Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis

Pancreas

Volumn 43, Issue 4, 2014, Pages 619-623

  Sun, Yu ^a   Yang, Shaoshi ^a   Sun, Ning ^a   Chen, Jianqiu ^a,b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b NONE   (China)

Author keywords

Immunohistochemistry; p21; Pancreatic cancer; Stat1

Indexed keywords

PROTEIN P21; STAT1 PROTEIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; STAT1 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MIDDLE AGED; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TISSUE MICROARRAY; TUMOR DIFFERENTIATION; VERY ELDERLY; CANCER STAGING; CELL DIFFERENTIATION; CHEMISTRY; DOWN REGULATION; KAPLAN MEIER METHOD; MORTALITY; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PREDICTIVE VALUE; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SECONDARY; TIME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE PROGRESSION; DOWN-REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84898462512     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000074     Document Type: Article

References (33)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
2. Remmers N, Bailey JM, Mohr AM, et al. Molecular pathology of early pancreatic cancer. Cancer Biomark. 2010;9:421-440.
3. Arum CJ, Anderssen E, Viset T, et al. Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancer. Neoplasia. 2010;12:434-442.
4. Ikeda H, Old LJ, Schreiber RD. The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 2002;13:95-109.
5. Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 2000;19:2468-2473.
6. Papatriantafyllou M. Gene regulation: STATs control subset-specific enhancer activation. Nat Rev Immunol. 2013;13:7.
7. Ramana CV, Chatterjee-Kishore M, Nguyen H, et al. Complex roles of Stat1 in regulating gene expression. Oncogene. 2000;19:2619-2627.
8. Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene. 2000;19:2548-2556.
9. Mui AL. The role of STATs in proliferation, differentiation, and apoptosis. Cell Mol Life Sci. 1999;55:1547-1558.
10. Clevenger CV. Roles and regulation of stat family transcription factors in human breast cancer. Am J Pathol. 2004;165:1449-1460.
11. Durbin JE, Hackenmiller R, Simon MC, et al. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996;84:443-450.
12. + regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med. 2004;199:25-34.
13. Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res. 2002;8:945-954.
14. Schmitt MJ, Philippidou D, Reinsbach SE, et al. Interferon-F-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells. Cell Commun Signal. 2012;10:41.
15. Levy DE, Gilliland DG. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene. 2000;19:2505-2510.
16. Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996;84:431-442.
17. Kaplan DH, Shankaran V, Dighe AS, et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A. 1998;95:7556-7561.
18. Bromberg JF, Horvath CM, Wen Z, et al. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A. 1996;93:7673-7678.
19. Sahni M, Ambrosetti DC, Mansukhani A, et al. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev. 1999;13:1361-1366.
20. WAF1/CIP1 in early gastric carcinoma. Cancer. 2001;92:1828-1835.
21. Shariat SF, Tokunaga H, Zhou J, et al. p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol. 2004;22:1014-1024.
22. Shoji T, Tanaka F, Takata T, et al. Clinical significance of p21 expression in non-small cell lung cancer. J Clin Oncol. 2002;20:3865-3871.
23. WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation. Prostate Cancer Prostatic Dis. 2005;8:321-326.
24. Mattern J, Koomägi R, Volm M. Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma. Br J Cancer. 1996;73:931-934.
25. Gupta GP, Massagué J. Cancer metastasis: building a framework. Cell. 2006;127(4):679-695.
26. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2002;2:563-572.
27. Fidler IJ. The pathogenesis of cancer metastasis: the ?seed and soil? hypothesis revisited. Nat Rev Cancer. 2003;3:453-458.
28. Huang S, Bucana CD, van Arsdall M, et al. Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene. 2002;21:2504-2512.
29. Widschwendter A, Tonko-Geymayer S, Welte T, et al. Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer. Clin Cancer Res. 2002;8:3065-3074.
30. WAF1/CIP1 mediated by STAT1. Science. 1996;272:719-722.
31. Kumar A, Commane M, Flickinger TW, et al. Defective TNF-alpha -induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science. 1997;278:1630-1632.
32. Bowman T, Garcia R, Turkson J, et al. STATs in oncogenesis. Oncogene. 2000;19:2474-2488.
33. WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia. Cancer Res. 2001;61:8830-8837.