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Volumn 21, Issue 2, 2016, Pages 199-211

The fibrosis-cell death axis in heart failure

Author keywords

Cardiomyocyte; Cell death; Fibroblast; Fibrosis; Heart failure; Hypertrophy; Myofibroblast; TGF

Indexed keywords

C REACTIVE PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DISCOIDIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA; MYELOPEROXIDASE; OXYGEN; REACTIVE OXYGEN METABOLITE; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84959333658     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-016-9536-9     Document Type: Article
Times cited : (217)

References (138)
  • 1
    • 84922287672 scopus 로고    scopus 로고
    • Extracellular matrix assembly: a multiscale deconstruction
    • Mouw JK, Ou G, Weaver VM (2014) Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol 12:771–785
    • (2014) Nat Rev Mol Cell Biol , vol.12 , pp. 771-785
    • Mouw, J.K.1    Ou, G.2    Weaver, V.M.3
  • 2
    • 84922333220 scopus 로고    scopus 로고
    • Remodelling the extracellular matrix in development and disease
    • Bonnans C, Chou J, Werb Z (2014) Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol 12:786–801
    • (2014) Nat Rev Mol Cell Biol , vol.12 , pp. 786-801
    • Bonnans, C.1    Chou, J.2    Werb, Z.3
  • 3
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis: a common pathway to organ injury and failure
    • Rockey DC, Bell PD, Hill JA (2015) Fibrosis: a common pathway to organ injury and failure. N Engl J Med 12:1138–1149
    • (2015) N Engl J Med , vol.12 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 4
    • 84864477617 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
    • McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA et al (2012) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 8:803–869
    • (2012) Eur J Heart Fail , vol.8 , pp. 803-869
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3    Auricchio, A.4    Bohm, M.5    Dickstein, K.6    Falk, V.7    Filippatos, G.8    Fonseca, C.9    Gomez-Sanchez, M.A.10
  • 5
    • 84884294190 scopus 로고    scopus 로고
    • 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL et al (2013) 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 16:e147–e239
    • (2013) J Am Coll Cardiol , vol.16 , pp. e147-e239
    • Yancy, C.W.1    Jessup, M.2    Bozkurt, B.3    Butler, J.4    Casey, D.E.5    Drazner, M.H.6    Fonarow, G.C.7    Geraci, S.A.8    Horwich, T.9    Januzzi, J.L.10
  • 6
    • 34548184904 scopus 로고    scopus 로고
    • Clinical epidemiology of heart failure
    • Mosterd A, Hoes AW (2007) Clinical epidemiology of heart failure. Heart 9:1137–1146
    • (2007) Heart , vol.9 , pp. 1137-1146
    • Mosterd, A.1    Hoes, A.W.2
  • 7
    • 0027164801 scopus 로고
    • Ventricular remodelling: consequences and therapy
    • PID: 8365425
    • Sabbah HN, Goldstein S (1993) Ventricular remodelling: consequences and therapy. Eur Heart J 14:24–29
    • (1993) Eur Heart J , vol.14 , pp. 24-29
    • Sabbah, H.N.1    Goldstein, S.2
  • 9
    • 78650121847 scopus 로고    scopus 로고
    • Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
    • Bernardo BC, Weeks KL, Pretorius L, McMullen JR (2010) Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther 1:191–227
    • (2010) Pharmacol Ther , vol.1 , pp. 191-227
    • Bernardo, B.C.1    Weeks, K.L.2    Pretorius, L.3    McMullen, J.R.4
  • 10
    • 79955161098 scopus 로고    scopus 로고
    • The athlete’s heart vs. the failing heart: can signaling explain the two distinct outcomes?
