Arrestin-dependent activation of ERK and Src family kinases

Handbook of Experimental Pharmacology

Volumn 219, Issue , 2014, Pages 225-257

  Strungs, Erik G ^a   Luttrell, Louis M ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Arrestin; Extracellular signal regulated kinase; G protein coupled receptor; Signal transduction; Src family nonreceptor tyrosine kinase

Indexed keywords

CLATHRIN; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TYROSINE KINASE; RAF PROTEIN; RETINA S ANTIGEN; STRESS ACTIVATED PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; SCAFFOLD PROTEIN;

ARTICLE; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SPECIFICITY; INTERNALIZATION; INTRACELLULAR TRANSPORT; MIGRATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEIN TRANSPORT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ARRESTINS; CELL MEMBRANE; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84958526501     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-41199-1_12     Document Type: Article

References (149)

1. Ahn S, Maudsley S, Luttrell LM et al (1999) Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem 274:1185-1188
2. Ahn S, Kim J, Lucaveche CL et al (2002) Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem 277:26642-26651
3. Ahn S, Shenoy SK, Wei H et al (2004a) Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. J Biol Chem 279:35518-35525
4. Ahn S, Wei H, Garrison TR et al (2004b) Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. J Biol Chem 279:7807-7811
5. Aplin M, Christensen GL, Schneider M et al (2007) Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes. Basic Clin Pharmacol Toxicol 100:296-301
6. Appleton KM, Lee MH, Alele C (2013) Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity. Methods Enzymol 522:229-262
7. Aragay AM, Mellado M, Frade JM et al (1998) Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc Natl Acad Sci USA 95:2985-2990
8. Azzi M, Charest PG, Angers S et al (2003) Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci USA 100:11406-11411
9. Barlic J, Andrews JD, Kelvin AA et al (2000) Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI. Nat Immunol 1:227-233
10. Barnes WG, Reiter E, Violin JD et al (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 280:8041-8050
11. Bhandari D, Trejo J, Benovic JL et al (2007) Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem 282:36971-36979
12. Brahmbhatt AA, Klemke RL (2003) ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem 278:13016-13025
13. Breitman M, Kook S, Gimenez LE et al (2012) Silent scaffolds: inhibition of c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. J Biol Chem 287:19653-19664
14. Brinson RE, Harding T, Diliberto PA et al (1998) Regulation of a calcium-dependent tyrosine kinase in vascular smooth muscle cells by angiotensin II and platelet-derived growth factor. Dependence on calcium and the actin cytoskeleton. J Biol Chem 273:1711-1718
15. Burack WR, Shaw AS (2000) Signal transduction: hanging on a scaffold. Curr Opin Cell Biol 12:211-216
16. Carpenter G (2000) EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. Sci STKE 2000(15):pe1
17. Cheung R, Malik M, Ravyn V et al (2009) An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages. J Leukoc Biol 86:833-845
18. Choi KY, Satterberg B, Lyons DM et al (1994) Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78:499-512
19. Christopoulos A, Kenakin T (2002) G protein-coupled receptor allosterism and complexing. Pharmacol Rev 54:323-374
20. Chun KS, Lao HC, Trempus CS et al (2009) The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. Carcinogenesis 30:1620-1627
21. Coffa S, Breitman M, Hanson SM et al (2011a) The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation. PloS One 6:e28723
22. Coffa S, Breitman M, Spiller BW et al (2011b) A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding. Biochemistry 50:6951-6958
23. Daaka Y, Luttrell LM, Ahn S (1998) Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem 273:685-688
24. Dasgupta P, Rastogi S, Pillai S et al (2006) Nicotine induces cell proliferation by beta-arrestinmediated activation of Src and Rb-Raf-1 pathways. J Clin Invest 116:2208-2217
25. DeFea KA, Zalevsky J, Thoma MS et al (2000a) beta-Arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148:1267-1281
