메뉴 건너뛰기




Volumn 12, Issue 1, 2015, Pages

Transiently lowering tumor necrosis factor-aα synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

Author keywords

[No Author keywords available]

Indexed keywords

3,6' DITHIOTHALIDOMIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN BID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; 3,6'-DITHIOTHALIDOMIDE; ENOLASE; THALIDOMIDE; TUMOR NECROSIS FACTOR;

EID: 84928711417     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0237-4     Document Type: Article
Times cited : (113)

References (102)
  • 2
    • 34250730744 scopus 로고    scopus 로고
    • The characteristics of patients who do not seek medical treatment for traumatic brain injury
    • Setnik L, Bazarian JJ. The characteristics of patients who do not seek medical treatment for traumatic brain injury. Brain Inj. 2007;21(1):1-9.
    • (2007) Brain Inj , vol.21 , Issue.1 , pp. 1-9
    • Setnik, L.1    Bazarian, J.J.2
  • 3
    • 80053204468 scopus 로고    scopus 로고
    • Traumatic Brain Injury in the United States: Emergency Department Visits
    • Atlanta (GA): Centers for Disease Control and Prevention, National Center for Injury Prevention and Control;
    • Faul M, Xu L, Wald M, Coronado VG. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002-2006. Atlanta (GA): Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2010.
    • (2010) Hospitalizations and Deaths 2002-2006
    • Faul, M.1    Xu, L.2    Wald, M.3    Coronado, V.G.4
  • 5
    • 40349087560 scopus 로고    scopus 로고
    • Neurobehavioral sequelae of traumatic brain injury: evaluation and management
    • McAllister TW. Neurobehavioral sequelae of traumatic brain injury: evaluation and management. World Psychiatry. 2008;7(1):3-10.
    • (2008) World Psychiatry , vol.7 , Issue.1 , pp. 3-10
    • McAllister, T.W.1
  • 6
    • 79956358339 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDC). Surveillance for traumatic brain injury-related deaths-United States, 1997-2007
    • Coronado VG, Xu L, Basavaraju SV, McGuire LC, Wald MM, Faul MD, et al. Centers for Disease Control and Prevention (CDC). Surveillance for traumatic brain injury-related deaths-United States, 1997-2007. MMWR Surveill Summ. 2011;60(5):1-32.
    • (2011) MMWR Surveill Summ , vol.60 , Issue.5 , pp. 1-32
    • Coronado, V.G.1    Xu, L.2    Basavaraju, S.V.3    McGuire, L.C.4    Wald, M.M.5    Faul, M.D.6
  • 7
    • 68049106083 scopus 로고    scopus 로고
    • Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits
    • Yu S, Kaneko Y, Bae E, Stahl CE, Wang Y, van Loveren H, et al. Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits. Brain Res. 2009;1287:157-63.
    • (2009) Brain Res , vol.1287 , pp. 157-163
    • Yu, S.1    Kaneko, Y.2    Bae, E.3    Stahl, C.E.4    Wang, Y.5    Loveren, H.6
  • 8
    • 17844374868 scopus 로고    scopus 로고
    • Outcome from mild traumatic brain injury
    • Iverson GL. Outcome from mild traumatic brain injury. Curr Opinion Psychiatry. 2005;18:301-7.
    • (2005) Curr Opinion Psychiatry , vol.18 , pp. 301-307
    • Iverson, G.L.1
  • 9
    • 46149109507 scopus 로고    scopus 로고
    • Long-lasting sleep patterns of adult patients with minor traumatic brain injury (mTBI) and non-mTBI subjects
    • Schreiber S, Barkai G, Gur-Hartman T, Peles E, Tov N, Dolberg OT, et al. Long-lasting sleep patterns of adult patients with minor traumatic brain injury (mTBI) and non-mTBI subjects. Sleep Med. 2008;9:481-7.
    • (2008) Sleep Med , vol.9 , pp. 481-487
    • Schreiber, S.1    Barkai, G.2    Gur-Hartman, T.3    Peles, E.4    Tov, N.5    Dolberg, O.T.6
  • 10
    • 0025913996 scopus 로고
    • Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies, EURODEM Risk Factors Research Group
    • Mortimer JA, van Duijn CM, Chandra V, Fratiglioni L, Graves AB, Heyman A, et al. Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies, EURODEM Risk Factors Research Group. Int J Epidemiol. 1991;20 Suppl 2:S28-35.
    • (1991) Int J Epidemiol , vol.20 , Issue.SUPPL 2 , pp. S28-35
    • Mortimer, J.A.1    Duijn, C.M.2    Chandra, V.3    Fratiglioni, L.4    Graves, A.B.5    Heyman, A.6
  • 11
    • 0029018224 scopus 로고
    • Synergistic effects of traumatic head-injury and apolipoprotein-epsilon-4 in patients with Alzheimers-disease
    • Mayeux R, Ottman R, Maestre G, Ngai C, Tang MX, Ginsberg H, et al. Synergistic effects of traumatic head-injury and apolipoprotein-epsilon-4 in patients with Alzheimers-disease. Neurology. 1995;45:555-7.