    • Weeks KL, McMullen JR (2011) The athlete’s heart vs. the failing heart: can signaling explain the two distinct outcomes? Physiology (Bethesda) 2:97–105
    • (2011) Physiology (Bethesda) , vol.2 , pp. 97-105
    • Weeks, K.L.1    McMullen, J.R.2
  • 11
    • 84871518109 scopus 로고    scopus 로고
    • Molecular basis of physiological heart growth: fundamental concepts and new players
    • Maillet M, van Berlo JH, Molkentin JD (2013) Molecular basis of physiological heart growth: fundamental concepts and new players. Nat Rev Mol Cell Biol 1:38–48
    • (2013) Nat Rev Mol Cell Biol , vol.1 , pp. 38-48
    • Maillet, M.1    van Berlo, J.H.2    Molkentin, J.D.3
  • 12
    • 11144354044 scopus 로고    scopus 로고
    • The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron microscopy and amino acid analysis reveals low degree of reverse remodeling
    • Milting H, Jacob M, Kassner A, Heimann P, Mannherz HG, Becker G, Meyer HE, Bothig D, Arusoglu L, Morshuis M et al (2004) The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron microscopy and amino acid analysis reveals low degree of reverse remodeling. J Heart Lung Transplant 4:396–404
    • (2004) J Heart Lung Transplant , vol.4 , pp. 396-404
    • Milting, H.1    Jacob, M.2    Kassner, A.3    Heimann, P.4    Mannherz, H.G.5    Becker, G.6    Meyer, H.E.7    Bothig, D.8    Arusoglu, L.9    Morshuis, M.10
  • 13
    • 84873344021 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
    • Zeisberg M, Kalluri R (2013) Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol 3:C216–C225
    • (2013) Am J Physiol Cell Physiol , vol.3 , pp. C216-C225
    • Zeisberg, M.1    Kalluri, R.2
  • 14
    • 84897508169 scopus 로고    scopus 로고
    • Aging and cardiac fibrosis
    • n A, Frangogiannis NG (2011) Aging and cardiac fibrosis. Aging Dis 2:158–173
    • (2011) Aging Dis , vol.2 , pp. 158-173
    • n, A.1    Frangogiannis, N.G.2
  • 15
    • 78751507979 scopus 로고    scopus 로고
    • Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
    • Creemers EE, Pinto YM (2011) Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res 2:265–272
    • (2011) Cardiovasc Res , vol.2 , pp. 265-272
    • Creemers, E.E.1    Pinto, Y.M.2
  • 17
    • 0025770664 scopus 로고
    • Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system
    • Weber KT, Brilla CG (1991) Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 6:1849–1865
    • (1991) Circulation , vol.6 , pp. 1849-1865
    • Weber, K.T.1    Brilla, C.G.2
  • 19
    • 0037465434 scopus 로고    scopus 로고
    • Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms
    • Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, Polyakova V, Bauer EP, Klovekorn WP, Schaper J (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 7:984–991
    • (2003) Circulation , vol.7 , pp. 984-991
    • Hein, S.1    Arnon, E.2    Kostin, S.3    Schonburg, M.4    Elsasser, A.5    Polyakova, V.6    Bauer, E.P.7    Klovekorn, W.P.8    Schaper, J.9
  • 22
    • 84887615702 scopus 로고    scopus 로고
    • Biomarkers and diagnostics in heart failure
    • Gaggin HK, Januzzi JL Jr (2013) Biomarkers and diagnostics in heart failure. Biochim Biophys Acta 12:2442–2450
    • (2013) Biochim Biophys Acta , vol.12 , pp. 2442-2450
    • Gaggin, H.K.1    Januzzi, J.L.2
  • 25
    • 78650710691 scopus 로고    scopus 로고
    • Molecular pathways underlying cardiac remodeling during pathophysiological stimulation
    • Kehat I, Molkentin JD (2010) Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation 25:2727–2735
    • (2010) Circulation , vol.25 , pp. 2727-2735
    • Kehat, I.1    Molkentin, J.D.2
  • 27
    • 74049114704 scopus 로고    scopus 로고
    • Intramyocardial fibroblast myocyte communication
    • Kakkar R, Lee RT (2010) Intramyocardial fibroblast myocyte communication. Circ Res 1:47–57
