunity 8, 591-599 (1998
    • (1998) Immunity , vol.8 , pp. 591-599
    • Zhang, X.1    Sun, S.2    Hwang, I.3    Tough, D.F.4    Sprent, J.5
  • 216
    • 0033009888 scopus 로고    scopus 로고
    • Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    • Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar-Mather, T. P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189-220 (1999
    • (1999) Annu. Rev. Immunol , vol.17 , pp. 189-220
    • Biron, C.A.1    Nguyen, K.B.2    Pien, G.C.3    Cousens, L.P.4    Salazar-Mather, T.P.5
  • 217
    • 0023195335 scopus 로고
    • Intrapleural application of human leukocyte interferon (HLI) in breast cancer patients with ipsilateral pleural carcinomatosis
    • Jereb, B., Us Krasovec, M., Cervek, J., & Soos, E. Intrapleural application of human leukocyte interferon (HLI) in breast cancer patients with ipsilateral pleural carcinomatosis. J. Interferon Res. 7, 357-363 (1987
    • (1987) J. Interferon Res , vol.7 , pp. 357-363
    • Jereb, B.1    Us Krasovec, M.2    Cervek, J.3    Soos, E.4
  • 218
    • 0022870863 scopus 로고
    • Recombinant gamma interferon in advanced breast cancer: A phase II trial
    • Muss, H. B., et al. Recombinant gamma interferon in advanced breast cancer: a phase II trial. Invest. New Drugs 4, 377-381 (1986
    • (1986) Invest. New Drugs , vol.4 , pp. 377-381
    • Muss, H.B.1
  • 219
    • 0023770994 scopus 로고
    • Phase II trial of recombinant beta (IFN-betaser) interferon in the treatment of metastatic breast cancer
    • Barreras, L., Vogel, C. L., Koch, G., & Marcus, S. G. Phase II trial of recombinant beta (IFN-betaser) interferon in the treatment of metastatic breast cancer. Invest. New Drugs 6, 211-215 (1988
    • (1988) Invest. New Drugs , vol.6 , pp. 211-215
    • Barreras, L.1    Vogel, C.L.2    Koch, G.3    Marcus, S.G.4
  • 220
    • 0028900967 scopus 로고
    • Megestrol acetate plus alpha 2a interferon as second line therapy for postmenopausal patients with advanced breast cancer: Results of a multicentric phase II trial
    • Amoroso, D., et al. Megestrol acetate plus alpha 2a interferon as second line therapy for postmenopausal patients with advanced breast cancer: results of a multicentric phase II trial. Breast Cancer Res. Treat. 33, 265-268 (1995
    • (1995) Breast Cancer Res. Treat , vol.33 , pp. 265-268
    • Amoroso, D.1
  • 221
    • 0023630940 scopus 로고
    • A trial of human alpha interferon as an adjuvant agent in breast cancer after loco-regional recurrence
    • Fentiman, I. S., Balkwill, F. R., Cuzick, J., Hayward, J. L., & Rubens, R. D. A trial of human alpha interferon as an adjuvant agent in breast cancer after loco-regional recurrence. Eur. J. Surg. Oncol. 13, 425-428 (1987
    • (1987) Eur. J. Surg. Oncol , vol.13 , pp. 425-428
    • Fentiman, I.S.1    Balkwill, F.R.2    Cuzick, J.3    Hayward, J.L.4    Rubens, R.D.5
  • 222
    • 0027099925 scopus 로고
    • Adjuvant therapy with escalating doses of doxorubicin and cyclophosphamide with or without leukocyte alpha-interferon for stage II or III breast cancer
    • Buzdar, A. U., et al. Adjuvant therapy with escalating doses of doxorubicin and cyclophosphamide with or without leukocyte alpha-interferon for stage II or III breast cancer. J. Clin. Oncol. 10, 1540-1546 (1992
    • (1992) J. Clin. Oncol , vol.10 , pp. 1540-1546
    • Buzdar, A.U.1


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