메뉴 건너뛰기




Volumn 272, Issue , 2016, Pages 69-76

Novel pharmaceutical treatments for minimal traumatic brain injury and evaluation of animal models and methodologies supporting their development

Author keywords

Animal models of TBI; Exendin 4; N Acetyl L cycteine; Salubrinal; Thrombin; Traumatic brain injury

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; EXENDIN 4; NEUROPROTECTIVE AGENT; NEUROTROPHIC FACTOR; PROTEINASE ACTIVATED RECEPTOR; SALUBRINAL; THROMBIN;

EID: 84959057070     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2016.02.002     Document Type: Article
Times cited : (18)

References (114)
  • 2
    • 84870896985 scopus 로고    scopus 로고
    • Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity
    • Almonte, A.G., Qadri, L.H., Sultan, F.A., Watson, J.A., Mount, D.J., Rumbaugh, G., et al. Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity. J Neurochem 124 (2013), 109–122.
    • (2013) J Neurochem , vol.124 , pp. 109-122
    • Almonte, A.G.1    Qadri, L.H.2    Sultan, F.A.3    Watson, J.A.4    Mount, D.J.5    Rumbaugh, G.6
  • 3
    • 13644268431 scopus 로고    scopus 로고
    • The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem
    • Alvarez, E., Martínez, M.D., Roncero, I., Chowen, J.A., García-Cuartero, B., Gispert, J.D., et al. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. J Neurochem 92 (2005), 798–806.
    • (2005) J Neurochem , vol.92 , pp. 798-806
    • Alvarez, E.1    Martínez, M.D.2    Roncero, I.3    Chowen, J.A.4    García-Cuartero, B.5    Gispert, J.D.6
  • 4
    • 84860889573 scopus 로고    scopus 로고
    • The novel object recognition memory: neurobiology, test procedure, and its modifications
    • Antunes, M., Biala, G., The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process 13 (2012), 93–110.
    • (2012) Cogn Process , vol.13 , pp. 93-110
    • Antunes, M.1    Biala, G.2
  • 5
    • 79961047459 scopus 로고    scopus 로고
    • Tumor necrosis factor-α synthesis inhibitor, 3, 6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice
    • Baratz, R., Tweedie, D., Rubovitch, V., Luo, W., Yoon, J.S., Hoffer, B.J., et al. Tumor necrosis factor-α synthesis inhibitor, 3, 6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. J Neurochem 118:6 (2011), 1032–1042.
    • (2011) J Neurochem , vol.118 , Issue.6 , pp. 1032-1042
    • Baratz, R.1    Tweedie, D.2    Rubovitch, V.3    Luo, W.4    Yoon, J.S.5    Hoffer, B.J.6
  • 6
    • 84928711417 scopus 로고    scopus 로고
    • Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice
    • Baratz, R., Tweedie, D., Wang, J.Y., Rubovitch, V., Luo, W., Hoffer, B.J., et al. Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice. J Neuroinflamm, 12, 2015, 45.
    • (2015) J Neuroinflamm , vol.12 , pp. 45
    • Baratz, R.1    Tweedie, D.2    Wang, J.Y.3    Rubovitch, V.4    Luo, W.5    Hoffer, B.J.6
  • 7
    • 84856078575 scopus 로고    scopus 로고
    • TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
    • Belarbi, K., Jopson, T., Tweedie, D., Arellano, C., Luo, W., Greig, N.H., et al. TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflamn, 9, 2012, 23.
    • (2012) J Neuroinflamn , vol.9 , pp. 23
    • Belarbi, K.1    Jopson, T.2    Tweedie, D.3    Arellano, C.4    Luo, W.5    Greig, N.H.6
  • 8
    • 84949723640 scopus 로고    scopus 로고
    • Treatment of traumatic brain injury with anti-inflammatory drugs
    • Bergold, P.J., Treatment of traumatic brain injury with anti-inflammatory drugs. Exp Neurol. 275:Part 3 (2016), 367–380, 10.1016/j.expneurol.2015.05.024.
    • (2016) Exp Neurol. , vol.275 , pp. 367-380
    • Bergold, P.J.1
  • 9
    • 84929589979 scopus 로고    scopus 로고
    • Thrombin regulation of synaptic transmission and plasticity: implications for health and disease
    • Ben Shimon, M., Lenz, M., Ikenberg, B., Becker, D., Shavit Stein, E., Chapman, J., et al. Thrombin regulation of synaptic transmission and plasticity: implications for health and disease. Front Cell Neurosci, 9, 2015, 151.
    • (2015) Front Cell Neurosci , vol.9 , pp. 151
    • Ben Shimon, M.1    Lenz, M.2    Ikenberg, B.3    Becker, D.4    Shavit Stein, E.5    Chapman, J.6
  • 10
    • 85053686936 scopus 로고    scopus 로고
    • Animal models for concussion: molecular and cognitive assessments—relevance to sport and military concussions
    • F.H. Kobeissy Boca Raton, FL CRC Press (Chapter 46)
    • Bolouri, H., Zetterberg, H., Animal models for concussion: molecular and cognitive assessments—relevance to sport and military concussions. Kobeissy, F.H., (eds.) Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects, 2015, Boca Raton, FL, CRC Press (Chapter 46).
    • (2015) Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects
    • Bolouri, H.1    Zetterberg, H.2
  • 11
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of incretin hormone action
    • Campbell, J., Drucker, D., Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab 17 (2013), 819–837.
    • (2013) Cell Metab , vol.17 , pp. 819-837
    • Campbell, J.1    Drucker, D.2
  • 12
    • 26844501218 scopus 로고    scopus 로고
    • Animal models of head trauma
    • Cernak, I., Animal models of head trauma. NeuroRx 2:3 (2005), 410–422.
