Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: Toward understanding the functional consequences of cerebrovascular insults

Journal of Neuroscience

Volumn 28, Issue 3, 2008, Pages 732-736

  Maggio, Nicola ^a   Shavit, Efrat ^b   Chapman, Joab ^b   Segal, Menahem ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cerebrovascular insult; Hippocampus; LTP; PAR1; Seizure; Thrombin

Indexed keywords

THROMBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN SLICE; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CONTROLLED STUDY; HEAD INJURY; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEIZURE; SENSORY NERVE; TETANUS;

AFFERENT PATHWAYS; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; EPILEPSY; GLUTAMIC ACID; HEMOSTATICS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; PEPTIDE FRAGMENTS; POTASSIUM; PYRROLES; QUINAZOLINES; RATS; RATS, WISTAR; RECEPTOR, PAR-1; THROMBIN;

EID: 38549170323     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3665-07.2008     Document Type: Article

References (34)

1. Almonte AG, Hamill CE, Chhatwal JP, Wingo TS, Barber JA, Lyuboslavsky PN, David Sweatt J, Ressler KJ, White DA, Traynelis SF (2007) Learning and memory deficits in mice lacking protease activated receptor-1. Neurobiol Learn Mem 88:295-304.
2. Anderson WW, Collingridge GL (2001) The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events. J Neurosci Methods 108:71-83.
3. Beilin O, Gurwitz D, Korczyn AD, Chapman J (2001) Quantitative measurements of mouse brain thrombin-like and thrombin inhibition activities. Neuroreport 12:2347-2351.
4. Beilin O, Karussis DM, Korczyn AD, Gurwitz D, Aronovich R, Hantai D, Grigoriadis N, Mizrachi-Kol R, Chapman J (2005) Increased thrombin inhibition in experimental autoimmune encephalomyelitis. J Neurosci Res 79:351-359.
5. Camilo O, Goldstein LB (2004) Seizures and epilepsy after ischemic stroke. Stroke 35:1769-1775.
6. Claassen J, Jette N, Chum F, Green R, Schmidt M, Choi H, Jirsch J, Frontera JA, Connolly ES, Emerson RG, Mayer SA, Hirsch LJ (2007) Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology 69:1356-1365.
7. de Haan EH, Nys GM, Van Zandvoort MJ (2006) Cognitive function following stroke and vascular cognitive impairment. Curr Opin Neurol 19:559-564.
8. Gingrich MB, Traynelis SF (2000) Serine proteases and brain damage - is there a link? Trends Neurosci 23:399-407.
9. Gingrich MB, Junge CE, Lyuboslavsky P, Traynelis SF (2000) Potentiation of NMDA receptor function by the serine protease thrombin. J Neurosci 20:4582-4595.
10. Henon H, Pasquier F, Leys D (2006) Poststroke dementia. Cerebrovasc Dis 22:61-70.
11. Hua Y, Keep RF, Hoff JT, Xi G (2007) Brain injury after intracerebral hemorrhage: the role of thrombin and iron. Stroke 38:759-762.
12. Inaba Y, Ichikawa M, Inoue A, Itoh M, Kyogashima M, Sekiguchi Y, Nakamura S, Komiyama A, Koh C (2001) Plasma thrombin-antithrombin III complex is associated with the severity of experimental autoimmune encephalomyelitis. J Neurol Sci 185:89-93.
13. Jensen MS, Yaari Y (1988) The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy. Ann Neurol 24:591-598.
14. Jensen MS, Yaari Y (1997) Role of intrinsic burst firing, potassium accumulation, and electrical coupling in the elevated potassium model of hippocampal epilepsy. J Neurophysiol 77:1224-1233.
15. Junge CE, Sugawara T, Mannaioni G, Alagarsamy S, Conn PJ, Brat DJ, Chan PH, Traynelis SF (2003) The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia. Proc Natl Acad Sci USA 100:13019-13024.
16. Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF (2004) Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Exp Neurol 188:94-103.
17. Karabiyikoglu M, Hua Y, Keep RF, Ennis SR, Xi G (2004) Intracerebral hirudin injection attenuates ischemicdamageandneurologic deficits without altering local cerebral blood flow. J Cereb Blood Flow Metab 24:159-166.
18. Kumar V, Chapman JR (2007) Whole blood thrombin: development of a process for intraoperative production of human thrombin. J Extra Corpor Technol 39:18-23.
19. Lee CJ, Mannaioni G, Yuan H, Woo DH, Gingrich MB, Traynelis SF (2007) Astrocytic control of synaptic NMDA receptors. J Physiol 581:1057-1081.
20. Lee KR, Drury I, Vitarbo E, Hoff JT (1997) Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage. J Neurosurg 87:73-78.
21. Lee SY, Haydon PG (2007) Astrocytic glutamate targets NMDA receptors. J Physiol 581:887-888.
22. Li R, Huang FS, Abbas AK, Wigstrom H (2007) Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. BMC Neurosci 8:55.
23. Lin CL, Dumont AS, Lieu AS, Yen CP, Hwang SL, Kwan AL, Kassell NF, Howng SL (2003) Characterization of perioperative seizures and epilepsy following aneurysmal subarachnoid hemorrhage. J Neurosurg 99:978-985.
24. Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, Auberson YP, Wang YT (2004) Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304:1021-1024.
25. Luo W, Wang Y, Reiser G (2007) Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection. Brain Res Rev 56:331-345.
26. Maggio N, Segal M (2007) Striking variations in corticosteriod modulation of long term potentiation along the septotemporal axis of the hippocampus. J Neurosci 27:5757-5765.
27. Mizutani A, Saito H, Matsuki N (1996) Possible involvement of plasmin in long-term potentiation of rat hippocampal slices. Brain Res 739:276-281.
28. Paterson PY, Koh CS, Kwaan HC (1987) Role of the clotting system in the pathogenesis of neuroimmunologic disease. Fed Proc 46:91-96.
29. Sun DA, Sombati S, DeLorenzo RJ (2001) Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy." Stroke 32:2344-2350.
30. Tomimatsu Y, Idemoto S, Moriguchi S, Watanabe S, Nakanishi H (2002) Proteases involved in long-term potentiation. Life Sci 72:355-361.
31. Traynelis SF, Dingledine R (1988) Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J Neurophysiol 59:259-276.
32. Traynelis SF, Trejo J (2007) Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol 14:230-235.
33. Tsirka SE, Gualandris A, Amaral DG, Strickland S (1995) Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 377:340-344.
34. Xi G, Reiser G, Keep RF (2003) The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem 84:3-9.