A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding

Biochemistry

Volumn 50, Issue 32, 2011, Pages 6951-6958

  Coffa, Sergio ^a   Breitman, Maya ^a   Spiller, Benjamin W ^a   Gurevich, Vsevolod V ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; ALANINE-SCANNING MUTAGENESIS; ARRESTINS; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; G PROTEIN COUPLED RECEPTORS; KNOCKOUT MICE; MOLECULAR MECHANISM; PHOSPHORYLATED RECEPTORS; SIDE-CHAINS; SIGNALING CASCADES; SINGLE MUTATION; WILD TYPES;

AMINO ACIDS; CELL CULTURE; ENZYME ACTIVITY; MAMMALS; PHOSPHORYLATION; SIGNALING;

CRYSTAL STRUCTURE;

BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SCAFFOLD PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FIBROBLAST; KNOCKOUT MOUSE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ARRESTINS; BLOTTING, WESTERN; CELL LINE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMUNOPRECIPITATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-RAF;

EID: 80051498152     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200745k     Document Type: Article

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