    • (1995) Neurology , vol.45 , pp. 555-557
    • Mayeux, R.1    Ottman, R.2    Maestre, G.3    Ngai, C.4    Tang, M.X.5    Ginsberg, H.6
  • 12
    • 84875244671 scopus 로고    scopus 로고
    • Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
    • Tweedie D, Rachmany L, Rubovitch V, Zhang Y, Becker KG, Perez E, et al. Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury. Neurobiol Dis. 2013;54:1-11.
    • (2013) Neurobiol Dis , vol.54 , pp. 1-11
    • Tweedie, D.1    Rachmany, L.2    Rubovitch, V.3    Zhang, Y.4    Becker, K.G.5    Perez, E.6
  • 13
    • 84868029359 scopus 로고    scopus 로고
    • Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model
    • Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4(134):134ra60.
    • (2012) Sci Transl Med , vol.4 , Issue.134 , pp. 134ra60
    • Goldstein, L.E.1    Fisher, A.M.2    Tagge, C.A.3    Zhang, X.L.4    Velisek, L.5    Sullivan, J.A.6
  • 15
    • 84918569038 scopus 로고    scopus 로고
    • Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity
    • JAMA Neurol. 2014 [Epub ahead of print].
    • Gardner RC, Burke JF, Nettiksimmons J, Kaup A, Barnes DE, Yaffe K. Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity. JAMA Neurol. 2014 [Epub ahead of print].
    • Gardner, R.C.1    Burke, J.F.2    Nettiksimmons, J.3    Kaup, A.4    Barnes, D.E.5    Yaffe, K.6
  • 16
    • 84873452455 scopus 로고    scopus 로고
    • Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
    • Kumar A, Stoica BA, Sabirzhanov B, Burns MP, Faden AI, Loane DJ. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging. 2013;34(5):1397-411.
    • (2013) Neurobiol Aging , vol.34 , Issue.5 , pp. 1397-1411
    • Kumar, A.1    Stoica, B.A.2    Sabirzhanov, B.3    Burns, M.P.4    Faden, A.I.5    Loane, D.J.6
  • 17
    • 78449310195 scopus 로고    scopus 로고
    • Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies
    • Loane DJ, Faden AI. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci. 2010;31(12):596-604.
    • (2010) Trends Pharmacol Sci , vol.31 , Issue.12 , pp. 596-604
    • Loane, D.J.1    Faden, A.I.2
  • 18
    • 84892697645 scopus 로고    scopus 로고
    • Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup
    • Diaz-Arrastia R, Kochanek PM, Bergold P, Kenney K, Marx CE, Grimes CJ, et al. Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup. J Neurotrauma. 2014;31(2):135-58.
    • (2014) J Neurotrauma , vol.31 , Issue.2 , pp. 135-158
    • Diaz-Arrastia, R.1    Kochanek, P.M.2    Bergold, P.3    Kenney, K.4    Marx, C.E.5    Grimes, C.J.6
  • 19
    • 85027945267 scopus 로고    scopus 로고
    • Pattern of cerebrospinal immediate early gene c-fos expression in an ovine model of non-accidental head injury
    • Finnie JW, Blumbergs PC, Manavis J, Vink R. Pattern of cerebrospinal immediate early gene c-fos expression in an ovine model of non-accidental head injury. J Clin Neurosci. 2013;20:1759-61.
    • (2013) J Clin Neurosci , vol.20 , pp. 1759-1761
    • Finnie, J.W.1    Blumbergs, P.C.2    Manavis, J.3    Vink, R.4
  • 20
    • 84897845269 scopus 로고    scopus 로고
    • Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury
    • Greig NH, Tweedie D, Rachmany L, Li Y, Rubovitch V, Schreiber S, et al. Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimers Dement. 2014;10(1 Suppl):S62-75.
    • (2014) Alzheimers Dement , vol.10 , Issue.1 SUPPL , pp. S62-75
    • Greig, N.H.1    Tweedie, D.2    Rachmany, L.3    Li, Y.4    Rubovitch, V.5    Schreiber, S.6
  • 21
    • 78149437445 scopus 로고    scopus 로고
    • The molecular pathophysiology of concussive brain injury
    • Barkhoudarian G, Hovda DA, Giza C. The molecular pathophysiology of concussive brain injury. Clin Sports Med. 2011;30:33-48.
    • (2011) Clin Sports Med , vol.30 , pp. 33-48
    • Barkhoudarian, G.1    Hovda, D.A.2    Giza, C.3
  • 22
    • 66849128097 scopus 로고    scopus 로고
    • Pathophysiology of traumatic brain injury
    • Greve MW, Zink BJ. Pathophysiology of traumatic brain injury. Mt Sinai J Med. 2009;76:97-104.
