-
1
-
-
43649107045
-
Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes
-
Paz, M. L., González Maglio, D. H., Weill, F. S., Bustamante, J., and Leoni, J. (2008) Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes. Photodermatol. Photoimmunol. Photomed. 24, 115-122
-
(2008)
Photodermatol. Photoimmunol. Photomed.
, vol.24
, pp. 115-122
-
-
Paz, M.L.1
González Maglio, D.H.2
Weill, F.S.3
Bustamante, J.4
Leoni, J.5
-
3
-
-
33744455447
-
The role of mitochondria in ageing and carcinogenesis
-
Birch-Machin, M. A. (2006) The role of mitochondria in ageing and carcinogenesis. Clin. Exp. Dermatol. 31, 548-552
-
(2006)
Clin. Exp. Dermatol.
, vol.31
, pp. 548-552
-
-
Birch-Machin, M.A.1
-
4
-
-
84882876587
-
Stressed out mitochondria: The role of mitochondria in ageing and cancer focussing on strategies and opportunities in human skin
-
Tulah, A. S., and Birch-Machin, M. A. (2013) Stressed out mitochondria: the role of mitochondria in ageing and cancer focussing on strategies and opportunities in human skin. Mitochondrion 13, 444-453
-
(2013)
Mitochondrion
, vol.13
, pp. 444-453
-
-
Tulah, A.S.1
Birch-Machin, M.A.2
-
5
-
-
0036319021
-
Generation of reactive oxygen species by the mitochondrial electron transport chain
-
Liu, Y., Fiskum, G., and Schubert, D. (2002) Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80, 780-787
-
(2002)
J. Neurochem.
, vol.80
, pp. 780-787
-
-
Liu, Y.1
Fiskum, G.2
Schubert, D.3
-
6
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy, M. P. (2009) How mitochondria produce reactive oxygen species. Biochem. J. 417, 1-13
-
(2009)
Biochem. J.
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
7
-
-
77649179433
-
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
-
Tschopp, J., and Schroder, K. (2010) NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat. Rev. Immunol. 10, 210-215
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 210-215
-
-
Tschopp, J.1
Schroder, K.2
-
8
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., and Tschopp, J. (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
Pétrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
9
-
-
84881345531
-
Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum
-
Murphy, M. P. (2013) Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum. Cell Metab. 18, 145-146
-
(2013)
Cell Metab.
, vol.18
, pp. 145-146
-
-
Murphy, M.P.1
-
10
-
-
84916895128
-
Skin resistance to oxidative stress induced by resveratrol: From Nrf2 activation to GSH biosynthesis
-
Soeur, J., Eilstein, J., Léreaux, G., Jones, C., and Marrot, L. (2015) Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis. Free Radic. Biol. Med. 78, 213-223
-
(2015)
Free Radic. Biol. Med.
, vol.78
, pp. 213-223
-
-
Soeur, J.1
Eilstein, J.2
Léreaux, G.3
Jones, C.4
Marrot, L.5
-
11
-
-
83255164138
-
Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro
-
Demirovic, D., and Rattan, S. I. (2011) Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro. Biogerontology 12, 437-444
-
(2011)
Biogerontology
, vol.12
, pp. 437-444
-
-
Demirovic, D.1
Rattan, S.I.2
-
12
-
-
84860704002
-
Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases
-
Hegde, M. L., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S., and Szczesny, B. (2012) Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech. Ageing Dev. 133, 157-168
-
(2012)
Mech. Ageing Dev.
, vol.133
, pp. 157-168
-
-
Hegde, M.L.1
Mantha, A.K.2
Hazra, T.K.3
Bhakat, K.K.4
Mitra, S.5
Szczesny, B.6
-
13
-
-
79960311040
-
Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice
-
Hirota, A., Kawachi, Y., Yamamoto, M., Koga, T., Hamada, K., and Otsuka, F. (2011) Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice. Exp. Dermatol. 20, 664-668
-
(2011)
Exp. Dermatol.