    • (2010) Circ Res , vol.1 , pp. 47-57
    • Kakkar, R.1    Lee, R.T.2
  • 29
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 4:495–516
    • (2007) Toxicol Pathol , vol.4 , pp. 495-516
    • Elmore, S.1
  • 31
    • 79954606808 scopus 로고    scopus 로고
    • Programmed necrosis, not apoptosis, in the heart
    • Kung G, Konstantinidis K, Kitsis RN (2011) Programmed necrosis, not apoptosis, in the heart. Circ Res 8:1017–1036
    • (2011) Circ Res , vol.8 , pp. 1017-1036
    • Kung, G.1    Konstantinidis, K.2    Kitsis, R.N.3
  • 32
    • 0019127308 scopus 로고
    • Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution
    • Nag AC (1980) Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution. Cytobios 109:41–61
    • (1980) Cytobios , vol.109 , pp. 41-61
    • Nag, A.C.1
  • 33
    • 11144346203 scopus 로고    scopus 로고
    • Structural and functional characterisation of cardiac fibroblasts
    • Camelliti P, Borg TK, Kohl P (2005) Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res 1:40–51
    • (2005) Cardiovasc Res , vol.1 , pp. 40-51
    • Camelliti, P.1    Borg, T.K.2    Kohl, P.3
  • 34
    • 73349122017 scopus 로고    scopus 로고
    • Cardiac fibroblast: the renaissance cell
    • Souders CA, Bowers SL, Baudino TA (2009) Cardiac fibroblast: the renaissance cell. Circ Res 12:1164–1176
    • (2009) Circ Res , vol.12 , pp. 1164-1176
    • Souders, C.A.1    Bowers, S.L.2    Baudino, T.A.3
  • 38
    • 14844302670 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability
    • Rifkin DB (2005) Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability. J Biol Chem 9:7409–7412
    • (2005) J Biol Chem , vol.9 , pp. 7409-7412
    • Rifkin, D.B.1
  • 39
    • 35448991324 scopus 로고    scopus 로고
    • Extracellular control of TGFbeta signalling in vascular development and disease
    • ten Dijke P, Arthur HM (2007) Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol 11:857–869
    • (2007) Nat Rev Mol Cell Biol , vol.11 , pp. 857-869
    • ten Dijke, P.1    Arthur, H.M.2
  • 40
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G (1993) Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1:103–111
    • (1993) J Cell Biol , vol.1 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 41
    • 33847084614 scopus 로고    scopus 로고
    • Formation and function of the myofibroblast during tissue repair
    • Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Investig Dermatol 3:526–537
    • (2007) J Investig Dermatol , vol.3 , pp. 526-537
    • Hinz, B.1
  • 42
    • 0035159094 scopus 로고    scopus 로고
    • Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    • Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 9:2730–2741
    • (2001) Mol Biol Cell , vol.9 , pp. 2730-2741
    • Hinz, B.1    Celetta, G.2    Tomasek, J.J.3    Gabbiani, G.4    Chaponnier, C.5
  • 43
    • 80255123492 scopus 로고    scopus 로고
    • Abolishing myofibroblast arrhythmogenicity by pharmacological ablation of alpha-smooth muscle actin containing stress fibers
    • Rosker C, Salvarani N, Schmutz S, Grand T, Rohr S (2011) Abolishing myofibroblast arrhythmogenicity by pharmacological ablation of alpha-smooth muscle actin containing stress fibers. Circ Res 10:1120–1131
    • (2011) Circ Res , vol.10 , pp. 1120-1131
    • Rosker, C.1    Salvarani, N.2    Schmutz, S.3    Grand, T.4    Rohr, S.5
  • 44
    • 79952262784 scopus 로고    scopus 로고
    • Transforming growth factor-beta: governing the transition from inflammation to fibrosis in heart failure with preserved left ventricular function
    • Kapur NK (2011) Transforming growth factor-beta: governing the transition from inflammation to fibrosis in heart failure with preserved left ventricular function. Circ Heart Fail 1:5–7
