-
1
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2002) Inflammation and Alzheimer's disease. Neurobiol Aging 21: 383-421.
-
(2002)
Neurobiol Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
Cooper, N.R.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.L.10
Finch, C.E.11
Frautschy, S.12
Griffin, W.S.13
Hampel, H.14
Hull, M.15
Landreth, G.16
Lue, L.17
Mrak, R.18
Mackenzie, I.R.19
McGeer, P.L.20
O'Banion, M.K.21
Pachter, J.22
Pasinetti, G.23
Plata-Salaman, C.24
Rogers, J.25
Rydel, R.26
Shen, Y.27
Streit, W.28
Strohmeyer, R.29
Tooyoma, I.30
Van Muiswinkel, F.L.31
Veerhuis, R.32
Walker, D.33
Webster, S.34
Wegrzyniak, B.35
Wenk, G.36
Wyss-Coray, T.37
more..
-
2
-
-
0034752311
-
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
-
Allison AC, Cacabelos R, Lombardi VR, Alvarez XA, Vigo C (2001) Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog Neuro-Psychopharmacol Biol Psychiat 25: 1341-1357.
-
(2001)
Prog Neuro-Psychopharmacol Biol Psychiat
, vol.25
, pp. 1341-1357
-
-
Allison, A.C.1
Cacabelos, R.2
Lombardi, V.R.3
Alvarez, X.A.4
Vigo, C.5
-
3
-
-
0035162672
-
ARED: Human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins
-
Bakheet T, Frevel M, Williams BRG, Greer W, Khabar KSA (2001) ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res 29: 246-254.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 246-254
-
-
Bakheet, T.1
Frevel, M.2
Williams, B.R.G.3
Greer, W.4
Khabar, K.S.A.5
-
4
-
-
0034611980
-
Neuroinflammation and Alzheimer's disease: Critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E
-
discussion: 451-453
-
Bales KR, Du Y, Holtzman D, Cordell B, Paul SM (2000) Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E. Neurobiol Aging 21: 427-432. (discussion: 451-453.)
-
(2000)
Neurobiol Aging
, vol.21
, pp. 427-432
-
-
Bales, K.R.1
Du, Y.2
Holtzman, D.3
Cordell, B.4
Paul, S.M.5
-
5
-
-
0032100604
-
Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent
-
Bauer KS, Dixon SC, Figg WD (1998) Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent. Biochem Pharm 55: 1827-1834.
-
(1998)
Biochem Pharm
, vol.55
, pp. 1827-1834
-
-
Bauer, K.S.1
Dixon, S.C.2
Figg, W.D.3
-
6
-
-
0029976817
-
An essential role of NFκ3 in preventing TNF-α-induced cell death
-
Begg AA, Baltimore D (1996) An essential role of NFκ3 in preventing TNF-α-induced cell death. Science 274: 782-784.
-
(1996)
Science
, vol.274
, pp. 782-784
-
-
Begg, A.A.1
Baltimore, D.2
-
7
-
-
0033559114
-
Identification of AUF-1 ligands reveals vast diversity of early response gene mRNAS
-
Bhattacharya S, Giordano T, Brewer G, Malter JS (1999) Identification of AUF-1 ligands reveals vast diversity of early response gene mRNAS. Nucl Acids Res 27: 1464-1472.
-
(1999)
Nucl Acids Res
, vol.27
, pp. 1464-1472
-
-
Bhattacharya, S.1
Giordano, T.2
Brewer, G.3
Malter, J.S.4
-
8
-
-
0030250376
-
Inflammatory processes and anti-inflammatory drugs in Alzheimer's disease: A current appraisal
-
Breitner JCS (1997) Inflammatory processes and anti-inflammatory drugs in Alzheimer's disease: a current appraisal. Neurobiol Aging 17: 789-794.
-
(1997)
Neurobiol Aging
, vol.17
, pp. 789-794
-
-
Breitner, J.C.S.1
-
10
-
-
0026448114
-
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor
-
Buxbaum JD, Oishi M, Chen HI, Pankas-Kramarski R, Jaffe EA, Grandy SE, Greengard P (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A 1: 10075-10078.