, vol.20
, pp. 664-668
-
-
Hirota, A.1
Kawachi, Y.2
Yamamoto, M.3
Koga, T.4
Hamada, K.5
Otsuka, F.6
-
14
-
-
84902303333
-
Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
-
Gioscia-Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M.P., and Seals, D. R. (2014) Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J. Physiol. 592, 2549-2561
-
(2014)
J. Physiol.
, vol.592
, pp. 2549-2561
-
-
Gioscia-Ryan, R.A.1
LaRocca, T.J.2
Sindler, A.L.3
Zigler, M.C.4
Murphy, M.P.5
Seals, D.R.6
-
15
-
-
77955792985
-
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
-
Snow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., O'Sullivan, J. D., Fung, V., Smith, R. A., Murphy, M.P., and Taylor, K. M.; Protect Study Group. (2010) A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov. Disord. 25, 1670-1674
-
(2010)
Mov. Disord.
, vol.25
, pp. 1670-1674
-
-
Snow, B.J.1
Rolfe, F.L.2
Lockhart, M.M.3
Frampton, C.M.4
O'Sullivan, J.D.5
Fung, V.6
Smith, R.A.7
Murphy, M.P.8
Taylor, K.M.9
-
16
-
-
84925298301
-
Mitochondrial dysfunction and mitophagy in Parkinson's: From familial to sporadic disease
-
Ryan, B. J., Hoek, S., Fon, E. A., and Wade-Martins, R. (2015) Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends Biochem. Sci. 40, 200-210
-
(2015)
Trends Biochem. Sci.
, vol.40
, pp. 200-210
-
-
Ryan, B.J.1
Hoek, S.2
Fon, E.A.3
Wade-Martins, R.4
-
17
-
-
0035231595
-
Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues
-
Birch-Machin, M. A., and Turnbull, D. M. (2001) Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues. Methods Cell Biol. 65, 97-117
-
(2001)
Methods Cell Biol.
, vol.65
, pp. 97-117
-
-
Birch-Machin, M.A.1
Turnbull, D.M.2
-
18
-
-
0031409635
-
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
-
Kvam, E., and Tyrrell, R. M. (1997) Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation. Carcinogenesis 18, 2379-2384
-
(1997)
Carcinogenesis
, vol.18
, pp. 2379-2384
-
-
Kvam, E.1
Tyrrell, R.M.2
-
19
-
-
84255197177
-
DNA damage spectra induced by photosensitization
-
Epe, B. (2012) DNA damage spectra induced by photosensitization. Photochem. Photobiol. Sci. 11, 98-106
-
(2012)
Photochem. Photobiol. Sci.
, vol.11
, pp. 98-106
-
-
Epe, B.1
-
20
-
-
84896807477
-
Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue
-
Williams, J. D., Bermudez, Y., Park, S. L., Stratton, S. P., Uchida, K., Hurst, C. A., and Wondrak, G. T. (2014) Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue. J. Photochem. Photobiol. B 132, 56-65
-
(2014)
J. Photochem. Photobiol. B
, vol.132
, pp. 56-65
-
-
Williams, J.D.1
Bermudez, Y.2
Park, S.L.3
Stratton, S.P.4
Uchida, K.5
Hurst, C.A.6
Wondrak, G.T.7
-
21
-
-
84894518203
-
Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide
-
Oyewole, A. O., Wilmot, M.-C., Fowler, M., and Birch-Machin, M. A. (2014) Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide. FASEB J. 28, 485-494
-
(2014)
FASEB J.
, vol.28
, pp. 485-494
-
-
Oyewole, A.O.1
Wilmot, M.-C.2
Fowler, M.3
Birch-Machin, M.A.4
-
22
-
-
84856247297
-
Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells
-
Swalwell, H., Latimer, J., Haywood, R. M., and Birch-Machin, M. A. (2012) Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells. Free Radic. Biol. Med. 52, 626-634
-
(2012)
Free Radic. Biol. Med.