    • (2005) NeuroRx , vol.2 , Issue.3 , pp. 410-422
    • Cernak, I.1
  • 13
    • 67849128716 scopus 로고    scopus 로고
    • Critical roles for thrombin in acute and chronic inflammation
    • Chen, D., Dorling, A., Critical roles for thrombin in acute and chronic inflammation. J Thromb Haemost 7:Suppl. 1 (2009), 122–126.
    • (2009) J Thromb Haemost , vol.7 , pp. 122-126
    • Chen, D.1    Dorling, A.2
  • 14
    • 79952775054 scopus 로고    scopus 로고
    • Craniotomy: true sham for traumatic brain injury, or a sham of a sham?
    • Cole, J.T., Yarnell, A., Kean, W.S., Gold, E., Lewis, B., Ren, M., et al. Craniotomy: true sham for traumatic brain injury, or a sham of a sham?. J Neurotrauma 28 (2011), 359–369.
    • (2011) J Neurotrauma , vol.28 , pp. 359-369
    • Cole, J.T.1    Yarnell, A.2    Kean, W.S.3    Gold, E.4    Lewis, B.5    Ren, M.6
  • 15
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin, S.R., Thrombin signalling and protease-activated receptors. Nature 407 (2000), 258–264.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 16
    • 0034921205 scopus 로고    scopus 로고
    • Protease-activated receptors in vascular biology
    • Coughlin, S.R., Protease-activated receptors in vascular biology. Thromb Haemost 86 (2001), 298–307.
    • (2001) Thromb Haemost , vol.86 , pp. 298-307
    • Coughlin, S.R.1
  • 17
    • 0035085210 scopus 로고    scopus 로고
    • A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    • Culmsee, C., Zhu, X., Yu, Q.S., Chan, S.L., Camandola, S., Guo, Z., et al. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem 77 (2001), 220–228.
    • (2001) J Neurochem , vol.77 , pp. 220-228
    • Culmsee, C.1    Zhu, X.2    Yu, Q.S.3    Chan, S.L.4    Camandola, S.5    Guo, Z.6
  • 19
    • 84877868814 scopus 로고    scopus 로고
    • Challenges in the development of rodent models of mild traumatic brain injury
    • DeWitt, D.S., Perez-Polo, R., Hulsebosch, C.E., Dash, P.K., Robertson, C.S., Challenges in the development of rodent models of mild traumatic brain injury. J Neurotrauma 30:9 (2013), 688–701.
    • (2013) J Neurotrauma , vol.30 , Issue.9 , pp. 688-701
    • DeWitt, D.S.1    Perez-Polo, R.2    Hulsebosch, C.E.3    Dash, P.K.4    Robertson, C.S.5
  • 20
    • 0036829557 scopus 로고    scopus 로고
    • p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
    • Duan, W., Zhu, X., Ladenheim, B., Yu, Q.S., Guo, Z., Oyler, J., et al. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann Neurol 52 (2002), 597–606.
    • (2002) Ann Neurol , vol.52 , pp. 597-606
    • Duan, W.1    Zhu, X.2    Ladenheim, B.3    Yu, Q.S.4    Guo, Z.5    Oyler, J.6
  • 21
    • 84873306844 scopus 로고    scopus 로고
    • Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
    • Duarte, A., Candeias, E., Correia, S.C., Santos, R.X., Carvalho, C., Cardoso, S., et al. Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration. Biochim Biophys Acta 1832 (2013), 527–541.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 527-541
    • Duarte, A.1    Candeias, E.2    Correia, S.C.3    Santos, R.X.4    Carvalho, C.5    Cardoso, S.6
  • 23
    • 0025988594 scopus 로고
    • Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger n-acetylcysteine following experimental traumatic brain injury
    • Ellis, E.F., Dodson, L.Y., Police, R.J., Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger n-acetylcysteine following experimental traumatic brain injury. J Neurosurg 75 (1991), 774–779.
    • (1991) J Neurosurg , vol.75 , pp. 774-779
    • Ellis, E.F.1    Dodson, L.Y.2    Police, R.J.3
  • 24
    • 77954317073 scopus 로고    scopus 로고
    • One-trial object recognition in rats and mice: methodological and theoretical issues
    • Ennaceur, A., One-trial object recognition in rats and mice: methodological and theoretical issues. Behav Brain Res 215:2 (2010), 244–254.
    • (2010) Behav Brain Res , vol.215 , Issue.2 , pp. 244-254
    • Ennaceur, A.1
  • 25
    • 84964284793 scopus 로고    scopus 로고
    • Forebrain neuronal specific ablation of p53 gene provide protection in a cortical ischemic stroke model
    • Filichia, F., Shen, H., Zhou, X., Qi, X., Jin, K., Greig, N., et al. Forebrain neuronal specific ablation of p53 gene provide protection in a cortical ischemic stroke model. Neuroscience 295 (2015), 1–10.
    • (2015) Neuroscience , vol.295 , pp. 1-10
    • Filichia, F.1    Shen, H.2    Zhou, X.3    Qi, X.4    Jin, K.5    Greig, N.6
  • 26
    • 0028085099 scopus 로고
    • A new model of diffuse brain injury in rats. Part II: Morphological characterization
    • Foda, M.A., Marmarou, A., A new model of diffuse brain injury in rats. Part II: Morphological characterization. J Neurosurg 80 (1994), 301–313.
    • (1994) J Neurosurg , vol.80 , pp. 301-313
    • Foda, M.A.1    Marmarou, A.2
  • 27
    • 79951701971 scopus 로고    scopus 로고
    • Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases
    • Frankola, K., Greig, N.H., Luo, W., Tweedie, D., Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets 10 (2011), 391–403.
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 391-403
    • Frankola, K.1    Greig, N.H.2    Luo, W.3    Tweedie, D.4
  • 28
    • 77950625842 scopus 로고    scopus 로고
    • In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury
    • Frugier, T., Morganti-Kossmann, M.C., O'Reilly, D., McLean, C.A., In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury. J Neurotrauma 27 (2010), 497–507.