    • (2009) Mt Sinai J Med , vol.76 , pp. 97-104
    • Greve, M.W.1    Zink, B.J.2
  • 23
    • 0036835885 scopus 로고    scopus 로고
    • Traumatic brain injury
    • Finnie JW, Blumbergs PC. Traumatic brain injury. Vet Pathol. 2002;39(6):679-89.
    • (2002) Vet Pathol , vol.39 , Issue.6 , pp. 679-689
    • Finnie, J.W.1    Blumbergs, P.C.2
  • 27
    • 0036935538 scopus 로고    scopus 로고
    • Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system
    • Stoll G, Jander S, Schroeter M. Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Adv Exp Med Biol. 2002;513:87-113.
    • (2002) Adv Exp Med Biol , vol.513 , pp. 87-113
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 29
    • 55949104665 scopus 로고    scopus 로고
    • TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    • McCoy MK, Tansey MG. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation. 2008;5:45.
    • (2008) J Neuroinflammation , vol.5 , pp. 45
    • McCoy, M.K.1    Tansey, M.G.2
  • 30
    • 79951701971 scopus 로고    scopus 로고
    • Targeting TNF-aα to elucidate and ameliorate neuroinflammation in neurodegenerative diseases
    • Frankola KA, Greig NH, Luo W, Tweedie D. Targeting TNF-aα to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets. 2011;10(3):391-403.
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , Issue.3 , pp. 391-403
    • Frankola, K.A.1    Greig, N.H.2    Luo, W.3    Tweedie, D.4
  • 31
    • 78049266766 scopus 로고    scopus 로고
    • The roles of TNF in brain dysfunction and disease
    • Clark IA, Alleva LM, Vissel B. The roles of TNF in brain dysfunction and disease. Pharmacol Ther. 2010;128(3):519-48.
    • (2010) Pharmacol Ther , vol.128 , Issue.3 , pp. 519-548
    • Clark, I.A.1    Alleva, L.M.2    Vissel, B.3
  • 32
    • 77950625842 scopus 로고    scopus 로고
    • In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury
    • Frugier T, Morganti-Kossmann MC, O'Reilly D, McLean CA. In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury. J Neurotrauma. 2010;27:497-507.
    • (2010) J Neurotrauma , vol.27 , pp. 497-507
    • Frugier, T.1    Morganti-Kossmann, M.C.2    O'Reilly, D.3    McLean, C.A.4
  • 33
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-aα inhibitor and an effective neuroprotectant
    • Shohami E, Gallily R, Mechoulam R, Bass R, Ben-Hur T. Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-aα inhibitor and an effective neuroprotectant. J Neuroimmunol. 1997;72:169-77.
    • (1997) J Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben-Hur, T.5
  • 34
  • 35
    • 77953956929 scopus 로고    scopus 로고
    • Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice
    • Yang J, You Z, Kim HH, Hwang SK, Khuman J, Guo S, et al. Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. J Neurotrauma. 2010;27:1037-46.
    • (2010) J Neurotrauma , vol.27 , pp. 1037-1046
    • Yang, J.1    You, Z.2    Kim, H.H.3    Hwang, S.K.4    Khuman, J.5    Guo, S.6
  • 36
    • 84910666313 scopus 로고    scopus 로고
    • Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date
    • Tuttolomondo A, Pecoraro R, Pinto A. Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date. Drug Des Devel Ther. 2014;8:2221-38.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 2221-2238
    • Tuttolomondo, A.1    Pecoraro, R.2    Pinto, A.3
  • 37
    • 84880439339 scopus 로고    scopus 로고
    • Structural basis of signal transduction in the TNF receptor superfamily
    • Li J, Yin Q, Wu H. Structural basis of signal transduction in the TNF receptor superfamily. Adv Immunol. 2013;119:135-53.
    • (2013) Adv Immunol , vol.119 , pp. 135-153
    • Li, J.1    Yin, Q.2    Wu, H.3
  • 38
    • 84866751526 scopus 로고    scopus 로고
    • TNFaα in synaptic function: switching gears
    • Santello M, Volterra A. TNFaα in synaptic function: switching gears. Trends Neurosci. 2012;35(10):638-47.
    • (2012) Trends Neurosci , vol.35 , Issue.10 , pp. 638-647
    • Santello, M.1    Volterra, A.2
  • 39
    • 34547128958 scopus 로고    scopus 로고
    • TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice
    • Bermpohl D, You Z, Lo EH, Kim HH, Whalen MJ. TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice. J Cerebral Blood Flow Metabol. 2007;27:1806-18.
    • (2007) J Cerebral Blood Flow Metabol , vol.27 , pp. 1806-1818
    • Bermpohl, D.1    You, Z.2    Lo, E.H.3    Kim, H.H.4    Whalen, M.J.5
  • 40
    • 66649093643 scopus 로고    scopus 로고
    • Effect of traumatic brain injury on cognitive function in mice lacking p55 and p75 tumor necrosis factor receptors
    • Longhi L, Ortolano F, Zanier ER, Perego C, Stocchetti N, De Simoni MG. Effect of traumatic brain injury on cognitive function in mice lacking p55 and p75 tumor necrosis factor receptors. Acta Neurochir Suppl. 2008;102:409-13.