, vol.52
, pp. 626-634
-
-
Swalwell, H.1
Latimer, J.2
Haywood, R.M.3
Birch-Machin, M.A.4
-
23
-
-
80051472382
-
Ultraviolet-radiation induced skin inflammation: Dissecting the role of bioactive lipids
-
Nicolaou, A., Pilkington, S. M., and Rhodes, L. E. (2011) Ultraviolet-radiation induced skin inflammation: dissecting the role of bioactive lipids. Chem. Phys. Lipids 164, 535-543
-
(2011)
Chem. Phys. Lipids
, vol.164
, pp. 535-543
-
-
Nicolaou, A.1
Pilkington, S.M.2
Rhodes, L.E.3
-
24
-
-
80053909017
-
Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: The protective role of the Keap1/Nrf2/ ARE pathway
-
Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M., and Dinkova-Kostova, A. T. (2011) Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ ARE pathway. Cancer Prev. Res. (Phila.) 4, 1665-1674
-
(2011)
Cancer Prev. Res. (Phila.)
, vol.4
, pp. 1665-1674
-
-
Kalra, S.1
Zhang, Y.2
Knatko, E.V.3
Finlayson, S.4
Yamamoto, M.5
Dinkova-Kostova, A.T.6
-
25
-
-
58549105575
-
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
-
Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., Sporn, M. B., Gabrielson, K. L., Champion, H. C., Tuder, R. M., Kensler, T. W., and Biswal, S. (2009) Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc. Natl. Acad. Sci. USA 106, 250-255
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 250-255
-
-
Sussan, T.E.1
Rangasamy, T.2
Blake, D.J.3
Malhotra, D.4
El-Haddad, H.5
Bedja, D.6
Yates, M.S.7
Kombairaju, P.8
Yamamoto, M.9
Liby, K.T.10
Sporn, M.B.11
Gabrielson, K.L.12
Champion, H.C.13
Tuder, R.M.14
Kensler, T.W.15
Biswal, S.16
-
26
-
-
84872675316
-
The role of antioxidants in photoprotection: A critical review
-
Chen, L., Hu, J. Y., and Wang, S. Q. (2012) The role of antioxidants in photoprotection: a critical review. J. Am. Acad. Dermatol. 67, 1013-1024
-
(2012)
J. Am. Acad. Dermatol.
, vol.67
, pp. 1013-1024
-
-
Chen, L.1
Hu, J.Y.2
Wang, S.Q.3
-
27
-
-
79951657203
-
Antioxidants add protection to a broad-spectrum sunscreen
-
Wu, Y., Matsui, M. S., Chen, J. Z. S., Jin, X., Shu, C. M., Jin, G. Y., Dong, G. H., Wang, Y. K., Gao, X. H., Chen, H. D., and Li, Y. H. (2011) Antioxidants add protection to a broad-spectrum sunscreen. Clin. Exp. Dermatol. 36, 178-187
-
(2011)
Clin. Exp. Dermatol.
, vol.36
, pp. 178-187
-
-
Wu, Y.1
Matsui, M.S.2
Chen, J.Z.S.3
Jin, X.4
Shu, C.M.5
Jin, G.Y.6
Dong, G.H.7
Wang, Y.K.8
Gao, X.H.9
Chen, H.D.10
Li, Y.H.11
-
28
-
-
84892146466
-
Antioxidants and skin: An overview
-
Wageningen Academic Publishers, Wageningen, The Netherlands
-
Wu, Y., Chen, H. D., Li, Y. H., Gao, X. H., Preedy, V. R., and Preedy, V. R. (2012) Antioxidants and skin: an overview. In Handbook of Diet, Nutrition and the Skin, Vol. 2. pp. 68-90, Wageningen Academic Publishers, Wageningen, The Netherlands
-
(2012)
Handbook of Diet, Nutrition and the Skin
, vol.2
, pp. 68-90
-
-
Wu, Y.1
Chen, H.D.2
Li, Y.H.3
Gao, X.H.4
Preedy, V.R.5
Preedy, V.R.6
-
29
-
-
77956520830
-
Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion
-
Malhomme de la Roche, H., Seagrove, S., Mehta, A., Divekar, P., Campbell, S., and Curnow, A. (2010) Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: an investigation of human green tea ingestion. J. Photochem. Photobiol. B 101, 169-173
-
(2010)
J. Photochem. Photobiol. B
, vol.101
, pp. 169-173
-
-
Malhomme De La Roche, H.1
Seagrove, S.2
Mehta, A.3
Divekar, P.4
Campbell, S.5
Curnow, A.6
-
30
-
-
0035254601
-
Adaptive antioxidant response protects dermal fibroblasts from UVA-induced phototoxicity
-
Meewes, C., Brenneisen, P., Wenk, J., Kuhr, L., Ma, W., Alikoski, J., Poswig, A., Krieg, T., and Scharffetter-Kochanek, K. (2001) Adaptive antioxidant response protects dermal fibroblasts from UVA-induced phototoxicity. Free Radic. Biol. Med. 30, 238-247
-
(2001)
Free Radic. Biol. Med.