    • (2011) Circ Heart Fail , vol.1 , pp. 5-7
    • Kapur, N.K.1
  • 46
    • 80052851503 scopus 로고    scopus 로고
    • Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
    • Piera-Velazquez S, Li Z, Jimenez SA (2011) Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am J Pathol 3:1074–1080
    • (2011) Am J Pathol , vol.3 , pp. 1074-1080
    • Piera-Velazquez, S.1    Li, Z.2    Jimenez, S.A.3
  • 47
    • 84857824476 scopus 로고    scopus 로고
    • Regulation of endothelial cell plasticity by TGF-beta
    • van Meeteren LA, ten Dijke P (2012) Regulation of endothelial cell plasticity by TGF-beta. Cell Tissue Res 1:177–186
    • (2012) Cell Tissue Res , vol.1 , pp. 177-186
    • van Meeteren, L.A.1    ten Dijke, P.2
  • 52
    • 2442639010 scopus 로고    scopus 로고
    • Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos
    • Lincoln J, Alfieri CM, Yutzey KE (2004) Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn 2:239–250
    • (2004) Dev Dyn , vol.2 , pp. 239-250
    • Lincoln, J.1    Alfieri, C.M.2    Yutzey, K.E.3
  • 53
    • 33751191415 scopus 로고    scopus 로고
    • Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications
    • Ogawa M, LaRue AC, Drake CJ (2006) Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications. Blood 9:2893–2896
    • (2006) Blood , vol.9 , pp. 2893-2896
    • Ogawa, M.1    LaRue, A.C.2    Drake, C.J.3
  • 56
    • 35748974863 scopus 로고    scopus 로고
    • Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    • Spinale FG (2007) Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev 4:1285–1342
    • (2007) Physiol Rev , vol.4 , pp. 1285-1342
    • Spinale, F.G.1
  • 58
    • 84859759432 scopus 로고    scopus 로고
    • Identification of hypertrophy-and heart failure-associated genes by combining in vitro and in vivo models
    • Lu B, Yu H, Zwartbol M, Ruifrok WP, van Gilst WH, de Boer RA, Sillje HH (2012) Identification of hypertrophy-and heart failure-associated genes by combining in vitro and in vivo models. Physiol Genom 8:443–454
    • (2012) Physiol Genom , vol.8 , pp. 443-454
    • Lu, B.1    Yu, H.2    Zwartbol, M.3    Ruifrok, W.P.4    van Gilst, W.H.5    de Boer, R.A.6    Sillje, H.H.7
  • 61
    • 84555179609 scopus 로고    scopus 로고
    • Extracellular matrix degradation and remodeling in development and disease
    • PID: 21917992
    • Lu P, Takai K, Weaver VM, Werb Z (2011) Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. doi:10.1101/cshperspect.a005058
    • (2011) Cold Spring Harb Perspect Biol
    • Lu, P.1    Takai, K.2    Weaver, V.M.3    Werb, Z.4
  • 62
    • 13844312743 scopus 로고    scopus 로고
    • The cardiac fibroblast: therapeutic target in myocardial remodeling and failure
    • COI: 1:CAS:528:DC%2BD2MXisVWjtb8%3D, PID: 15822192
    • Brown RD, Ambler SK, Mitchell MD, Long CS (2005) The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 45:657–687
    • (2005) Annu Rev Pharmacol Toxicol , vol.45 , pp. 657-687
    • Brown, R.D.1    Ambler, S.K.2    Mitchell, M.D.3    Long, C.S.4
  • 64
    • 33847252976 scopus 로고    scopus 로고
    • Atrial fibrosis and the mechanisms of atrial fibrillation
    • Everett TH 4th, Olgin JE (2007) Atrial fibrosis and the mechanisms of atrial fibrillation. Heart Rhythm 3(Suppl):S24–S27
    • (2007) Heart Rhythm , vol.3 , pp. S24-S27
    • Everett, T.H.1    Olgin, J.E.2
  • 66
    • 39349099135 scopus 로고    scopus 로고
    • Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
    • Burstein B, Nattel S (2008) Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 8:802–809
    • (2008) J Am Coll Cardiol , vol.8 , pp. 802-809
    • Burstein, B.1    Nattel, S.2
  • 68
    • 84880748603 scopus 로고    scopus 로고
    • Pathological ventricular remodeling: mechanisms: part 1 of 2