    • (2008) Acta Neurochir Suppl , vol.102 , pp. 409-413
    • Longhi, L.1    Ortolano, F.2    Zanier, E.R.3    Perego, C.4    Stocchetti, N.5    Simoni, M.G.6
  • 41
    • 84881190695 scopus 로고    scopus 로고
    • Tumor necrosis factor in traumatic brain injury: effects of genetic deletion of p55 or p75 receptor
    • Longhi L, Perego C, Ortolano F, Aresi S, Fumagalli S, Zanier ER, et al. Tumor necrosis factor in traumatic brain injury: effects of genetic deletion of p55 or p75 receptor. J Cereb Blood Flow Metab. 2013;33(8):1182-9.
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.8 , pp. 1182-1189
    • Longhi, L.1    Perego, C.2    Ortolano, F.3    Aresi, S.4    Fumagalli, S.5    Zanier, E.R.6
  • 43
    • 0242691672 scopus 로고    scopus 로고
    • Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity
    • Zhu X, Giordano T, Yu QS, Holloway HW, Perry T, Lahiri DK, et al. Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity. J Med Chem. 2003;46:5222-9.
    • (2003) J Med Chem , vol.46 , pp. 5222-5229
    • Zhu, X.1    Giordano, T.2    Yu, Q.S.3    Holloway, H.W.4    Perry, T.5    Lahiri, D.K.6
  • 44
    • 79961047459 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice
    • Baratz R, Tweedie D, Rubovitch V, Luo W, Yoon JS, Hoffer BJ, et al. Tumor necrosis factor-alpha synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. J Neurochem. 2011;118:1032-42.
    • (2011) J Neurochem , vol.118 , pp. 1032-1042
    • Baratz, R.1    Tweedie, D.2    Rubovitch, V.3    Luo, W.4    Yoon, J.S.5    Hoffer, B.J.6
  • 46
    • 25444529946 scopus 로고    scopus 로고
    • Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice
    • Milman A, Rosenberg A, Weizman R, Pick CG. Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice. J Neurotrauma. 2005;22:1003-10.
    • (2005) J Neurotrauma , vol.22 , pp. 1003-1010
    • Milman, A.1    Rosenberg, A.2    Weizman, R.3    Pick, C.G.4
  • 47
    • 0029867314 scopus 로고    scopus 로고
    • A review of the validity and variability of the elevated plus-maze as an animal model of anxiety
    • Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav. 1996;54:21-30.
    • (1996) Pharmacol Biochem Behav , vol.54 , pp. 21-30
    • Hogg, S.1
  • 48
    • 0026660230 scopus 로고
    • A 2-trial memory task with automated recording - study in young and aged rats
    • Dellu F, Mayo W, Cherkaoui J, Lemoal M, Simon H. A 2-trial memory task with automated recording - study in young and aged rats. Brain Res. 1992;588:132-9.
    • (1992) Brain Res , vol.588 , pp. 132-139
    • Dellu, F.1    Mayo, W.2    Cherkaoui, J.3    Lemoal, M.4    Simon, H.5
  • 49
    • 0032964675 scopus 로고    scopus 로고
    • Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition
    • Dix SL, Aggleton JP. Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behav Brain Res. 1999;99:191-200.
    • (1999) Behav Brain Res , vol.99 , pp. 191-200
    • Dix, S.L.1    Aggleton, J.P.2
  • 50
    • 0031103406 scopus 로고    scopus 로고
    • Object recognition in mice: improvement of memory by glucose
    • Meisser C. Object recognition in mice: improvement of memory by glucose. Neurobiol Learning Memory. 1997;67:172-5.
    • (1997) Neurobiol Learning Memory , vol.67 , pp. 172-175
    • Meisser, C.1
  • 51
    • 79953668869 scopus 로고    scopus 로고
    • The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)
    • Edut S, Rubovitch V, Schreiber S, Pick CG. The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI). Psychopharmacol. 2011;214:877-89.
    • (2011) Psychopharmacol , vol.214 , pp. 877-889
    • Edut, S.1    Rubovitch, V.2    Schreiber, S.3    Pick, C.G.4
  • 52
    • 34548363736 scopus 로고    scopus 로고
    • The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)
    • Amaral D, Scharfman H, Lavenex P. The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Prog Brain Res. 2007;163:3-22. 788-790.
    • (2007) Prog Brain Res , vol.163 , pp. 3-22
    • Amaral, D.1    Scharfman, H.2    Lavenex, P.3
  • 53
    • 69949092092 scopus 로고    scopus 로고
    • NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory
    • Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, et al. NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron. 2009;63(5):643-56.