, vol.30
, pp. 238-247
-
-
Meewes, C.1
Brenneisen, P.2
Wenk, J.3
Kuhr, L.4
Ma, W.5
Alikoski, J.6
Poswig, A.7
Krieg, T.8
Scharffetter-Kochanek, K.9
-
31
-
-
0028036392
-
Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin
-
Shindo, Y., Witt, E., Han, D., Epstein, W., and Packer, L. (1994) Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J. Invest. Dermatol. 102, 122-124
-
(1994)
J. Invest. Dermatol.
, vol.102
, pp. 122-124
-
-
Shindo, Y.1
Witt, E.2
Han, D.3
Epstein, W.4
Packer, L.5
-
32
-
-
84860530952
-
Nrf2 links epidermal barrier function with antioxidant defense
-
Schäfer, M., Farwanah, H., Willrodt, A.-H., Huebner, A. J., Sandhoff, K., Roop, D., Hohl, D., Bloch, W., and Werner, S. (2012) Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol. Med. 4, 364-379
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 364-379
-
-
Schäfer, M.1
Farwanah, H.2
Willrodt, A.-H.3
Huebner, A.J.4
Sandhoff, K.5
Roop, D.6
Hohl, D.7
Bloch, W.8
Werner, S.9
-
33
-
-
84863825248
-
Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents
-
Magesh, S., Chen, Y., and Hu, L. (2012) Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med. Res. Rev. 32, 687-726
-
(2012)
Med. Res. Rev.
, vol.32
, pp. 687-726
-
-
Magesh, S.1
Chen, Y.2
Hu, L.3
-
34
-
-
77953741269
-
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
-
Ungvari, Z., Bagi, Z., Feher, A., Recchia, F. A., Sonntag, W. E., Pearson, K., de Cabo, R., and Csiszar, A. (2010) Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am. J. Physiol. Heart Circ. Physiol. 299, H18-H24
-
(2010)
Am. J. Physiol. Heart Circ. Physiol.
, vol.299
, pp. H18-H24
-
-
Ungvari, Z.1
Bagi, Z.2
Feher, A.3
Recchia, F.A.4
Sonntag, W.E.5
Pearson, K.6
De Cabo, R.7
Csiszar, A.8
-
35
-
-
84865502968
-
Flavonoids as antioxidants in plants: Location and functional significance
-
Agati, G., Azzarello, E., Pollastri, S., and Tattini, M. (2012) Flavonoids as antioxidants in plants: location and functional significance. Plant Sci. 196,67-76
-
(2012)
Plant Sci.
, vol.196
, pp. 67-76
-
-
Agati, G.1
Azzarello, E.2
Pollastri, S.3
Tattini, M.4
-
36
-
-
0022899335
-
The antioxidant role of vitamin C
-
Bendich, A., Machlin, L. J., Scandurra, O., Burton, G. W., and Wayner, D. D. M. (1986) The antioxidant role of vitamin C. Adv. Free Radic. Biol. Med. 2, 419-444
-
(1986)
Adv. Free Radic. Biol. Med.
, vol.2
, pp. 419-444
-
-
Bendich, A.1
Machlin, L.J.2
Scandurra, O.3
Burton, G.W.4
Wayner, D.D.M.5
-
37
-
-
78650478990
-
Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: A randomized controlled trial
-
Rizwan, M., Rodriguez-Blanco, I., Harbottle, A., Birch-Machin, M. A., Watson, R. E. B., and Rhodes, L. E. (2011) Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. Br. J. Dermatol. 164, 154-162
-
(2011)
Br. J. Dermatol.
