Mechanisms of resistance of NSCLC to interferons Correlation with receptor regulation and type I IFN gene deletion

International Journal of Oncology

Volumn 10, Issue 5, 1997, Pages 933-938

  Hasthorpe, Suzanne ^a,c   Holland, Kerry A ^b   Nink, Virginia ^a   Lawler, Celine B ^a   Hertzog, Paul J ^b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Gene deletion; Interferon; NSCLC; Receptors

Indexed keywords

INTERFERON BETA SERINE; INTERFERON RECEPTOR; RECOMBINANT ALPHA2A INTERFERON;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; GENE DELETION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL;

EID: 0030994594     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Diaz MO, Rubin CM, Harden A, Ziemin S, Larson RA, Le Beau MM and Rowley JD: Deletions of interferon genes in acute lymphoblastic leukemia. N Engl J Med 322: 77-82, 1990.
2. Diaz MO, Ziemin S, Le Beau MM, Pitha P, Cholcote RR and Rowley JD: Homozygous deletion of the alpha-a and beta-1 interferon genes in human leukemia and derived cell lines. Proc Natl Acad Sci USA 85: 5259-5263, 1988.
3. Olopade OI, Jenkins RB, Ransom DT, Malik K, Pomykala H, Nobori T, Cowan JM, Rowley JD and Diaz MO: Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas. Cancer Res 52: 2523-2529, 1992.
4. Cannon-Albright LA, Goldgar DE, Meyer LJ, Lewis CM, Anderson DE, Fountain JW, Hegi ME, Weisman RW, Petty EM, Bale AE, Olopade OI, Diaz MO, Kwiatkowski MW, Piepkorn MW, Zone JJ and Skolnick MH: Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science 258: 1148-1152, 1992.
5. Lukeis R, Ball D, Irving L, Garson M and Hasthorpe S: Chromosome abnormalities in non-small cell lung cancer pleural effusions: cytogenetic indicators of disease subgroups. Genes Chromosom Cancer 8: 262-269, 1993.
6. Olopade OI, Buchhagen DL, Malik K, Nobori T, Bader S, Gazdar AF, Minna JD and Diaz MO: Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers. Cancer Res 53: 2410-2415, 1993.
7. Kamb A: Cell-cycle regulators and cancer. Trends Genet 11: 136-140, 1995.
8. Pitha PM: Interferons: a new class of tumor suppressor genes? Cancer Cells 2: 215-216, 1990.
9. Lengyel P: Tumor-suppressor genes: news about the interferon connection. Proc Natl Acad Sci USA 90: 5893-5895, 1993.
10. Kamb A, Gruis NA, Weaver-Feldhaus J, Lui Q, Harshman K, Tavtigian SV, Stocken E, Day RS, Johnson BE and Skolnick MH: A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-440, 1994.
11. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K and Carson DA: Deletions of the cyclin-dependent-kinase-4 inhibitor gene in multiple human cancers. Nature 369: 753-756, 1994.
12. Jilbert AR, Hertzog PJ, Burrell CJ, Gowans EJ, Linnane AW and Marmion BP: Production of a monoclonal antibody to human interferon-α (IFN-α) and its use to identify IFN-α-producing cells in virus infection in vivo. Microb Pathog 1: 159-168, 1986.
13. Khan NUD, Pulford KAF, Farquharson MA, Howatson A, Stewart C, Jackson R, McNicol AM and Foulis AK: The distribution of immunoreactive interferon-alpha in normal human tissues. Immunology 66: 201-206, 1989.
14. Greenway AL, Overall ML, Sattayasai N, Rowley MJ, Hertzog PJ, McMullen GL, Cheetham BF and Marzuki S: Selective production of interferon-alpha subtypes by cultured peripheral blood mononuclear cells and lymphoblastoid cell lines. Immunology 75: 182-188, 1992.
15. Hwang SY, Greenway AL, McMullen GL and Hertzog PJ: Detection of cells producing murine interferon-α-1 using antipeptide antibodies. Immun Cell Biol 72: 234-240, 1994.