    • (2010) J Neurotrauma , vol.27 , pp. 497-507
    • Frugier, T.1    Morganti-Kossmann, M.C.2    O'Reilly, D.3    McLean, C.A.4
  • 29
    • 80052645534 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues for type 2 diabetes mellitus: current and emerging agents
    • Gallwitz, B., Glucagon-like peptide-1 analogues for type 2 diabetes mellitus: current and emerging agents. Drugs 71 (2013), 1675–1688.
    • (2013) Drugs , vol.71 , pp. 1675-1688
    • Gallwitz, B.1
  • 30
    • 79952037352 scopus 로고    scopus 로고
    • Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex
    • Gao, X., Chen, J., Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex. J Neuropathol Exp Neurol 70:3 (2011), 183–191.
    • (2011) J Neuropathol Exp Neurol , vol.70 , Issue.3 , pp. 183-191
    • Gao, X.1    Chen, J.2
  • 31
    • 0034660448 scopus 로고    scopus 로고
    • Potentiation of NMDA receptor function by the serine protease thrombin
    • Gingrich, M.B., Junge, C.E., Lyuboslavsky, P., Traynelis, S.F., Potentiation of NMDA receptor function by the serine protease thrombin. J Neurosci 20 (2000), 4582–4595.
    • (2000) J Neurosci , vol.20 , pp. 4582-4595
    • Gingrich, M.B.1    Junge, C.E.2    Lyuboslavsky, P.3    Traynelis, S.F.4
  • 32
    • 0034284153 scopus 로고    scopus 로고
    • Serine proteases and brain damage—is there a link?
    • Gingrich, M.B., Traynelis, S.F., Serine proteases and brain damage—is there a link?. Trends Neurosci 23 (2000), 399–407.
    • (2000) Trends Neurosci , vol.23 , pp. 399-407
    • Gingrich, M.B.1    Traynelis, S.F.2
  • 34
    • 84897845269 scopus 로고    scopus 로고
    • Incretinmimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury
    • Greig, N.H., Tweedie, D., Rachmany, L., Li, Y., Rubovitch, V., Schreiber, S., et al. Incretinmimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimers Dement 10:1 (2014), S62–S75.
    • (2014) Alzheimers Dement , vol.10 , Issue.1 , pp. S62-S75
    • Greig, N.H.1    Tweedie, D.2    Rachmany, L.3    Li, Y.4    Rubovitch, V.5    Schreiber, S.6
  • 35
    • 0021811144 scopus 로고
    • High-dose glucocorticoid treatment improves neurological recovery in head-injured mice
    • Hall, E.D., High-dose glucocorticoid treatment improves neurological recovery in head-injured mice. J Neurosurg 62 (1985), 882–887.
    • (1985) J Neurosurg , vol.62 , pp. 882-887
    • Hall, E.D.1
  • 36
    • 33745035900 scopus 로고    scopus 로고
    • Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats
    • Hicdonmez, T., Kanter, M., Tiryaki, M., Parsak, T., Cobanoglu, S., Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats. Neurochem Res 31 (2006), 473–481.
    • (2006) Neurochem Res , vol.31 , pp. 473-481
    • Hicdonmez, T.1    Kanter, M.2    Tiryaki, M.3    Parsak, T.4    Cobanoglu, S.5
  • 37
    • 84872814431 scopus 로고    scopus 로고
    • Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study
    • Hoffer, M.E., Balaban, C., Slade, M.D., Tsao, J.W., Hoffer, B., Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study. PLoS ONE, 8(1), 2013, e54163.
    • (2013) PLoS ONE , vol.8 , Issue.1 , pp. e54163
    • Hoffer, M.E.1    Balaban, C.2    Slade, M.D.3    Tsao, J.W.4    Hoffer, B.5
  • 38
    • 84897848470 scopus 로고    scopus 로고
    • Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
    • Hölscher, C., Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J Endocrinol 221:1 (2014), T31–T41.
    • (2014) J Endocrinol , vol.221 , Issue.1 , pp. T31-T41
    • Hölscher, C.1
  • 39
    • 68349121367 scopus 로고    scopus 로고
    • Closed head injury in a mouse model results in molecular changes indicating inflammatory responses
    • Israelsson, C., Wang, Y., Kylberg, A., Pick, C.G., Hoffer, B.J., Ebendal, T., Closed head injury in a mouse model results in molecular changes indicating inflammatory responses. J Neurotrauma 26:8 (2009), 1307–1314.
    • (2009) J Neurotrauma , vol.26 , Issue.8 , pp. 1307-1314
    • Israelsson, C.1    Wang, Y.2    Kylberg, A.3    Pick, C.G.4    Hoffer, B.J.5    Ebendal, T.6
  • 40
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J.D., et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13 (1999), 76–86.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6
  • 41
    • 84899912346 scopus 로고    scopus 로고
    • Reversal of trauma-induced amnesia in mice by a thrombin receptor antagonist
    • Itzekson, Z., Maggio, N., Milman, A., Shavit, E., Pick, C.G., Chapman, J., Reversal of trauma-induced amnesia in mice by a thrombin receptor antagonist. J Mol Neurosci 53:1 (2014), 87–95.
    • (2014) J Mol Neurosci , vol.53 , Issue.1 , pp. 87-95
    • Itzekson, Z.1    Maggio, N.2    Milman, A.3    Shavit, E.4    Pick, C.G.5    Chapman, J.6
  • 42
    • 2942608168 scopus 로고    scopus 로고
    • Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes
    • Junge, C.E., Lee, C.J., Hubbard, K.B., Zhang, Z., Olson, J.J., Hepler, J.R., et al. Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Exp Neurol 188 (2004), 94–103.
    • (2004) Exp Neurol , vol.188 , pp. 94-103
    • Junge, C.E.1    Lee, C.J.2    Hubbard, K.B.3    Zhang, Z.4    Olson, J.J.5    Hepler, J.R.6
  • 43
  • 44
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi, A., Kang, M.I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24 (2004), 7130–7139.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6
  • 46
    • 84937849044 scopus 로고    scopus 로고
    • Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
    • Kondo, A., Shahpasand, K., Mannix, R., Qiu, J., Moncaster, J., Chen, C.H., et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature 523:7561 (2015), 431–436, 10.1038/nature14658.