, vol.164
, pp. 154-162
-
-
Rizwan, M.1
Rodriguez-Blanco, I.2
Harbottle, A.3
Birch-Machin, M.A.4
Watson, R.E.B.5
Rhodes, L.E.6
-
38
-
-
84928164175
-
Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices
-
Genrikhs, E. E., Stelmashook, E. V., Popova, O. V., Kapay, N. A., Korshunova, G. A., Sumbatyan, N. V., Skrebitsky, V. G., Skulachev, V. P., and Isaev, N. K. (2015) Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices. J. Drug Target. 23, 347-352
-
(2015)
J. Drug Target
, vol.23
, pp. 347-352
-
-
Genrikhs, E.E.1
Stelmashook, E.V.2
Popova, O.V.3
Kapay, N.A.4
Korshunova, G.A.5
Sumbatyan, N.V.6
Skrebitsky, V.G.7
Skulachev, V.P.8
Isaev, N.K.9
-
39
-
-
0348136710
-
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
-
Jauslin, M. L., Meier, T., Smith, R. A., and Murphy, M. P. (2003) Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J. 17, 1972-1974
-
(2003)
FASEB J.
, vol.17
, pp. 1972-1974
-
-
Jauslin, M.L.1
Meier, T.2
Smith, R.A.3
Murphy, M.P.4
-
40
-
-
79952144564
-
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
-
Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., Porteous, C. M., Smith, R. A., Saeed, S., Carré, J. E., Singer, M., Gems, D., Hartley, R. C., Partridge, L., and Murphy, M. P. (2011) Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab. 13, 340-350
-
(2011)
Cell Metab.
, vol.13
, pp. 340-350
-
-
Cochemé, H.M.1
Quin, C.2
McQuaker, S.J.3
Cabreiro, F.4
Logan, A.5
Prime, T.A.6
Abakumova, I.7
Patel, J.V.8
Fearnley, I.M.9
James, A.M.10
Porteous, C.M.11
Smith, R.A.12
Saeed, S.13
Carré, J.E.14
Singer, M.15
Gems, D.16
Hartley, R.C.17
Partridge, L.18
Murphy, M.P.19
-
41
-
-
20444392739
-
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools
-
James, A. M., Cochemé, H. M., Smith, R. A. J., and Murphy, M. P. (2005) Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J. Biol. Chem. 280, 21295-21312
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21295-21312
-
-
James, A.M.1
Cochemé, H.M.2
Smith, R.A.J.3
Murphy, M.P.4
-
42
-
-
0035895888
-
Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties
-
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., and Murphy, M. P. (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J. Biol. Chem. 276, 4588-4596
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4588-4596
-
-
Kelso, G.F.1
Porteous, C.M.2
Coulter, C.V.3
Hughes, G.4
Porteous, W.K.5
Ledgerwood, E.C.6
Smith, R.A.J.7
Murphy, M.P.8
-
43
-
-
84881048250
-
Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines
-
Dashdorj, A., Jyothi, K. R., Lim, S., Jo, A., Nguyen, M. N., Ha, J., Yoon, K.-S., Kim, H. J., Park, J.-H., Murphy, M. P., and Kim, S. S. (2013) Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. BMC Med. 11, 178
-
(2013)
BMC Med.
, vol.11
, pp. 178
-
-
Dashdorj, A.1
Jyothi, K.R.2
Lim, S.3
Jo, A.4
Nguyen, M.N.5
Ha, J.6
Yoon, K.-S.7
Kim, H.J.8
Park, J.-H.9
Murphy, M.P.10
Kim, S.S.11
-
44
-
-
70349627246
-
MitoQ administration prevents endotoxin-induced cardiac dysfunction
-
Supinski, G. S., Murphy, M. P., and Callahan, L. A. (2009) MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R1095-R1102
-
(2009)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.297
, pp. R1095-R1102
-
-
Supinski, G.S.1
Murphy, M.P.2
Callahan, L.A.3
-
45
-
-
77956496245
-
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients
-
Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., and Murphy, M. P. (2010) The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int. 30, 1019-1026
-
(2010)
Liver Int.