    • Burchfield JS, Xie M, Hill JA (2013) Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation 4:388–400
    • (2013) Circulation , vol.4 , pp. 388-400
    • Burchfield, J.S.1    Xie, M.2    Hill, J.A.3
  • 70
    • 84897937637 scopus 로고    scopus 로고
    • Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
    • Heijman J, Voigt N, Nattel S, Dobrev D (2014) Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circ Res 9:1483–1499
    • (2014) Circ Res , vol.9 , pp. 1483-1499
    • Heijman, J.1    Voigt, N.2    Nattel, S.3    Dobrev, D.4
  • 71
    • 53449094760 scopus 로고    scopus 로고
    • Depressed coronary flow reserve is associated with decreased myocardial capillary density in patients with heart failure due to idiopathic dilated cardiomyopathy
    • Tsagalou EP, Anastasiou-Nana M, Agapitos E, Gika A, Drakos SG, Terrovitis JV, Ntalianis A, Nanas JN (2008) Depressed coronary flow reserve is associated with decreased myocardial capillary density in patients with heart failure due to idiopathic dilated cardiomyopathy. J Am Coll Cardiol 17:1391–1398
    • (2008) J Am Coll Cardiol , vol.17 , pp. 1391-1398
    • Tsagalou, E.P.1    Anastasiou-Nana, M.2    Agapitos, E.3    Gika, A.4    Drakos, S.G.5    Terrovitis, J.V.6    Ntalianis, A.7    Nanas, J.N.8
  • 73
    • 0027955166 scopus 로고
    • Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy
    • Bogoyevitch MA, Glennon PE, Andersson MB, Clerk A, Lazou A, Marshall CJ, Parker PJ, Sugden PH (1994) Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. J Biol Chem 2:1110–1119
    • (1994) J Biol Chem , vol.2 , pp. 1110-1119
    • Bogoyevitch, M.A.1    Glennon, P.E.2    Andersson, M.B.3    Clerk, A.4    Lazou, A.5    Marshall, C.J.6    Parker, P.J.7    Sugden, P.H.8
  • 74
    • 0030071564 scopus 로고    scopus 로고
    • Role of transiently altered sarcolemmal membrane permeability and basic fibroblast growth factor release in the hypertrophic response of adult rat ventricular myocytes to increased mechanical activity in vitro
    • Kaye D, Pimental D, Prasad S, Maki T, Berger HJ, McNeil PL, Smith TW, Kelly RA (1996) Role of transiently altered sarcolemmal membrane permeability and basic fibroblast growth factor release in the hypertrophic response of adult rat ventricular myocytes to increased mechanical activity in vitro. J Clin Investig 2:281–291
    • (1996) J Clin Investig , vol.2 , pp. 281-291
    • Kaye, D.1    Pimental, D.2    Prasad, S.3    Maki, T.4    Berger, H.J.5    McNeil, P.L.6    Smith, T.W.7    Kelly, R.A.8
  • 76
    • 36348982148 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function
    • Virag JA, Rolle ML, Reece J, Hardouin S, Feigl EO, Murry CE (2007) Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function. Am J Pathol 5:1431–1440
    • (2007) Am J Pathol , vol.5 , pp. 1431-1440
    • Virag, J.A.1    Rolle, M.L.2    Reece, J.3    Hardouin, S.4    Feigl, E.O.5    Murry, C.E.6
  • 77
    • 78049438071 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 mediates isoproterenol-induced cardiac hypertrophy through activation of the extracellular regulated kinase
    • House SL, House BE, Glascock B, Kimball T, Nusayr E, Schultz JE, Doetschman T (2010) Fibroblast growth factor 2 mediates isoproterenol-induced cardiac hypertrophy through activation of the extracellular regulated kinase. Mol Cell Pharmacol 4:143–154
    • (2010) Mol Cell Pharmacol , vol.4 , pp. 143-154
    • House, S.L.1    House, B.E.2    Glascock, B.3    Kimball, T.4    Nusayr, E.5    Schultz, J.E.6    Doetschman, T.7
  • 78
    • 84860524460 scopus 로고    scopus 로고
    • Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF beta/Smad activation and cardiac fibrosis induced by angiotensin II
