Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 9988-9993

  Shukla, Arun K ^a   Violin, Jonathan D ^a   Whalen, Erin J ^a   Gesty Palmer, Diane ^a   Shenoy, Sudha K ^a   Lefkowitz, Robert J ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NONE   (United States)

Author keywords

7TMRS; BRET; Phosphorylation

Indexed keywords

BETA ARRESTIN; BETA ARRESTIN 2; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MEMBRANE RECEPTOR;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BIOSENSOR; CONFORMATIONAL TRANSITION; MUTANT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ARRESTINS; BIOPHYSICS; BIOSENSING TECHNIQUES; CELLS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN CONFORMATION; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS;

EID: 48249126790     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804246105     Document Type: Article

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