, vol.30
, pp. 1019-1026
-
-
Gane, E.J.1
Weilert, F.2
Orr, D.W.3
Keogh, G.F.4
Gibson, M.5
Lockhart, M.M.6
Frampton, C.M.7
Taylor, K.M.8
Smith, R.A.J.9
Murphy, M.P.10
-
46
-
-
68549112975
-
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy
-
Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A., Cochemé, H. M., Murphy, M. P., and Dominiczak, A. F. (2009) Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension 54, 322-328
-
(2009)
Hypertension
, vol.54
, pp. 322-328
-
-
Graham, D.1
Huynh, N.N.2
Hamilton, C.A.3
Beattie, E.4
Smith, R.A.5
Cochemé, H.M.6
Murphy, M.P.7
Dominiczak, A.F.8
-
47
-
-
0041419866
-
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
-
Saretzki, G., Murphy, M. P., and von Zglinicki, T. (2003) MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2, 141-143
-
(2003)
Aging Cell
, vol.2
, pp. 141-143
-
-
Saretzki, G.1
Murphy, M.P.2
Von Zglinicki, T.3
-
48
-
-
34447558681
-
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases
-
James, A. M., Sharpley, M. S., Manas, A. R., Frerman, F. E., Hirst, J., Smith, R. A., and Murphy, M. P. (2007) Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J. Biol. Chem. 282, 14708-14718
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14708-14718
-
-
James, A.M.1
Sharpley, M.S.2
Manas, A.R.3
Frerman, F.E.4
Hirst, J.5
Smith, R.A.6
Murphy, M.P.7
-
49
-
-
56049120778
-
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis
-
Lowes, D. A., Thottakam, B. M., Webster, N. R., Murphy, M. P., and Galley, H. F. (2008) The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic. Biol. Med. 45, 1559-1565
-
(2008)
Free Radic. Biol. Med.
, vol.45
, pp. 1559-1565
-
-
Lowes, D.A.1
Thottakam, B.M.2
Webster, N.R.3
Murphy, M.P.4
Galley, H.F.5
-
50
-
-
23444451267
-
Intracellular generation of reactive oxygen species by contracting skeletal muscle cells
-
McArdle, F., Pattwell, D. M., Vasilaki, A., McArdle, A., and Jackson, M. J. (2005) Intracellular generation of reactive oxygen species by contracting skeletal muscle cells. Free Radic. Biol. Med. 39, 651-657
-
(2005)
Free Radic. Biol. Med.
, vol.39
, pp. 651-657
-
-
McArdle, F.1
Pattwell, D.M.2
Vasilaki, A.3
McArdle, A.4
Jackson, M.J.5
-
51
-
-
0032804054
-
Extracellular calcium modulates generation of reactive oxygen species by the contracting diaphragm
-
Supinski, G., Nethery, D., Stofan, D., and DiMarco, A. (1999) Extracellular calcium modulates generation of reactive oxygen species by the contracting diaphragm. J. Appl. Physiol. 87, 2177-2185
-
(1999)
J. Appl. Physiol.
, vol.87
, pp. 2177-2185
-
-
Supinski, G.1
Nethery, D.2
Stofan, D.3
DiMarco, A.4
-
52
-
-
84865142044
-
Tiron protects against UVB-induced senescence-like characteristics in human dermal fibroblasts by the inhibition of superoxide anion production and glutathione depletion
-
Fang, Y., Hu, X.-H., Jia, Z.-G., Xu, M.-H., Guo, Z.-Y., and Gao, F.-H. (2012) Tiron protects against UVB-induced senescence-like characteristics in human dermal fibroblasts by the inhibition of superoxide anion production and glutathione depletion. Australas. J. Dermatol. 53, 172-180
-
(2012)
Australas. J. Dermatol.
, vol.53
, pp. 172-180
-
-
Fang, Y.1
Hu, X.-H.2
Jia, Z.-G.3
Xu, M.-H.4
Guo, Z.-Y.5
Gao, F.-H.6
-
53
-
-
0026576564
-
The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage
-
Krishna, C. M., Liebmann, J. E., Kaufman, D., DeGraff, W., Hahn, S. M., McMurry, T., Mitchell, J. B., and Russo, A. (1992) The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch. Biochem. Biophys. 294, 98-106
-
(1992)
Arch. Biochem. Biophys.