    • Ma F, Li Y, Jia L, Han Y, Cheng J, Li H, Qi Y, Du J (2012) Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF beta/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS ONE 5:e35144
    • (2012) PLoS ONE , vol.5 , pp. e35144
    • Ma, F.1    Li, Y.2    Jia, L.3    Han, Y.4    Cheng, J.5    Li, H.6    Qi, Y.7    Du, J.8
  • 79
    • 77955500182 scopus 로고    scopus 로고
    • Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
    • Melendez GC, McLarty JL, Levick SP, Du Y, Janicki JS, Brower GL (2010) Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension 2:225–231
    • (2010) Hypertension , vol.2 , pp. 225-231
    • Melendez, G.C.1    McLarty, J.L.2    Levick, S.P.3    Du, Y.4    Janicki, J.S.5    Brower, G.L.6
  • 81
    • 84908160751 scopus 로고    scopus 로고
    • Noncoding RNAs and myocardial fibrosis
    • COI: 1:CAS:528:DC%2BC2cXhsFylsbvK, PID: 25200283
    • Thum T (2014) Noncoding RNAs and myocardial fibrosis. Nat Rev Cardiol 11:655–663
    • (2014) Nat Rev Cardiol , vol.11 , pp. 655-663
    • Thum, T.1
  • 85
    • 84899982846 scopus 로고    scopus 로고
    • miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-beta/Smad3 signaling
    • Zhang Y, Huang XR, Wei LH, Chung AC, Yu CM, Lan HY (2014) miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-beta/Smad3 signaling. Mol Ther 5:974–985
    • (2014) Mol Ther , vol.5 , pp. 974-985
    • Zhang, Y.1    Huang, X.R.2    Wei, L.H.3    Chung, A.C.4    Yu, C.M.5    Lan, H.Y.6
  • 88
    • 73349108105 scopus 로고    scopus 로고
    • ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice
    • Liu Q, Sargent MA, York AJ, Molkentin JD (2009) ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice. Circ Res 11:1110–1117
    • (2009) Circ Res , vol.11 , pp. 1110-1117
    • Liu, Q.1    Sargent, M.A.2    York, A.J.3    Molkentin, J.D.4
  • 91
    • 84879766943 scopus 로고    scopus 로고
    • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge
    • Porter K, Lin Y, Liton PB (2013) Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. PLoS ONE 7:e68668
    • (2013) PLoS ONE , vol.7 , pp. e68668
    • Porter, K.1    Lin, Y.2    Liton, P.B.3
  • 93
    • 80052804497 scopus 로고    scopus 로고
    • Nix Nought Nothing: fairy tale or real deal
    • Dorn GW 2nd (2011) Nix Nought Nothing: fairy tale or real deal. J Mol Cell Cardiol 4:497–500
    • (2011) J Mol Cell Cardiol , vol.4 , pp. 497-500
    • Dorn, G.W.1
  • 94
    • 38349184844 scopus 로고    scopus 로고
    • Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation
    • Diwan A, Wansapura J, Syed FM, Matkovich SJ, Lorenz JN, Dorn GW 2nd (2008) Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation 3:396–404
    • (2008) Circulation , vol.3 , pp. 396-404
    • Diwan, A.1    Wansapura, J.2    Syed, F.M.3    Matkovich, S.J.4    Lorenz, J.N.5    Dorn, G.W.6
  • 97
    • 0028851160 scopus 로고
    • Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
    • Desmouliere A, Redard M, Darby I, Gabbiani G (1995) Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1:56–66
    • (1995) Am J Pathol , vol.1 , pp. 56-66
    • Desmouliere, A.1    Redard, M.2    Darby, I.3    Gabbiani, G.4
  • 99
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • Gabbiani G (2003) The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 4:500–503
    • (2003) J Pathol , vol.4 , pp. 500-503
    • Gabbiani, G.1
  • 100
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ (1998) Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Investig 3:538–549
    • (1998) J Clin Investig , vol.3 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6    Hovell, C.7    Arthur, M.J.8
  • 101
    • 0035136844 scopus 로고    scopus 로고
    • TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)
    • Strutz F, Zeisberg M, Renziehausen A, Raschke B, Becker V, van Kooten C, Muller G (2001) TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int 2:579–592