26. DeFea KA, Vaughn ZD, O'Bryan EM et al (2000b) The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestin-dependent scaffolding complex. Proc Natl Acad Sci USA 97:11086-11091
27. Della Rocca GJ, Maudsley SR, Daaka Y et al (1999) Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. J Biol Chem 274:13978-13984
28. DeRooij J, Zwartkruis FL, Verheijen MH et al (1998) Epac is a Rap1 guanine nucleotide exchange factor directly activated by cAMP. Nature 396:474-477
29. DeWire SM, Kim J, Whalen EJ et al (2008) Beta-arrestin-mediated signaling regulates protein synthesis. J Biol Chem 283:10611-10620
30. Dikic I, Tokiwa G, Lev S et al (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547-550
31. Dikic I, Dikic I, Schlessinger J (1998) Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J Biol Chem 273:14301-14308
32. Drake MT, Violin JD, Whalen EJ et al (2008) beta-Arrestin-biased agonism at the beta2-adrenergic receptor. J Biol Chem 283:5669-5676
33. Elorza A, Samago S, Mayor F Jr (2000) Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. Mol Pharmacol 57:778-783
34. Elorza A, Penela P, Sarnago S et al (2003) MAPK-dependent degradation of G protein-coupled receptor kinase 2. J Biol Chem 278:29164-29173
35. Erpel T, Courtneidge SA (1995) Src family protein tyrosine kinases and cellular signal transduction pathways. Curr Opin Cell Biol 7:176-182
36. Fan G, Shumay E, Malbon CC et al (2001) c-Src tyrosine kinase binds the beta2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization. J Biol Chem 276:13240-13247
37. Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53:1-24
38. Fessart D, Simaan M, Laporte SA (2005) c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin-mediated internalization. Mol Endocrinol 19:491-503
39. Fessart D, Simaan M, Zimmerman B et al (2007) Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex. J Cell Sci 120:1723-1732
40. Fong AM, Premont RT, Richardson RM et al (2002) Defective lymphocyte chemotaxis in betaarrestin2-and GRK6-deficient mice. Proc Natl Acad Sci USA 99:7478-7483
41. Freedman NJ, Lefkowitz RJ (1996) Desensitization of G protein-coupled receptors. Recent Prog Horm Res 51:319-351
42. Galandrin S, Bouvier M (2006) Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 70:1575-1584
43. Galet C, Ascoli M (2008) Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells. Cell Signal 20:1822-2829
44. Ge L, Ly Y, Hollenberg M et al (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem 278:34418-34426
45. Ge L, Shenoy SK, Lefkowitz RJ et al (2004) Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and-J Biol Chem 279 55419-55424 breast cancer cells requires both beta-arrestin-1 and-2. J Biol Chem 279:55419-55424
46. Gesty-Palmer D, El Shewy H, Kohout TA et al (2005) beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. J Biol Chem 280:32157-32167
47. Gesty-Palmer D, Chen M, Reiter E et al (2006) Distinct beta-arrestin-and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem 281:10856-10864
48. Gesty-Palmer D, Flannery P, Yuan L et al (2009) A beta-arrestin biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med 1:1ra1
49. Gesty-Palmer D, Liao S, Yuan L et al (2013) beta-Arrestin pathway-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo. Mol Endocrinol 27:296-314
50. Ghalayini AJ, Desai N, Smith KR et al (2002) Light-dependent association of Src with photoreceptor rod outer segment membrane proteins in vivo. J Biol Chem 277:1469-1476
51. Hanson SM, Cleghorn WM, Francis DJ et al (2007) Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J Mol Biol 368:375-387
52. Haskell MD, Slack JK, Parsons JT et al (2001) c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes. Chem Rev 101:2425-2440
53. Hawes BE, van Biesen T, Koch WJ et al (1995) Distinct pathways of Gi-and Gq-mediated mitogen activated protein kinase activation. J Biol Chem 270:17148-17153
54. Heitzler D, Durand G, Gallay N et al (2012) Competing G protein-coupled receptor kinases balance G protein and beta-arrestin signaling. Mol Syst Biol 8:590
55. Holloway AC, Qian H, Pipolo L et al (2002) Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Mol Pharmacol 61:768-777
56. Hunton DL, Barnes WG, Kim J et al (2005) Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol 67:1229-1236
57. Hupfeld CJ, Resnik JL, Ugi S et al (2005) Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors J Biol Chem 280 1016-1023 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem 280:1016-1023