, vol.294
, pp. 98-106
-
-
Krishna, C.M.1
Liebmann, J.E.2
Kaufman, D.3
DeGraff, W.4
Hahn, S.M.5
McMurry, T.6
Mitchell, J.B.7
Russo, A.8
-
54
-
-
0142075358
-
Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions
-
Silveira, L. R., Pereira-Da-Silva, L., Juel, C., and Hellsten, Y. (2003) Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions. Free Radic. Biol. Med. 35, 455-464
-
(2003)
Free Radic. Biol. Med.
, vol.35
, pp. 455-464
-
-
Silveira, L.R.1
Pereira-Da-Silva, L.2
Juel, C.3
Hellsten, Y.4
-
55
-
-
70349464469
-
Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures
-
Cantu, D., Schaack, J., and Patel, M. (2009) Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures. PLoS One 4, e7095
-
(2009)
PLoS One
, vol.4
, pp. e7095
-
-
Cantu, D.1
Schaack, J.2
Patel, M.3
-
56
-
-
0034592848
-
Inactivation of iron responsive element-binding capacity and aconitase function of iron regulatory protein-1 of skin cells by ultraviolet A
-
Giordani, A., Martin, M.-E., Beaumont, C., Santus, R., and Morlière, P. (2000) Inactivation of iron responsive element-binding capacity and aconitase function of iron regulatory protein-1 of skin cells by ultraviolet A. Photochem. Photobiol. 72, 746-752
-
(2000)
Photochem. Photobiol.
, vol.72
, pp. 746-752
-
-
Giordani, A.1
Martin, M.-E.2
Beaumont, C.3
Santus, R.4
Morlière, P.5
-
57
-
-
39049114182
-
Intracellular labile iron
-
Breuer, W., Shvartsman, M., and Cabantchik, Z. I. (2008) Intracellular labile iron. Int. J. Biochem. Cell Biol. 40, 350-354
-
(2008)
Int. J. Biochem. Cell Biol.
, vol.40
, pp. 350-354
-
-
Breuer, W.1
Shvartsman, M.2
Cabantchik, Z.I.3
-
58
-
-
17144378216
-
Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis
-
Rouault, T. A., and Tong, W.-H. (2005) Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat. Rev. Mol. Cell Biol. 6, 345-351
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 345-351
-
-
Rouault, T.A.1
Tong, W.-H.2
-
59
-
-
84941008828
-
Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons
-
E-pub ahead of print
-
Thomsen, M. S., Andersen, M. V., Christoffersen, P. R., Jensen, M. D., Lichota, J., and Moos, T. (2015) Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. [E-pub ahead of print] Neurobiol. Dis. 10.1016/j.nbd.2015.03.013
-
(2015)
Neurobiol. Dis.
-
-
Thomsen, M.S.1
Andersen, M.V.2
Christoffersen, P.R.3
Jensen, M.D.4
Lichota, J.5
Moos, T.6
-
60
-
-
84923070858
-
Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders
-
Mena, N. P., Urrutia, P. J., Lourido, F., Carrasco, C. M., and Núñez, M. T. (2015) Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders. Mitochondrion 21, 92-105
-
(2015)
Mitochondrion
, vol.21
, pp. 92-105
-
-
Mena, N.P.1
Urrutia, P.J.2
Lourido, F.3
Carrasco, C.M.4
Núñez, M.T.5
-
61
-
-
84937118633
-
Possible involvement of iron-induced oxidative insults in neurodegeneration
-
Asano, T., Koike, M., Sakata, S., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, H., Uchiyama, Y., Hattori, N., and Iwai, K. (2015) Possible involvement of iron-induced oxidative insults in neurodegeneration. Neurosci. Lett. 588, 29-35
-
(2015)
Neurosci. Lett.