    • (2001) Kidney Int , vol.2 , pp. 579-592
    • Strutz, F.1    Zeisberg, M.2    Renziehausen, A.3    Raschke, B.4    Becker, V.5    van Kooten, C.6    Muller, G.7
  • 102
    • 1542343906 scopus 로고    scopus 로고
    • Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation
    • Grotendorst GR, Rahmanie H, Duncan MR (2004) Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation. FASEB J 3:469–479
    • (2004) FASEB J , vol.3 , pp. 469-479
    • Grotendorst, G.R.1    Rahmanie, H.2    Duncan, M.R.3
  • 103
    • 0030249501 scopus 로고    scopus 로고
    • Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-beta 1
    • Sigel AV, Centrella M, Eghbali-Webb M (1996) Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-beta 1. J Mol Cell Cardiol 9:1921–1929
    • (1996) J Mol Cell Cardiol , vol.9 , pp. 1921-1929
    • Sigel, A.V.1    Centrella, M.2    Eghbali-Webb, M.3
  • 105
    • 33744914050 scopus 로고    scopus 로고
    • Evolving concepts of apoptosis in idiopathic pulmonary fibrosis
    • Thannickal VJ, Horowitz JC (2006) Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 4:350–356
    • (2006) Proc Am Thorac Soc , vol.4 , pp. 350-356
    • Thannickal, V.J.1    Horowitz, J.C.2
  • 107
    • 0029816341 scopus 로고    scopus 로고
    • The cellular derivation and the life span of the myofibroblast
    • Gabbiani G (1996) The cellular derivation and the life span of the myofibroblast. Pathol Res Pract 7:708–711
    • (1996) Pathol Res Pract , vol.7 , pp. 708-711
    • Gabbiani, G.1
  • 109
    • 84893761804 scopus 로고    scopus 로고
    • Effective myofibroblast dedifferentiation by concomitant inhibition of TGF-beta signaling and perturbation of MAPK signaling
    • Kosla J, Dvorakova M, Dvorak M, Cermak V (2013) Effective myofibroblast dedifferentiation by concomitant inhibition of TGF-beta signaling and perturbation of MAPK signaling. Eur J Cell Biol 12:363–373
    • (2013) Eur J Cell Biol , vol.12 , pp. 363-373
    • Kosla, J.1    Dvorakova, M.2    Dvorak, M.3    Cermak, V.4
  • 110
    • 84948175046 scopus 로고    scopus 로고
    • Modulation of cardiac fibrosis by Kruppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes
    • Sawaki D, Hou L, Tomida S, Sun J, Zhan H, Aizawa K, Son BK, Kariya T, Takimoto E, Otsu K et al (2015) Modulation of cardiac fibrosis by Kruppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes. Cardiovasc Res 4:420–430
    • (2015) Cardiovasc Res , vol.4 , pp. 420-430
    • Sawaki, D.1    Hou, L.2    Tomida, S.3    Sun, J.4    Zhan, H.5    Aizawa, K.6    Son, B.K.7    Kariya, T.8    Takimoto, E.9    Otsu, K.10
  • 112
    • 1642463859 scopus 로고    scopus 로고
    • Inflammatory mediators in chronic heart failure: an overview
    • Anker SD, von Haehling S (2004) Inflammatory mediators in chronic heart failure: an overview. Heart 4:464–470
    • (2004) Heart , vol.4 , pp. 464-470
    • Anker, S.D.1    von Haehling, S.2
  • 113
    • 0030226423 scopus 로고    scopus 로고
    • Basic mechanisms in heart failure: the cytokine hypothesis
    • Seta Y, Shan K, Bozkurt B, Oral H, Mann DL (1996) Basic mechanisms in heart failure: the cytokine hypothesis. J Card Fail 3:243–249
    • (1996) J Card Fail , vol.3 , pp. 243-249
    • Seta, Y.1    Shan, K.2    Bozkurt, B.3    Oral, H.4    Mann, D.L.5
  • 115
    • 0031977811 scopus 로고    scopus 로고
    • Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure
    • Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, Mabuchi N, Sawaki M, Kinoshita M (1998) Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 2:391–398
    • (1998) J Am Coll Cardiol , vol.2 , pp. 391-398
    • Tsutamoto, T.1    Hisanaga, T.2    Wada, A.3    Maeda, K.4    Ohnishi, M.5    Fukai, D.6    Mabuchi, N.7    Sawaki, M.8    Kinoshita, M.9
  • 116