58. Ignatova EG, Belcheva MM, Bohn LM et al (1999) Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence. J Neurosci 19:56-63
59. Imamura T, Huang J, Dalle S et al (2001) beta-Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. J Biol Chem 276:43663-43667
60. Jafri F, El-Shewy HM, Lee MH et al (2006) Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor " signalsome". J Biol Chem 281:19346-19357
61. Kenakin TP (1996) Receptor conformational induction versus selection: All part of the same energy landscape. Trends Pharmacol Sci 17:190-191
62. Kenakin T, Miller LE (2010) Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev 62:265-304
63. Kendall RT, Strungs EG, Rachidi SM et al (2011) The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1, Ile4, Ile8]angiotensin II regulates a robust G protein-independent signaling network. J Biol Chem 286:19880-19891
64. Kim J, Ahn S, Ren XR (2005) Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci USA 102:1442-1447
65. Kim J, Zhang L, Peppel K et al (2008) Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circ Res 103:70-79
66. Kim J, Ahn S, Rajagopal K et al (2009) Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J Biol Chem 284:11953-11962
67. Kohout TA, Nicholas SL, Perry SJ et al (2004) Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J Biol Chem 279:23214-23222
68. Kolch W, Heldecker G, Kochs G et al (1993) Protein kinase C alpha activates Raf-1 by direct phosphorylation. Nature 364:249-255
69. Kryiakis JM, Avruch J (1996) Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 271:24313-24316
70. Kuo F-T, Lu T-L, Fu H-W (2006) Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1. Cell Signal 18:1914-1923
71. Lee M-H, El-Shewy HM, Luttrell DK et al (2008) Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription. J Biol Chem 283:2088-2097
72. Lee SH, Hollingsworth R, Kwon HY et al (2012) beta-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis. Glia 60:1366-1377
73. Lefkowitz RJ, Pierce KL, Luttrell LM (2002) Dancing with different partners: PKA phosphorylation of seven membrane-spanning receptors regulates their G protein coupling specificity. Mol Pharm 62:971-974
74. Lev S, Moreno H, Martinez R et al (1995) Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 376:737-745
75. Li X, Hunter D, Morris J et al (1998) A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. J Biol Chem 273:9361-9364
76. Lin FT, Krueger KM, Kendall HE et al (1997) Clathrin-mediated endocytosis of the betaadrenergic receptor is regulated by phosphorylation/ dephosphorylation of beta-arrestin1. J Biol Chem 272:31051-31057
77. Lin FT, Miller WE, Luttrell LM et al (1999) Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem 274:15971-15974
78. Lin FT, Chen W, Shenoy S et al (2002) Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry 41:10692-10699
79. Liu X, Pawson T (1994) Biochemistry of the Src protein-tyrosine kinase: regulation by SH2 and SH3 domains. Recent Prog Horm Res 49:149-160
80. Luttrell LM (2003) Location, Location, Location. Spatial and temporal regulation of MAP kinases by G protein-coupled receptors. J Mol Endo 30:117-126
81. Luttrell LM, Gesty-Palmer D (2010) Beyond desensitization: physiological relevance of arrestindependent signaling. Pharmacol Rev 62:305-330
82. Luttrell LM, Kenakin TP (2011) Refining efficacy: allosterism and bias in G protein-coupled receptor signaling. Methods Mol Biol 756:3-35
83. Luttrell LM, Lefkowitz RJ (2002) The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115:455-465
84. Luttrell DK, Luttrell LM (2004) Not so strange bedfellows: G-protein-coupled receptors and Src family kinases. Oncogene 23:7969-7978
85. Luttrell LM, Hawes BE, van Biesen T et al (1996) Role of c-Src in G protein-coupled receptor-and Gbetagamma subunit-mediated activation of mitogen activated protein kinases. J Biol Chem 271:19443-19450
86. Luttrell LM, Della Rocca GJ, Van Biesen T et al (1997) Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. J Biol Chem 272:4637-4644
87. Luttrell LM, Ferguson SS, Daaka Y et al (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283:655-661
88. Luttrell LM, Roudabush FL, Choy EW et al (2001) Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci USA 98:2449-2454
89. Machesky LM (1997) Cell motility: complex dynamics at the leading edge. Curr Biol 7: R164-R167 Maudsley S, Martin B, Luttrell LM (2005) Perspectives in pharmacology: the origins of diversity and specificity in G protein-coupled receptor signaling. J Pharmacol Exp Ther 314:485-494