    • (2015) Nature , vol.523 , Issue.7561 , pp. 431-436
    • Kondo, A.1    Shahpasand, K.2    Mannix, R.3    Qiu, J.4    Moncaster, J.5    Chen, C.H.6
  • 48
    • 2342491481 scopus 로고    scopus 로고
    • The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha
    • Leker, R.R., Aharonowiz, M., Greig, N.H., Ovadia, H., The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Exp Neurol 187 (2004), 478–486.
    • (2004) Exp Neurol , vol.187 , pp. 478-486
    • Leker, R.R.1    Aharonowiz, M.2    Greig, N.H.3    Ovadia, H.4
  • 49
    • 77953094551 scopus 로고    scopus 로고
    • Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
    • Li, Y., Tweedie, D., Mattson, M.P., Holloway, H.W., Greig, N.H., Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells. J Neurochem 113 (2010), 1621–1631.
    • (2010) J Neurochem , vol.113 , pp. 1621-1631
    • Li, Y.1    Tweedie, D.2    Mattson, M.P.3    Holloway, H.W.4    Greig, N.H.5
  • 50
    • 84863115597 scopus 로고    scopus 로고
    • Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
    • Li, Y., Chigurupati, S., Holloway, H.W., Mughal, M., Tweedie, D., Bruestle, D.A., et al. Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis. PLoS ONE, 7, 2012, e32008.
    • (2012) PLoS ONE , vol.7 , pp. e32008
    • Li, Y.1    Chigurupati, S.2    Holloway, H.W.3    Mughal, M.4    Tweedie, D.5    Bruestle, D.A.6
  • 51
    • 59049087723 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
    • Li, Y., Perry, T., Kindy, M.S., Harvey, B.K., Tweedie, D., Holloway, H.W., et al. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. PNAS 106 (2009), 1285–1290.
    • (2009) PNAS , vol.106 , pp. 1285-1290
    • Li, Y.1    Perry, T.2    Kindy, M.S.3    Harvey, B.K.4    Tweedie, D.5    Holloway, H.W.6
  • 52
    • 77950352189 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    • Li, Y., Duffy, K.B., Ottinger, M.A., Ray, B., Bailey, J.A., Holloway, H.W., et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis 19 (2010), 1205–1219.
    • (2010) J Alzheimers Dis , vol.19 , pp. 1205-1219
    • Li, Y.1    Duffy, K.B.2    Ottinger, M.A.3    Ray, B.4    Bailey, J.A.5    Holloway, H.W.6
  • 53
    • 84955199683 scopus 로고    scopus 로고
    • Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice
    • Li, Y., Bader, M., Tamargo, I., Rubovitch, V., Tweedie, D., Pick, C.G., et al. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice. J Neurochem. 135:6 (2015), 1203–1217.
    • (2015) J Neurochem. , vol.135 , Issue.6 , pp. 1203-1217
    • Li, Y.1    Bader, M.2    Tamargo, I.3    Rubovitch, V.4    Tweedie, D.5    Pick, C.G.6
  • 54
    • 0023807637 scopus 로고
    • Controlled cortical impact: a new experimental brain injury model
    • Lighthall, J.W., Controlled cortical impact: a new experimental brain injury model. J Neurotrauma 5 (1988), 1–15.
    • (1988) J Neurotrauma , vol.5 , pp. 1-15
    • Lighthall, J.W.1
  • 55
    • 0013821074 scopus 로고
    • Experimental studies in head injury. I. Some factors influencing results of model experiments
    • Lindgren, S., Rinder, L., Experimental studies in head injury. I. Some factors influencing results of model experiments. Biophysik 2 (1965), 320–329.
    • (1965) Biophysik , vol.2 , pp. 320-329
    • Lindgren, S.1    Rinder, L.2
  • 56
    • 84868498340 scopus 로고    scopus 로고
    • Paradoxical thrombosis, part 2, anticoagulant and antiplatelet therapy
    • Lippi, G., Favaloro, E.J., Franchini, M., Paradoxical thrombosis, part 2, anticoagulant and antiplatelet therapy. J Thromb Thrombolysis 34 (2012), 367–373.
    • (2012) J Thromb Thrombolysis , vol.34 , pp. 367-373
    • Lippi, G.1    Favaloro, E.J.2    Franchini, M.3
  • 57
    • 36549089651 scopus 로고    scopus 로고
    • Protease-activated receptors in the brain: receptor expression, activation and functions in neurodegeneration and neuroprotection
    • Luo, W., Wang, Y., Reiser, G., Protease-activated receptors in the brain: receptor expression, activation and functions in neurodegeneration and neuroprotection. Brain Res Rev 56 (2007), 331–345.
    • (2007) Brain Res Rev , vol.56 , pp. 331-345
    • Luo, W.1    Wang, Y.2    Reiser, G.3
  • 58
    • 67249139255 scopus 로고    scopus 로고
    • Delayed treatment with a p53 inhibitor enhances recovery in stroke brain
    • Luo, Y., Kuo, C.C., Shen, H., Chou, J., Greig, N.H., Hoffer, B.J., et al. Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol 65 (2009), 520–530.
    • (2009) Ann Neurol , vol.65 , pp. 520-530
    • Luo, Y.1    Kuo, C.C.2    Shen, H.3    Chou, J.4    Greig, N.H.5    Hoffer, B.J.6
  • 59
    • 63849136046 scopus 로고    scopus 로고
    • Systemic inflammatory response following acute traumatic brain injury
    • Lu, J., Goh, S.J., Tng, P.Y., Deng, Y.Y., Ling, E.A., Moochhala, S., Systemic inflammatory response following acute traumatic brain injury. Front Biosci 14 (2009), 3795–3813.