    • (2009) Neuron , vol.63 , Issue.5 , pp. 643-656
    • Saab, B.J.1    Georgiou, J.2    Nath, A.3    Lee, F.J.4    Wang, M.5    Michalon, A.6
  • 54
    • 84873114590 scopus 로고    scopus 로고
    • Structural plasticity in the dentate gyrus- revisiting a classic injury model
    • Perederiy JV, Westbrook GL. Structural plasticity in the dentate gyrus- revisiting a classic injury model. Front Neural Circuits. 2013;7:17.
    • (2013) Front Neural Circuits , vol.7 , pp. 17
    • Perederiy, J.V.1    Westbrook, G.L.2
  • 55
    • 84873416770 scopus 로고    scopus 로고
    • Selective TNF inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients treated with perispinal etanercept
    • Tobinick E, Kim NM, Reyzin G, Rodriguez-Romanacce H, DePuy V. Selective TNF inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients treated with perispinal etanercept. CNS Drugs. 2012;26(12):1051-70.
    • (2012) CNS Drugs , vol.26 , Issue.12 , pp. 1051-1070
    • Tobinick, E.1    Kim, N.M.2    Reyzin, G.3    Rodriguez-Romanacce, H.4    DePuy, V.5
  • 57
    • 84868458245 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
    • Tweedie D, Rachmany L, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice. Exp Neurol. 2013;239:170-82.
    • (2013) Exp Neurol , vol.239 , pp. 170-182
    • Tweedie, D.1    Rachmany, L.2    Rubovitch, V.3    Lehrmann, E.4    Zhang, Y.5    Becker, K.G.6
  • 58
    • 84895926390 scopus 로고    scopus 로고
    • Network dysfunction after traumatic brain injury
    • Sharp DJ, Scott G, Leech R. Network dysfunction after traumatic brain injury. Nat Rev Neurol. 2014;10(3):156-66.
    • (2014) Nat Rev Neurol , vol.10 , Issue.3 , pp. 156-166
    • Sharp, D.J.1    Scott, G.2    Leech, R.3
  • 60
    • 34447558496 scopus 로고    scopus 로고
    • Traumatic brain injury: assessment, resuscitation and early management
    • Moppett IK. Traumatic brain injury: assessment, resuscitation and early management. Br J Anaesth. 2007;99:18-31.
    • (2007) Br J Anaesth , vol.99 , pp. 18-31
    • Moppett, I.K.1
  • 62
    • 0031882913 scopus 로고    scopus 로고
    • The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
    • Grell M, Wajant H, Zimmermann G, Scheurich P. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc Natl Acad Sci U S A. 1998;95(2):570-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.2 , pp. 570-575
    • Grell, M.1    Wajant, H.2    Zimmermann, G.3    Scheurich, P.4
  • 63
    • 0036548875 scopus 로고    scopus 로고
    • Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2
    • Fontaine V, Mohand-Said S, Hanoteau N, Fuchs C, Pfizenmaier K, Eisel U. Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci. 2002;22(7):RC216.
    • (2002) J Neurosci , vol.22 , Issue.7 , pp. RC216
    • Fontaine, V.1    Mohand-Said, S.2    Hanoteau, N.3    Fuchs, C.4    Pfizenmaier, K.5    Eisel, U.6
  • 64
    • 0037092420 scopus 로고    scopus 로고
    • Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways
    • Yang L, Lindholm K, Konishi Y, Li R, Shen Y. Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways. J Neurosci. 2002;22(8):3025-32.
    • (2002) J Neurosci , vol.22 , Issue.8 , pp. 3025-3032
    • Yang, L.1    Lindholm, K.2    Konishi, Y.3    Li, R.4    Shen, Y.5
  • 65
    • 3543046113 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway
    • Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem. 2004;279(31):32869-81.
    • (2004) J Biol Chem , vol.279 , Issue.31 , pp. 32869-32881
    • Marchetti, L.1    Klein, M.2    Schlett, K.3    Pfizenmaier, K.4    Eisel, U.L.5
  • 66
    • 0028866022 scopus 로고
    • The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
    • Grell M, Douni E, Wajant H, Löhden M, Clauss M, Maxeiner B, et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell. 1995;83(5):793-802.
    • (1995) Cell , vol.83 , Issue.5 , pp. 793-802
    • Grell, M.1    Douni, E.2    Wajant, H.3    Löhden, M.4    Clauss, M.5    Maxeiner, B.6
  • 67
    • 0029551303 scopus 로고
    • Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF. J Inflamm
    • Grell M. Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF. J Inflamm. 1995-1996;47(1-2):8-17
    • (1995) , vol.47 , Issue.1-2 , pp. 8-17
    • Grell, M.1
  • 68
    • 77952291438 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
    • Park KM, Bowers WJ. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal. 2010;22(7):977-83.