-
(1992)
Proc Natl Acad Sci U S A
, vol.1
, pp. 10075-10078
-
-
Buxbaum, J.D.1
Oishi, M.2
Chen, H.I.3
Pankas-Kramarski, R.4
Jaffe, E.A.5
Grandy, S.E.6
Greengard, P.7
-
11
-
-
0036311159
-
Transforming growth factor-α-induced transcription of the Alzheimer β-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads
-
Burton T, Liang B, Dibrov A, Amara F (2002) Transforming growth factor-α-induced transcription of the Alzheimer β-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads. Biochem Biophys Res Commun 295: 713-723.
-
(2002)
Biochem Biophys Res Commun
, vol.295
, pp. 713-723
-
-
Burton, T.1
Liang, B.2
Dibrov, A.3
Amara, F.4
-
12
-
-
0032516626
-
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
-
Carballo E, Lai WS, Blackshear P (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281: 1001-1005.
-
(1998)
Science
, vol.281
, pp. 1001-1005
-
-
Carballo, E.1
Lai, W.S.2
Blackshear, P.3
-
13
-
-
44349183414
-
Thionation reaction of Lawesson's reagents
-
Cava MP, Levinson MI (1985) Thionation reaction of Lawesson's reagents. Tetrahedron 41: 5061-5087.
-
(1985)
Tetrahedron
, vol.41
, pp. 5061-5087
-
-
Cava, M.P.1
Levinson, M.I.2
-
14
-
-
0028788194
-
Au-rich elements: Characterization and importance in mRNA degradation
-
Chen C-YA, Shyu A-B (1995) Au-rich elements: characterization and importance in mRNA degradation. TIBS 20: 465-470.
-
(1995)
TIBS
, vol.20
, pp. 465-470
-
-
Chen, C.-Y.A.1
Shyu, A.-B.2
-
16
-
-
0028889206
-
Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1
-
Das S, Potter H (1995) Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron 4: 447-456.
-
(1995)
Neuron
, vol.4
, pp. 447-456
-
-
Das, S.1
Potter, H.2
-
17
-
-
0034746363
-
The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR
-
Dean JLE, Wait R, Mahtani KR, Sully G, Clark AR, Saklatvala J (2001) The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol 21: 721-730.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 721-730
-
-
Dean, J.L.E.1
Wait, R.2
Mahtani, K.R.3
Sully, G.4
Clark, A.R.5
Saklatvala, J.6
-
18
-
-
0032442852
-
Smads: Transcriptional activators of TGF-β responses
-
Derynck R, Zhang Y, Feng XH (1998) Smads: transcriptional activators of TGF-β responses. Cell 95: 737-740.
-
(1998)
Cell
, vol.95
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.H.3
-
19
-
-
0025042316
-
Synthesis, central nervous system activity and teratogenicity of a homothalidomide
-
Eger K, Jalalian M, Verspohl EJ, Lupke NP (1990) Synthesis, central nervous system activity and teratogenicity of a homothalidomide. Arzneimittelforschung 40: 1073-1075.
-
(1990)
Arzneimittelforschung
, vol.40
, pp. 1073-1075
-
-
Eger, K.1
Jalalian, M.2
Verspohl, E.J.3
Lupke, N.P.4
-
20
-
-
0032526427
-
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAS
-
Fan XC, Steitz JA (1998) Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAS. EMBO J 17: 3448-3460.
-
(1998)
EMBO J
, vol.17
, pp. 3448-3460
-
-
Fan, X.C.1
Steitz, J.A.2
-
21
-
-
0033555659
-
ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
-
Ford L, Watson J, Keene JD, Wilusz J (1999) ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev 13: 188-201.
