CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors

Experimental Hematology

Volumn 27, Issue 8, 1999, Pages 1315-1321

  Platanias, Leonidas C ^a   Uddin, Shahab ^a   Bruno, Edward ^a   Korkmaz, Mete ^a   Ahmad, Sarfraz ^a   Alsayed, Yazan ^a   Van Den Berg, David ^a   Druker, Brian J ^b   Wickrema, Amittha ^a   Hoffman, Ronald ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Hematopoiesis; Interferons; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; ANTISENSE OLIGONUCLEOTIDE; RECOMBINANT INTERFERON;

ARTICLE; BURST FORMING UNIT E; CELL GROWTH; CELL PROLIFERATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; DAUDI CELL; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BURKITT LYMPHOMA; ERYTHROID PROGENITOR CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH INHIBITORS; HEMATOPOIESIS; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-GAMMA, RECOMBINANT; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CRK; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0032806841     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00060-0     Document Type: Article

References (31)

1. Petska S., Langer J.A., Zoon K.C., Samuel C.E. Interferons and their actions. Annu Rev Biochem. 56:1987;727.
2. Platanias L.C. Interferons. Laboratory to clinic investigations. Curr Opin Oncol. 7:1995;560.
3. Darnell J.E., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular proteins. Science. 264:1994;1415.
4. Uddin S., Yenush L., Sun X.-J., Sweet M.E., White M.F., Platanias L.C. Interferon α engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3′-kinase. J Biol Chem. 270:1995;15938.
5. Platanias L.C., Uddin S., Yetter A., Sun X.-J., White M.F. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate-2. J Biol Chem. 271:1996;278.
6. Uddin S., Fish E.N., Sher D., Gardziola C., White M.F., Platanias L.C. Activation of the phosphatidylinositol 3′-kinase serine kinase by interferon α J Immunol. 158:1997;2390.
7. Ahmad S., Alsayed Y., Druker B.J., Platanias L.C. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. J Biol Chem. 272:1997;29991.
8. Sawasdikosol S., Ravichandran K.S., Kay Lee K., Chang J.-H., Burakoff S.J. Crk interacts with tyrosine-phosphorylated p116 upon T cell activation. J Biol Chem. 270:1995;2893.
9. Reedquist K.A., Fukazawa T., Panchamoorthy G., Langdom W.Y., Shoelson S.E., Druker B.J., Band H. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine exchange protein C3G. J Biol Chem. 271:1996;8435.
10. Smit L., Van De Horst G., Borst J. Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and CrkL adaptors. J Biol Chem. 271:1996;8564.
11. Cook S., Rubinfeld B., Albert I., McCormick F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12:1993;3475.
12. Kitayama H., Sugimoto Y., Matsuzaki T., Ikawa Y., Noda M. A ras-related gene with transformation suppressor activity. Cell. 56:1989;77.
13. Kitayama H., Matsuzaki T., Ikawa Y., Noda M. Genetic analysis of the Kirsten-ras-revertant 1 gene. potentiation of its tumor suppressor activity by specific point mutations Proc Natl Acad Sci U S A. 87:1990;4284.
14. M' Rabet L., Coffer P., Zwartkruis F., Franke B., Segal A.W., Keonderman L., Bos L. Activation of the small GTPase rap1 in human neutrophils. Blood. 92:1998;2133.
15. Reedquist K.A., Bos J.L. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes. J Biol Chem. 273:1998;4494.
16. +-mediated activation of Rap1 in human platelets. EMBO J. 16:1997;252.
17. Yetter A., Uddin S., Krolewski J.J., Jiao H., Yi T., Platanias L.C. Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. J Biol Chem. 270:1995;18179.
18. Bruno E., Horrigan S.K., Van Den Berg D., Rozler E., Fitting P., Moss S.T., Westbrook C., Hoffman R. The smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-β on human hematopoiesis. Blood. 91:1998;1917.
19. Methia N., Louache F., Vainchenker W., Wendlig F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood. 82:1993;1395.
20. Brandt J., Srour E.F., van Besien K., Briddell R.A., Hoffman R. Cytokine-dependent long term culture of highly enriched precursors of hematopoietic progenitor cells from human marrow. J Clin Invest. 82:1988;1017.
21. Wickrema A., Krantz S.B., Winkelmann J.C., Bondurant M.C. Differentiation and erythropoietin gene expression in human erythroid progenitor cells. Blood. 80:1992;1940.
22. Jacobs-Helber S.M., Wickrema A., Lawson A., Sun Z., Sawyer S.T. AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells. Mol Cell Biol. 18:1998;3699.
23. Barber D.L., Mason J.M., Fukazawa T., Reedquist K.A., Druker B.J., Band H., D'Andrea A.D. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and its association with Crk adaptor proteins. Blood. 89:1997;3166.
24. Chin H., Saito T., Arai A., Yamamoto K., Kamiyama R., Miyasaka N., Miura O. Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2 and Cbl in hematopoietic cells. Biochem Biophys Res Commun. 239:1997;412.
25. CBL. J Biol Chem. 272:1997;10248.
26. Raefsky E.L., Platanias L.C., Zoumbos N.C., Young N.S. Studies of interferon as a regulator of hematopoiesis. J Immunol. 135:1985;2507.
27. Broxmeyer H.E., Lu L., Platzer E., Feit C., Juliano L., Rubin B.Y. Comparative analysis of the influence of human gamma, alpha, and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E), and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol. 131:1983;1300.
28. Uddin S., Fish E.N., Sher D., Gardziola C., Colamonici O.R., Kellum M., Pitha P.M., White M.F., Platanias L.C. The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon α receptors. Blood. 90:1997;2574.
29. Tanaka S., Morishita T., Hashimoto Y., Hattori S., Nakamura S., Shibua M., Matuoka K., Takenawa T., Kurata T., Nagashima K., Matsuda M. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci U S A. 91:1994;3443.
30. Fish E.N., Uddin S., Korkmaz M., Majchrzak B., Druker B.J., Platanias L.C. Activation of a CrkL-Stat5 signaling complex by Type I interferons. J Biol Chem. 274:1999;571.
31. Boussiotis V.A., Freeman G.J., Berezovskaya A., Barber D.L., Nadler L.M. Maintenance of human T cell anergy. Blocking of IL-2 gene transcription by activated Rap1. Science. 278:1997;124.