    • (2010) Cell Signal , vol.22 , Issue.7 , pp. 977-983
    • Park, K.M.1    Bowers, W.J.2
  • 69
    • 34548726106 scopus 로고    scopus 로고
    • TNF-aα inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets
    • Tweedie D, Sambamurti K, Greig NH. TNF-aα inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr Alzheimer Res. 2007;4:378-85.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 378-385
    • Tweedie, D.1    Sambamurti, K.2    Greig, N.H.3
  • 70
    • 79959707187 scopus 로고    scopus 로고
    • Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls
    • Ponsford J, Cameron P, Fitzgerald M, Grant M, Mikocka-Walus A. Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls. J Neurotrauma. 2011;28:937-46.
    • (2011) J Neurotrauma , vol.28 , pp. 937-946
    • Ponsford, J.1    Cameron, P.2    Fitzgerald, M.3    Grant, M.4    Mikocka-Walus, A.5
  • 71
    • 42449108717 scopus 로고    scopus 로고
    • Cognitive and Neurobiological Research Consortium. The predictive brain state: timing deficiency in traumatic brain injury?
    • Ghajar J, Ivry RB. Cognitive and Neurobiological Research Consortium. The predictive brain state: timing deficiency in traumatic brain injury? Neurorehabil Neural Repair. 2008;22(3):217-27.
    • (2008) Neurorehabil Neural Repair , vol.22 , Issue.3 , pp. 217-227
    • Ghajar, J.1    Ivry, R.B.2
  • 72
    • 50149121229 scopus 로고    scopus 로고
    • Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury
    • Israelsson C, Bengtsson H, Kylberg A, Kullander K, Lewén A, Hillered L, et al. Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury. J Neurotrauma. 2008;25(8):959-74.
    • (2008) J Neurotrauma , vol.25 , Issue.8 , pp. 959-974
    • Israelsson, C.1    Bengtsson, H.2    Kylberg, A.3    Kullander, K.4    Lewén, A.5    Hillered, L.6
  • 73
    • 68349121367 scopus 로고    scopus 로고
    • Closed head injury in a mouse model results in molecular changes indicating inflammatory responses
    • Israelsson C, Wang Y, Kylberg A, Pick CG, Hoffer BJ, Ebendal T. Closed head injury in a mouse model results in molecular changes indicating inflammatory responses. J Neurotrauma. 2009;26(8):1307-14.
    • (2009) J Neurotrauma , vol.26 , Issue.8 , pp. 1307-1314
    • Israelsson, C.1    Wang, Y.2    Kylberg, A.3    Pick, C.G.4    Hoffer, B.J.5    Ebendal, T.6
  • 74
    • 0027400847 scopus 로고
    • Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion: influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand
    • Taupin V, Toulmond S, Serrano A, Benavides J, Zavala F. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion: influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol. 1993;42:177-85.
    • (1993) J Neuroimmunol , vol.42 , pp. 177-185
    • Taupin, V.1    Toulmond, S.2    Serrano, A.3    Benavides, J.4    Zavala, F.5
  • 75
    • 0028364659 scopus 로고
    • Closed head injury triggers early production of TNF-aα and IL-6 by brain tissue
    • Shohami E, Novikov M, Bass R, Yamin A, Gallily R. Closed head injury triggers early production of TNF-aα and IL-6 by brain tissue. J Cereb Blood Flow Metab. 1994;14:615-9.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 615-619
    • Shohami, E.1    Novikov, M.2    Bass, R.3    Yamin, A.4    Gallily, R.5
  • 76
    • 0030852741 scopus 로고    scopus 로고
    • Production of tumor necrosis factor-alpha and interleukin-1beta by human cerebral microvascular endothelium after percussive trauma
    • Gourin CG, Shackford SR. Production of tumor necrosis factor-alpha and interleukin-1beta by human cerebral microvascular endothelium after percussive trauma. J Trauma. 1997;42(6):1101-7.
    • (1997) J Trauma , vol.42 , Issue.6 , pp. 1101-1107
    • Gourin, C.G.1    Shackford, S.R.2
  • 77
    • 0033103686 scopus 로고    scopus 로고
    • Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment
    • Knoblach SM, Fan L, Faden AI. Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment. J Neuroimmunol. 1999;95(1-2):115-25.
    • (1999) J Neuroimmunol , vol.95 , Issue.1-2 , pp. 115-125
    • Knoblach, S.M.1    Fan, L.2    Faden, A.I.3
  • 78
  • 79
    • 84861473274 scopus 로고    scopus 로고
    • Tumor necrosis factor-aα synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation. Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease
    • Tweedie D, Ferguson RA, Fishman K, Frankola KA, Van Praag H, Holloway HW, et al. Tumor necrosis factor-aα synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation. Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation. 2012;9:106.
    • (2012) J Neuroinflammation , vol.9 , pp. 106
    • Tweedie, D.1    Ferguson, R.A.2    Fishman, K.3    Frankola, K.A.4    Praag, H.5    Holloway, H.W.6
  • 80
    • 84861411831 scopus 로고    scopus 로고
    • Early intervention with a small molecule inhibitor for tumor necrosis factor-aα prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease
    • Gabbita SP, Srivastava MK, Eslami P, Johnson MF, Kobritz NK, Tweedie D, et al. Early intervention with a small molecule inhibitor for tumor necrosis factor-aα prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2012;9:99.
