Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice

Journal of Neurotrauma

Volumn 22, Issue 9, 2005, Pages 1003-1010

  Milman, A ^a   Rosenberg, A ^a   Weizman, R ^a,b   Pick, Chaim G ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b TEL AVIV COMMUNITY MENTAL HEALTH CENTER   (Israel)

Author keywords

Cognitive deficits; Concussive head trauma model; Depressive like behavior; Mild traumatic brain injury

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BRAIN INJURY; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; EMOTIONAL DISORDER; MALE; MAZE TEST; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PATHOLOGICAL ANATOMY; POSTCONCUSSION SYNDROME; SPATIAL ORIENTATION; STATISTICAL SIGNIFICANCE; TASK PERFORMANCE; VICTIM;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES; COGNITION DISORDERS; DEPRESSION; MALE; MICE;

EID: 25444529946     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2005.22.1003     Document Type: Article

References (32)

1. BARTUS, R.T., PONTECORVO, M.J., FLICKER, C., et al. (1986). Behavioral recovery following bilateral lesions of the nucleus basalis does not occur spontaneously. Pharmacol. Biochem. Behav. 24, 1287-1292.
2. BOHNEN, N., and JOLLES, J. (1992). Neurobehavioral aspects of postconcussive symptoms after mild head injury. J. Nerv. Ment. Dis. 180, 683-692.
3. BULLINGER, M. (2002). The TBI consensus group. Quality of life in patients with traumatic brain injury-basic issues, assessment and recommendations. Restor. Neurol. Neurosci. 20, 111-124.
4. BUSCH, C.R., and ALPERN, H.P. (1998). Depression after mild traumatic brain injury: a review of a current research. Neuropsychol. Rev. 8, 95-108.
5. DE ANGELIS, M.M., HAYES, R.L., and LYETH, B.C. (1992). Traumatic brain injury causes a decrease in M2 muscarinic cholinergic receptor binding in the rat brain. Brain Res. 653, 39-44.
6. DE KRUIJK, J.R., TWIJNSTRA, A., MEERHOFF, S., and LEFFERS, P. (2001). Management of mild traumatic brain injury: lack of consensus in Europe. Brain Inj. 15, 117-123.
7. GOODLETT, C.R., NICHOLS, J.M., HALLORAN, R.W., and WEST, J.R. (1989). Long-term deficits in water maze spatial conditional alternation performance following retrohippocampal lesions in rats. Behav. Brain Res. 32, 63-67.
8. GRAHAM, D.I., MCINTOSH, T.K., MAXWELL, W.L., and NICOLL, J.A. (2000). Recent advances in neurotrauma. J. Neuropathol. Exp. Neurol. 59, 641-651.
9. HAMM, R.J., LYETH, B.C., JENKINS, L.W., ODELL, D.M., and PIKE, B.R. (1993). Selective cognitive impairment following traumatic brain injury in rats. Behav. Brain Res. 51, 169-173.
10. HEINRICHS, S.C., STENZEL-POORE, M.P., GOLD, L.H., BATTENBERG, E., BLOOM, F.E., and KOOB, G.F. (1996). Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor. Neuroscience 74, 303-311.
11. HICKS, R.R., SMITH, D.H., LOWENSTEIN, D.H., SAINT MARIE, R., and MCINTOSH, T.K. (1993). Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus. J. Neurotrauma 10, 405-414.
12. HOGG, S., MOSER, P.C., and SANGER, D.J. (1998a). Mild traumatic lesion of the right parietal cortex of the rat: selective behavioral deficits in the absence of neurological impairment. Behav. Brain Res. 93, 143-155.
13. HOGG, S., SANGER, D.J., and MOSER, P.C. (1998b). Mild traumatic lesion of the right parietal cortex in the rat: characterisation of a conditioned freezing deficit and its reversal by dizocilpine. Behav. Brain Res. 93, 157-165.
14. HSIANG, J.N., YEUNG, T., and YU, A.L. (1997). High-risk mild head injury. J. Neurosurg. 87, 234-238.
15. KIBBY, M.Y., and LONG, C.J. (1996). Minor head injury: attempts at clarifying the confusion. Brain Inj. 10, 159-186.
16. LAURER, H.L., and MCINTOSH, T.K. (1999). Experimental models of brain trauma. Curr. Opin. Neurol. 12, 715-721.
17. LEVIN, H.S., MATTIS, S., RUFF, R.M., et al. (1987). Neurobehavioral outcome following minor head injury: a three-center study. J. Neurosurg. 66, 234-243.
18. MARGULIES, S. (2000). The postconcussion syndrome after mild head trauma: is brain damage overdiagnosed? Part 1. J. Clin. Neurosci. 7, 400-408.
19. MUNDY, W.R., and TILSON, H.A. (1988). Behavioral impairment in the rat after colchicine lesions of the hippocampus and nucleus basalis. Neurotoxicology 9, 511-520.
20. PAN, W., KASTIN, A.J., RIGAI, T., MCLAY, R., and PICK, C.G. (2003). Increased hippocampal uptake of tumor necrosis factor-alpha and behavioral changes in mice. Exp. Brain Res. 149, 195-199.
21. PORSOLT, R.D., BERTIN, A., and JALFRE, M. (1977). Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 229, 327-336.
22. RAPOPORT, M.J., MCCULLAGH, S., STREINER, D., and FEINSTEIN, A. (2003). The clinical significance of major depression following mild traumatic brain injury. Psychosomatics 44, 31-37.
23. RIMEL, R.W., GIORDANI, B., and BARTH, J.T. (1982). Moderate head injury: completing the clinical spectrum of brain trauma. Neurosurgery 11, 344-351.
24. SMITH, D.H., NAKAMURA, M., MCINTOSH, T.K., et al. (1998). Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein. Am. J. Pathol. 153, 1005-1010.
25. STRUGAR, J., SASS, K.J., and BUCHANAN, C.P. (1993). Long-term consequences of minimal brain injury: loss of consciousness does not predict memory impairment. J. Trauma 34, 555-559.
26. TAGHZOUTI, K., SIMON, H., LOUILOT, A., et al. (1985). Behavioral study after local injection of 6-hydroxydopamine into the nucleus accumbens in the rat. Brain Res. 344, 9-20.
27. TRAHAN, D.E., ROSS, C.E., and TRAHAN, S.L. (2001). Relationships among postconcussional-type symptoms, depression, and anxiety in neurologically normal young adults and victims of mild brain injury. Arch. Clin. Neuropsychol. 16, 435-445.
28. UMILE, E.M., SANDEL, M.E., ALAVI, A., TERRY, C.M., and PLOTKIN, R.C. (2002). Dynamic imaging in mild traumatic brain injury: support for the theory of medial temporal vulnerability. Arch. Phys. Med. Rehabil. 83, 1506-1513.
29. WAXWEILER, R.J., THURMAN, D., and SNIEZEK, J. (1995). Monitoring the impact of traumatic brain injury: a review and update. J. Neurotrauma 12, 509-516.
30. WILLNER, P. (1990). Animal models of depression: an overview. Pharmacol. Ther. 45, 425-455.
31. WINOCUR, G. (1985). The hippocampus and the thalamus: their roles in short- and long-term memory and the effects of interference. Behav. Brain Res. 16, 135-154.
32. ZOHAR, O., SCHREIBER, S., GETSLEV, V., SCHWARTZ, J.P., MULLINS, G., and PICK, C.G. (2003). Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice. Neuroscience 118, 949-955.