    • (2009) Front Biosci , vol.14 , pp. 3795-3813
    • Lu, J.1    Goh, S.J.2    Tng, P.Y.3    Deng, Y.Y.4    Ling, E.A.5    Moochhala, S.6
  • 60
    • 84881367333 scopus 로고    scopus 로고
    • Thrombin regulation of synaptic plasticity: implications for physiology and pathology
    • Maggio, N., Itsekson, Z., Dominissini, D., Blatt, I., Amariglio, N., Rechavi, G., et al. Thrombin regulation of synaptic plasticity: implications for physiology and pathology. Exp Neurol 247 (2013), 595–604.
    • (2013) Exp Neurol , vol.247 , pp. 595-604
    • Maggio, N.1    Itsekson, Z.2    Dominissini, D.3    Blatt, I.4    Amariglio, N.5    Rechavi, G.6
  • 61
    • 84904266705 scopus 로고    scopus 로고
    • The anticoagulant activated protein. C. (aPC) promotes metaplasticity in the hippocampus through an EPCR-PAR1-S1P1 receptors dependent mechanism
    • Maggio, N., Itsekson, Z., Ikenberg, B., Strehl, A., Vlachos, A., Blatt, I., et al. The anticoagulant activated protein. C. (aPC) promotes metaplasticity in the hippocampus through an EPCR-PAR1-S1P1 receptors dependent mechanism. Hippocampus 24 (2014), 1030–1038.
    • (2014) Hippocampus , vol.24 , pp. 1030-1038
    • Maggio, N.1    Itsekson, Z.2    Ikenberg, B.3    Strehl, A.4    Vlachos, A.5    Blatt, I.6
  • 62
    • 38549170323 scopus 로고    scopus 로고
    • Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: toward understanding the functional consequences of cerebrovascular insults
    • Maggio, N., Shavit, E., Chapman, J., Segal, M., Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: toward understanding the functional consequences of cerebrovascular insults. J Neurosci 28 (2008), 732–736.
    • (2008) J Neurosci , vol.28 , pp. 732-736
    • Maggio, N.1    Shavit, E.2    Chapman, J.3    Segal, M.4
  • 63
    • 84889585590 scopus 로고    scopus 로고
    • Prolonged systemic inflammation persistently modifies synaptic plasticity in the hippocampus: modulation by the stress hormones
    • Maggio, N., Shavit-Stein, E., Dori, A., Blatt, I., Chapman, J., Prolonged systemic inflammation persistently modifies synaptic plasticity in the hippocampus: modulation by the stress hormones. Front Mol Neurosci, 6, 2013, 46.
    • (2013) Front Mol Neurosci , vol.6 , pp. 46
    • Maggio, N.1    Shavit-Stein, E.2    Dori, A.3    Blatt, I.4    Chapman, J.5
  • 64
    • 0036409858 scopus 로고    scopus 로고
    • Effects of divided attention on episodic memory in chronic traumatic brain injury: a function of severity and strategy
    • Mangels, J.A., Craik, F.I., Levine, B., Schwartz, M.L., Stuss, D.T., Effects of divided attention on episodic memory in chronic traumatic brain injury: a function of severity and strategy. Neuropsychologia 40:13 (2002), 2369–2385.
    • (2002) Neuropsychologia , vol.40 , Issue.13 , pp. 2369-2385
    • Mangels, J.A.1    Craik, F.I.2    Levine, B.3    Schwartz, M.L.4    Stuss, D.T.5
  • 65
  • 66
    • 55949104665 scopus 로고    scopus 로고
    • TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    • McCoy, M.K., Tansey, M.G., TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation, 5, 2008, 45.
    • (2008) J Neuroinflammation , vol.5 , pp. 45
    • McCoy, M.K.1    Tansey, M.G.2
  • 67
    • 25444529946 scopus 로고    scopus 로고
    • Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice
    • Milman, A., Rosenberg, A., Weizman, R., Pick, C.G., Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice. J Neurotrauma 22:9 (2005), 1003–1010.
    • (2005) J Neurotrauma , vol.22 , Issue.9 , pp. 1003-1010
    • Milman, A.1    Rosenberg, A.2    Weizman, R.3    Pick, C.G.4
  • 68
    • 34447558496 scopus 로고    scopus 로고
    • Traumatic brain injury: assessment, resuscitation and early management
    • Moppett, I., Traumatic brain injury: assessment, resuscitation and early management. Br J Anaesth 99 (2007), 18–31.
    • (2007) Br J Anaesth , vol.99 , pp. 18-31
    • Moppett, I.1
  • 69
    • 29044447857 scopus 로고    scopus 로고
    • Experimental models of traumatic brain injury: do we really need to build a better mousetrap?
    • Morales, D.M., Marklund, N., Lebold, D., Thompson, H.J., Pitkanen, A., Maxwell, W.L., et al. Experimental models of traumatic brain injury: do we really need to build a better mousetrap?. Neuroscience 136:4 (2005), 971–989.
    • (2005) Neuroscience , vol.136 , Issue.4 , pp. 971-989
    • Morales, D.M.1    Marklund, N.2    Lebold, D.3    Thompson, H.J.4    Pitkanen, A.5    Maxwell, W.L.6
  • 70
    • 84907759430 scopus 로고    scopus 로고
    • Decreased bursting and novel object-specific cell firing in the hippocampus after mild traumatic brain injury
    • Munyon, C., Eakin, K.C., Sweet, J.A., Miller, J.P., Decreased bursting and novel object-specific cell firing in the hippocampus after mild traumatic brain injury. Brain Research 1582 (2014), 220–226.
    • (2014) Brain Research , vol.1582 , pp. 220-226
    • Munyon, C.1    Eakin, K.C.2    Sweet, J.A.3    Miller, J.P.4
  • 71
    • 79953661325 scopus 로고    scopus 로고
    • Animal models of traumatic brain injury: a critical evaluation
    • O'Connor, W.T., Smyth, A., Gilchrist, M.D., Animal models of traumatic brain injury: a critical evaluation. Pharmacol Ther 130 (2011), 106–113.
