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Volumn 33, Issue 4, 2013, Pages 145-153

Biological rationale and clinical use of interferon in the classical BCR-ABL-negative myeloproliferative neoplasms

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BCR ABL PROTEIN; BETA INTERFERON; CASPASE 4; CASPASE 8; HYDROXYUREA; INTERFERON; JANUS KINASE 2; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RECOMBINANT ALPHA INTERFERON; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON;

EID: 84876138022     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0120     Document Type: Review
Times cited : (42)

References (45)
  • 1
    • 0037217859 scopus 로고    scopus 로고
    • Pilot study of pegylated interferon- alpha 2b in patients with essential thrombocythemia
    • Alvarado Y, Cortes J, et al. 2003. Pilot study of pegylated interferon- alpha 2b in patients with essential thrombocythemia. Cancer Chemother Pharmacol 51(1):81-86.
    • (2003) Cancer Chemother Pharmacol , vol.51 , Issue.1 , pp. 81-86
    • Alvarado, Y.1    Cortes, J.2
  • 2
    • 0018098799 scopus 로고
    • Interferon affects both G1 and S + G2 in cells stimulated from quiescence to growth
    • Balkwill F, Taylor-Papadimitriou J. 1978. Interferon affects both G1 and S + G2 in cells stimulated from quiescence to growth. Nature 274(5673):798-800.
    • (1978) Nature , vol.274 , Issue.5673 , pp. 798-800
    • Balkwill, F.1    Taylor-Papadimitriou, J.2
  • 3
    • 79551491928 scopus 로고    scopus 로고
    • Philadelphia-negative classical myeloproliferative neoplasms: Critical concepts and management recommendations from European LeukemiaNet
    • Barbui T, Barosi G, et al. 2011. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 29(6):761-770.
    • (2011) J Clin Oncol , vol.29 , Issue.6 , pp. 761-770
    • Barbui, T.1    Barosi, G.2
  • 4
    • 0023722383 scopus 로고
    • Treatment of essential thrombocythaemia by alpha 2a interferon
    • Bellucci S, Harousseau JL, et al. 1988. Treatment of essential thrombocythaemia by alpha 2a interferon. Lancet 2(8617):960- 961.
    • (1988) Lancet , vol.2 , Issue.8617 , pp. 960-961
    • Bellucci, S.1    Harousseau, J.L.2
  • 5
    • 0023622360 scopus 로고
    • Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia
    • Carlo-Stella C, Cazzola M, et al. 1987. Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia. Blood 70(4):1014-1019.
    • (1987) Blood , vol.70 , Issue.4 , pp. 1014-1019
    • Carlo-Stella, C.1    Cazzola, M.2
  • 6
    • 0037790592 scopus 로고    scopus 로고
    • Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
    • Chawla-Sarkar M, Lindner DJ, et al. 2003. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8(3):237-249.
    • (2003) Apoptosis , vol.8 , Issue.3 , pp. 237-249
    • Chawla-Sarkar, M.1    Lindner, D.J.2
  • 7
    • 0032519537 scopus 로고    scopus 로고
    • Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis
    • Dai CH, Price JO, et al. 1998. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood 91(4):1235-1242.
    • (1998) Blood , vol.91 , Issue.4 , pp. 1235-1242
    • Dai, C.H.1    Price, J.O.2
  • 8
    • 0035085720 scopus 로고    scopus 로고
    • Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts
    • Eickelberg O, Pansky A, et al. 2001. Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts. FASEB J 15(3):797-806.
    • (2001) FASEB J , vol.15 , Issue.3 , pp. 797-806
    • Eickelberg, O.1    Pansky, A.2
  • 9
    • 0026653870 scopus 로고
    • Identification of double-stranded RNA-binding domains in the interferon-induced doublestranded RNA-activated p68 kinase
    • Feng GS, Chong K, et al. 1992. Identification of double-stranded RNA-binding domains in the interferon-induced doublestranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A 89(12):5447-5451.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.12 , pp. 5447-5451
    • Feng, G.S.1    Chong, K.2
  • 10
    • 0023880591 scopus 로고
    • Alpha-interferon therapy for essential thrombocythaemia
    • Giles FJ, Singer CR, et al. 1988. Alpha-interferon therapy for essential thrombocythaemia. Lancet 2(8602):70-72.