    • (2012) J Neuroinflammation , vol.9 , pp. 99
    • Gabbita, S.P.1    Srivastava, M.K.2    Eslami, P.3    Johnson, M.F.4    Kobritz, N.K.5    Tweedie, D.6
  • 81
    • 84874790917 scopus 로고    scopus 로고
    • 3,6'-Dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation
    • Yoon JS, Lee JH, Tweedie D, Mughal MR, Chigurupati S, Greig NH, et al. 3,6'-Dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation. J Neurosci Res. 2013;91(5):671-80.
    • (2013) J Neurosci Res , vol.91 , Issue.5 , pp. 671-680
    • Yoon, J.S.1    Lee, J.H.2    Tweedie, D.3    Mughal, M.R.4    Chigurupati, S.5    Greig, N.H.6
  • 83
    • 47549105126 scopus 로고    scopus 로고
    • The touchscreen cognitive testing method for rodents: how to get the best out of your rat
    • Bussey TJ, Padain TL, Skillings EA, Winters BD, Morton AJ, Saksida LM. The touchscreen cognitive testing method for rodents: how to get the best out of your rat. Learn Mem. 2008;2008(15):516-23.
    • (2008) Learn Mem , vol.2008 , Issue.15 , pp. 516-523
    • Bussey, T.J.1    Padain, T.L.2    Skillings, E.A.3    Winters, B.D.4    Morton, A.J.5    Saksida, L.M.6
  • 84
    • 33846147022 scopus 로고    scopus 로고
    • Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice
    • Tashlykov V, Katz Y, Gazit V, Zohar O, Schreiber S, Pick CG. Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice. Brain Res. 2007;1130(1):197-205.
    • (2007) Brain Res , vol.1130 , Issue.1 , pp. 197-205
    • Tashlykov, V.1    Katz, Y.2    Gazit, V.3    Zohar, O.4    Schreiber, S.5    Pick, C.G.6
  • 85
    • 78650117820 scopus 로고    scopus 로고
    • Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice
    • Wakade C, Sukumari-Ramesh S, Laird MD, Dhandapani KM, Vender JR. Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice. J Neurosurg. 2010;113(6):1195-201.
    • (2010) J Neurosurg , vol.113 , Issue.6 , pp. 1195-1201
    • Wakade, C.1    Sukumari-Ramesh, S.2    Laird, M.D.3    Dhandapani, K.M.4    Vender, J.R.5
  • 86
    • 79959740838 scopus 로고    scopus 로고
    • Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice
    • Han X, Tong J, Zhang J, Farahvar A, Wang E, Yang J, et al. Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice. J Neurotrauma. 2011;28(6):995-1007.
    • (2011) J Neurotrauma , vol.28 , Issue.6 , pp. 995-1007
    • Han, X.1    Tong, J.2    Zhang, J.3    Farahvar, A.4    Wang, E.5    Yang, J.6
  • 87
    • 84865748485 scopus 로고    scopus 로고
    • 3,6'-Dithiothalidomide, a new TNF-aα synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit
    • Russo I, Caracciolo L, Tweedie D, Choi SH, Greig NH, Barlati S, et al. 3,6'-Dithiothalidomide, a new TNF-aα synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit. J Neurochem. 2012;122(6):1181-92.
    • (2012) J Neurochem , vol.122 , Issue.6 , pp. 1181-1192
    • Russo, I.1    Caracciolo, L.2    Tweedie, D.3    Choi, S.H.4    Greig, N.H.5    Barlati, S.6
  • 88
    • 84856078575 scopus 로고    scopus 로고
    • TNF-aα protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
    • Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, et al. TNF-aα protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation. 2012;9:23.
    • (2012) J Neuroinflammation , vol.9 , pp. 23
    • Belarbi, K.1    Jopson, T.2    Tweedie, D.3    Arellano, C.4    Luo, W.5    Greig, N.H.6
  • 90
    • 84885022290 scopus 로고    scopus 로고
    • TNF-aα induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology
    • Ali MS, Starke RM, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, et al. TNF-aα induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology. J Cereb Blood Flow Metab. 2013;33(10):1564-73.
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.10 , pp. 1564-1573
    • Ali, M.S.1    Starke, R.M.2    Jabbour, P.M.3    Tjoumakaris, S.I.4    Gonzalez, L.F.5    Rosenwasser, R.H.6
  • 91
    • 77958542029 scopus 로고    scopus 로고
    • Therapeutic evaluation of etanercept in a model of traumatic brain injury
    • Chio CC, Lin JW, Chang MW, Wang CC, Kuo JR, Yang CZ, et al. Therapeutic evaluation of etanercept in a model of traumatic brain injury. J Neurochem. 2010;115(4):921-9.