    • (2011) Pharmacol Ther , vol.130 , pp. 106-113
    • O'Connor, W.T.1    Smyth, A.2    Gilchrist, M.D.3
  • 73
    • 0036182251 scopus 로고    scopus 로고
    • Induction of differentiation by glucagon-like peptide-1: a novel neurotrophic factor in PC12 cells
    • Perry, T., Lahiri, D.K., Chen, D., Zhou, J., Shaw, K.T., Egan, J.M., et al. Induction of differentiation by glucagon-like peptide-1: a novel neurotrophic factor in PC12 cells. J Pharmacol Exp Ther 300 (2002), 958–966.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 958-966
    • Perry, T.1    Lahiri, D.K.2    Chen, D.3    Zhou, J.4    Shaw, K.T.5    Egan, J.M.6
  • 74
    • 0036721026 scopus 로고    scopus 로고
    • Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    • Perry, T., Haughey, N.J., Mattson, M.P., Egan, J.M., Greig, N.H., Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther 302 (2002), 881–888.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 881-888
    • Perry, T.1    Haughey, N.J.2    Mattson, M.P.3    Egan, J.M.4    Greig, N.H.5
  • 75
    • 0041733259 scopus 로고    scopus 로고
    • The glucagon-like peptides: a double-edged therapeutic sword?
    • Perry, T., Greig, N.H., The glucagon-like peptides: a double-edged therapeutic sword?. Trends Pharmacol Sci 24 (2003), 377–383.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 377-383
    • Perry, T.1    Greig, N.H.2
  • 76
    • 22144491473 scopus 로고    scopus 로고
    • Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease
    • Perry, T., Greig, N.H., Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease. Curr Alzheimer Res 2 (2005), 377–385.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 377-385
    • Perry, T.1    Greig, N.H.2
  • 77
    • 33846501672 scopus 로고    scopus 로고
    • Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    • Perry, T., et al. Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp Neurol 203 (2007), 293–301.
    • (2007) Exp Neurol , vol.203 , pp. 293-301
    • Perry, T.1
  • 78
    • 34447643258 scopus 로고    scopus 로고
    • Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity
    • Plesnila, N., von Baumgarten, L., Retiounskaia, M., Engel, D., Ardeshiri, A., Zimmermann, R., et al. Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity. Cell Death Differ 14 (2007), 1529–1541.
    • (2007) Cell Death Differ , vol.14 , pp. 1529-1541
    • Plesnila, N.1    von Baumgarten, L.2    Retiounskaia, M.3    Engel, D.4    Ardeshiri, A.5    Zimmermann, R.6
  • 79
    • 84896690648 scopus 로고    scopus 로고
    • Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α
    • Rachmany, L., Tweedie, D., Rubovitch, V., Yu, Q.S., Li, Y., Wang, J.Y., et al. Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α. PLoS ONE, 8(11), 2013, e79837.
    • (2013) PLoS ONE , vol.8 , Issue.11 , pp. e79837
    • Rachmany, L.1    Tweedie, D.2    Rubovitch, V.3    Yu, Q.S.4    Li, Y.5    Wang, J.Y.6
  • 80
    • 84892579498 scopus 로고    scopus 로고
    • Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice
    • Rachmany, L., Tweedie, D., Li, Y., Rubovitch, V., Holloway, H.W., Miller, J., et al. Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice. Age 35:5 (2013), 1621–1636.
    • (2013) Age , vol.35 , Issue.5 , pp. 1621-1636
    • Rachmany, L.1    Tweedie, D.2    Li, Y.3    Rubovitch, V.4    Holloway, H.W.5    Miller, J.6
  • 81
    • 84959183330 scopus 로고    scopus 로고
    • Mark/Par-1 marking the polarity of migrating neurons
    • Reiner, O., Sapir, T., Mark/Par-1 marking the polarity of migrating neurons. Adv Exp Med Biol 800 (2014), 97–111.
    • (2014) Adv Exp Med Biol , vol.800 , pp. 97-111
    • Reiner, O.1    Sapir, T.2
  • 85
    • 84862748768 scopus 로고    scopus 로고
    • Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    • Salcedo, I., Tweedie, D., Li, Y., Greig, N.H., Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders. Br J Pharmacol 166 (2012), 1586–1599.
    • (2012) Br J Pharmacol , vol.166 , pp. 1586-1599
    • Salcedo, I.1    Tweedie, D.2    Li, Y.3    Greig, N.H.4
  • 86
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signalling in platelets in haemostasis and thrombosis
    • Sambrano, G.R., Weiss, E.J., Zheng, Y.W., Huang, W., Coughlin, S.R., Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 413 (2001), 74–78.
    • (2001) Nature , vol.413 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 87
    • 84923996036 scopus 로고    scopus 로고
    • Pharmacological applications of antioxidants: lights and shadows
    • Saso, L., Firuzi, O., Pharmacological applications of antioxidants: lights and shadows. Curr Drug Targets 15 (2014), 1177–1199.
    • (2014) Curr Drug Targets , vol.15 , pp. 1177-1199
    • Saso, L.1    Firuzi, O.2
  • 88
    • 84866522881 scopus 로고    scopus 로고
    • The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury
    • Saykally, J.N., Rachmany, L., Hatic, H., Shaer, A., Rubovitch, V., Pick, C.G., et al. The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury. Neuroscience 223 (2012), 305–314.
    • (2012) Neuroscience , vol.223 , pp. 305-314
    • Saykally, J.N.1    Rachmany, L.2    Hatic, H.3    Shaer, A.4    Rubovitch, V.5    Pick, C.G.6
  • 89
    • 0033521550 scopus 로고    scopus 로고
    • Immediate in vivo response of the cortex and the blood–brain barrier following dynamic cortical deformation in the rat
    • Shreiber, D.I., Smith, D.H., Meaney, D.F., Immediate in vivo response of the cortex and the blood–brain barrier following dynamic cortical deformation in the rat. Neurosci Lett 259:1 (1999), 5–8.