-
(1999)
Genes Dev
, vol.13
, pp. 188-201
-
-
Ford, L.1
Watson, J.2
Keene, J.D.3
Wilusz, J.4
-
22
-
-
0035186865
-
Thalidomide and its analogues inhibit lipopolysacharide-mediated induction of cyclooxygenase-2
-
Fujita J, Mestre JR, Zeldis K, Subbaramaiah K, Dannenberg AJ (2001) Thalidomide and its analogues inhibit lipopolysacharide-mediated induction of cyclooxygenase-2. Clin Cancer Res 7: 3349-3355.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3349-3355
-
-
Fujita, J.1
Mestre, J.R.2
Zeldis, K.3
Subbaramaiah, K.4
Dannenberg, A.J.5
-
23
-
-
0031922062
-
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain
-
Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y (1998) Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. Am J Pathol 152: 983-92.
-
(1998)
Am J Pathol
, vol.152
, pp. 983-992
-
-
Funato, H.1
Yoshimura, M.2
Yamazaki, T.3
Saido, T.C.4
Ito, Y.5
Yokofujita, J.6
Okeda, R.7
Ihara, Y.8
-
24
-
-
0005775566
-
Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells
-
Goldgaber D, Harris HW, Hla T, Maciag T, Donnelly RJ, Jacobsen JS, Vitek MP, Gajdusek DC (1989) Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A 86: 7606-7610.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7606-7610
-
-
Goldgaber, D.1
Harris, H.W.2
Hla, T.3
Maciag, T.4
Donnelly, R.J.5
Jacobsen, J.S.6
Vitek, M.P.7
Gajdusek, D.C.8
-
25
-
-
0001360461
-
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
-
Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LT, White CL 3rd, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86: 7611-7615.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7611-7615
-
-
Griffin, W.S.1
Stanley, L.C.2
Ling, C.3
White, L.4
MacLeod, V.5
Perrot, L.T.6
White III, C.L.7
Araoz, C.8
-
26
-
-
0025098538
-
Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level
-
Han J, Brown T, Beutler B (1990) Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171: 465-475.
-
(1990)
J Exp Med
, vol.171
, pp. 465-475
-
-
Han, J.1
Brown, T.2
Beutler, B.3
-
27
-
-
0032100486
-
Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset
-
Haslett P, Corral L, Albert M, Kaplan G (1998) Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. J Expl Med 187: 1885-1889.
-
(1998)
J Expl Med
, vol.187
, pp. 1885-1889
-
-
Haslett, P.1
Corral, L.2
Albert, M.3
Kaplan, G.4
-
28
-
-
0033103805
-
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
-
Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10: 387-398.
-
(1999)
Immunity
, vol.10
, pp. 387-398
-
-
Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
Cominelli, F.4
Kollias, G.5
-
29
-
-
0028589117
-
Translational control of cytokine expression by 3'AU-rich sequences
-
Kruys V, Huez G (1994) Translational control of cytokine expression by 3'AU-rich sequences. Biochemie 76: 862-866.
-
(1994)
Biochemie
, vol.76
, pp. 862-866
-
-
Kruys, V.1
Huez, G.2
-
30
-
-
0024432688
-
Translational blockade imposed by cytokine-derived UA-rich sequences
-
Kruys V, Marinx O, Shaw G, Deschamps J, Huez G (1989) Translational blockade imposed by cytokine-derived UA-rich sequences. Science 245: 852-855.
-
(1989)
Science
, vol.245
, pp. 852-855
-
-
Kruys, V.1
Marinx, O.2
Shaw, G.3
Deschamps, J.4
Huez, G.5
-
32
-
-
0033947102
-
Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue
-
Lahiri DK, Ge Y (2000) Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue. Brain Res Brain Res Protoc 5: 257-265.
-
(2000)
Brain Res Brain Res Protoc
, vol.5
, pp. 257-265
-
-
Lahiri, D.K.1
Ge, Y.2
-
33
-
-
0029114162
-
Promoter activity of the gene encoding the β-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1
-
Lahiri DK, Nall C (1995) Promoter activity of the gene encoding the β-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Brain Res Mol Brain Res 32: 233-240.