, vol.588
, pp. 29-35
-
-
Asano, T.1
Koike, M.2
Sakata, S.3
Takeda, Y.4
Nakagawa, T.5
Hatano, T.6
Ohashi, S.7
Funayama, M.8
Yoshimi, K.9
Asanuma, M.10
Toyokuni, S.11
Mochizuki, H.12
Uchiyama, Y.13
Hattori, N.14
Iwai, K.15
-
62
-
-
84255160826
-
Iron, oxidative stress and the example of solar ultraviolet A radiation
-
Aroun, A., Zhong, J. L., Tyrrell, R. M., and Pourzand, C. (2012) Iron, oxidative stress and the example of solar ultraviolet A radiation. Photochem. Photobiol. Sci. 11, 118-134
-
(2012)
Photochem. Photobiol. Sci.
, vol.11
, pp. 118-134
-
-
Aroun, A.1
Zhong, J.L.2
Tyrrell, R.M.3
Pourzand, C.4
-
63
-
-
56149121299
-
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury
-
Uchiyama, A., Kim, J.-S., Kon, K., Jaeschke, H., Ikejima, K., Watanabe, S., and Lemasters, J. J. (2008) Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology 48, 1644-1654
-
(2008)
Hepatology
, vol.48
, pp. 1644-1654
-
-
Uchiyama, A.1
Kim, J.-S.2
Kon, K.3
Jaeschke, H.4
Ikejima, K.5
Watanabe, S.6
Lemasters, J.J.7
-
64
-
-
0344154421
-
Labile iron pool: The main determinant of cellular response to oxidative stress
-
Kruszewski, M. (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat. Res. 531, 81-92
-
(2003)
Mutat. Res.
, vol.531
, pp. 81-92
-
-
Kruszewski, M.1
-
65
-
-
84925511536
-
Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone
-
Maher, P., and Kontoghiorghes, G. J. (2015) Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone. Neurochem. Res. 40, 609-620
-
(2015)
Neurochem. Res.
, vol.40
, pp. 609-620
-
-
Maher, P.1
Kontoghiorghes, G.J.2
-
66
-
-
47249094614
-
Maturation of iron-sulfur proteins in eukaryotes: Mechanisms, connected processes, and diseases
-
Lill, R., and Mühlenhoff, U. (2008) Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases. Annu. Rev. Biochem. 77, 669-700
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 669-700
-
-
Lill, R.1
Mühlenhoff, U.2
-
67
-
-
9444269879
-
Influence of oral antioxidants on ultraviolet radiation-induced skin damage in humans
-
Swindells, K., and Rhodes, L. E. (2004) Influence of oral antioxidants on ultraviolet radiation-induced skin damage in humans. Photodermatol. Photoimmunol. Photomed. 20, 297-304
-
(2004)
Photodermatol. Photoimmunol. Photomed.
, vol.20
, pp. 297-304
-
-
Swindells, K.1
Rhodes, L.E.2
-
68
-
-
84856220825
-
Strategies to target mitochondria and oxidative stress by antioxidants: Key points and perspectives
-
Edeas, M. (2011) Strategies to target mitochondria and oxidative stress by antioxidants: key points and perspectives. Pharm. Res. 28, 2771-2779
-
(2011)
Pharm. Res.
, vol.28
, pp. 2771-2779
-
-
Edeas, M.1
-
69
-
-
4344691399
-
A review of the epidemiological evidence for the 'antioxidant hypothesis'
-
Stanner, S. A., Hughes, J., Kelly, C. N. M., and Buttriss, J. (2004) A review of the epidemiological evidence for the 'antioxidant hypothesis'. Public Health Nutr. 7, 407-422
-
(2004)
Public Health Nutr.
, vol.7
, pp. 407-422
-
-
Stanner, S.A.1
Hughes, J.2
Kelly, C.N.M.3
Buttriss, J.4
-
70
-
-
84892368437
-
Antioxidants as therapies: Can we improve on nature?
-
Murphy, M. P. (2014) Antioxidants as therapies: can we improve on nature? Free Radic. Biol. Med. 66, 20-23
-
(2014)
Free Radic. Biol. Med.
, vol.66
, pp. 20-23
-
-
Murphy, M.P.1
|