    • (1999) Neurosci Lett , vol.259 , Issue.1 , pp. 5-8
    • Shreiber, D.I.1    Smith, D.H.2    Meaney, D.F.3
  • 90
    • 46149109507 scopus 로고    scopus 로고
    • Long-lasting sleep patterns of adult patients with minor traumatic brain injury (mTBI) and non-mTBI subjects
    • Schreiber, S., Barkai, G., Gur-Hartman, T., Peles, E., Tov, N., Dolberg, O.T., et al. Long-lasting sleep patterns of adult patients with minor traumatic brain injury (mTBI) and non-mTBI subjects. Sleep Med 9 (2008), 481–484.
    • (2008) Sleep Med , vol.9 , pp. 481-484
    • Schreiber, S.1    Barkai, G.2    Gur-Hartman, T.3    Peles, E.4    Tov, N.5    Dolberg, O.T.6
  • 91
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant
    • Shohami, E., Gallily, R., Mechoulam, R., Bass, R., Ben-Hur, T., Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant. J Neuroimmunol 72 (1997), 169–177.
    • (1997) J Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben-Hur, T.5
  • 92
    • 64849083719 scopus 로고    scopus 로고
    • Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1
    • Schuepbach, R.A., Feistritzer, C., Fernández, J.A., Griffin, J.H., Riewald, M., Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost 101 (2009), 724–733.
    • (2009) Thromb Haemost , vol.101 , pp. 724-733
    • Schuepbach, R.A.1    Feistritzer, C.2    Fernández, J.A.3    Griffin, J.H.4    Riewald, M.5
  • 93
    • 82555195545 scopus 로고    scopus 로고
    • Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects
    • Siller-Matula, J.M., Schwameis, M., Blann, A., Mannhalter, C., Jilma, B., Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects. Thromb Haemost 106 (2011), 1020–1033.
    • (2011) Thromb Haemost , vol.106 , pp. 1020-1033
    • Siller-Matula, J.M.1    Schwameis, M.2    Blann, A.3    Mannhalter, C.4    Jilma, B.5
  • 94
    • 77955856308 scopus 로고    scopus 로고
    • Mild fluid percussion injury in mice produces evolving selective axonal pathology and cognitive deficits relevant to human brain injury
    • Spain, A., Daumas, S., Lifshitz, J., Rhodes, J., Andrews, P.J., Horsburgh, K., et al. Mild fluid percussion injury in mice produces evolving selective axonal pathology and cognitive deficits relevant to human brain injury. J Neurotrauma 27:8 (2010), 1429–1438.
    • (2010) J Neurotrauma , vol.27 , Issue.8 , pp. 1429-1438
    • Spain, A.1    Daumas, S.2    Lifshitz, J.3    Rhodes, J.4    Andrews, P.J.5    Horsburgh, K.6
  • 95
    • 79955370074 scopus 로고    scopus 로고
    • Increased platelet aggregation and in vivo platelet activation after granulocyte colony-stimulating factor administration. A randomised controlled trial
    • Spiel, A.O., Bartko, J., Schwameis, M., Firbas, C., Siller-Matula, J., Schuetz, M., et al. Increased platelet aggregation and in vivo platelet activation after granulocyte colony-stimulating factor administration. A randomised controlled trial. Thromb Haemost 105 (2011), 655–662.
    • (2011) Thromb Haemost , vol.105 , pp. 655-662
    • Spiel, A.O.1    Bartko, J.2    Schwameis, M.3    Firbas, C.4    Siller-Matula, J.5    Schuetz, M.6
  • 96
    • 84919384972 scopus 로고    scopus 로고
    • The role of soluble adenylyl cyclase in neurite outgrowth
    • Stiles, T., Kapiloff, M.S., Goldberg, J.L., The role of soluble adenylyl cyclase in neurite outgrowth. Biochim Biophys Acta 1842:12 Pt B (2014), 2561–2568.
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.12 , pp. 2561-2568
    • Stiles, T.1    Kapiloff, M.S.2    Goldberg, J.L.3
  • 97
    • 33846147022 scopus 로고    scopus 로고
    • Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice
    • Tashlykov, V., Katz, Y., Gazit, V., Zohar, O., Schreiber, S., Pick, C.G., Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice. Brain Res 1130 (2007), 197–205.
    • (2007) Brain Res , vol.1130 , pp. 197-205
    • Tashlykov, V.1    Katz, Y.2    Gazit, V.3    Zohar, O.4    Schreiber, S.5    Pick, C.G.6
  • 100
    • 84910666313 scopus 로고    scopus 로고
    • Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date
    • Tuttolomondo, A., Pecoraro, R., Pinto, A., Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date. Drug Des Devel Ther 8 (2014), 2221–2238.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 2221-2238
    • Tuttolomondo, A.1    Pecoraro, R.2    Pinto, A.3
  • 101
    • 33947269318 scopus 로고    scopus 로고
    • Apoptotic and behavioral sequelae of mild brain trauma in mice
    • Tweedie, D., Milman, A., Holloway, H.W., Li, Y., Harvey, B.K., Shen, H., et al. Apoptotic and behavioral sequelae of mild brain trauma in mice. J Neuroscie Res 85:4 (2007), 805–815.
    • (2007) J Neuroscie Res , vol.85 , Issue.4 , pp. 805-815
    • Tweedie, D.1    Milman, A.2    Holloway, H.W.3    Li, Y.4    Harvey, B.K.5    Shen, H.6
  • 102
    • 34548726106 scopus 로고    scopus 로고
    • TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets
    • Tweedie, D., Sambamurti, K., Greig, N.H., TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr Alzheimer Res 4 (2007), 378–385.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 378-385
    • Tweedie, D.1    Sambamurti, K.2    Greig, N.H.3
  • 103
    • 84861473274 scopus 로고    scopus 로고
    • TNF-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease
    • Tweedie, D., Ferguson, R.A., Fishman, K., Frankola, K.A., Van Praag, H., Holloway, H.W., et al. TNF-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflamm, 9, 2012, 106.
