-
1
-
-
63649108380
-
The roles of TLRs, RLRs and NLRs in pathogen recognition
-
Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009;21:317-337.
-
(2009)
Int Immunol
, vol.21
, pp. 317-337
-
-
Kawai, T.1
Akira, S.2
-
2
-
-
33947629255
-
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
-
Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol 2007;19:3-10.
-
(2007)
Semin Immunol
, vol.19
, pp. 3-10
-
-
Miyake, K.1
-
3
-
-
2342525996
-
Regulation of phagosome maturation by signals from Toll-like receptors
-
Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from Toll-like receptors. Science 2004;304:1014-1018.
-
(2004)
Science
, vol.304
, pp. 1014-1018
-
-
Blander, J.M.1
Medzhitov, R.2
-
4
-
-
84870189452
-
Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling
-
Gosu V, Basith S, Kwon OP, Choi S. Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling. Molecules 2012;17:13503-13529.
-
(2012)
Molecules
, vol.17
, pp. 13503-13529
-
-
Gosu, V.1
Basith, S.2
Kwon, O.P.3
Choi, S.4
-
5
-
-
33646147362
-
Toll-like receptor function and signaling
-
Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006;117:979-987.
-
(2006)
J Allergy Clin Immunol
, vol.117
, pp. 979-987
-
-
Kaisho, T.1
Akira, S.2
-
6
-
-
25844484501
-
CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviraltreated HIV-infected adults
-
Coopera CL, Davisb HL, Angela JB, et al. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviraltreated HIV-infected adults. AIDS 2005;19:1473-1479.
-
(2005)
AIDS
, vol.19
, pp. 1473-1479
-
-
Coopera, C.L.1
Davisb, H.L.2
Angela, J.B.3
-
7
-
-
80051794923
-
Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: A phase IIb study
-
Klimek L, Willers J, Hammann-Haenni A, et al. Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study. Clin Exp Allergy 2011;41: 1305-1312.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 1305-1312
-
-
Klimek, L.1
Willers, J.2
Hammann-Haenni, A.3
-
8
-
-
70449127697
-
Safety and efficacy of PF-3512676 for the treatment of stage IV renal cell carcinoma: An open-label, multicenter phase I/II study
-
Thompson JA, Kuzel T, Drucker BJ, et al. Safety and efficacy of PF-3512676 for the treatment of stage IV renal cell carcinoma: an open-label, multicenter phase I/II study. Clin Genitourin Cancer 2009;7:E58-E65.
-
(2009)
Clin Genitourin Cancer
, vol.7
-
-
Thompson, J.A.1
Kuzel, T.2
Drucker, B.J.3
-
9
-
-
55249083982
-
Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma
-
Hofmann MA, Kors C, Audring H, et al. Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma. J Immunother 2008; 31:520-527.
-
(2008)
J Immunother
, vol.31
, pp. 520-527
-
-
Hofmann, M.A.1
Kors, C.2
Audring, H.3
-
10
-
-
0037098178
-
How should meta-regression analyses be undertaken and interpreted?
-
Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med 2002;21:1559-1573.
-
(2002)
Stat Med
, vol.21
, pp. 1559-1573
-
-
Thompson, S.G.1
Higgins, J.P.2
-
11
-
-
84862907845
-
In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: A phase 1/2 study
-
Kim YH, Gratzinger D, Harrison C, et al. In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study. Blood 2012;119: 355-363.
-
(2012)
Blood
, vol.119
, pp. 355-363
-
-
Kim, Y.H.1
Gratzinger, D.2
Harrison, C.3
-
12
-
-
78049420571
-
In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study
-
Brody JD, Ai WZ, Czerwinski DK, et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol 2010;28:4324-3432.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4324-3432
-
-
Brody, J.D.1
Ai, W.Z.2
Czerwinski, D.K.3
-
13
-
-
78650300359
-
Phase i trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma
-
Kim YH, Girardi M, Duvic M, et al. Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma. J Am Acad Dermatol 2010;63:975-983.
-
(2010)
J Am Acad Dermatol
, vol.63
, pp. 975-983
-
-
Kim, Y.H.1
Girardi, M.2
Duvic, M.3
-
14
-
-
71849087609
-
Phase i study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer
-
Yamada K, Nakao M, Fukuyama C, et al. Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer. Cancer Sci 2010;101:188-195.
-
(2010)
Cancer Sci
, vol.101
, pp. 188-195
-
-
Yamada, K.1
Nakao, M.2
Fukuyama, C.3
-
15
-
-
67650487106
-
Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma
-
Friedberg JW, Kelly JL, Neuberg D, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol 2009;146:282-291.