-
(1995)
Brain Res Mol Brain Res
, vol.32
, pp. 233-240
-
-
Lahiri, D.K.1
Nall, C.2
-
34
-
-
0036660457
-
Current drug targets for Alzheimer's disease treatment
-
Lahiri, D.K., Farlow, M.R., Greig, N.H., Sambamurti, K. (2002) Current drug targets for Alzheimer's disease treatment. Drug Dev Res 56: 267-281.
-
(2002)
Drug Dev Res
, vol.56
, pp. 267-281
-
-
Lahiri, D.K.1
Farlow, M.R.2
Greig, N.H.3
Sambamurti, K.4
-
35
-
-
0038705106
-
Role of cytokines in the gene expression of amyloid β-protein precursor: Identification of a 5'-UTR-Binding nuclear factor and its implications in Alzheimer's disease
-
Lahiri DK, Chen D, Vivien D, Ge YW, Greig NH, Rogers JT (2003a) Role of cytokines in the gene expression of amyloid β-protein precursor: Identification of a 5'-UTR-Binding nuclear factor and its implications in Alzheimer's disease. J Alz Dis 5: 81-90.
-
(2003)
J Alz Dis
, vol.5
, pp. 81-90
-
-
Lahiri, D.K.1
Chen, D.2
Vivien, D.3
Ge, Y.W.4
Greig, N.H.5
Rogers, J.T.6
-
36
-
-
0037315878
-
A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease
-
Lahiri DK, Farlow MR, Sambamurti K, Greig NH, Giacobini E, Schneider LS (2003b) A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr Drug Targets 4: 97-112.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 97-112
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
Greig, N.H.4
Giacobini, E.5
Schneider, L.S.6
-
37
-
-
0033049125
-
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
-
Lai WS, Carballo E, Strum JR, Kennington EA, Phillips RS, Blackshear PJ (1999) Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 19: 4311-4323.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4311-4323
-
-
Lai, W.S.1
Carballo, E.2
Strum, J.R.3
Kennington, E.A.4
Phillips, R.S.5
Blackshear, P.J.6
-
38
-
-
0035693924
-
Inflammation, autotoxicity and Alzheimer disease
-
McGeer PL, McGeer EG (2001) Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22: 799-809.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 799-809
-
-
McGeer, P.L.1
McGeer, E.G.2
-
39
-
-
0037279427
-
New insights into the pharmacological and toxicological effects of thalidomide
-
Meierhofer C, Wiedermann CJ (2003) New insights into the pharmacological and toxicological effects of thalidomide. Curr Opin Drug Discov Devel 6: 92-99.
-
(2003)
Curr Opin Drug Discov Devel
, vol.6
, pp. 92-99
-
-
Meierhofer, C.1
Wiedermann, C.J.2
-
40
-
-
0027230553
-
Thalidomide exerts its inhibitory action on tumor necrosis factor α by enhancing mRNA degradation
-
Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G (1993) Thalidomide exerts its inhibitory action on tumor necrosis factor α by enhancing mRNA degradation. J Exp Med 177: 1675-1680.
-
(1993)
J Exp Med
, vol.177
, pp. 1675-1680
-
-
Moreira, A.L.1
Sampaio, E.P.2
Zmuidzinas, A.3
Frindt, P.4
Smith, K.A.5
Kaplan, G.6
-
41
-
-
0035690976
-
Interleukin-1, neuroinflammation, and Alzheimer's disease
-
Mrak RE, Griffin WS (2001) Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging 22: 903-908.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 903-908
-
-
Mrak, R.E.1
Griffin, W.S.2
-
42
-
-
0026476297
-
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
-
Nitsch RM, Slack BE, Wurtman RJ, Growdon JH (1992) Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258: 304-307.
-
(1992)
Science
, vol.258
, pp. 304-307
-
-
Nitsch, R.M.1
Slack, B.E.2
Wurtman, R.J.3
Growdon, J.H.4
-
43
-
-
0036007215
-
5′-OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis
-
Price DK, Ando Y, Kruger E, Weiss M, Figg WD (2002) 5′ -OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis. Ther Drug Monitoring 24: 104-110.