    • (1988) Lancet , vol.2 , Issue.8602 , pp. 70-72
    • Giles, F.J.1    Singer, C.R.2
  • 11
    • 84867261125 scopus 로고    scopus 로고
    • Experience with pegylated Interferon alpha-2a in advanced myeloproliferative neoplasms in an international cohort of 118 patients
    • Gowin K, Thapaliya P, et al. 2012. Experience with pegylated Interferon alpha-2a in advanced myeloproliferative neoplasms in an international cohort of 118 patients. Haematologica 97(10):1570-1573.
    • (2012) Haematologica , vol.97 , Issue.10 , pp. 1570-1573
    • Gowin, K.1    Thapaliya, P.2
  • 12
    • 79951740151 scopus 로고    scopus 로고
    • Type i interferon inhibits interleukin-1 production and inflammasome activation
    • Guarda G, Braun M, et al. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-223.
    • (2011) Immunity , vol.34 , Issue.2 , pp. 213-223
    • Guarda, G.1    Braun, M.2
  • 13
    • 0024543864 scopus 로고
    • In vivo and in vitro inhibitory effect of alpha-interferon on megakaryocyte colony growth in essential thrombocythaemia
    • Gugliotta L, Bagnara GP, et al. 1989. In vivo and in vitro inhibitory effect of alpha-interferon on megakaryocyte colony growth in essential thrombocythaemia. Br J Haematol 71(2):177-181.
    • (1989) Br J Haematol , vol.71 , Issue.2 , pp. 177-181
    • Gugliotta, L.1    Bagnara, G.P.2
  • 14
    • 33745706982 scopus 로고    scopus 로고
    • PEG intron treatment in 90 patients with essential thrombocythemia (ET) final report of a phase II study
    • Gugliotta L, Bulgarelli S, Vianelli N, Russo D, Candoni A, Rupoli S, et al. 2005. PEG intron treatment in 90 patients with essential thrombocythemia (ET) final report of a phase II study. ASH Annual Meeting Abstracts 106(11):2600.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , Issue.11 , pp. 2600
    • Gugliotta, L.1    Bulgarelli, S.2    Vianelli, N.3    Russo, D.4    Candoni, A.5    Rupoli, S.6
  • 15
    • 81255210738 scopus 로고    scopus 로고
    • A new era for IFN-alpha in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms
    • Hasselbalch HC. 2011. A new era for IFN-alpha in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Expert Rev Hematol 4(6):637-655.
    • (2011) Expert Rev Hematol , vol.4 , Issue.6 , pp. 637-655
    • Hasselbalch, H.C.1
  • 16
    • 0032479056 scopus 로고    scopus 로고
    • IFNgamma induction of p21WAF1 in prostate cancer cells: Role in cell cycle, alteration of phenotype and invasive potential
    • Hobeika AC, Etienne W, et al. 1998. IFNgamma induction of p21WAF1 in prostate cancer cells: role in cell cycle, alteration of phenotype and invasive potential. Int J Cancer 77(1):138-145.
    • (1998) Int J Cancer , vol.77 , Issue.1 , pp. 138-145
    • Hobeika, A.C.1    Etienne, W.2
  • 17
    • 67649976491 scopus 로고    scopus 로고
    • PEG-IFN-alpha-2a therapy in patients with myelofibrosis: A study of the French Groupe d'Etudes des Myelofibroses (GEM) and France Intergroupe des syndromes Myeloproliferatifs (FIM)
    • Ianotto JC, Kiladjian JJ, et al. 2009. PEG-IFN-alpha-2a therapy in patients with myelofibrosis: a study of the French Groupe d'Etudes des Myelofibroses (GEM) and France Intergroupe des syndromes Myeloproliferatifs (FIM). Br J Haematol 146(2):223-225.
    • (2009) Br J Haematol , vol.146 , Issue.2 , pp. 223-225
    • Ianotto, J.C.1    Kiladjian, J.J.2
  • 18
    • 0030953789 scopus 로고    scopus 로고
    • Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells
    • Iwase S, Furukawa Y, et al. 1997. Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells. J Biol Chem 272(19):12406-12414.