    • (2012) J Neuroinflamm , vol.9 , pp. 106
    • Tweedie, D.1    Ferguson, R.A.2    Fishman, K.3    Frankola, K.A.4    Van Praag, H.5    Holloway, H.W.6
  • 104
    • 84868458245 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
    • Tweedie, D., Rachmany, L., Rubovitch, V., Lehrmann, E., Zhang, Y., Becker, K.G., et al. Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice. Exp Neurol 239 (2013), 170–182.
    • (2013) Exp Neurol , vol.239 , pp. 170-182
    • Tweedie, D.1    Rachmany, L.2    Rubovitch, V.3    Lehrmann, E.4    Zhang, Y.5    Becker, K.G.6
  • 105
    • 84954026166 scopus 로고    scopus 로고
    • Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4
    • Tweedie, D., Rachmany, L., Rubovitch, V., Li, Y., Holloway, H.W., Lehrmann, E., et al. Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4. Alzheimers Dement 12:1 (2016), 34–48.
    • (2016) Alzheimers Dement , vol.12 , Issue.1 , pp. 34-48
    • Tweedie, D.1    Rachmany, L.2    Rubovitch, V.3    Li, Y.4    Holloway, H.W.5    Lehrmann, E.6
  • 106
    • 34447527791 scopus 로고    scopus 로고
    • Pathophysiology of traumatic brain injury
    • Werner, C., Engelhard, K., Pathophysiology of traumatic brain injury. Br J Anaesth 99:1 (2007), 4–9.
    • (2007) Br J Anaesth , vol.99 , Issue.1 , pp. 4-9
    • Werner, C.1    Engelhard, K.2
  • 107
    • 0032717916 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats
    • Xiong, Y., Peterson, P.L., Lee, C.P., Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J Neurotrauma 16 (1999), 1067–1082.
    • (1999) J Neurotrauma , vol.16 , pp. 1067-1082
    • Xiong, Y.1    Peterson, P.L.2    Lee, C.P.3
  • 108
    • 77953956929 scopus 로고    scopus 로고
    • Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice
    • Yang, J., You, Z., Kim, H.H., Hwang, S.K., Khuman, J., Guo, S., et al. Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. J Neurotrauma 27 (2010), 1037–1046.
    • (2010) J Neurotrauma , vol.27 , pp. 1037-1046
    • Yang, J.1    You, Z.2    Kim, H.H.3    Hwang, S.K.4    Khuman, J.5    Guo, S.6
  • 109
    • 84927644468 scopus 로고    scopus 로고
    • Post-trauma administration of the pifithrin-α oxygen analogue improves histological and functional outcomes after experimental traumatic brain injury
    • Yang, L., Chu, Y.H., Tweedie, D., Yu, Q.S., Pick, C.G., Hoffer, B.J., et al. Post-trauma administration of the pifithrin-α oxygen analogue improves histological and functional outcomes after experimental traumatic brain injury. Exp Neurol 269 (2015), 56–66.
    • (2015) Exp Neurol , vol.269 , pp. 56-66
    • Yang, L.1    Chu, Y.H.2    Tweedie, D.3    Yu, Q.S.4    Pick, C.G.5    Hoffer, B.J.6
  • 110
    • 84874790917 scopus 로고    scopus 로고
    • 3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation
    • Yoon, J.S., Lee, J.H., Tweedie, D., Mughal, M.R., Chigurupati, S., Greig, N.H., et al. 3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation. J Neurosci Res 91 (2013), 671–680.
    • (2013) J Neurosci Res , vol.91 , pp. 671-680
    • Yoon, J.S.1    Lee, J.H.2    Tweedie, D.3    Mughal, M.R.4    Chigurupati, S.5    Greig, N.H.6
  • 111
    • 84867506098 scopus 로고    scopus 로고
    • Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury
    • Zhao, Z., Loane, D.J., Murray, M.G., Stoica, B.A., Faden, A.I., Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury. J Neurotrauma 29:15 (2012), 2475–2489.
    • (2012) J Neurotrauma , vol.29 , Issue.15 , pp. 2475-2489
    • Zhao, Z.1    Loane, D.J.2    Murray, M.G.3    Stoica, B.A.4    Faden, A.I.5
  • 112
    • 0037038332 scopus 로고    scopus 로고
    • Novel p53 inhibitors with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives
    • Zhu, X., Yu, Q.S., Cutler, R.G., Culmsee, C.W., Holloway, H.W., Lahiri, D.K., et al. Novel p53 inhibitors with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives. J Med Chem 45 (2002), 5090–5097.
    • (2002) J Med Chem , vol.45 , pp. 5090-5097
    • Zhu, X.1    Yu, Q.S.2    Cutler, R.G.3    Culmsee, C.W.4    Holloway, H.W.5    Lahiri, D.K.6
  • 113
    • 0242691672 scopus 로고    scopus 로고
    • Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity
    • Zhu, X., Giordano, T., Yu, Q.S., Holloway, H.W., Perry, T., Lahiri, D.K., et al. Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity. J Med Chem 46 (2003), 5222–5229.
    • (2003) J Med Chem , vol.46 , pp. 5222-5229
    • Zhu, X.1    Giordano, T.2    Yu, Q.S.3    Holloway, H.W.4    Perry, T.5    Lahiri, D.K.6
  • 114
    • 0038066572 scopus 로고    scopus 로고
    • Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice
    • Zohar, O., Schreiber, S., Getslev, V., Schwartz, J.P., Mullins, P.G., Pick, C.G., Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice. Neuroscience 118:4 (2003), 949–955.
    • (2003) Neuroscience , vol.118 , Issue.4 , pp. 949-955
    • Zohar, O.1    Schreiber, S.2    Getslev, V.3    Schwartz, J.P.4    Mullins, P.G.5    Pick, C.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.