-
(2002)
Ther Drug Monitoring
, vol.24
, pp. 104-110
-
-
Price, D.K.1
Ando, Y.2
Kruger, E.3
Weiss, M.4
Figg, W.D.5
-
45
-
-
0033525735
-
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
-
Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN (1999) Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences. J Biol Chem 274: 6421-6431.
-
(1999)
J Biol Chem
, vol.274
, pp. 6421-6431
-
-
Rogers, J.T.1
Leiter, L.M.2
McPhee, J.3
Cahill, C.M.4
Zhan, S.S.5
Potter, H.6
Nilsson, L.N.7
-
46
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR (2002a) An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem 277: 45518-45528.
-
(2002)
J Biol Chem
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
Eder, P.S.4
Huang, X.5
Gunshin, H.6
Leiter, L.7
McPhee, J.8
Sarang, S.S.9
Utsuki, T.10
Greig, N.H.11
Lahiri, D.K.12
Tanzi, R.E.13
Bush, A.I.14
Giordano, T.15
Gullans, S.R.16
-
47
-
-
0036672706
-
Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region
-
Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig NH, Sarang SS, Gullans SR (2002b) Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci 19: 77-82.
-
(2002)
J Mol Neurosci
, vol.19
, pp. 77-82
-
-
Rogers, J.T.1
Randall, J.D.2
Eder, P.S.3
Huang, X.4
Bush, A.I.5
Tanzi, R.E.6
Venti, A.7
Payton, S.M.8
Giordano, T.9
Nagano, S.10
Cahill, C.M.11
Moir, R.12
Lahiri, D.K.13
Greig, N.H.14
Sarang, S.S.15
Gullans, S.R.16
-
48
-
-
0036370776
-
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
-
Sambamurti K, Greig NH, Lahiri DK (2002) Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med 1: 1-31.
-
(2002)
Neuromolecular Med
, vol.1
, pp. 1-31
-
-
Sambamurti, K.1
Greig, N.H.2
Lahiri, D.K.3
-
49
-
-
0026080801
-
Thalidomide selectively inhibits tumor necrosis factor of a production by stimulated human monocytes
-
Sampaio EP, Sarno EN, Gallily R, Cohn ZA, Kaplan G (1991) Thalidomide selectively inhibits tumor necrosis factor of a production by stimulated human monocytes. J Exp Med 173: 699-703.
-
(1991)
J Exp Med
, vol.173
, pp. 699-703
-
-
Sampaio, E.P.1
Sarno, E.N.2
Gallily, R.3
Cohn, Z.A.4
Kaplan, G.5
-
50
-
-
0027304271
-
The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum
-
Sampaio EP, Kaplan G, Miranda A, Nery JA, Miguel CP, Viana SM, Sarno EN (1993) The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. J Infect Dis 168: 408-414.
-
(1993)
J Infect Dis
, vol.168
, pp. 408-414
-
-
Sampaio, E.P.1
Kaplan, G.2
Miranda, A.3
Nery, J.A.4
Miguel, C.P.5
Viana, S.M.6
Sarno, E.N.7
-
51
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
52
-
-
0035912825
-
Phenserine regulates translation of beta-amyloid precursor mRNA by a putative interleukin-1 responsive element, a target for drug development
-
Shaw KT, Utsuki T, Rogers J, Yu Q-S, Sambamurti K, Brossi A, Ge Y-W, Lahiri DK, Greig NH (2001) Phenserine regulates translation of beta-amyloid precursor mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci U S A 98: 7605-7610.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 7605-7610
-
-
Shaw, K.T.1
Utsuki, T.2
Rogers, J.3
Yu, Q.-S.4
Sambamurti, K.5
Brossi, A.6
Ge, Y.-W.7
Lahiri, D.K.8
Greig, N.H.9
-
53
-
-
0034089871
-
Tranforming growth factor-β1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stablization of mRNA
-
Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD (2000) Tranforming growth factor-β1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stablization of mRNA. J Biol Chem 275: 6628-6635.