    • (1997) J Biol Chem , vol.272 , Issue.19 , pp. 12406-12414
    • Iwase, S.1    Furukawa, Y.2
  • 19
    • 35648966599 scopus 로고    scopus 로고
    • PEG-IFN-alpha-2b therapy in BCR-ABL-negative myeloproliferative disorders: Final result of a phase 2 study
    • Jabbour E, Kantarjian H, et al. 2007. PEG-IFN-alpha-2b therapy in BCR-ABL-negative myeloproliferative disorders: final result of a phase 2 study. Cancer 110(9):2012-2018.
    • (2007) Cancer , vol.110 , Issue.9 , pp. 2012-2018
    • Jabbour, E.1    Kantarjian, H.2
  • 20
    • 0028985113 scopus 로고
    • Interferon-alpha activates cytotoxic function but inhibits interleukin-2-mediated proliferation and tumor necrosis factor-alpha secretion by immature human natural killer cells
    • Jewett A, Bonavida B. 1995. Interferon-alpha activates cytotoxic function but inhibits interleukin-2-mediated proliferation and tumor necrosis factor-alpha secretion by immature human natural killer cells. J Clin Immunol 15(1):35-44.
    • (1995) J Clin Immunol , vol.15 , Issue.1 , pp. 35-44
    • Jewett, A.1    Bonavida, B.2
  • 21
    • 0027244255 scopus 로고
    • The in vitro effects of interferongamma, interferon-alpha, and tumour-necrosis factor-alpha on erythroid burst-forming unit growth in patients with nonleukaemic myeloproliferative disorders
    • Kanfer EJ, Price CM, et al. 1993. The in vitro effects of interferongamma, interferon-alpha, and tumour-necrosis factor-alpha on erythroid burst-forming unit growth in patients with nonleukaemic myeloproliferative disorders. Eur J Haematol 50(5):250-254.
    • (1993) Eur J Haematol , vol.50 , Issue.5 , pp. 250-254
    • Kanfer, E.J.1    Price, C.M.2
  • 22
    • 54049141336 scopus 로고    scopus 로고
    • Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
    • Kiladjian JJ, Cassinat B, et al. 2008. Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood 112(8):3065-3072.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3065-3072
    • Kiladjian, J.J.1    Cassinat, B.2
  • 23
    • 79955947379 scopus 로고    scopus 로고
    • The renaissance of interferon therapy for the treatment of myeloid malignancies
    • Kiladjian JJ, Mesa RA, et al. 2011. The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood 117(18):4706-4715.
    • (2011) Blood , vol.117 , Issue.18 , pp. 4706-4715
    • Kiladjian, J.J.1    Mesa, R.A.2
  • 24
    • 27144539129 scopus 로고    scopus 로고
    • Pegylated interferon for the treatment of high risk essential thrombocythemia: Results of a phase II study
    • Langer C, Lengfelder E, et al. 2005. Pegylated interferon for the treatment of high risk essential thrombocythemia: results of a phase II study. Haematologica 90(10):1333-1338.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1333-1338
    • Langer, C.1    Lengfelder, E.2
  • 25
    • 0023777531 scopus 로고
    • Effect of alpha-interferon therapy on bone marrow fibrosis in hairy cell leukemia
    • Laughlin M, Islam A, et al. 1988. Effect of alpha-interferon therapy on bone marrow fibrosis in hairy cell leukemia. Blood 72(3):936-939.
    • (1988) Blood , vol.72 , Issue.3 , pp. 936-939
    • Laughlin, M.1    Islam, A.2
  • 26
    • 0022338499 scopus 로고
    • Therapy with interferon (recombinant IFN-alpha-2C) in myeloproliferative diseases with severe thrombocytoses
    • Linkesch W, Gisslinger H, et al. 1985. [Therapy with interferon (recombinant IFN-alpha-2C) in myeloproliferative diseases with severe thrombocytoses]. Acta Med Austriaca 12(5):123- 127.
    • (1985) Acta Med Austriaca , vol.12 , Issue.5 , pp. 123-127
    • Linkesch, W.1    Gisslinger, H.2
  • 27
    • 77952955507 scopus 로고    scopus 로고
    • Interferon-alpha targets JAK2V617Fpositive hematopoietic progenitor cells and acts through the p38 MAPK pathway
    • Lu M, Zhang W, et al. 2010. Interferon-alpha targets JAK2V617Fpositive hematopoietic progenitor cells and acts through the p38 MAPK pathway. Exp Hematol 38(6):472-480.