90. McDonald PH, Chow CW, Miller WE et al (2000) Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science 290:1574-1577
91. Meng D, Lynch MJ, Huston E et al (2009) MEK1 binds directly to beta-arrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. J Biol Chem 284:11425-11435
92. Miller WE, Maudsley S, Ahn S et al (2000) Beta-Arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1- dependent targeting of c-SRC in receptor endocytosis. J Biol Chem 275:11312-11319
93. Miller WE, McDonald PH, Cai SF et al (2001) Identification of a motif in the carboxyl terminus of beta-arrestin2 responsible for activation of JNK3. J Biol Chem 276:27770-27777
94. Miura S, Zhang J, Matsuo Y et al (2004) Activation of extracellular signal-activated kinase by angiotensin II-induced Gq-independent epidermal growth factor receptor transactivation. Hypertens Res 27:765-770
95. Mossa O, Ashton AW, Fraig M et al (2008) Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res 68:4097-4104
96. Nobles KN, Guan Z, Xiao K et al (2007) The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and-2. J Biol Chem 282:21370-21381
97. Nobles KN, Xiao K, Ahn S et al (2011) Distinct phosphorylation sites on the ?(2)-adrenergic receptor establish a barcode that encodes differential functions of ?-arrestin. Sci Signal 4:51.
98. Noma T, Lemaire A, Naga Prasad SV et al 2007) Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection J Clin Invest 117 2445-2458
99. Oakley RH, Laporte SA, Holt JA et al (2000) Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 275:17201-17210
100. Ozawa K, Whalen EJ, Nelson CD et al (2008) S-nitrosylation of beta-arrestin regulates betaadrenergic receptor trafficking. Mol Cell 31:395-405
101. Parent JL, Labrecque P, Orsini MJ et al (1999) Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced COOH terminus in agonist-promoted receptor internalization. J Biol Chem 274:8941-8948
102. Pearson G, Robinson F, Beers G. T et al (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiologic functions. Endocr Rev 22:153-183
103. Penela P, Elorza A, Sarnago S et al (2001) Beta-arrestin-and c-Src-dependent degradation of G-protein-coupled receptor kinase 2. EMBO J 20:5129-5138
104. Pierce KL, Luttrell LM, Lefkowitz RJ (2001a) New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539
105. Pierce KL, Tohgo A, Ahn S et al (2001b) Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. J Biol Chem 276:23155-23160
106. Pitcher JA, Tesmer JG, Freeman JL et al (1999) Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem 274:34531-34534
107. Prenzel N, Zwick E, Daub H et al (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888
108. Ren XR, Reiter E, Ahn S et al (2005) Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci USA 102:1448-1453
109. Ross EM, Wilkie TM (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795-827
110. Samama P, Cotecchia S, Costa T et al (1993) A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4636
111. Sarnago S, Elorza A, Mayor F Jr (1999) Agonist-dependent phosphorylation of the G proteincoupled receptor kinase 2 (GRK2) by Src tyrosine kinase. J Biol Chem 274:34411-34416
112. Scott MG, Le Rouzic E, Perianin A et al (2002) Differential nucleocytoplasmic shuttling of betaarrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2. J Biol Chem 277:37693-37701
113. Scott MG, Pierotti V, Storez H et al (2006) Cooperative regulation of extracellular signalregulated kinase activation and cell shape change by filamin A and beta-arrestins. Mol Cell Biol 26:3432-3445
114. Seo J, Tsakem EL, Breitman M et al (2011) Identification of arrestin-3-specific residues necessary for JNK3 kinase activation. J Biol Chem 286:27894-27901
115. Seta K, Nanamori M, Modrall JG et al (2002) AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol Chem 277:9268-9277
116. Shenoy SK (2007) Seven-transmembrane receptors and ubiquitination. Circ Res 100:1142-1154
117. Shenoy SK, Lefkowitz RJ (2003) Trafficking pattern of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem 278:14498-14506
118. Shenoy SK, Lefkowitz RJ (2005) Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem 280:15315-15324
119. Shenoy SK, McDonald PH, Kohout TA et al (2001) Regulation of receptor fate by ubiquitination of activated beta2-adrenergic receptor and beta-arrestin. Science 294:1307-1313