-
(2000)
J Biol Chem
, vol.275
, pp. 6628-6635
-
-
Sheng, H.1
Shao, J.2
Dixon, D.A.3
Williams, C.S.4
Prescott, S.M.5
DuBois, R.N.6
Beauchamp, R.D.7
-
54
-
-
84883833410
-
Thalidomide in the treatment of lepra reaction
-
Sheskin J (1965) Thalidomide in the treatment of lepra reaction. Clin Pharmacol Ther 6: 303-310
-
(1965)
Clin Pharmacol Ther
, vol.6
, pp. 303-310
-
-
Sheskin, J.1
-
55
-
-
0028986193
-
NFκB: A lesson in family values
-
Thanos D, Maniatis T (1995) NFκB: a lesson in family values. Cell 80: 529-532.
-
(1995)
Cell
, vol.80
, pp. 529-532
-
-
Thanos, D.1
Maniatis, T.2
-
56
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, Breteler MM, Stricker BH (2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. New Engl J Med 345: 1515-1521.
-
(2001)
New Engl J Med
, vol.345
, pp. 1515-1521
-
-
Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
Launer, L.J.4
Van Duijn, C.M.5
Stijnen, T.6
Breteler, M.M.7
Stricker, B.H.8
-
57
-
-
0035038917
-
Inflammation and Alzheimer disease: The good, the bad, and the ugly
-
Weninger SC, Yankner BA (2001) Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med 7: 527-528.
-
(2001)
Nat Med
, vol.7
, pp. 527-528
-
-
Weninger, S.C.1
Yankner, B.A.2
-
58
-
-
0035914429
-
Structural remodeling of an A+U-rich RNA element by cation or AUF1 binding
-
Wilson GM, Sutphen K, Moutafis M, Sinha S, Brewer G (2001) Structural remodeling of an A+U-rich RNA element by cation or AUF1 binding. J Biol Chem 276: 38400-38409.
-
(2001)
J Biol Chem
, vol.276
, pp. 38400-38409
-
-
Wilson, G.M.1
Sutphen, K.2
Moutafis, M.3
Sinha, S.4
Brewer, G.5
-
59
-
-
0030872398
-
Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay
-
Xu NH, Chen CA, Shyu A-B (1997) Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay. Mol Cell Biol 17: 4611-4621.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4611-4621
-
-
Xu, N.H.1
Chen, C.A.2
Shyu, A.-B.3
-
60
-
-
0034806974
-
Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover
-
Xu N, Chen CA, Shyu A-B (2001) Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover. Mol Cell Biol 21: 6960-6971.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6960-6971
-
-
Xu, N.1
Chen, C.A.2
Shyu, A.-B.3
-
61
-
-
0035696257
-
Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence
-
Zandi PP, Breitner JC (2001) Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence. Neurobiol Aging 22: 811-817.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 811-817
-
-
Zandi, P.P.1
Breitner, J.C.2
-
62
-
-
0242691672
-
Thiothalidomides: Novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity
-
Zhu XX, Giordano T, Yu QS, Holloway HW, Perry TA, Lahiri DK, Brossi A, Greig NH (2003) Thiothalidomides: Novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity. J Med Chem 46: 5222-5229
-
(2003)
J Med Chem
, vol.46
, pp. 5222-5229
-
-
Zhu, X.X.1
Giordano, T.2
Yu, Q.S.3
Holloway, H.W.4
Perry, T.A.5
Lahiri, D.K.6
Brossi, A.7
Greig, N.H.8
-
63
-
-
1842607579
-
Genetic aspects of Alzheimer's disease
-
Żekanowski C, Religa D, Graff C, Filipek S, Kuźnicki J (2004) Genetic aspects of Alzheimer's disease. Acta Neurobiol Exp (Wars) 64: 19-31.
-
(2004)
Acta Neurobiol Exp (Wars)
, vol.64
, pp. 19-31
-
-
Zekanowski, C.1
Religa, D.2
Graff, C.3
Filipek, S.4
Kuźnicki, J.5
|