    • (2010) J Neurochem , vol.115 , Issue.4 , pp. 921-929
    • Chio, C.C.1    Lin, J.W.2    Chang, M.W.3    Wang, C.C.4    Kuo, J.R.5    Yang, C.Z.6
  • 92
    • 33846815363 scopus 로고    scopus 로고
    • The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model
    • Lee CJ, Kim KW, Lee HM, Nahm FS, Lim YJ, Park JH, et al. The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model. Spinal Cord. 2007;45(2):149-57.
    • (2007) Spinal Cord , vol.45 , Issue.2 , pp. 149-157
    • Lee, C.J.1    Kim, K.W.2    Lee, H.M.3    Nahm, F.S.4    Lim, Y.J.5    Park, J.H.6
  • 93
    • 62049083008 scopus 로고    scopus 로고
    • Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury
    • Koopmans GC, Deumens R, Buss A, Geoghegan L, Myint AM, Honig WH, et al. Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury. Exp Neurol. 2009;216(2):490-8.
    • (2009) Exp Neurol , vol.216 , Issue.2 , pp. 490-498
    • Koopmans, G.C.1    Deumens, R.2    Buss, A.3    Geoghegan, L.4    Myint, A.M.5    Honig, W.H.6
  • 94
    • 52649116978 scopus 로고    scopus 로고
    • Effect of thalidomide on signal transduction pathways and secondary damage in experimental spinal cord trauma
    • Genovese T, Mazzon E, Esposito E, Di Paola R, Caminiti R, Meli R, et al. Effect of thalidomide on signal transduction pathways and secondary damage in experimental spinal cord trauma. Shock. 2008;30(3):231-40.
    • (2008) Shock , vol.30 , Issue.3 , pp. 231-240
    • Genovese, T.1    Mazzon, E.2    Esposito, E.3    Paola, R.4    Caminiti, R.5    Meli, R.6
  • 95
    • 33748319204 scopus 로고    scopus 로고
    • Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers
    • July
    • U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. July 2005 < http://www.fda.gov/downloads/Drugs/Guidances/UCM078932.pdf > (viewed Nov. 19, 2014).
    • (2005)
  • 96
    • 84881091385 scopus 로고    scopus 로고
    • Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro
    • Mahony C, Erskine L, Niven J, Greig NH, Figg WD, Vargesson N. Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro. Proc Natl Acad Sci U S A. 2013;110(31):12703-8.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.31 , pp. 12703-12708
    • Mahony, C.1    Erskine, L.2    Niven, J.3    Greig, N.H.4    Figg, W.D.5    Vargesson, N.6
  • 97
    • 84890275854 scopus 로고    scopus 로고
    • Reply to D'Amato et al. and Zeldis et al.: Screening of thalidomide derivatives in chicken and zebrafish embryos
    • Vargesson N, Mahony C, Erskine L, Niven J, Greig NH, Figg WD. Reply to D'Amato et al. and Zeldis et al.: Screening of thalidomide derivatives in chicken and zebrafish embryos. Proc Natl Acad Sci U S A. 2013;110(50):E4820.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.50 , pp. E4820
    • Vargesson, N.1    Mahony, C.2    Erskine, L.3    Niven, J.4    Greig, N.H.5    Figg, W.D.6
  • 98
    • 0029926093 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury
    • Shohami E, Bass R, Wallach D, Yamin A, Gallily R. Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury. J Cereb Blood Flow Metab. 1996;16(3):378-84.
    • (1996) J Cereb Blood Flow Metab , vol.16 , Issue.3 , pp. 378-384
    • Shohami, E.1    Bass, R.2    Wallach, D.3    Yamin, A.4    Gallily, R.5
  • 99
    • 0033178340 scopus 로고    scopus 로고
    • Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury
    • Sullivan PG, Bruce-Keller AJ, Rabchevsky AG, Christakos S, Clair DK, Mattson MP, et al. Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci. 1999;19:6248-56.
    • (1999) J Neurosci , vol.19 , pp. 6248-6256
    • Sullivan, P.G.1    Bruce-Keller, A.J.2    Rabchevsky, A.G.3    Christakos, S.4    Clair, D.K.5    Mattson, M.P.6
  • 101
    • 84904963126 scopus 로고    scopus 로고
    • Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence
    • Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E. Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. CNS Drugs. 2014;28:679-97.
    • (2014) CNS Drugs , vol.28 , pp. 679-697
    • Ignatowski, T.A.1    Spengler, R.N.2    Dhandapani, K.M.3    Folkersma, H.4    Butterworth, R.F.5    Tobinick, E.6
  • 102
    • 84884204132 scopus 로고    scopus 로고
    • Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research
    • Morris GP, Clark IA, Zinn R, Vissel B. Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiol Learn Mem. 2013;105:40-53.
    • (2013) Neurobiol Learn Mem , vol.105 , pp. 40-53
    • Morris, G.P.1    Clark, I.A.2    Zinn, R.3    Vissel, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.