Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury

Experimental Neurology

Volumn 269, Issue , 2015, Pages 56-66

  Yang, L Y ^a   Chu, Y H ^a   Tweedie, D ^b   Yu, Q S ^b   Pick, C G ^c   Hoffer, B J ^d   Greig, N H ^b   Wang, J Y ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Controlled cortical impact; P53; PFT oxygen analog; Pifithrin (PFT ); Traumatic brain injury (TBI)

Indexed keywords

GLUTAMIC ACID; MESSENGER RNA; PIFITHRIN ALPHA; PIFITHRIN ALPHA OXYGEN ANALOG; PROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; NEUROPROTECTIVE AGENT; OXYGEN; PIFITHRIN; TOLUENE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; BRAIN CONTUSION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EXCITOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; P21 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUMA GENE; RAT; TRAUMATIC BRAIN INJURY; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN INJURIES; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; BENZOTHIAZOLES; BRAIN INJURIES; CELL SURVIVAL; DISEASE MODELS, ANIMAL; MALE; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TOLUENE; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84927644468     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.03.015     Document Type: Article

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