Mg2+/Mn2+-dependent phosphatase 1a is involved in regulating pregnane X receptor'mediated cytochrome p450 3A4 gene expression

Drug Metabolism and Disposition

Volumn 43, Issue 3, 2015, Pages 385-391

  Pondugula, Satyanarayana R ^a   Flannery, Patrick C ^a   Apte, Udayan ^d   Babu, Jeganathan Ramesh ^a   Geetha, Thangiah ^b   Rege, Shraddha D ^a   Chen, Taosheng ^c   Abbott, Kodye L ^a  

^a AUBURN UNIVERSITY   (United States)

^b AUBURN UNIVERSITY AT MONTGOMERY   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; MAGNESIUM MANGANESE DEPENDENT PHOSPHATASE 1A; PREGNANE X RECEPTOR; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE; CYTOCHROME P450 3A; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PHOSPHATASE 2C; STEROID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOCHROME P450 3A4 GENE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SILENCING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER REGENERATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENE EXPRESSION; GENETICS; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METABOLISM; PROMOTER REGION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIN-DEPENDENT KINASES; CYTOCHROME P-450 CYP3A; DOWN-REGULATION; GENE EXPRESSION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; PHOSPHOPROTEIN PHOSPHATASES; PROMOTER REGIONS, GENETIC; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84921759817     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.062083     Document Type: Article

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