Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices

Journal of Drug Targeting

Volumn 23, Issue 4, 2015, Pages 347-352

  Genrikhs, Elisaveta E ^a,b   Stelmashook, Elena V ^a,b   Popova, Olga V ^a,b   Kapay, Nadezhda A ^a,b   Korshunova, Galina A ^b   Sumbatyan, Natalya V ^b   Skrebitsky, Vladimir G ^a   Skulachev, Vladimir P ^b   Isaev, Nickolay K ^a,b  

^a RESEARCH CENTER OF NEUROLOGY   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Amyloid beta; C12TPP; Hippocampus; Neuroprotection; SkQT1; SkQTR1; Thymoquinone

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; DODECYLTRIPHENYLPHOSPHONIUM; NEUROPROTECTIVE AGENT; PHOSPHINE DERIVATIVE; RHODAMINE; RHODAMINE 19; SKQT1; SKQTR1; THYMOQUINONE; UNCLASSIFIED DRUG; 10-(P-TOLUQUINONYL)DECYLTRIPHENYLPHOSPHONIUM; AMYLOID BETA-PROTEIN (1-42); BENZOQUINONE DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG STRUCTURE; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MALE; MEMORY; MITOCHONDRION; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX; TRAUMATIC BRAIN INJURY; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HIPPOCAMPAL CA1 REGION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; WISTAR RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BENZOQUINONES; CA1 REGION, HIPPOCAMPAL; DISEASE MODELS, ANIMAL; INJECTIONS, INTRAPERITONEAL; LONG-TERM POTENTIATION; MALE; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR;

EID: 84928164175     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2014.997736     Document Type: Article

References (30)

1. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res 2000;14:323-8.
2. Abdel-Zaher AO, Mostafa MG, Farghly HM, et al. Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by thymoquinone attenuates the development of morphine tolerance and dependence in mice. Eur J Pharmacol 2013; 702:62-70.
3. Alhebshi AH, Gotoh M, Suzuki I. Thymoquinone protects cultured rat primary neurons against amyloid b-induced neurotoxicity. Biochem Biophys Res Commun 2013;433:362-7.
4. Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 1998;95: 23-9.
5. Houghton PJ, Zarka R, de las Heras B, et al. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995;61: 33-6.
6. Hosseinzadeh H, Parvardeh S, Asl MN, et al. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 2007;14:621-7.
7. Khan A, Vaibhav K, Javed H, et al. Attenuation of Ab-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Mol Cell Biochem 2012;369: 55-65.
8. Kapay NA, Isaev NK, Stelmashook EV, et al. In vivo injected mitochondria-targeted plastoquinone antioxidant SkQR1 prevents b-amyloid-induced decay of long-term potentiation in rat hippocampal slices. Biochemistry (Mosc) 2011;76: 1367-70.
9. Kapay NA, Popova OV, Isaev NK, et al. Mitochondria-targeted plastoquinone antioxidant SkQ1 prevents amyloid-b-induced impairment of long-term potentiation in rat hippocampal slices. J Alzheimer's Dis 2013;36:377-83.
10. Isaev NK, Novikova SV, Stelmashook EV, et al. Mitochondriatargeted plastoquinone antioxidant SkQR1 decreases traumainduced neurological deficit in rat. Biochemistry (Mosc) 2012;77: 996-9.
11. Silachev DN, Isaev NK, Pevzner IB, et al. The mitochondriatargeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk. PLoS One 2012; 7:e51553.
12. Severina II, Severin FF, Korshunova GA, et al. In search of novel highly active mitochondria-targeted antioxidants: thymoquinone and its cationic derivatives. FEBS Lett 2013;587: 2018-24.
13. Feeney DM, Boyeson MG, Linn RT, et al. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 1981;211:67-77.
14. Hicks SP, D'Amato CJ. Locating corticospinal neurons by retrograde axonal transport of horseradish peroxidase. Exp Neurol 1977; 56:410-20.
15. De Ryck M, Van Reempts J, Borgers M, et al. Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 1989;20:1383-90.
16. Jolkkonen J, Puurunen K, Rantakumi S, et al. Behavioral effects of the alpha(2)-adrenoceptor antagonist, atipamezole, after focal cerebral ischemia in rats. Eur J Pharmacol 2000;400: 211-19.
17. Bakeeva LE, Barskov IV, Egorov MV, et al. Mitochondriatargeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS-and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke). Biochemistry (Moscow) 2008;73: 1288-99.
18. Plotnikov EY, Silachev DN, Chupyrkina AA, et al. Newgeneration Skulachev ions exhibiting nephroprotective and neuroprotective properties. Biochemistry (Moscow) 2010;75: 145-50.
19. Skulachev MV, Antonenko YN, Anisimov VN, et al. Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies. Curr Drug Targets 2011; 12:800-26.
20. Skulachev VP, Anisimov VN, Antonenko YN, et al. An attempt to prevent senescence: a mitochondrial approach. Biochim Biophys Acta 2009;1787:437-61.
21. Slemmer JE, Shacka JJ, Sweeney MI, et al. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 2009;15:404-14.
22. Abrahamson EE, Ikonomovic MD, Dixon CE, et al. Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. Ann Neurol 2009;66:407-14.
23. Schmitt K, Grimm A, Kazmierczak A, et al. Insights into mitochondrial dysfunction: aging, amyloid-b, and tau-A deleterious trio. Antioxid Redox Signal 2012;16:1456-66.
24. Chakrabarti S, Munshi S, Banerjee K, et al. Mitochondrial dysfunction during brain aging: role of oxidative stress and modulation by antioxidant supplementation. Aging Dis 2011;2: 242-56.
25. Reddy PH, Reddy TP. Mitochondria as a therapeutic target for aging and neurodegenerative diseases. Curr Alzheimer Res 2011;8: 393-409.
26. Skulachev VP. Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases. J Alzheimers Dis 2012;28:283-9.
27. Skulachev VP, Isaev NK, Kapay NA, et al. Mitochondria-targeted antioxidants and alzheimer's disease. In: Preedy VR, ed. Aging: oxidative stress and dietary antioxidants. London, UK: Academic Press/Elsevier 2014:195-201.
28. Malenka RC, Nicoll RA. Long-term potentiation-a decade of progress? Science 1999;285:1870-4.
29. Ma T, Hoeffer CA, Wong H, et al. Amyloid betainduced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci 2011;31: 5589-95.
30. McManus MJ, Murphy MP, Franklin JL. The mitochondriatargeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci 2011;31: 15703-15.