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • Levine B, Kalman J, Mayer L, Fillit HM, Packer M (1990) Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 4:236–241
    • (1990) N Engl J Med , vol.4 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3    Fillit, H.M.4    Packer, M.5
  • 118
    • 0032772911 scopus 로고    scopus 로고
    • The role of TNF in cardiovascular disease
    • Ferrari R (1999) The role of TNF in cardiovascular disease. Pharmacol Res 2:97–105
    • (1999) Pharmacol Res , vol.2 , pp. 97-105
    • Ferrari, R.1
  • 120
    • 84896973126 scopus 로고    scopus 로고
    • TGF-beta activation and function in immunity
    • COI: 1:CAS:528:DC%2BC2cXovVemtrs%3D, PID: 24313777
    • Travis MA, Sheppard D (2014) TGF-beta activation and function in immunity. Annu Rev Immunol 32:51–82
    • (2014) Annu Rev Immunol , vol.32 , pp. 51-82
    • Travis, M.A.1    Sheppard, D.2
  • 126
    • 84892506135 scopus 로고    scopus 로고
    • Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling
    • Turner NA (2014) Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling. Vasc Pharmacol 1:1–7
    • (2014) Vasc Pharmacol , vol.1 , pp. 1-7
    • Turner, N.A.1
  • 127
    • 84955693617 scopus 로고    scopus 로고
    • MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis
    • PID: 26585673
    • Nagpal V, Rai R, Place AT, Murphy SB, Verma SK, Ghosh AK, Vaughan DE (2015) MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis. Circulation 133(3):291–301
    • (2015) Circulation , vol.133 , Issue.3 , pp. 291-301
    • Nagpal, V.1    Rai, R.2    Place, A.T.3    Murphy, S.B.4    Verma, S.K.5    Ghosh, A.K.6    Vaughan, D.E.7
  • 130
    • 84878469136 scopus 로고    scopus 로고
    • Heart repair by cardiac reprogramming
    • Nam YJ, Song K, Olson EN (2013) Heart repair by cardiac reprogramming. Nat Med 4:413–415
    • (2013) Nat Med , vol.4 , pp. 413-415
    • Nam, Y.J.1    Song, K.2    Olson, E.N.3
  • 131
    • 84883569291 scopus 로고    scopus 로고
    • Epidemiology of heart failure
    • Roger VL (2013) Epidemiology of heart failure. Circ Res 6:646–659
    • (2013) Circ Res , vol.6 , pp. 646-659
    • Roger, V.L.1
  • 132
    • 84886799951 scopus 로고    scopus 로고
    • Targeting sarcoplasmic reticulum calcium ATPase by gene therapy
    • Gwathmey JK, Yerevanian A, Hajjar RJ (2013) Targeting sarcoplasmic reticulum calcium ATPase by gene therapy. Hum Gene Ther 11:937–947
    • (2013) Hum Gene Ther , vol.11 , pp. 937-947
    • Gwathmey, J.K.1    Yerevanian, A.2    Hajjar, R.J.3
  • 135
    • 70449112931 scopus 로고    scopus 로고
    • A novel approach to improve cardiac performance: cardiac myosin activators
    • Teerlink JR (2009) A novel approach to improve cardiac performance: cardiac myosin activators. Heart Fail Rev 4:289–298
    • (2009) Heart Fail Rev , vol.4 , pp. 289-298
    • Teerlink, J.R.1
  • 136
    • 80052806071 scopus 로고    scopus 로고
    • Cardiac myosin activation part 1: from concept to clinic
    • Malik FI, Morgan BP (2011) Cardiac myosin activation part 1: from concept to clinic. J Mol Cell Cardiol 4:454–461
    • (2011) J Mol Cell Cardiol , vol.4 , pp. 454-461
    • Malik, F.I.1    Morgan, B.P.2
  • 137
    • 84954389267 scopus 로고    scopus 로고
    • Omecamtiv mecarbil: a novel cardiac myosin activator for the treatment of heart failure
    • COI: 1:CAS:528:DC%2BC2MXitVGgtrrE, PID: 26587768
    • Liu LC, Dorhout B, van der Meer P, Teerlink JR, Voors AA (2016) Omecamtiv mecarbil: a novel cardiac myosin activator for the treatment of heart failure. Expert Opin Investig Drugs 25:117–127
    • (2016) Expert Opin Investig Drugs , vol.25 , pp. 117-127
    • Liu, L.C.1    Dorhout, B.2    van der Meer, P.3    Teerlink, J.R.4    Voors, A.A.5


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