    • (2010) Exp Hematol , vol.38 , Issue.6 , pp. 472-480
    • Lu, M.1    Zhang, W.2
  • 28
    • 0022359194 scopus 로고
    • Treatment with recombinant interferon-alpha-2C: Multiple myeloma and thrombocythaemia in myeloproliferative diseases
    • Ludwig H, Cortelezzi A, et al. 1985. Treatment with recombinant interferon-alpha-2C: multiple myeloma and thrombocythaemia in myeloproliferative diseases. Oncology 42 Suppl 1:19-25.
    • (1985) Oncology , vol.42 , Issue.SUPPL. 1 , pp. 19-25
    • Ludwig, H.1    Cortelezzi, A.2
  • 29
    • 0021871106 scopus 로고
    • Suppression of normal human erythropoiesis by gamma interferon in vitro. Role of monocytes and T lymphocytes
    • Mamus SW, Beck-Schroeder S, et al. 1985. Suppression of normal human erythropoiesis by gamma interferon in vitro. Role of monocytes and T lymphocytes. J Clin Invest 75(5):1496-1503.
    • (1985) J Clin Invest , vol.75 , Issue.5 , pp. 1496-1503
    • Mamus, S.W.1    Beck-Schroeder, S.2
  • 30
    • 0028206204 scopus 로고
    • Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha
    • Messora C, Bensi L, et al. 1994. Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha. Br J Haematol 86(2):402-404.
    • (1994) Br J Haematol , vol.86 , Issue.2 , pp. 402-404
    • Messora, C.1    Bensi, L.2
  • 31
    • 0029966249 scopus 로고    scopus 로고
    • Influence of interferon-alpha on cytokine expression by the bone marrow microenvironment- impact on treatment of myeloproliferative disorders
    • Peschel C, Aulitzky WE, et al. 1996. Influence of interferon-alpha on cytokine expression by the bone marrow microenvironment- impact on treatment of myeloproliferative disorders. Leuk Lymphoma 22 Suppl 1:129-134.
    • (1996) Leuk Lymphoma 22 Suppl , vol.1 , pp. 129-134
    • Peschel, C.1    Aulitzky, W.E.2
  • 32
    • 84876153604 scopus 로고    scopus 로고
    • Dynamics of mutant alleles in patients with advanced essential thrombocythemia (ET) or polycythemia (PV) during pegylated interferon-alfa-2A (PEG-IFN-{alpha}-2A; Pegasys) therapy
    • Quintas-Cardama A, Abdel-Wahab O, Levine RL. 2011. Dynamics of mutant alleles in patients with advanced essential thrombocythemia (ET) or polycythemia (PV) during pegylated interferon-alfa-2A (PEG-IFN-{alpha}-2A; Pegasys) therapy. ASH Annual Meeting Abstracts 118(21):281.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 281
    • Quintas-Cardama, A.1    Abdel-Wahab, O.2    Levine, R.L.3
  • 33
    • 73949090770 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera
    • Quintas-Cardama A, Kantarjian H, et al. 2009. Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera. J Clin Oncol 27(32):5418-5424.
    • (2009) J Clin Oncol , vol.27 , Issue.32 , pp. 5418-5424
    • Quintas-Cardama, A.1    Kantarjian, H.2
  • 34
    • 77951491478 scopus 로고    scopus 로고
    • Recent advances on the immunomodulatory effects of IFN-alpha: Implications for cancer immunotherapy and autoimmunity
    • Rizza P, Moretti F, et al. 2010. Recent advances on the immunomodulatory effects of IFN-alpha: implications for cancer immunotherapy and autoimmunity. Autoimmunity 43(3):204-209.
    • (2010) Autoimmunity , vol.43 , Issue.3 , pp. 204-209
    • Rizza, P.1    Moretti, F.2
  • 35
    • 0029099045 scopus 로고
    • Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia
    • Sacchi S, Kantarjian H, et al. 1995. Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia. J Clin Oncol 13(9):2401-2407.
    • (1995) J Clin Oncol , vol.13 , Issue.9 , pp. 2401-2407
    • Sacchi, S.1    Kantarjian, H.2
  • 36
    • 33646470836 scopus 로고    scopus 로고
    • A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: Feasibility, clinical and biologic effects, and impact on quality of life
    • Samuelsson J, Hasselbalch H, et al. 2006. A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: feasibility, clinical and biologic effects, and impact on quality of life. Cancer 106(11):2397-2405.