16. Tovey MG, Streuli M, Gresser I, Gugenheim J, Blanchard B, Guymarho J, Vignaux F and Gigou M: Interferon messenger RNA is produced constitutively in the organs of normal individuals. Proc Natl Acad Sci USA 84: 5038-5042, 1987.
17. Trent JM, Olson S and Lawn RM: Chromosomal localization of human leucocyte, fibroblast, and immune interferon genes by means of in situ hybridization. Proc Natl Acad Sci USA 9: 7809-7813, 1982.
18. Pitha PM, Slate NB, Raj NB and Ruddle FH: Human β interferon gene localization and expression in somatic cell hybrids. Mol Cell Biol 2: 564-570, 1982.
19. Langer JA and Pestka S: Interferon receptors. Immunol Today 9: 393-400, 1988.
20. Uze G, Lutfalla G, Bandu M-T, Proudhon D and Mogensen KE: Behaviour of a cloned murine interferon α/β receptor expressed in homospecific or heterospecific background. Proc Natl Acad Sci USA 89: 4774-4778, 1992.
21. Novick D, Cohen B and Rubenstein M: Soluble interferon-alpha receptor molecules are present in body fluids. FEBS Lett 314: 445-448, 1994.
22. Hwang SY, Hertzog PJ, Holland KA, Sumarsono SH, Tymms MJ, Hamilton JA, Whitty G, Bertoncello I and Kola I: A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc Natl Acad Sci USA 92: 11284-11288, 1995.
23. Shearer M and Taylor-Papadimitriou J: Regulation of cell growth by interferon. Cancer Metastasis Rev 6: 199-221, 1987.
24. Billard C, Sigaux F, Castaigne S, Valensi F, Flandrin G, Degos L, Falcott E and Auguet M: Treatment of hairy cell leukemia with recombinant alpha interferon. II. In vivo down-regulation of alpha interferon receptors on tumour cells. Blood 67: 821-826, 1986.
25. Faltynek CR, Princler GL, Rossio JL, Ruscetti FW, Maluish AE, Abrams PG and Foon KA: Relationship of the clinical response and binding of recombinant interferon alpha in patients with lymphoproliferative diseases. Blood 67: 1077-1082, 1986.
26. Hertzog PJ, Johns TG, Callister KA, Dinatale A and Linnane AW: Comparitive antiproliferative and receptor binding activities of interferons α and β on lymphoblastoid and melanoma cells. Biochem Int 22: 1095-1102, 1990.
27. Pfeffer LM and Donner DB: The down-regulation of α-interferon receptors in human lymphoblastoid cells; relation to cellular responsiveness to the antiproliferative action of α-interferon. Cancer Res 50: 2654-2657, 1990.
28. Colamonici OR, Domanski P, Platanias LC and Diaz MO: Correlation between interferon (IFN) a resistance and deletion of the IFN α/β genes in acute leukemia cell lines suggests selection against the IFN system. Blood 80: 744-749, 1992.
29. Miyakoshi J, Dobler KD, Allalunis-Turner J, McKean JDS, Petruk K, Allen PBR, Aronyk KN, Weir B, Hyuser-Wierenga D, Fulton D, Urtasun RC and Day RS: Absence of IFNa and IFNβ genes from the human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons. Cancer Res 50: 278-283, 1990.
30. Lukeis R, Irving L, Garson M and Hasthorpe S: Cytogenetics of non-small cell lung cancer: analysis of consistent non-random abnormalities. Genes Chromosom Cancer 2: 116-124, 1990.
31. Mosmann T: Rapid colorimetric assay for cell growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
32. Denizot F and Lang R: Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89: 271-277, 1986.
33. Loveland BE, Johns TG, MacKay IR, Vaillant F, Wang Z-X and Hertzog PJ: Validation of the MTT assay for enumeration of cells in proliferative and antiproliferative assays. Biochem Int 27: 501-510, 1992.