Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: The protective role of the Keap1/Nrf2/ARE pathway

Cancer Prevention Research

Volumn 4, Issue 10, 2011, Pages 1665-1674

  Kalra, Sukirti ^a   Zhang, Ying ^a   Knatko, Elena V ^a   Finlayson, Stewart ^a   Yamamoto, Masayuki ^b   Dinkova Kostova, Albena T ^a,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; DNA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; SULFORAPHANE; TIOGUANINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SKIN; ULTRAVIOLET RADIATION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADMINISTRATION, ORAL; ANIMALS; AZATHIOPRINE; CELLS, CULTURED; CYTOPROTECTION; CYTOSKELETAL PROTEINS; DNA; DNA DAMAGE; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SKIN; THIOGUANINE; ULTRAVIOLET RAYS;

EID: 80053909017     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-11-0137     Document Type: Article

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