Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Ma, Feifei ^a   Li, Yulin ^a   Jia, Lixin ^a   Han, Yalei ^a   Cheng, Jizhong ^a   Li, Huihua ^c   Qi, Yongfen ^a   Du, Jie ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; COLLAGEN TYPE 1; INTERLEUKIN 6; SMAD PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; COLLAGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC FIBROBLAST; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REPRESSION; FIBROBLAST; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

MUS;

ANGIOTENSIN II; ANIMALS; COLLAGEN; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; INTERLEUKIN-6; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; PHOSPHORYLATION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84860524460     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035144     Document Type: Article

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