120. Shenoy SK, Drake MT, Nelson CD et al (2006) beta-Arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem 281:1261-1273
121. Shenoy SK, Barak LS, Xiao K et al (2007) Ubiquitination of beta-arrestin links seventransmembrane receptor endocytosis and ERK activation. J Biol Chem 282:29549-29562
122. Shenoy SK, Xiao K, Venkataramanan V et al (2008) Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem 283:22166-22176
123. Shenoy SK, Modi AS, Shukla AK et al (2009) Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci USA 106:6650-6655
124. Shukla AK, Violin JD, Whalen EJ et al (2008) Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proc Natl Acad Sci USA 105:9988-9993
125. Song X, Raman D, Gurevich EV et al (2006) Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm. J Biol Chem 281:21491-21499
126. Song X, Coffa S, Fu H et al (2009) How does arrestin assemble MAPKs into a signaling complex? J Biol Chem 284:685-695
127. Stoffel RH III, Pitcher JA, Lefkowitz RJ (1997) Targeting G protein-coupled receptor kinases to their receptor substrates. J Membr Biol 157:1-8
128. Stokoe D, Macdonald SG, Cadwallader K et al (1994) Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1467
129. Stork PJ (2002) ERK signaling: duration, duration, duration. Cell Cycle 1:315-317
130. Sullivan SK, McGrath DA, Grigoriadis D et al (1999) Pharmacological and signaling analysis of human chemokine receptor CCR-7 stably expressed in HEK-293 cells: high-affinity binding of recombinant ligands MIP-3beta and SLC stimulates multiple signaling cascades Biochem Biophys Res Commun 263 685-690 cells: high-affinity binding of recombinant ligands MIP-3beta and SLC stimulates multiple signaling cascades. Biochem Biophys Res Commun 263:685-690
131. Superti,Furga G Courtneidge SA (1995) Structure-function relationships in Src family and related protein tyrosine kinases. Bioessays 17:321-330
132. Talbot J, Joly E, Prentki M et al (2012) Beta-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic ? INS832/13 cells. Mol Cell Endocrinol 364:65-70
133. Terrillon S, Bouvier M (2004) Receptor activity-independent recruitment of beta-arrestin2 reveals specific signalling modes. EMBO J 23:3950-3961
134. Tohgo A, Pierce KL, Choy EW et al (2002) beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem 277:9429-9436
135. Tohgo A, Choy EW, Gesty-Palmer D et al (2003) The stability of the G protein-coupled receptorbeta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 278:6258-6267
136. Van Biesen T, Hawes BE, Luttrell DK et al (1995) Receptor tyrosine kinase-and Gbetagammamediated MAP kinase activation by a common signalling pathway. Nature 376:781-784
137. Vossler MR, Yao H, York RD et al (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf-and Rap-1-dependent pathway. Cell 89:73-82
138. Wang Y, Tang Y, Teng L et al (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7:139-147
139. Wei H, Ahn S, Shenoy SK et al (2003) Independent G protein and beta-arrestin2 mediated activation of ERK by angiotensin. Proc Natl Acad Sci USA 100:10782-10787
140. Werbonat Y, Kleutges N, Jakobs KH et al (2000) Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors. J Biol Chem 275:21969-21974
141. Whalen EJ, Rajagopal S, Lefkowitz RJ (2011) Therapeutic potential of ?-arrestin-and G proteinbiased agonists. Trends Mol Med 17:126-139
142. Whitmarsh AJ, Cavanagh J, Tournier C et al (1998) A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281:1671-1674
143. Wisler JW, DeWire SM, Whalen EJ et al (2007) A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci USA 104:16657-16662
144. Wu J, Dent P, Jelinek T et al (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate. Science 62:1065-1068
145. Xiao K, Shenoy SK, Nobles K et al (2004) Activation-dependent conformational changes in betaarrestin 2. J Biol Chem 279:55744-55753
146. Xiao K, Sun J, Kim J et al (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci USA 107:15299-15304
147. Zidar DA, Violin JD, Whalen EJ et al (2009) Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci USA 106:9649-9654
148. Zimmerman B, Simaan M, Lee M-H et al (2009) C-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cell Signal 21:103-110
149. Zoudilova M, Kumar P, Ge L et al (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem 282:20634-20646