-
(2009)
Br J Haematol
, vol.146
, pp. 282-291
-
-
Friedberg, J.W.1
Kelly, J.L.2
Neuberg, D.3
-
16
-
-
35948987594
-
Phase i trial of Tolllike receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non-Hodgkins lymphoma
-
Leonard JP, Link BK, Emmanouilides C, et al. Phase I trial of Tolllike receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non-Hodgkins lymphoma. Clin Cancer Res 2007;13:6168-6174.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6168-6174
-
-
Leonard, J.P.1
Link, B.K.2
Emmanouilides, C.3
-
17
-
-
34247389227
-
Phase II trial of a Toll- Like receptor 9-activating oligonucleotide in patients with metastatic melanoma
-
Pashenkov M, Goëss G, Wagner C, et al. Phase II trial of a Toll- Like receptor 9-activating oligonucleotide in patients with metastatic melanoma. J Clin Oncol 2006;24:5716-5724.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5716-5724
-
-
Pashenkov, M.1
Goëss, G.2
Wagner, C.3
-
18
-
-
79960110662
-
Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-smallcell lung cancer
-
Hirsh V, Paz-Ares L, Boyer M, et al. Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-smallcell lung cancer. J Clin Oncol 2011;29:2667-2674.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2667-2674
-
-
Hirsh, V.1
Paz-Ares, L.2
Boyer, M.3
-
19
-
-
84855184648
-
A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung Cancer
-
Manegold C, van Zandwijk N, Szczesna A, et al. A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung Cancer. Ann Oncol 2012;23:72-77.
-
(2012)
Ann Oncol
, vol.23
, pp. 72-77
-
-
Manegold, C.1
Van Zandwijk, N.2
Szczesna, A.3
-
20
-
-
77952898416
-
Improving the immunogenicity of pneumococcal conjugate vaccine in HIV-infected adults with a Toll-like receptor 9 agonist adjuvant: A randomized, controlled Trial
-
Sgaard OS, Lohse N, Harboe ZB, et al. Improving the immunogenicity of pneumococcal conjugate vaccine in HIV-infected adults with a Toll-like receptor 9 agonist adjuvant: a randomized, controlled Trial. Clin Infect Dis 2010;51:42-50.
-
(2010)
Clin Infect Dis
, vol.51
, pp. 42-50
-
-
Sgaard, O.S.1
Lohse, N.2
Harboe, Z.B.3
-
21
-
-
50549084485
-
Randomized phase II trial of a Toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
-
Manegold C, Gravenor D, Woytowitz D, et al. Randomized phase II trial of a Toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3979-3986.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3979-3986
-
-
Manegold, C.1
Gravenor, D.2
Woytowitz, D.3
-
22
-
-
11344257404
-
CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
-
Cooper CL, Davis HL, Morris ML, et al. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J Clin Immunol 2004;24:693-701.
-
(2004)
J Clin Immunol
, vol.24
, pp. 693-701
-
-
Cooper, C.L.1
Davis, H.L.2
Morris, M.L.3
-
23
-
-
69249125380
-
Randomized phase 2/3 trial of CpG oligodeoxynucleotide PF-3512676 alone or with dacarbazine for patients with unresectable stage III and IV melanoma
-
Weber JS, Zarour H, Redman B, et al. Randomized phase 2/3 trial of CpG oligodeoxynucleotide PF-3512676 alone or with dacarbazine for patients with unresectable stage III and IV melanoma. Cancer 2009;115:3944-3954.
-
(2009)
Cancer
, vol.115
, pp. 3944-3954
-
-
Weber, J.S.1
Zarour, H.2
Redman, B.3
-
24
-
-
36348931521
-
Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10 101 in patients with chronic hepatitis C virus
-
McHutchison JG, Bacon BR, Gordon SC, et al. Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10 101 in patients with chronic hepatitis C virus. Hepatology 2007;46:1341-1349.
-
(2007)
Hepatology
, vol.46
, pp. 1341-1349
-
-
McHutchison, J.G.1
Bacon, B.R.2
Gordon, S.C.3
-
25
-
-
34547789747
-
Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10 101 (ACTILON), an investigational synthetic Toll-like receptor 9 agonist
-
Vicari AP, Schmalbach T, Lekstrom-Himes J, et al. Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10 101 (ACTILON), an investigational synthetic Toll-like receptor 9 agonist. Antivir Ther 2007;12:741-751.
-
(2007)
Antivir Ther
, vol.12
, pp. 741-751
-
-
Vicari, A.P.1
Schmalbach, T.2
Lekstrom-Himes, J.3
-
26
-
-
7444242674
-
Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-Class CpG oligodeoxynucleotide TLR9 agonist
-
Krieg AM, Efler SM, Wittpoth M, et al. Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-Class CpG oligodeoxynucleotide TLR9 agonist. J Immunother 2004;27:460-471.
-
(2004)
J Immunother
, vol.27
, pp. 460-471
-
-
Krieg, A.M.1
Efler, S.M.2
Wittpoth, M.3
-
27
-
-
84875219804
-
The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma
-
Beeh KM, Kanniess F, Wagner F, et al. The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma. J Allergy Clin Immunol 2013;131:866-874.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 866-874
-
-
Beeh, K.M.1
Kanniess, F.2
Wagner, F.3
-
28
-
-
37849002321
-
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
-
Krieg AM. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008;27:161-167.
-
(2008)
Oncogene
, vol.27
, pp. 161-167
-
-
Krieg, A.M.1
|