Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells

Xenobiotica

Volumn 46, Issue 5, 2016, Pages 393-405

  Shang, Wei ^a   Liu, Jie ^a   Chen, Ruini ^a   Ning, Rui ^a   Xiong, Jing ^a   Liu, Wei ^a   Mao, Zhao ^a   Hu, Gang ^a   Yang, Jian ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Carboxylesterase1 and 2 (CES1 and CES2); cytochrome P450 3A4 (CYP450); differentiated embryonic chondrocyte expressed gene 1 (DEC1); fluoxetine (FLX); pregnane X receptor (PXR)

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 1; CARBOXYLESTERASE 2; CYTOCHROME P450 3A4; DIFFERENTIATED EMBRYONIC CHONDROCYTE EXPRESSED GENE 1; FLUOXETINE; PEPTIDES AND PROTEINS; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG; CES1 PROTEIN, HUMAN; CES2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; DEC1 PROTEIN, HUMAN; STEROID RECEPTOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; RNA INTERFERENCE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEP-G2 CELL LINE; HYDROLYSIS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CYTOCHROME P-450 CYP3A; FLUOXETINE; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; HYDROLYSIS; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84958107314     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2015.1082209     Document Type: Article

References (49)

1. Alvarado-Esquivel C, Sifuentes-Alvarez A, Salas-Martinez C. (2015). Depression in teenager pregnant women in a public hospital in a northern mexican city: prevalence and correlates. J Clin Med Res 7: 525-33
2. Alwon BM, Solomon G, Hussain F, Wright DJ. (2015). A detailed analysis of online pharmacy characteristics to inform safe usage by patients. Int J Clin Pharm 37: 148-58
3. Antolino-Lobo I, Meulenbelt J, Nijmeijer SM, et al. (2011). 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. Toxicol Lett 203: 82-91
4. Banerjee M, Chen T. (2014). Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1. Biochem Pharmacol 92: 389-402
5. Ben-Moshe Z, Alon S, Mracek P, et al. (2014). The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Nucleic Acids Res 42: 3750-67
6. Boudjelal M, Taneja R, Matsubara S, et al. (1997). Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev 11: 2052-65
7. Chang TK. (2009). Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines. AAPS J 11: 590-601
8. Cho Y, Noshiro M, Choi M, et al. (2009). The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 76: 1360-9
9. DeVane CL, Donovan JL, Liston HL, et al. (2004). Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers. J Clin Psychopharmacol 24: 4-10
10. Feng XM, Xiong J, Qin H, et al. (2012). Fluoxetine induces hepatic lipid accumulation via both promotion of the SREBP1c-related lipogenesis and reduction of lipolysis in primary mouse hepatocytes. CNS Neurosci Ther 18: 974-80
11. Fujimoto K, Shen M, Noshiro M, et al. (2001). Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun 280: 164-71
12. Goodwin B, Moore JT. (2004). CAR: detailing new models. Trends Pharmacol Sci 25: 437-41
13. Guengerich FP. (1999). Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39: 1-17
14. Haduch A, Wojcikowski J, Daniel WA. (2006). The effect of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and newer antidepressant drugs on the activity and level of rat CYP3A. Eur Neuropsychopharmacol. 16: 178-86
15. Iizuka K, Horikawa Y. (2008). Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping. Biochem Biophys Res Commun 374: 95-100
16. Ko KW, Erickson B, Lehner R. (2009). Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes. Biochimica et biophysica acta 1791: 1133-43
17. Krasowski MD, Ni A, Hagey LR, Ekins S. (2011). Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol 334: 39-48
18. Kullak-Ublick GA, Stieger B, Meier PJ. (2004). Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126: 322-42
19. Lin JH, Lu AY. (2001). Interindividual variability in inhibition and induction of cytochrome P450 enzymes. Annu Rev Pharmacol Toxicol 41: 535-67
20. Liu FJ, Song X, Yang D, et al. (2008). The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. Biochem J 409: 243-50
21. Lopez AD, Mathers CD, Ezzati M, et al. (2006). Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367: 1747-57
22. Lutz JD, VandenBrink BM, Babu KN, et al. (2013). Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems. Drug Metab Dispos. 41: 2056-65
23. Mao Z, Luan X, Cao G, et al. (2012). DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol 84: 701-11
24. Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, et al. (2013). CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. J Exp Med 210: 1603-19
25. Nelson MH, Birnbaum AK, Remmel RP. (2001). Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors. Epilepsy Res 44: 71-82
26. Nishi K, Huang H, Kamita SG, et al. (2006). Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys 445: 115-23
27. Orsolini L, Bellantuono C. (2015). Serotonin reuptake inhibitors and breastfeeding: a systematic review. Hum Psychopharmacol 30: 4-20
28. Parkinson A. (2001). Biotransformation of xenobiotics, in the Casarett and Doull's toxicology. In: Klaassen CD., ed. The basic science of poisons. New York: McGraw-Hill Companies. 139-62
29. Pondugula SR, Flannery PC, Apte U, et al. (2015). Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediatedcytochrome p450 3A4 gene expression. Drug Metab Dispos 43: 385-91
30. Poso A, Honkakoski P. (2006). Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies. Mini Rev Med Chem 6: 937-47
31. Raeder MB, Ferno J, Glambek M, et al. (2006). Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett 395: 185-90
32. Roques BB, Leghait J, Lacroix MZ, et al. (2013). The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism. Biochem Pharmacol 86: 997-1039
33. Satoh T, Hosokawa M. (2006). Structure, function and regulation of carboxylesterases. Chemico-Biol Interact 162: 195-211
34. Shen M, Yoshida E, Yan W, et al. (2002). Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. J Biol Chem 277: 50112-20
35. Shi D, Yang J, Yang D, et al. (2006). Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. J Pharmacol Exp Ther 319: 1477-84
36. Shou M, Hayashi M, Pan Y, et al. (2008). Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction. Drug Metab Dispos 36: 2355-70
37. Sivertsson L, Edebert I, Palmertz MP, et al. (2013). Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation. Mol Pharmacol 83: 659-70
38. Spina E, Avenoso A, Scordo MG, et al. (2002). Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction. J Clin Psychopharmacol 22: 419-23
39. Stamou M, Wu X, Kania-Korwel I, et al. (2014). Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependentdifferences. Drug Metab Dispos 42: 239-44
40. Staudinger JL, Xu C, Cui YJ, Klaassen CD. (2010). Nuclear receptor-mediated regulation of carboxylesterase expression and activity. Expert Opin Drug Metab Toxicol 6: 261-71
41. Tang M, Mukundan M, Yang J, et al. (2006). Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol Exp Ther 319: 1467-76
42. Thomsen R, Rasmussen HB, Linnet K. (2014). In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors. Drug Metab Dispos 42: 126-33
43. Tian D, Hu Z. (2014). CYP3A4-mediated pharmacokinetic interactions in cancer therapy. Curr Drug Metab 15: 808-17
44. Werk AN, Cascorbi I. (2014). Functional gene variants of CYP3A4. Clin Pharmacol Ther 96: 340-8
45. Wu MH, Yan B, Humerickhouse R, Dolan ME. (2002). Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells. Clin Cancer Res 8: 2696-700
46. Xiao D, Chen YT, Yang D, Yan B. (2012). Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation. Biochem Pharmacol 84: 232-9
47. Yang J, Yan B. (2007). Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci 95: 13-22
48. Yang J, Hao C, Yang D, et al. (2010). Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes. Toxicol Lett 197: 219-26
49. Yang D, Pearce RE, Wang X, et al. (2009). Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem Pharmacol 77: 238-47