    • (2006) Cancer , vol.106 , Issue.11 , pp. 2397-2405
    • Samuelsson, J.1    Hasselbalch, H.2
  • 37
    • 0023688229 scopus 로고
    • Recombinant interferon-alpha for treatment of polycythaemia vera
    • Silver RT. 1988. Recombinant interferon-alpha for treatment of polycythaemia vera. Lancet 2(8607):403.
    • (1988) Lancet , vol.2 , Issue.8607 , pp. 403
    • Silver, R.T.1
  • 38
    • 33746307253 scopus 로고    scopus 로고
    • Long-term effects of the treatment of polycythemia vera with recombinant interferon-alpha
    • Silver RT. 2006. Long-term effects of the treatment of polycythemia vera with recombinant interferon-alpha. Cancer 107(3): 451-458.
    • (2006) Cancer , vol.107 , Issue.3 , pp. 451-458
    • Silver, R.T.1
  • 39
    • 79959232873 scopus 로고    scopus 로고
    • Recombinant interferon-alpha may retard progression of early primary myelofibrosis: A preliminary report
    • Silver RT, Vandris K, et al. 2011. Recombinant interferon-alpha may retard progression of early primary myelofibrosis: a preliminary report. Blood 117(24):6669-6672.
    • (2011) Blood , vol.117 , Issue.24 , pp. 6669-6672
    • Silver, R.T.1    Vandris, K.2
  • 40
    • 0029997033 scopus 로고    scopus 로고
    • Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest
    • Tiefenbrun N, Melamed D, et al. 1996. Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. Mol Cell Biol 16(7):3934-3944.
    • (1996) Mol Cell Biol , vol.16 , Issue.7 , pp. 3934-3944
    • Tiefenbrun, N.1    Melamed, D.2
  • 41
    • 84872383163 scopus 로고    scopus 로고
    • Complete hematological, molecular and histological remissions without cytoreduct treatment lasting after pegylated-interferon {alpha}-2a (peg- IFN{alpha}-2a) therapy in polycythemia vera (PV): Long term results of a phase 2 trial
    • Turlure P, Cambier N, Roussel M. 2011. Complete hematological, molecular and histological remissions without cytoreduct treatment lasting after pegylated-interferon {alpha}-2a (peg- IFN{alpha}-2a) therapy in polycythemia vera (PV): long term results of a phase 2 trial. ASH Annual Meeting Abstracts 2011(118):280.
    • (2011) ASH Annual Meeting Abstracts , vol.2011 , Issue.118 , pp. 280
    • Turlure, P.1    Cambier, N.2    Roussel, M.3
  • 42
    • 51549092094 scopus 로고    scopus 로고
    • The impact of PEGylation on biological therapies
    • Veronese FM, Mero A. 2008. The impact of PEGylation on biological therapies. BioDrugs 22(5):315-329.
    • (2008) BioDrugs , vol.22 , Issue.5 , pp. 315-329
    • Veronese, F.M.1    Mero, A.2
  • 43
    • 0034665904 scopus 로고    scopus 로고
    • Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietininduced signaling through induction of SOCS-1
    • Wang Q, Miyakawa Y., et al. 2000. Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietininduced signaling through induction of SOCS-1. Blood 96(6):2093-2099.
    • (2000) Blood , vol.96 , Issue.6 , pp. 2093-2099
    • Wang, Q.1    Miyakawa, Y.2
  • 44
    • 0030785597 scopus 로고    scopus 로고
    • The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc
    • Weihua X, Lindner DJ, et al. 1997. The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. Proc Natl Acad Sci U S A 94(14):7227-7232.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.14 , pp. 7227-7232
    • Weihua, X.1    Lindner, D.J.2
  • 45
    • 0031962954 scopus 로고    scopus 로고
    • Effect of interferonalpha therapy on bone marrow fibrosis in chronic myelogenous leukemia
    • Wilhelm M, Bueso-Ramos C, et al. 1998. Effect of interferonalpha therapy on bone marrow fibrosis in chronic myelogenous leukemia. Leukemia 12(1):65-70.
    • (1998) Leukemia , vol.12 , Issue.1 , pp. 65-70
    • Wilhelm, M.1    Bueso-Ramos, C.2


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